Bin Wang, Jiawei Pei, Hui Zhang, Jia Li, Yamei Dang, He Liu, Yuan Wang, Liang Zhang, Libin Qi, Yuewu Yang, Linfeng Cheng, Yangchao Dong, Airong Qian, Zhikai Xu, Yingfeng Lei, Fanglin Zhang, Wei Ye
Hantaviruses, the causative agent for two types of hemorrhagic fevers, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), are distributed from Eurasia to America. HFRS and HPS have mortality rates of up to 15% or 45%, respectively. Currently, no certified therapeutic has been licensed to treat hantavirus infection. In this study, we discovered that benidipine hydrochloride, a calcium channel blocker, inhibits the entry of hantaviruses in vitro . Moreover, an array of calcium channel inhibitors, such as cilnidipine, felodipine, amlodipine, manidipine, nicardipine, and nisoldipine, exhibit similar antiviral properties...
2022: Frontiers in Pharmacology