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https://www.readbyqxmd.com/read/29679592/multiple-coagulation-factor-deficiency-protein-2-as-a-crucial-component-in-metastasis-of-human-oral-cancer
#1
Megumi Fukamachi, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Kazuaki Fushimi, Hiroki Kasama, Manabu Iyoda, Yasuyuki Minakawa, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Multiple coagulation factor deficiency protein 2 (MCFD2), a binding partner of lectin mannose binding 1 (LMAN1), causes combined deficiencies of coagulation factors V and VIII. MCFD2 function in inherited hematologic disorders is well elucidated; however, little is known about its role in human tumorigenesis. The aim of the current study was to investigate the states of MCFD2 in oral squamous cell carcinoma (OSCC). The expression of MCFD2 was up-regulated significantly in all cell lines examined. Evaluation of the cellular functions associated with tumoral metastasis showed that MCFD2 knockdown (shMCFD2) cells exhibited significantly lower cellular invasiveness and migration and higher cellular adhesion compared with shControl cells...
April 18, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29662195/ngr-asn-gly-arg-targeted-delivery-of-coagulase-to-tumor-vasculature-arrests-cancer-cell-growth
#2
Khaled Seidi, Rana Jahanban-Esfahlan, Hassan Monhemi, Peyman Zare, Babak Minofar, Amir Daei Farshchi Adli, Davoud Farajzadeh, Ramezan Behzadi, Mehran Mesgari Abbasi, Heidi A Neubauer, Richard Moriggl, Nosratollah Zarghami, Tahereh Javaheri
Induction of selective thrombosis and infarction in tumor-feeding vessels represents an attractive strategy to combat cancer. Here we took advantage of the unique coagulation properties of staphylocoagulase and genetically engineered it to generate a new fusion protein with novel anti-cancer properties. This novel bi-functional protein consists of truncated coagulase (tCoa) and an NGR (GNGRAHA) motif that recognizes CD13 and αv β3 integrin receptors, targeting it to tumor endothelial cells. Herein, we report that tCoa coupled by its C-terminus to an NGR sequence retained its normal binding activity with prothrombin and av β3 integrins, as confirmed in silico and in vitro...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29657559/activation-peptide-of-the-coagulation-factor-xiii-ap-f13a1-as-a-new-biomarker-for-the-screening-of-colorectal-cancer
#3
Julien Peltier, Jean-Pierre Roperch, Stéphane Audebert, Jean-Paul Borg, Luc Camoin
Background: Colorectal cancer (CRC) remains a major cause of cancer fatalities in developed countries. The risk of death is correlated to the stage of CRC during the primary diagnosis. Early diagnosis is closely associated with enhanced survival rate. We therefore investigated the AP-F13A1 as a potential protein marker of CRC. Methods: The protein expression of FXIII in 40 serum samples was evaluated by enzyme-linked immunosorbent assays. Additionally, targeted proteomic assays (LC-PRM) were used to evaluate the expression of the activation peptide of F13A1 (AP-F13A1) in a further 113 serum samples...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#4
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29653085/prognostic-significance-of-pre-resection-albumin-fibrinogen-ratio-in-patients-with-non-small-cell-lung-cancer-a-propensity-score-matching-analysis
#5
Shuaishuai Chen, Haixi Yan, Juping Du, Jun Li, Bo Shen, Haijian Ying, Ying Zhang, Shiyong Chen
BACKGROUND: Nutrition and coagulation play important roles in cancer progression. This study was aimed to investigate the value of the albumin/fibrinogen ratio (AFR) in non-small cell lung cancer (NSCLC) patients, through a propensity score matching (PSM) method. METHODS: We retrospectively analyzed 529 NSCLC patients underwent surgical resection from 2010 to 2015. PSM was used to eliminate possible biases. A Cox proportional hazards regression model was performed to evaluate the prognostic value of AFR in NSCLC...
April 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29644460/phase-ii-study-of-cisplatin-pemetrexed-combined-with-bevacizumab-followed-by-pemetrexed-bevacizumab-maintenance-therapy-in-patients-with-egfr-wild-advanced-non-squamous-non-small-cell-lung-cancer
#6
Toshirou Fukushima, Yuuki Wakatsuki, Takashi Kobayashi, Kei Sonehara, Kazunari Tateishi, Manabu Yamamoto, Takeshi Masubuchi, Fumiaki Yoshiike, Kazuya Hirai, Tsutomu Hachiya, Tomonobu Koizumi
PURPOSE: This phase II study was performed to evaluate the efficacy and safety of cisplatin/pemetrexed combined with 15 mg/kg of bevacizumab followed by pemetrexed/bevacizumab maintenance therapy as first-line chemotherapy in advanced non-squamous non-small cell lung cancer (NSCLC) limited to epidermal growth factor receptor (EGFR)-wild type. PATIENTS AND METHODS: Fifty patients with advanced or metastatic EGFR-wild type NSCLC aged < 75 years old were enrolled in the study...
April 11, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29621007/disseminated-intravascular-coagulation-is-it-fact-or-fancy
#7
Jae C Chang
: 'Disseminated intravascular coagulation (DIC)' occurs commonly in critical illnesses such as sepsis, trauma, cancer, and complications of surgery and pregnancy. Mortality is very high. The pathogenesis has been ascribed to tissue factor-initiated coagulation disorder, resulting in disseminated microblood clots that are made of platelets, plasma factors, fibrins, and blood cells. True DIC depletes coagulation factors and consumes platelets, and activates fibrinolysis. 'DIC' is assumed to orchestrate thrombocytopenia, microangiopathic hemolytic anemia and hypoxic multiorgan dysfunction syndrome, and causes hemorrhagic disorder due to depleted coagulation factors...
April 4, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29620218/quercetin-protects-rat-cortical-neurons-against-traumatic-brain-injury
#8
Guoliang Du, Zongmao Zhao, Yonghan Chen, Zonghao Li, Yaohui Tian, Zhifeng Liu, Bin Liu, Jianqiang Song
Previous studies have demonstrated that traumatic brain injury (TBI) may cause neurological deficits and neuronal cell apoptosis. Quercetin, one of the most widely distributed flavonoids, possesses anti‑inflammatory, anti‑blood coagulation, anti‑ischemic and anti‑cancer activities, and neuroprotective effects in the context of brain injury. The purpose of the present study was to investigate the neuroprotective effects of quercetin in TBI. A total of 75 rats were randomly arranged into 3 groups as follows: Sham group (Sham); TBI group (TBI); and TBI + quercetin group (Que)...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29610261/association-of-cancer-cell-type-and-extracellular-vesicles-with-coagulopathy-in-patients-with-lung-cancer-and-stroke
#9
Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang
BACKGROUND AND PURPOSE: Coagulopathy is an important cause of stroke in cancer patients. However, underlying mechanisms and clinical factors related to coagulopathy remain unclear. We hypothesized that certain characteristics of cancer affect coagulopathy in patients with lung cancer and ischemic stroke. METHODS: Consecutive patients with active lung cancer and acute ischemic stroke were prospectively studied. Volume and pattern of acute brain infarcts and plasma levels of circulating tumor extracellular vesicles (EVs) were measured using flow cytometry...
April 2, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29599304/aspirin-in-the-management-of-patients-with-prostate-cancer-undergoing-radiotherapy-friend-or-foe
#10
REVIEW
Bianca Mascan, Laure Marignol
Aspirin has cyclooxygenase-2 (COX2)-mediated anti-inflammatory and anti-coagulant properties that may confer a positive effect in preventing and limiting the progression of prostate cancer. Prostate cancer has been shown to have poor treatment outcomes due to therapeutic resistance; therefore, COX2 inhibition caused by aspirin could represent an opportunity to augment current therapies. This is particularly of interest to patients undergoing radiation therapy (RT) where inflammation is a common side-effect...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29588087/mechanism-and-management-of-cancer-associated-thrombosis
#11
REVIEW
Mikio Mukai, Toru Oka
Thromboembolism is considered to have a substantial impact on outcomes in patients with cancer. Although progress in cancer therapy and the advent of new anticancer agents such as molecular targeted drugs have improved the outcomes of patients with cancer, the incidence of cancer-therapy-related thromboembolism is increasing, and the management of this adverse reaction has become a major problem. Cancer is intimately related to thrombosis. Thrombus formation results from the complex interaction of various factors, such as tissue factors, coagulation abnormalities, activated platelet activation, activated adhesion activation, and endothelial cell dysfunction...
March 24, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29584534/the-pro-inflammatory-role-of-platelets-in-cancer
#12
A K Olsson, J Cedervall
Thrombosis is a frequent issue in cancer patients. Tumor-induced platelet activation and coagulation does not only constitute a significant risk for thrombosis, but also contribute to tumor progression by promoting critical processes such as angiogenesis and metastasis. In addition to their role in hemostasis, platelets are increasingly recognized as regulators of inflammation. By modulating the immune system, platelets regulate several aspects of cancer-associated pathology. Platelets influence the inflammatory response in cancer by affecting the activation status of the endothelium and by recruiting leukocytes to primary and metastatic tumor sites, as well as to distant organs unaffected by tumor growth...
March 27, 2018: Platelets
https://www.readbyqxmd.com/read/29579357/venous-thromboembolic-events-in-idiopathic-inflammatory-myopathy-occurrence-and-relation-to-disease-onset
#13
Aleksandra Antovic, Antonella Notarnicola, John Svensson, Ingrid E Lundberg, Marie Holmqvist
OBJECTIVES: To assess the incidence of venous thromboembolism (VTE) in patients with idiopathic inflammatory myopathies (IIM), and compare the incidence in IIM to the incidence in the general population. To identify patient categories at high risk and investigate the development of risk in relation to IIM diagnosis. METHODS: Using nationwide registers we identified a cohort of 440 individuals with newly diagnosed IIM and 4459 individuals from the general population...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29573822/efficacy-of-soft-coagulation-in-retroperitoneal-lymphadenectomy-for-ovarian-cancer
#14
Ayumu Matsuoka, Shinichi Tate, Kyoko Nishikimi, Makio Shozu
No abstract text is available yet for this article.
March 21, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29569666/circulating-tumor-dna-and-liquid-biopsy-opportunities-challenges-and-recent-advances-in-detection-technologies
#15
REVIEW
Lena Gorgannezhad, Muhammad Umer, Md Nazmul Islam, Nam-Trung Nguyen, Muhammad J A Shiddiky
Cell-free DNA (cfDNA) refers to short fragments of acellular nucleic acids detectable in almost all body fluids, including blood, and is involved in various physiological and pathological phenomena such as immunity, coagulation, aging, and cancer. In cancer patients, a fraction of hematogenous cfDNA originates from tumors, termed circulating tumor DNA (ctDNA), and may carry the same mutations and genetic alterations as those of a primary tumor. Thus, ctDNA potentially provides an opportunity for noninvasive assessment of cancer...
March 23, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29566097/the-gag-specific-branched-peptide-nt4-reduces-angiogenesis-and-invasiveness-of-tumor-cells
#16
Luisa Bracci, Elisabetta Mandarini, Jlenia Brunetti, Lorenzo Depau, Alessandro Pini, Lucia Terzuoli, Silvia Scali, Chiara Falciani
Heparan sulfate proteoglycans, HSPGs, modulate major transformations of cancer cells, leading to tumor growth, invasion and metastasis. HSPGs also regulate neo-angiogenesis which prompts cancer progression and metastatic spread. A different aspect of heparin and analogs is their prominent role in the coagulation of blood. The interplay between coagulation and metastasis is being actively studied: anticoagulants such as heparin-derivatives have anticancer activity and procoagulants, such as thrombin, positively modulate proliferation, migration and invasion...
2018: PloS One
https://www.readbyqxmd.com/read/29565466/single-nucleotide-variant-profiles-of-viable-single-circulating-tumour-cells-reveal-ctc-behaviours-in-breast-cancer
#17
Yipeng Wang, Liping Guo, Lin Feng, Wen Zhang, Ting Xiao, Xuebing Di, Guoji Chen, Kaitai Zhang
Circulating tumour cell (CTC) behaviours are distinct from those of bulk tissues. Thus, treatments to eliminate CTCs differ from the regimens followed to reduce the primary tumour and its metastases. Accordingly, comprehensively deciphering the single nucleotide variant (SNV) profiles in CTCs, which partially determine CTC behaviours, is a priority. Using viable CTCs isolated with the oHSV1‑hTERT‑GFP virus coupled with fluorescence‑activated cell sorting (FACS), the whole genome was amplified using the multiple annealing and looping‑based amplification cycle (MALBAC) method...
May 2018: Oncology Reports
https://www.readbyqxmd.com/read/29561276/the-primary-haemostasis-is-more-preserved-in-thrombocytopenic-patients-with-liver-cirrhosis-than-cancer
#18
Pernille Just Vinholt, Anne B Alnor, Mads Nybo, Anne-Mette Hvas
: In thrombocytopenia, differences in haemostatic capacity may explain discrepancies in bleeding risk between patients with cancer and patients with liver cirrhosis. The objective was to compare the haemostatic capacity in different thrombocytopenic patient populations. We evaluated platelet aggregation using impedance aggregometry (Multiplate Analyzer), von Willebrand factor antigen (VWF:Ag), VWF:ristocetin-cofactor activity (VWF:RCo), activated partial thromboplastin time (aPTT), coagulation factor VIII, fibrinogen, and thrombin generation in adult hospitalized patients with platelet count less than 80 × 10/l...
March 19, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29556320/interventional-radiofrequency-ablation-a-promising-therapeutic-modality-in-the-management-of-malignant-biliary-and-pancreatic-duct-obstruction
#19
M Mizandari, J Kumar, M Pai, T Chikovani, T Azrumelashvili, I Reccia, N Habib
Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK) is a new addition to this class of tools. It is an endoluminal Radiofrequency (RF) catheter which works on the principle of ablation and induces coagulative necrosis to recanalize the obstructed duct...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29554700/procoagulant-effects-of-low-level-platelet-activation-and-its-inhibition-by-colchicine
#20
Caroline J Reddel, Gabrielle J Pennings, Jennifer L Curnow, Vivien M Chen, Leonard Kritharides
Platelets play an important role in diseases such as cardiovascular disease and cancer, especially through their release of extracellular vesicles (EVs) and role in thrombosis. The effects of the anti-inflammatory drug colchicine on platelets are not well understood. We investigated the effect of colchicine on the release of pro-coagulant EVs from platelets under low-level activation. Citrated platelet-rich plasma (PRP) from healthy donors was incubated with 2 mM colchicine or vehicle at 37°C for 30 minutes with gentle rotation...
March 19, 2018: Thrombosis and Haemostasis
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