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Respiratory aspiration

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https://www.readbyqxmd.com/read/29039734/computational-analysis-of-a-species-d-human-adenovirus-provides-evidence-of-a-novel-virus
#1
Emilio E Espínola, Julio C Barrios, Graciela Russomando, Santiago Mirazo, Juan Arbiza
A human adenovirus (HAdV) species D, was isolated from a hospitalised child with severe lower respiratory infection. It was initially detected in the nasopharyngeal aspirate of the child followed by conventional PCR amplification of the hexon, penton base, and fibre genes. Sanger DNA sequencing and phylogenetic analyses showed characteristics of a recombinant genome not described before. Next Generation Sequencing analysis was performed to reconstruct its complete DNA genome after viral isolation in adenocarcinoma human cell line (A549)...
October 17, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29035085/lung-microbiota-is-related-to-smoking-status-and-to-development-of-ards-in-critically-ill-trauma-patients
#2
Ariane R Panzer, Susan V Lynch, Chaz Langelier, Jason D Christie, Kathryn McCauley, Mary Nelson, Christopher K Cheung, Neal L Benowitz, Mitchell J Cohen, Carolyn S Calfee
RATIONALE: Cigarette smoking is associated with increased risk of acute respiratory distress syndrome (ARDS) in patients following severe trauma; however, mechanisms underlying this association are unknown. OBJECTIVES: To determine whether cigarette smoking contributes to ARDS development following trauma by altering community composition of the lung microbiota Methods: We studied lung microbiota of mechanically ventilated patients admitted to the intensive care unit (ICU) following severe blunt trauma using 16S rRNA gene amplicon sequencing of endotracheal aspirate (ETA) samples obtained upon ICU admission (n=74) and at 48 hours post-admission (n=30)...
October 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29031240/colonization-of-oropharynx-and-lower-respiratory-tract-in-critical-patients-risk-of-ventilator-associated-pneumonia
#3
Ivany Machado de Carvalho Baptista, Frederico Canato Martinho, Gustavo Giacomelli Nascimento, Carlos Eduardo da Rocha Santos, Renata Falchete do Prado, Marcia Carneiro Valera
OBJECTIVE: To investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (BAL), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard DNA-DNA hybridisation. Also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship between VAP (ventilator-associated pneumonia) and bacterial species studied...
October 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29028159/serologically-diagnosed-acute-human-bocavirus-1-infection-in-childhood-community-acquired-pneumonia
#4
Amanda C Nascimento-Carvalho, Ana-Luisa Vilas-Boas, Maria-Socorro H Fontoura, Man Xu, Tytti Vuorinen, Maria Söderlund-Venermo, Olli Ruuskanen, Cristiana M Nascimento-Carvalho
AIM: To assess the role of human bocavirus 1 (HBoV1) as a causative agent of non-severe community-acquired pneumonia (CAP) in children. METHODS: Patients aged 2-59 months with non-severe CAP (respiratory complaints and radiographic pulmonary infiltrate/consolidation) attending a University Hospital in Salvador, Brazil were enrolled in a prospective cohort. From 820 recruited children in a clinical trial (ClinicalTrials.gov NCT01200706), nasopharyngeal aspirate (NPA), and acute and convalescent serum samples were obtained from 759 (92...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29026864/gastroparesis-as-the-sole-presenting-feature-of-neuromyelitis-optica
#5
Ahmed Salahudeen, Tejal Mistry
A 33-year-old African-American woman recently diagnosed with severe idiopathic gastroparesis was readmitted for hypoxic respiratory failure secondary to aspiration pneumonia. A fiber-optic endoscopic evaluation of swallow study revealed severe pharyngeal dysphagia. Brain magnetic resonance imaging showed an ill-defined lesion in the posterior aspect of the medulla concerning for a demyelinating process. Serum neuromyelitis optica immunoglobulin G returned positive. Neuromyelitis optica treatment resulted in the patient's clinical improvement...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29021189/presence-of-atopy-increases-the-risk-of-asthma-relapse
#6
Laurel Teoh, Ian M Mackay, Peter P Van Asperen, Jason P Acworth, Mark Hurwitz, John W Upham, Weng Hou Siew, Claire Y T Wang, Theo P Sloots, Teresa Neeman, Anne B Chang
OBJECTIVES: To describe the point prevalence of respiratory viruses/atypical bacteria using PCR and evaluate the impact of respiratory viruses/atypical bacteria and atopy on acute severity and clinical recovery in children with hospitalised and non-hospitalised asthma exacerbations. DESIGN: This was a prospective study performed during 2009-2011. SETTING: The study was performed in the emergency departments of two hospitals. PATIENTS: 244 children aged 2-16 years presenting with acute asthma to the emergency departments were recruited...
October 11, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28991822/respiratory-viruses-in-invasively-ventilated-critically-ill-patients-a-prospective-multicenter-observational-study
#7
Frank van Someren Gréve, Nicole P Juffermans, Lieuwe D J Bos, Jan M Binnekade, Annemarije Braber, Olaf L Cremer, Evert de Jonge, Richard Molenkamp, David S Y Ong, Sjoerd P H Rebers, Angelique M E Spoelstra-de Man, Koenraad F van der Sluijs, Peter E Spronk, Kirsten D Verheul, Monique C de Waard, Rob B P de Wilde, Tineke Winters, Menno D de Jong, Marcus J Schultz
OBJECTIVES: The presence of respiratory viruses and the association with outcomes were assessed in invasively ventilated ICU patients, stratified by admission diagnosis. DESIGN: Prospective observational study. SETTING: Five ICUs in the Netherlands. PATIENTS: Between September 1, 2013, and April 30, 2014, 1,407 acutely admitted and invasively ventilated patients were included. INTERVENTIONS: None...
October 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28974507/isolated-ascites-in-a-newborn-with-apple-peel-jejunal-atresia
#8
Otilia Osmulikevici, Elizabeth Renji, Bruce Jaffray, Nicholas Embleton
Isolated fetal ascites was diagnosed at 20 weeks in a primiparous woman with no significant medical history. Progressive fetal ascites worsened after 28 weeks and resulted in fetal hydroceles. Delivery was by caesarian section at 33 weeks, preceded by reduction of fetal ascites under ultrasound guidance. Following delivery, the baby required further reduction of abdominal fluid and endotracheal intubation to provide respiratory support. An extensive set of investigations, including metabolic and genetic screening, was performed; all results were negative...
October 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28970804/inappropriate-timing-of-swallow-in-the-respiratory-cycle-causes-breathing-swallowing-discoordination
#9
Naomi Yagi, Yoshitaka Oku, Shinsuke Nagami, Yoshie Yamagata, Jun Kayashita, Akira Ishikawa, Kazuhisa Domen, Ryosuke Takahashi
Rationale: Swallowing during inspiration and swallowing immediately followed by inspiration increase the chances of aspiration and may cause disease exacerbation. However, the mechanisms by which such breathing-swallowing discoordination occurs are not well-understood. Objectives: We hypothesized that breathing-swallowing discoordination occurs when the timing of the swallow in the respiratory cycle is inappropriate. To test this hypothesis, we monitored respiration and swallowing activity in healthy subjects and in patients with dysphagia using a non-invasive swallowing monitoring system...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28970723/high-yield-reproducible-rat-model-recapitulating-human-barrett-s-carcinogenesis
#10
Daisuke Matsui, Ashten N Omstead, Juliann E Kosovec, Yoshihiro Komatsu, Emily J Lloyd, Hailey Raphael, Ronan J Kelly, Ali H Zaidi, Blair A Jobe
AIM: To efficiently replicate the biology and pathogenesis of human esophageal adenocarcinoma (EAC) using the modified Levrat model of end-to-side esophagojejunostomy. METHODS: End-to-side esophagojejunostomy was performed on rats to induce gastroduodenoesophageal reflux to develop EAC. Animals were randomly selected and serially euthanized at 10 (n = 6), 17 (n = 8), 24 (n = 9), 31 (n = 6), 38 (n = 6), and 40 (n = 6) wk postoperatively. The esophagi were harvested for downstream histopathology and gene expression...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28969451/brain-abscess-in-children-a-rare-but-serious-infection
#11
Zumrut Sahbudak Bal, Cenk Eraslan, Elif Bolat, Gulhadiye Avcu, Nilgun Kultursay, Ferda Ozkinay, Zafer Kurugol, Fadil Vardar
Brain abscess is a rare disease in childhood requiring prompt medical and/or surgical treatment. The objective was to review presentation, management, and outcome of brain abscess in children. We reviewed the clinical and radiological features and outcomes of 18 children (10 females, 8 males), with a median age of 48 months (range 1-182), that presented with brain abscesses and admitted to a tertiary pediatric infectious department between December 2010 and January 2017. One (5.5%) patient underwent craniotomy and 14 (77...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28968829/the-ns1-protein-of-respiratory-syncytial-virus-blocks-glucocorticoid-receptor-nuclear-translocation-by-targeting-ipo13-may-account-for-glucocorticoid-insensitive
#12
Jun Xie, Xiaoru Long, Leiqiong Gao, Sisi Chen, Keting Zhao, Wei Li, Na Zhou, Na Zang, Yu Deng, Luo Ren, Lijia Wang, Zhengxiu Luo, Wenwei Tu, Xiaodong Zhao, Zhou Fu, Xiaohong Xie, Enmei Liu
In spite of their powerful anti-inflammatory effect, glucocorticoids have shown no significant clinical benefit in respiratory syncytial virus (RSV)-induced bronchiolitis, the reason for which remains unclear. Upon glucocorticoid binding, the cytoplasmic glucocorticoid receptor (GR) translocates to the nucleus with the help of importin-13 (IPO13). Here, we report that RSV infection reduced GR nuclear translocation in the nasopharyngeal aspirate (NPA) of the RSV-infected infants, lungs of infected mice, and A549 cells, which coincided with decreased IPO13 expression...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28967190/multimodality-imaging-characteristics-of-tension-pyopneumothorax-secondary-to-pulmonary-carcinoma-in-a-cat
#13
Jaehwan Kim, Hakyoung Yoon, Soyoung Kim, Kidong Eom
A 3-year-old Himalayan cat was presented with respiratory distress. Radiography showed multiple gas opacity foci, with the locations dependent on patient positioning, and severe pleural effusion with a contralateral mediastinal shift. A large volume of fluid and air was aspirated, and the fluid components were consistent with a nonseptic exudate. A pulmonary mass, pleural nodules, and an air-fluid interface with air bubbles trapped in fibrous septations were identified using thoracic ultrasonography and CT...
October 1, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28963878/human-parainfluenza-virus-surveillance-in-pediatric-patients-with-lower-respiratory-tract-infections-a-special-view-of-parainfluenza-type-4
#14
Luciano M Thomazelli, Danielle B L de Oliveira, Giuliana S Durigon, Brett Whitaker, Shifaq Kamili, Eitan N Berezin, Edison L Durigon
OBJECTIVE: Characterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections. METHODS: Real-time assays were used to identify strains of human parainfluenza virus and other common respiratory viruses in nasopharyngeal aspirates. One thousand and two children presenting with acute lower respiratory tract illnesses were enrolled from February 2008 to August 2010...
September 27, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28953251/respiratory-morbidity-in-children-with-repaired-congenital-esophageal-atresia-with-or-without-tracheoesophageal-fistula
#15
REVIEW
Maria Francesca Patria, Stefano Ghislanzoni, Francesco Macchini, Mara Lelii, Alessandro Mori, Ernesto Leva, Nicola Principi, Susanna Esposito
Congenital esophageal atresia with or without tracheoesophageal fistula (CEA ± TEF) is a relatively common malformation that occurs in 1 of 2500-4500 live births. Despite the refinement of surgical techniques, a considerable proportion of children experience short- and long-term respiratory complications, which can significantly affect their health through adulthood. This review focuses on the underlying mechanisms and clinical presentation of respiratory morbidity in children with repaired CEA ± TEF. The reasons for the short-term pulmonary impairments are multifactorial and related to the surgical complications, such as anastomotic leaks, stenosis, and recurrence of fistula...
September 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28951965/niemann-pick-disease-type-c-in-the-newborn-period-a-single-center-experience
#16
Ersin Gumus, Goknur Haliloglu, Asuman Nur Karhan, Hulya Demir, Figen Gurakan, Meral Topcu, Aysel Yuce
Niemann-Pick disease type C (NPC) is a neurovisceral lysosomal storage disorder with a great variation in clinical spectrum and age at presentation. Clinical features of 10 NPC patients who presented in the newborn period between 1993 and 2015 at our center were retrospectively analyzed. Males and females were equally distributed; there was a history of parental consanguinity (n = 8) and first-degree relative with NPC (n = 3). Patients were symptomatic between 1 and 10 days (mean 3.6 ± 2.6 days). Age at diagnosis was between 1 and 30 days (mean 14...
September 27, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28950420/performance-of-a-tracheostomy-removal-protocol-for-pediatric-patients-in-rehabilitation-after-acquired-brain-injury-factors-associated-with-timing-and-possibility-of-decannulation
#17
Marco Pozzi, Sara Galbiati, Federica Locatelli, Emilio Clementi, Sandra Strazzer
OBJECTIVES: We assessed the performance of a tracheostomy decannulation protocol privileging safety over quickness, in pediatric patients undergoing rehabilitation from severe acquired brain injury. We analyzed factors associated with decannulation timing and possibility and examined cases of failure. HYPOTHESIS: A safe decannulation protocol should minimize failures. STUDY DESIGN: Retrospective observational study. PATIENT SELECTION: Patients aged 0-17 admitted to rehabilitation with tracheostomy in the last 15 years (n = 123)...
September 26, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28950377/preoperative-short-term-plus-postoperative-physical-therapy-versus-postoperative-physical-therapy-alone-for-patients-undergoing-lung-cancer-surgery-retrospective-analysis-of-a-nationwide-inpatient-database
#18
Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
OBJECTIVES: The aim of this study is to determine whether physical therapy (PT) within 3 days before lung cancer surgery combined with postoperative PT reduces 30-day mortality and the incidence of postoperative pulmonary complications (PPCs) compared with postoperative PT alone. METHODS: This retrospective cohort study, using the Japanese Diagnosis Procedure Combination database, included patients aged ≥18 years who underwent non-small-cell lung cancer surgery and received PT on postoperative Day 1 or 2 between 2010 and 2015...
August 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28947901/evaluation-of-nxtag-respiratory-pathogen-panel-and-comparison-with-xtag-respiratory-viral-panel-fast-v2-and-film-array-respiratory-panel-for-detecting-respiratory-pathogens-in-nasopharyngeal-aspirates-and-swine-avian-origin-influenza-a-subtypes-in-culture-isolates
#19
K H Chan, K K W To, P T W Li, T L Wong, R Zhang, K K H Chik, G Chan, C C Y Yip, H L Chen, I F N Hung, J F W Chan, K Y Yuen
This study evaluated a new multiplex kit, Luminex NxTAG Respiratory Pathogen Panel, for respiratory pathogens and compared it with xTAG RVP Fast v2 and FilmArray Respiratory Panel using nasopharyngeal aspirate specimens and culture isolates of different swine/avian-origin influenza A subtypes (H2N2, H5N1, H7N9, H5N6, and H9N2). NxTAG RPP gave sensitivity of 95.2%, specificity of 99.6%, PPV of 93.5%, and NPV of 99.7%. NxTAG RPP, xTAG RVP, and FilmArray RP had highly concordant performance among each other for the detection of respiratory pathogens...
2017: Advances in Virology
https://www.readbyqxmd.com/read/28943167/bordetella-bronchiseptica-infection
#20
M Ducours, P Rispal, M P Danjean, Y Imbert, E Dupont, E M Traissac, S Grosleron
OBJECTIVE: To collect data of all patients admitted to hospital with a positive test to Bordetella bronchiseptica between 2001 and 2015. METHODS: We performed a retrospective monocentric study of all hospitalized patients over the past 15 years with a positive test to B. bronchiseptica. RESULTS: Nine patients were included between 2001 and 2015; two presented with infectious relapses, i.e. a total of 14 positive test samples were observed...
September 21, 2017: Médecine et Maladies Infectieuses
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