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Muscle sinergy

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https://www.readbyqxmd.com/read/15916929/lc-esi-ms-ms-determination-of-4-hydroxy-trans-2-nonenal-michael-adducts-with-cysteine-and-histidine-containing-peptides-as-early-markers-of-oxidative-stress-in-excitable-tissues
#1
Marica Orioli, Giancarlo Aldini, Giangiacomo Beretta, Roberto Maffei Facino, Marina Carini
A sensitive, selective, specific and rapid liquid chromatographic-electrospray ionization tandem mass spectrometric assay was developed and validated for the simultaneous determination in skeletal muscle of the Michael adducts between 4-hydroxy-trans-2-nonenal (HNE), one of the most reactive lipid peroxidation-driven unsaturated aldehyde, and glutathione (GSH) and the endogenous histidine-containing dipeptides carnosine (CAR) and anserine (ANS), with the final aim to use conjugated adducts as specific and unequivocal markers of lipid peroxidation...
November 15, 2005: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/15578740/profiling-histidine-containing-dipeptides-in-rat-tissues-by-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#2
Giancarlo Aldini, Marica Orioli, Marina Carini, Roberto Maffei Facino
The histidine-containing dipeptides carnosine (CAR) and structurally related anserine (ANS) and homocarnosine (HCAR), widely distributed in vertebrate organisms, have recently been proposed as endogenous quenchers for highly cytotoxic alpha,beta-unsaturated aldehydes generated by peroxidation. A sensitive, selective, specific and rapid liquid chromatographic/electrospray ionization tandem mass spectrometric assay was developed and validated for the simultaneous determination of these peptides in biological matrices in order to establish their plasma/tissue distribution...
December 2004: Journal of Mass Spectrometry: JMS
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