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https://www.readbyqxmd.com/read/29245181/revealing-a-new-mode-of-sensitization-induced-by-mechanical-circulatory-support-devices-impact-of-anti-at1-r-antibodies
#1
X Zhang, J Mirocha, T Aintablian, S Dimbil, J Moriguchi, F Arabia, J A Kobashigawa, N L Reinsmoen
BACKGROUND: Increased levels of angiotensin II type 1 receptor (AT1 R) antibody have been shown to be associated with allograft rejection. This study aims to determine the rate of development of antibody to AT1 R after Mechanical Circulatory Support Device (MCS) implantation, and if development of strong binding AT1 R antibodies is associated with survival. METHODS: 88 patients who had one MCS implantation were accessed based on serum availability. MCS in this cohort included pneumatic bilateral paracorporeal ventricular assist device, continuous flow left ventricular assist device, and total artificial heart...
December 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29245173/patient-perception-of-disease-related-symptoms-and-complications-in-relapsing-polychondritis
#2
Marcela A Ferrada, Peter C Grayson, Shubhasree Banerjee, Keith Sikora, Robert Colbert, Ninet Sinaii, James D Katz
OBJECTIVE: To assess patient-reported symptoms and burden of disease in relapsing polychondritis (RP). METHODS: Patients with RP completed a disease-specific online survey to identify symptoms attributed to illness. Patients were divided into subgroups based upon presence or absence of ear/nose, airway, or joint involvement. Pathway to diagnosis, treatment, and disease-related complications were assessed within each subgroup. RESULTS: Data from 304 respondents were included in this analysis...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245172/comment-on-how-fetal-growth-restriction-and-preterm-birth-affects-cardiac-morphology-and-function-during-infancy
#3
P P Bassareo, G Mercuro
We read with great interest the recent paper by Cohen et al regarding the early morphological and functional changes induced by intrauterine growth restriction on the heart and detected during echocardiography(1). In particular, the authors found increases in left ventricular sphericity and posterior and relative wall thicknesses. They also noted that the diastolic function, measured with tissue Doppler imaging, dropped. This article is protected by copyright. All rights reserved.
December 15, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29245168/-school-entrance-examination-for-lateral-entrants-what-can-and-what-should-they-be-able-to-do-a-discussion-contribution-based-on-the-data-from-the-health-authority-frankfurt-am-main-2006-2016
#4
Maria Karathana, Bernhard Krackhardt, Manuela Schade, Ursel Heudorf
Question The medical investigation of school beginners is one of the essential tasks of the child and youth services of the health authorities. While in all federal states in Germany, the examination of all school beginners is legally clearly stipulated, the situation for "lateral entry", that is, children of school age, who are moving from a foreign country to a local German community and attending school there, is not clearly regulated in the respective school laws. This article presents the experiences of the lateral entry investigations in Frankfurt am Main...
December 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29245153/catheter-ablation-of-focal-atrial-tachycardia-using-remote-magnetic-navigation
#5
Xiao-Yu Liu, Peter Karl Jacobsen, Steen Pehrson, Xu Chen
OBJECTIVES: The outcomes of catheter ablation in focal atrial tachycardia (AT) using remote magnetic navigation (RMN) are still controversial. The objectives of this study were to assess the acute and long-term outcomes of catheter ablation in focal AT using RMN. BACKGROUND: A total of 53 patients with focal AT who underwent catheter ablation using RMN were included. Thirty-six patients had structural heart disease, including previous atrial fibrillation ablation and heart surgery (abnormal group), and the remaining 17 patients had no structural heart disease (normal group)...
December 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29245138/cardiac-sarcoidosis-presenting-as-arrhythmogenic-right-ventricular-cardiomyopathy-dysplasia-with-ventricular-aneurysms-a-case-report
#6
Marija Petrovic, L Maximilian Buja, Biswajit Kar, Jure Colnaric, Sarita Damaraju, Bihong Zhao, Bindu Akkanti, Milan Radovanovic, Rajko Radovancevic, Pranav Loyalka, Igor D Gregoric
A 70-year old Caucasian man with recurrent ventricular tachycardia and progressive biventricular failure attributed to arrhythmogenic right ventricular cardiomyopathy/dysplasia was evaluated for heart transplantation. Cardiac ventriculography revealed an abnormal left ventricle with five saccular aneurysms. Heart transplantation was performed. Pathology of the explanted heart showed multifocal sarcoid granulomas. Replacement fibrosis was widespread in both ventricles and associated with saccular aneurysms. No genetic basis was identified...
November 10, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29244836/energy-compensation-after-sprint-and-high-intensity-interval-training
#7
Matthew M Schubert, Elyse Palumbo, Rebekah F Seay, Katie K Spain, Holly E Clarke
BACKGROUND: Many individuals lose less weight than expected in response to exercise interventions when considering the increased energy expenditure of exercise (ExEE). This is due to energy compensation in response to ExEE, which may include increases in energy intake (EI) and decreases in non-exercise physical activity (NEPA). We examined the degree of energy compensation in healthy young men and women in response to interval training. METHODS: Data were examined from a prior study in which 24 participants (mean age, BMI, & VO2max = 28 yrs, 27...
2017: PloS One
https://www.readbyqxmd.com/read/29244818/postural-control-during-quiet-bipedal-standing-in-rats
#8
Tetsuro Funato, Yota Sato, Soichiro Fujiki, Yamato Sato, Shinya Aoi, Kazuo Tsuchiya, Dai Yanagihara
The control of bipedal posture in humans is subject to non-ideal conditions such as delayed sensation and heartbeat noise. However, the controller achieves a high level of functionality by utilizing body dynamics dexterously. In order to elucidate the neural mechanism responsible for postural control, the present study made use of an experimental setup involving rats because they have more accessible neural structures. The experimental design requires rats to stand bipedally in order to obtain a water reward placed in a water supplier above them...
2017: PloS One
https://www.readbyqxmd.com/read/29244812/optimal-occlusion-uniformly-partitions-red-blood-cells-fluxes-within-a-microvascular-network
#9
Shyr-Shea Chang, Shenyinying Tu, Kyung In Baek, Andrew Pietersen, Yu-Hsiu Liu, Van M Savage, Sheng-Ping L Hwang, Tzung K Hsiai, Marcus Roper
In animals, gas exchange between blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood cell. Red blood cells must deform to squeeze through these narrow vessels, transiently blocking or occluding the vessels they pass through. Although the dynamics of vessel occlusion have been studied extensively, it remains an open question why microvessels need to be so narrow. We study occlusive dynamics within a model microvascular network: the embryonic zebrafish trunk. We show that pressure feedbacks created when red blood cells enter the finest vessels of the trunk act together to uniformly partition red blood cells through the microvasculature...
December 15, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29244798/amplitude-integrated-electroencephalography-during-the-first-72-hours-after-birth-in-neonates-diagnosed-prenatally-with-congenital-heart-disease
#10
Mirthe J Mebius, Nathalie J E Oostdijk, Sara J Kuik, Arend F Bos, Rolf M F Berger, Caterina M Bilardo, Elisabeth M W Kooi, Hendrik J Ter Horst
BACKGROUND: Little is known on amplitude-integrated electroencephalography (aEEG) during the first days after birth in neonates with CHD. Our aim was, therefore, to assess electro-cortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG. METHODS: Neonates with CHD that were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244793/effects-of-epinephrine-on-hemodynamic-changes-during-cardiopulmonary-resuscitation-in-a-neonatal-piglet-model
#11
Michael Wagner, Po-Yin Cheung, Elliott S Li, Tze-Fun Lee, Min Lu, Megan O'Reilly, Monika Olischar, Georg M Schmölzer
BACKGROUND: Asphyxia is the most common reason for newborns to fail to make a successful fetal to neonatal transition. There is currently a lack of data evaluating hemodynamic effects of epinephrine during neonatal cardiopulmonary resuscitation. METHODS: Twenty-four newborn piglets were exposed to asphyxia. Thereafter, positive pressure ventilation was commenced for 30 s, followed by chest compressions (CC). Piglets were randomized into three experimental groups: 3:1 compression:ventilation ratio; CC during sustained inflation (SI) at a rate of 90 CC per minute, or CC during SI at a rate of 120 CC per minute...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244649/big-heart-small-ring
#12
Igor Kravets
No abstract text is available yet for this article.
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29244648/diagnostic-value-of-the-physical-examination-in-patients-with-dyspnea
#13
REVIEW
Richard A Shellenberger, Bathmapriya Balakrishnan, Sindhu Avula, Ariadne Ebel, Sufiya Shaik
We reviewed the evidence for the diagnostic accuracy of the physical examination in diagnosing pneumonia, pleural effusion, chronic obstructive pulmonary disease, and congestive heart failure in patients with dyspnea and found that the physical examination has reliable diagnostic accuracy for these common conditions.
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29244531/effects-of-natural-peptides-from-food-proteins-on-angiotensin-converting-enzyme-activity-and-hypertension
#14
Melanie Martin, Andreas Deussen
Cardiovascular diseases are the leading cause of death. The underlying pathophysiology is largely contributed by an overactivation of the renin-angiotensin-aldosterone-system (RAAS). Herein, angiotensin II (AngII) is a key mediator not only in blood pressure control and vascular tone regulation, but also involved in inflammation, endothelial dysfunction, atherosclerosis, hypertension and congestive heart failure. Since more than three decades suppression of AngII generation by inhibition of the angiotensin-converting enzyme (ACE) or blockade of the AngII-receptor has shown clinical benefit by reducing hypertension, atherosclerosis and other inflammation-associated cardiovascular diseases...
December 15, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29244228/high-resolution-hyperpolarized-metabolic-imaging-of-the-rat-heart-using-k-t-pca-and-k-t-sparse
#15
Patrick Wespi, Jonas Steinhauser, Grzegorz Kwiatkowski, Sebastian Kozerke
No abstract text is available yet for this article.
December 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29244161/the-impact-of-coronary-anomalies-on-the-outcome-in-aortic-valve-surgery-comparison-of-bicuspid-aortic-valve-versus-tricuspid-aortic-valve-morphotype
#16
Shiho Naito, Johannes Petersen, Hermann Reichenspurner, Evaldas Girdauskas
OBJECTIVES: The association of anomalous anatomy of coronary arteries and bicuspid aortic valve (BAV) has been sporadically reported. Our aim was to evaluate the prevalence of coronary anomalies between BAV and tricuspid aortic valve (TAV) and to analyse their impact on major adverse cardiac events during and after aortic valve surgery. METHODS: A total of 1099 consecutive patients who received preoperative coronary evaluation and elective aortic valve replacement/repair between January 2013 and July 2016 at our institution were involved...
December 12, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29244159/pre-clinical-model-of-severe-glutathione-peroxidase-3-deficiency-and-chronic-kidney-disease-results-in-coronary-artery-thrombosis-and-depressed-left-ventricular-function
#17
Paul Pang, Molly Abbott, Malyun Abdi, Quynh-Anh Fucci, Nikita Chauhan, Murti Mistri, Brandon Proctor, Matthew Chin, Bin Wang, Wenqing Yin, Tzong-Shi Lu, Arvin Halim, Kenneth Lim, Diane E Handy, Joseph Loscalzo, Andrew M Siedlecki
Background: Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease in the presence of chronic kidney disease due to an accumulation of reactive oxygen species and decreased microvascular perfusion of the myocardium. Methods: To isolate the exclusive effect of GPx3 deficiency in kidney disease-induced cardiac disease, we studied the GPx3 knockout mouse strain (GPx3-/-) in the setting of surgery-induced CKD...
December 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29244142/an-autofluorescence-based-method-for-the-isolation-of-highly-purified-ventricular-cardiomyocytes
#18
Veronica Larcher, Paolo Kunderfranco, Marco Vacchiano, Pierluigi Carullo, Marco Erreni, Irene Salamon, Federico Simone Colombo, Enrico Lugli, Marta Mazzola, Achille Anselmo, Gianluigi Condorelli
Aims: The aim of our study was to set up a simple and reliable isolation method of living ventricular cardiomyocytes (vCMs) for molecular and biological studies. Methods: A standard technique for the retrograde perfusion of an enzymatic solution was used to isolate cardiac cells from adult mouse heart. Fluorescence-activated cell sorting (FACS) on adult murine cardiac ventricle cells was performed, comparing the intrinsic autofluorescence in the FITC channel and the forward scatter (FSC) parameter in order to isolate highly fluorescent cells...
December 13, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29244075/the-athlete-s-heart-is-a-proarrhythmic-heart-and-what-that-means-for-clinical-decision-making
#19
Hein Heidbuchel
Recurring questions when dealing with arrhythmias in athletes are about the cause of the arrhythmia and, more importantly, about the eligibility of the athlete to continue sports activities. In essence, the relation between sports and arrhythmias can be understood along three lines: sports as arrhythmia trigger on top of an underlying problem, sports as arrhythmic substrate promotor, or sports as substrate inducer. Often, there is no sharp divider line between these entities. The athlete's heart, a heart that adapts so magically to cope with the demands of exercise, harbours many structural and functional changes that by themselves predispose to arrhythmia development, at the atrial, nodal and ventricular levels...
December 13, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29244074/the-heart-regulates-the-endocrine-response-to-heart-failure-cardiac-contribution-to-circulating-neprilysin
#20
Mattia Arrigo, Nicolas Vodovar, Hélène Nougué, Malha Sadoune, Chris J Pemberton, Pamela Ballan, Pierre-Olivier Ludes, Nicolas Gendron, Alain Carpentier, Bernard Cholley, Philippe Bizouarn, Alain Cohen-Solal, Jagmeet P Singh, Jackie Szymonifka, Christian Latremouille, Jane-Lise Samuel, Jean-Marie Launay, Julien Pottecher, A Mark Richards, Quynh A Truong, David M Smadja, Alexandre Mebazaa
Aims: Heart failure (HF) is accompanied by major neuroendocrine changes including the activation of the natriuretic peptide (NP) pathway. Using the unique model of patients undergoing implantation of the CARMAT total artificial heart and investigating regional differences in soluble neprilysin (sNEP) in patients with reduced or preserved systolic function, we studied the regulation of the NP pathway in HF. Methods and results: Venous blood samples from two patients undergoing replacement of the failing ventricles with a total artificial heart were collected before implantation and weekly thereafter until post-operative week 6...
December 13, 2017: European Heart Journal
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