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JOURNAL ARTICLE
Semil Selcen Gocmez, Nejat Gacar, Tijen Utkan, Gulcin Gacar, Philip J Scarpace, Nihal Tumer
Resveratrol, a polyphenol phytoalexine, has been shown to play a neuroprotective role in the neurodegenerative process in Alzheimer's disease (AD) and improve memory function in dementia. However, the in vivo effect of resveratrol in normal aging models of learning and memory has not yet been evaluated. Therefore, the present neurobehavioral study was undertaken to evaluate the effect of resveratrol on cognitive impairment induced by aging in passive avoidance and Morris water maze (MWM) tests. Male Wistar albino rats were divided into four groups: young control (4month), young resveratrol (4month+RESV), old control (24month) and old resveratrol (24month+RESV)...
May 2016: Neurobiology of Learning and Memory
#22
JOURNAL ARTICLE
Yun-Sung Lim, Seong Keun Kwon, Joo Hyun Park, Chang Gun Cho, Seok-Won Park, Woo Kyung Kim
OBJECTIVES/HYPOTHESIS: Oral ulcers are very common and can compromise the quality of life of patients with pain. The objective of this study was to evaluate mucosal healing with curcumin in an animal oral ulcer model. STUDY DESIGN: Experimental study. METHODS: Twenty New Zealand white rabbits were used. Round filter paper 6 mm in diameter was soaked with 15 μl 50% acetic acid and applied over the upper labial gingiva, creating a uniform circular ulcer...
February 2016: Laryngoscope
#23
JOURNAL ARTICLE
Nihat Akbulut, E Sebnem Kursun, M Kemal Tumer, Kivanc Kamburoglu, Ugur Gulsen
OBJECTIVE: To evaluate the safety and efficacy of an 810-nm diode laser for treatment of benign oral soft tissue lesions. MATERIALS AND METHODS: Treatment with the 810-nm diode laser was applied to a group of eighteen patients with pathological frenulum and epulis fissuratum; five patients with oral lichen planus, oral leukoplakia, and mucous membrane pemphigoid; and four patients with pyogenic granuloma. RESULTS: Although the conventional surgery wound heals in a fairly short time, in the present study, the simple oral soft tissue lesions healed within two weeks, the white and vesiculobullous lesions healed completely within six weeks, and the pyogenic granuloma lesions healed within four weeks...
April 2013: European Journal of Dentistry
#24
MULTICENTER STUDY
Hakan Erdem, Nazif Elaldi, Nefise Öztoprak, Gonul Sengoz, Oznur Ak, Selcuk Kaya, Asuman Inan, Saygın Nayman-Alpat, Ayşegül Ulu-Kilic, Abdullah Umut Pekok, Alper Gunduz, Mustafa G Gozel, Filiz Pehlivanoglu, Kadriye Yasar, Hava Yılmaz, Mustafa Hatipoglu, Gonul Cicek-Senturk, Fusun Z Akcam, Ahmet C Inkaya, Esra Kazak, Ayşe Sagmak-Tartar, Recep Tekin, Derya Ozturk-Engin, Yasemin Ersoy, Oguz Resat Sipahi, Tumer Guven, Gunay Tuncer-Ertem, Selma Alabay, Ayhan Akbulut, Ilker I Balkan, Oral Oncul, Birsen Cetin, Saim Dayan, Gulden Ersoz, Ahmet Karakas, Nail Ozgunes, Alper Sener, Aysegul Yesilkaya, Ayse Erturk, Sibel Gundes, Oguz Karabay, Fatma Sirmatel, Selma Tosun, Vedat Turhan, Aysun Yalci, Yasemin Akkoyunlu, Emsal Aydın, Husrev Diktas, Sukran Kose, Asim Ulcay, Derya Seyman, Umit Savasci, Hakan Leblebicioglu, Haluk Vahaboglu
BACKGROUND: The aim of this study was to delineate mortality indicators in pneumococcal meningitis with special emphasis on therapeutic implications. METHODS: This retrospective, multicenter cohort study involved a 15-year period (1998-2012). Culture-positive cases (n=306) were included solely from 38 centers. RESULTS: Fifty-eight patients received ceftriaxone plus vancomycin empirically. The rest were given a third-generation cephalosporin alone...
February 2014: International Journal of Infectious Diseases: IJID
#25
JOURNAL ARTICLE
Seda Savranoglu, Tugba Boyunegmez Tumer
Spirulina platensis (SP) has been considered as potential food source of 21st century due to its remarkable nutrient profile and therapeutic benefits. However, the cytochrome P450 (CYP)-mediated drug/chemical interaction potential of SP has not yet been pursued. We investigated the effects of SP on the expressions and enzymatic activities of main CYP isozymes. After the rats were orally administered with SP daily for 5 consecutive weeks, there were significant downregulations in hepatic expression levels and inhibition in enzymatic activities of CYP1A2 and CYP2E1 compared to controls...
September 2013: International Journal of Toxicology
#26
JOURNAL ARTICLE
Fatih Ezgu, Sara Senaca, Mehmet Gunduz, Leyla Tumer, Alev Hasanoglu, Ulku Tiras, Rukiye Unsal, Sevcan A Bakkaloglu
Very early onset Toni-Debré-Fanconi Syndrome, a disorder of proximal renal tubules of the kidney which results in the increased urinary excretion of glucose, amino acids, uric acid, phosphate and bicarbonate, could be the manifestation of various inborn errors. Defects of oxidative phosphorylation are a heterogeneous group of disorders with various clinical presentations. Recently, patients with early liver failure, renal tubulopathy and encephalopathy due to the mutations in the BCS1L gene coding for a structural protein in mitochondrial complex III have been described...
October 10, 2013: Gene
#27
Diana Cimpoesu, Lucian Stoica, Anda Paulet, Antoniu Petris
SESSION TYPE: Critical Care Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: The incidence of cardiac involvement among patients with hydatid disease is 0.5-3%, and a pericardial site of implantation is even less common [3]. Severe complications impose a prompt diagnosis and treatment in ED. The management is very critical and time-dependent if the patient develops an anaphylactic shock with cardiopulmonary arrest risk. We present a rare case of multiple pericardial hydatid cysts that resulted in anaphylactic shock...
October 1, 2012: Chest
#28
JOURNAL ARTICLE
Hakan Erdem, Murat Dizbay, Selma Karabey, Selcuk Kaya, Tuna Demirdal, Iftihar Koksal, Asuman Inan, Ibrahim Erayman, Oznur Ak, Aysegul Ulu-Kilic, Omer Karasahin, Ayhan Akbulut, Nazif Elaldi, Gulden Yilmaz, Aslihan Candevir, Hanefi Cem Gul, Ibak Gonen, Oral Oncul, Turan Aslan, Emel Azak, Recep Tekin, Zeliha Kocak Tufan, Ercan Yenilmez, Bilgin Arda, Gokay Gungor, Birsen Cetin, Sukran Kose, Hale Turan, Halis Akalin, Oguz Karabay, Aygul Dogan-Celik, Adem Albayrak, Tumer Guven, Guven Celebi, Nail Ozgunes, Yasemin Ersoy, Fatma Sirmatel, Nefise Oztoprak, Ilker Inanc Balkan, Fatma Nurhayat Bayazit, Hasan Ucmak, Serkan Oncu, Davut Ozdemir, Derya Ozturk-Engin, Mehmet Bitirgen, Fehmi Tabak, Filiz Akata, Ayşe Willke, Levent Gorenek, Salman Shaheer Ahmed, Yesim Tasova, Asim Ulcay, Saim Dayan, Saban Esen, Hakan Leblebicioglu, Begin Altun, Serhat Unal
BACKGROUND: In the past, Staphylococcus aureus infections have displayed various patterns of epidemiologic curves in hospitals, particularly in intensive care units (ICUs). This study aimed to characterize the current trend in a nationwide survey of ICUs in Turkey. METHODS: A total of 88 ICUs from 36 Turkish tertiary hospitals were included in this retrospective study, which was performed during the first 3 months of both 2008 (period [P] 1) and 2011 (P2). A P value ≤...
November 2013: American Journal of Infection Control
#29
JOURNAL ARTICLE
Robert E Carroll, Richard V Benya, Danielle Kim Turgeon, Shaiju Vareed, Malloree Neuman, Luz Rodriguez, Madhuri Kakarala, Philip M Carpenter, Christine McLaren, Frank L Meyskens, Dean E Brenner
Curcumin is derived from the spice tumeric and has antiinflammatory and antineoplastic effects in vitro and in animal models, including preventing aberrant crypt foci (ACF) and adenomas in murine models of colorectal carcinogenesis. Inhibiting the production of the procarcinogenic eicosanoids prostaglandin E₂ (PGE₂) and 5-hydroxyeicosatetraenoic acid (5-HETE) can suppress carcinogenesis in rodents. Curcumin reduces mucosal concentrations of PGE₂ (via inhibition of cyclooxygenases 1 and 2) and 5-HETE (via inhibition of 5-lipoxygenase) in rats...
March 2011: Cancer Prevention Research
#30
JOURNAL ARTICLE
Cigdem Seher Kasapkara, Fatih Suheyl Ezgu, Ilyas Okur, Leyla Tumer, Gursel Biberoglu, Alev Hasanoglu
Hyperammonemia occurs mainly in patients with branched-chain organic acidemias such as propionic, methylmalonic, and isovaleric acidemias. Its pathophysiological process is mainly via the competitive inhibition of N-acetylglutamate synthetase. Oral carglumic acid (N-carbamylglutamate) administration can correct hyperammonemia in neonates with propionic and methylmalonic acidemias, thus avoiding dialysis therapy. Isovaleric acidemia is an autosomal recessive disease of leucine metabolism due to deficiency of isovaleryl-CoA dehydrogenase...
June 2011: European Journal of Pediatrics
#31
JOURNAL ARTICLE
Feng-Lin Yen, Tzu-Hui Wu, Cheng-Wei Tzeng, Liang-Tzung Lin, Chun-Ching Lin
Curcumin (CUR), a natural polyphenol isolated from tumeric ( Curcuma longa ), has been documented to possess antioxidant and anticancer activities. Unfortunately, the compound has poor aqueous solubility, which results in poor bioavailability following high doses by oral administration. To improve the solubility of CUR, we developed a novel curcumin nanoparticle system (CURN) and investigated its physicochemical properties as well as its enhanced dissolution mechanism. Our results indicated that CURN improved the physicochemical properties of CUR, including a reduction in particle size and the formation of an amorphous state with hydrogen bonding, both of which increased the drug release of the compound...
June 23, 2010: Journal of Agricultural and Food Chemistry
#32
JOURNAL ARTICLE
Maha E Houssen, Amany Ragab, Abeer Mesbah, Ayman Z El-Samanoudy, Gamal Othman, Amal F Moustafa, Farid A Badria
OBJECTIVE: To assess the efficacy of a combination of Boswellia serrata, licorice root (Glycyrrhiza glabra) and Tumeric root (Curcuma longa) as natural leukotriene inhibitor, antiinflammatory and antioxidant products respectively in controlling bronchial asthma. SUBJECTS AND METHODS: The study comprised 63 patients with bronchial asthma that are further subdivided into two groups .Group 1 receiving oral capsule (combined herb) in a soft-gelatin capsule 3 times daily for 4weeks and group 2 receiving placebo...
July 2010: Clinical Biochemistry
#33
JOURNAL ARTICLE
Fatih Ezgü, Leyla Tümer, Ferda Ozbay, Alev Hasanoglu, Gürsel Biberoğlu, Cemalettin Aybay
BACKGROUND: Homocysteine, fibrinogen and antibodies to oxidised LDL were shown to be important markers of atherosclerosis in adults. AIM: To investigate the levels of these three risk factors in prepubertal obese children. METHODS: Fasting homocysteine, fibrinogen and antibodies to oxidised LDL, plasma lipids, insulin, HbA1c and blood glucose levels were investigated in 30 prepubertal obese and 28 control children 6-9 years old. Investigations in the obese group were repeated after an oral glucose tolerance test...
October 2009: Journal of Pediatric Endocrinology & Metabolism: JPEM
#34
JOURNAL ARTICLE
Bilgin Özmen, Erhan Eser, Sabriye Özkaya Kafesçiler, Tümer Pala, Feyzullah Güçlü, Zeliha Hekimsoy
The aim of this study is to test the psychometric properties and the responsiveness of the original (status) version of Turkish DTSQ. The study sample included 88 patients with diabetes mellitus who were evaluated in three consecutive time points. The first data collection time point was during their initial contact to the clinic, and the two following (3rd month and 6th month) were during the monitoring visits to the Celal Bayar University Endocrinology Department in 2007. After the adaptation of the DTSQ to Turkish language by following standard procedures, this instrument was applied to the patients along with WBQ-12 and World Health Organization Quality of Life Measure (WHOQOL-Bref)...
December 2010: Acta Diabetologica
#35
JOURNAL ARTICLE
Claire M Mach, Lata Mathew, Scott A Mosley, Razelle Kurzrock, Judith A Smith
BACKGROUND: Curcumin is a food chemical present in tumeric (Curcuma longa) that has pharmacological activity to suppress carcinogenesis and inhibits multiple signaling pathways such as nuclear factor kappaB (NF-kappaB), cyclooxygenase-2 (Cox-2) and interleukin-8 (IL-8). Oral curcumin has poor oral bioavailability limiting its clinical activity; however, a patent pending liposomal formulation of curcumin was developed to improve drug delivery and has demonstrated activity in multiple cancers...
June 2009: Anticancer Research
#36
JOURNAL ARTICLE
Victoria Y L Ung, Rae R Foshaug, Sarah M MacFarlane, Thomas A Churchill, Jason S G Doyle, Beate C Sydora, Richard N Fedorak
Curcumin is a tumeric-derived, water-insoluble polyphenol with potential beneficial health effects for humans. It has been shown to have preventive as well as therapeutic effects in chemically induced murine models of colitis. To investigate whether curcumin exerts a similar effect on the spontaneous colitis in interleukin (IL)-10 gene-deficient mice, we gavaged these mice daily for 2 weeks with 200 mg/kg per day curcumin emulsified in carboxymethyl cellulose, a food additive generally used as a viscosity modifier...
May 2010: Digestive Diseases and Sciences
#37
JOURNAL ARTICLE
Canan A Agirtan, Taner Akar, Seher Akbas, Recep Akdur, Cahide Aydin, Gulsen Aytar, Suat Ayyildiz, Sevgi Baskan, Tugba Belgemen, Ozdecan Bezirci, Ufuk Beyazova, Fatma Yucel Beyaztas, Bora Buken, Erhan Buken, Aysu D Camurdan, Demet Can, Sevgi Canbaz, Gurol Cantürk, Meltem Ceyhan, Abdulhakim Coskun, Ahmet Celik, Fusun C Cetin, Ayse Gul Coskun, Adnan Dağçinar, Yildiz Dallar, Birol Demirel, Billur Demirogullari, Orhan Derman, Dilek Dilli, Yusuf Ersahin, Burcu Eşiyok, Gulin Evinc, Ozlem Gencer, Bahar Gökler, Hamit Hanci, Elvan Iseri, Aysun Baransel Isir, Nukhet Isiten, Gulsev Kale, Ferda Karadag, Nuray Kanbur, Birim Kiliç, Ebru Kultur, Derya Kurtay, Asli Kuruoglu, Suha Miral, Aysun B Odabasi, Resmiye Oral, Filiz Simsek Orhon, Cengiz Ozbesler, Dilsad Foto Ozdemir, M Selim Ozkok, Elif Ozmert, Didem B Oztop, Hamit Ozyürek, Figen Pasli, Yildiz Peksen, Onur Polat, Figen Sahin, Ahmet Rifat Sahin, Serpil Salacin, Emine Suskan, Burak Tander, Deniz Tekin, Ozlem Teksam, Ulku Tiras, Yilmaz Tomak, Ali Riza Tumer, Ahmet Turla, Betul Ulukol, Runa Uslu, Fatma V Tas, Nilgun Vatandas, Sevtap Velipasaoglu, Fatih Yagmur, Aydin Yağmurlu, Songul Yalcin, Sukruye Yavuz, Kadriye Yurdakok
OBJECTIVES: The University of Iowa Child Protection Program collaborated with Turkish professionals to develop a training program on child abuse and neglect during 2002-2006 with the goals of increasing professional awareness and number of multidisciplinary teams (MDT), regional collaborations, and assessed cases. This paper summarizes the 5-year outcome. METHODS: A team of instructors evaluated needs and held training activities in Turkey annually, and provided consultation when needed...
April 2009: Child Abuse & Neglect
#38
JOURNAL ARTICLE
Tolga Aksu, Erdem Tümer Güler, Omaç Tüfekçioğlu, Ayşegül Oz Aksu
A 26-year-old male patient presented with complaints of pain, dyspnea, and hemoptysis of one-week history, while on oral anticoagulation treatment that had been started two years before upon the diagnosis of pulmonary thromboembolism. Transthoracic echocardiography showed two mass lesions in the right atrium and inferior vena cava, measuring 3.5x3 cm and 1.5x1 cm, respectively. The possibility of vegetation or secondary cardiac tumor was excluded by further examinations and, considering consistent oral anticoagulation, no other cause could be determined related to thrombus formation...
December 2008: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
#39
JOURNAL ARTICLE
C Tümer, Y Aksoy, G N Güncü, R M Nohutcu, K Kilinc, T F Tözüm
Detection of progression level of peri-implantitis may help in the prevention of oral implant failure. C-telopeptide pyridinoline crosslinks of Type I collagen (ICTP) and osteocalcin (OC) are specific markers of bone turnover and bone degradation. Determination of the ICTP and OC levels in the peri-implant sulcus fluid (PISF) may predict the metabolic and/or inflammatory changes in the peri-implant bone. The aim of this clinical study was to evaluate ICTP and OC levels in the PISF for oral implants with and without peri-implant bone destruction and correlate these levels with the traditional clinical peri-implant parameters (probing depth, plaque index, gingival index and gingival bleeding time index) and radiographic bone level measurements...
December 2008: Journal of Oral Rehabilitation
#40
JOURNAL ARTICLE
Ahmet Aslan, Muhyittin Temiz, Sibel Hakverdi, Gurbuz Polat, Cemil Tumer, Abdulkerim Temiz, Elif Canbolant
OBJECTIVE: We aimed to investigate the effect of mesalamine on healing of experimental colon anastomosis model. MATERIAL/METHODS: Forty adult male Wistar albino rats were performed segmentary colonic resection and end-to-end anastomosis. Animals were randomly divided into four groups: group I, anastomosis group, received no treatment (GI, n=8); group II, anastomosis+oral mesalamine group (100mg/kg/day); group III, anastomosis+rectal mesalamine (2mL) group, (GIII, n=8); group IV, anastomosis+oral mesalamine+rectal mesalamine (GIV, n=8) group...
February 2008: International Journal of Surgery
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