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https://www.readbyqxmd.com/read/28209729/edoxaban-for-the-prevention-of-thromboembolism-in-patients-with-atrialfibrillation-and-bioprosthetic-valves
#1
Anthony P Carnicelli, Raffaele De Caterina, Jonathan L Halperin, Giulia Renda, Christian T Ruff, Marco Trevisan, Francesco Nordio, Michele F Mercuri, Elliott Antman, Robert P Giugliano
Atrial fibrillation (AF) and valvular heart disease (VHD) frequently coexist and independently increase mortality1. Bioprosthetic valve implantation (surgical or transcatheter), is a common, increasingly utilized treatment for VHD2. Patients with AF and bioprosthetic valves require anticoagulation to prevent thromboembolic events. Non-vitamin K oral anticoagulants (NOACs) are safe and efficacious alternatives to vitamin K antagonists for anticoagulation in AF. However, guidelines recommend against NOACs in patients with bioprosthetic valves, citing a lack of supporting data...
February 16, 2017: Circulation
https://www.readbyqxmd.com/read/28183793/clinical-information-has-low-sensitivity-for-postmortem-diagnosis-of-heart-valve-disease
#2
Sean Coffey, Andrew R Harper, Benjamin J Cairns, Ian Sd Roberts, Bernard D Prendergast
BACKGROUND: Accuracy of routinely collected information concerning cause of death is essential for public health and health systems planning. Since clinical examination has relatively low sensitivity for detection of valvular heart disease (VHD), mortality data based on clinical information alone might routinely underestimate the number of deaths due to VHD. METHODS: We compared autopsy findings against premortem clinical information for 8198 consecutive adult postmortems (mean age 69...
February 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28170314/heart-disease-mortality-in-the-life-span-study-1950-2008
#3
Ikuno Takahashi, Yukiko Shimizu, Eric J Grant, John Cologne, Kotaro Ozasa, Kazunori Kodama
Based on the findings from the Radiation Effects Research Foundation's studies of the cohort of Japanese atomic bomb survivors, it has been reported that total-body irradiation at 0.5-1.0 Gy could be responsible for increased rates of mortality from broad-based categories of cardiovascular disease (CVD), i.e., stroke and heart disease. However, CVD consists of various subtypes that have potentially different radiation dose responses, as well as subtype-specific risks that have not been fully evaluated. Potential problems with changes in the coding rules for the International Classification of Diseases (ICD) and the underlying causes and trends in CVD mortality in Japan also need to be considered...
February 7, 2017: Radiation Research
https://www.readbyqxmd.com/read/28127033/advanced-imaging-in-valvular-heart-disease
#4
REVIEW
Jeroen J Bax, Victoria Delgado
Although echocardiography remains the mainstay imaging technique for the evaluation of patients with valvular heart disease (VHD), innovations in noninvasive imaging in the past few years have provided new insights into the pathophysiology and quantification of VHD, early detection of left ventricular (LV) dysfunction, and advanced prognostic assessment. The severity grading of valve dysfunction has been refined with the use of Doppler echocardiography, cardiac magnetic resonance (CMR), and CT imaging. LV ejection fraction remains an important criterion when deciding whether patients should be referred for surgery...
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28124181/drosophila-dunc-115-mediates-axon-projection-through-actin-binding
#5
Christopher Roblodowski, Qi He
A central step in organizing the central nervous system development is the growth cone of an axon navigating through guidance cues to reach its specific target. While a great deal of this process has been understood especially in identifying the extracellular guidance cues and their membrane receptors, much less is known about how guidance signals are further relayed to the actin filaments that are central to the mobility of the growth cone. The previous results from our laboratory have shown that Drosophila gene dunc-115 regulates axon projection in the eye and the central nervous system...
March 2017: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/28079786/fatal-postoperative-systemic-pulmonary-hypertension-in-benfluorex-induced-valvular-heart-disease-surgery-a-case-report
#6
Christophe Baufreton, Patrick Bruneval, Marie-Christine Rousselet, Pierre-Vladimir Ennezat, Olivier Fouquet, Raphael Giraud, Carlo Banfi
RATIONALE: Drug-induced valvular heart disease (DI-VHD) remains an under-recognized entity. PATIENT CONCERNS: This report describes a heart valve replacement which was complicated by intractable systemic pulmonary arterial hypertension in a 61-year-old female with severe restrictive mitral and aortic disease. The diagnosis of valvular disease was preceded by a history of unexplained respiratory distress. The patient had been exposed to benfluorex for 6.5 years. DIAGNOSES: The diagnostic procedure documented specific drug-induced valvular fibrosis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28055132/identifying-future-drinkers-behavioral-analysis-of-monkeys-initiating-drinking-to-intoxication-is-predictive-of-future-drinking-classification
#7
Erich J Baker, Nicole A R Walter, Alex Salo, Pablo Rivas, Sharon Moore, Steven Gonzales, Kathleen A Grant
BACKGROUND: The Monkey Alcohol and Tissue Research Resource (MATRR) is a repository and analytics platform for detailed data derived from well-documented Non-Human Primate (NHP) alcohol self-administration studies. This macaque model has demonstrated categorical drinking norms reflective of human drinking populations, resulting in consumption pattern classifications of Very Heavy Drinking (VHD), Heavy Drinking (HD), Binge Drinking (BD), and Low Drinking (LD) individuals. Here we expand on previous findings that suggest ethanol drinking patterns during initial drinking to intoxication can reliably predict future drinking category assignment...
January 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28004413/direct-oral-anticoagulant-use-in-nonvalvular-atrial-fibrillation-with-valvular-heart-disease-a-systematic-review
#8
REVIEW
Ryan E Owens, Rajesh Kabra, Carrie S Oliphant
Direct oral anticoagulants (DOACs) are indicated for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF), which, according to the American College of Cardiology/American Heart Association/Heart Rhythm Society atrial fibrillation (AF) guidelines, excludes patients with rheumatic mitral stenosis, a mechanical or bioprosthetic heart valve, or mitral valve repair. However, the data regarding use of DOACs in AF patients with other types of valvular heart disease (VHD) are unclear. We aimed to summarize and evaluate the literature regarding the safety and efficacy of DOAC use in NVAF patients with other types of VHD...
December 22, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27908608/a-hospital-based-survey-of-patients-with-severe-valvular-heart-disease-in-china
#9
Po Hu, Xian-Bao Liu, Jie Liang, Qi-Feng Zhu, Chao-Xia Pu, Meng-Yao Tang, Jian-An Wang
OBJECTIVES: Due to increasing aging, the epidemiology of VHD may have changed in China. This study aimed to provide contemporary information on the prevalence, distribution patterns, and etiology of severe VHD in China. METHODS: This was a retrospective survey at Second Affiliated Hospital of Zhejiang University, which included all consecutive patients between 2010 and 2015. RESULTS: In all, 139,496 patients were enrolled. Among severe valve diseases, MR was the most frequent (n=946, 0...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27866807/genome-wide-analysis-of-the-nucleus-accumbens-identifies-dna-methylation-signals-differentiating-low-binge-from-heavy-alcohol-drinking
#10
Rita Cervera-Juanes, Larry J Wilhelm, Byung Park, Kathleen A Grant, Betsy Ferguson
Alcohol use disorders encompass a range of drinking levels and behaviors, including low, binge and heavy drinking. In this regard, investigating the neural state of individuals who chronically self-administer lower doses of alcohol may provide insight into mechanisms that prevent the escalation of alcohol use. DNA methylation is one of the epigenetic mechanisms that stabilizes adaptations in gene expression and has been associated with alcohol use. Thus, we investigated DNA methylation, gene expression and the predicted neural effects in the nucleus accumbens core (NAcc) of male rhesus macaques categorized as "low" or "binge" drinkers, compared to "alcohol-naïve" and "heavy" drinkers based on drinking patterns during a 12 month alcohol self-administration protocol...
November 10, 2016: Alcohol
https://www.readbyqxmd.com/read/27684846/clinical-significance-of-hyperhomocysteinemia-in-infective-endocarditis-a-case-control-study
#11
Domenico Iossa, Rosa Molaro, Roberto Andini, Antonio Parrella, Maria Paola Ursi, Irene Mattucci, Lucia De Vincentiis, Giovanni Dialetto, Riccardo Utili, Emanuele Durante-Mangoni
Blood coagulation plays a key role in the pathogenesis of infective endocarditis (IE). Conditions associated with thrombophilia could enhance IE vegetation formation and promote embolic complications.In this study, we assessed prevalence, correlates, and clinical consequences of hyper-homocysteinemia (h-Hcy) in IE.Homocysteine (Hcy) plasma levels were studied in 246 IE patients and 258 valvular heart disease (VHD) patients, as well as in 106 healthy controls.IE patients showed Hcy levels comparable to VHD patients (14...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27639157/prevalence-and-predictors-of-valvular-heart-disease-in-patients-with-systemic-lupus-erythematosus
#12
REVIEW
Florencia Vivero, Cristina Gonzalez-Echavarri, Beatriz Ruiz-Estevez, Irene Maderuelo, Guillermo Ruiz-Irastorza
OBJECTIVES: We aimed to study the frequency, severity and predictors of valvular heart disease (VHD) in our lupus cohort. MATERIAL AND METHODS: 211 patients were included. A transthoracic echocardiogram was used for this study. Significant valvular lesions were classified into two groups: valvular thickening and valvular dysfunction. Univariate logistic regression was performed in order to find associations with valvular thickening and dysfunction. Those variables with a p value ≤0...
December 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27623745/calculating-the-cost-and-risk-of-comorbidities-in-total-joint-arthroplasty-in-the-united-states
#13
Joshua W Hustedt, Oren Goltzer, Daniel D Bohl, James F Fraser, Nina J Lara, Mark J Spangehl
BACKGROUND: With increased scrutiny regarding the cost and safety of health care delivery, there is increasing interest in judicious patient selection for total joint arthroplasty (TJA) procedures. It is unknown which comorbidities incur the greatest increase in risk to the patient and cost to the system after TJA. Therefore, this study sought to characterize the association of common preoperative comorbidities with both the risk for postoperative in-hospital complications and the total hospital cost in patients undergoing TJA...
August 9, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27496855/comparison-of-dabigatran-and-warfarin-in-patients-with-atrial-fibrillation-and-valvular-heart-disease-the-re-ly-trial-randomized-evaluation-of-long-term-anticoagulant-therapy
#14
RANDOMIZED CONTROLLED TRIAL
Michael D Ezekowitz, Rangadham Nagarakanti, Herbert Noack, Martina Brueckmann, Claire Litherland, Mark Jacobs, Andreas Clemens, Paul A Reilly, Stuart J Connolly, Salim Yusuf, Lars Wallentin
BACKGROUND: The RE-LY trial (Randomized Evaluation of Long-Term Anticoagulant Therapy) compared dabigatran 150 and 110 mg twice daily with warfarin in 18 113 patients with atrial fibrillation. Those with prosthetic heart valves, significant mitral stenosis, and valvular heart disease (VHD) requiring intervention were excluded. Others with VHD were included. METHODS: This is a post hoc analysis of the RE-LY trial. RESULTS: There were 3950 patients with any VHD: 3101 had mitral regurgitation, 1179 with tricuspid regurgitation, 817 had aortic regurgitation, 471 with aortic stenosis, and 193 with mild mitral stenosis...
August 23, 2016: Circulation
https://www.readbyqxmd.com/read/27487042/drug-induced-or-rheumatic-valvular-heart-disease-in-patients-exposed-to-benfluorex
#15
Florent Le Ven, Zarrin Alavi, Yannick Jobic, Yves Etienne, Romain Didier, Raphaël Porcher
There is a risk of misdiagnosis between benfluorex-induced VHD and acute rheumatic fever (ARF)-related VHD due to common characteristics of both etiologies. We aimed at estimating the probability for a patient exposed to benfluorex presenting with VHD to have, at the same time, a history of ARF-related VHD. Such epidemiological approach could help at reducing the risk of misdiagnosis. We used INSEE data and related literature as well as various modeling hypotheses to drive and test a formula for calculating the probability of a patient presenting with VHD and a history of benfluorex intake to have a prior history of ARF-related VHD...
2016: PloS One
https://www.readbyqxmd.com/read/27486163/management-of-hypertension-in-patients-with-mild-to-moderate-aortic-stenosis-navigating-the-seas
#16
EDITORIAL
Patrick T O'Gara
No abstract text is available yet for this article.
August 9, 2016: Circulation
https://www.readbyqxmd.com/read/27469320/risk-factors-associated-with-bleeding-after-multi-antithrombotic-therapy-during-implantation-of-cardiac-implantable-electronic-devices
#17
Kohei Ishibashi, Koji Miyamoto, Tsukasa Kamakura, Mitsuru Wada, Ikutaro Nakajima, Yuko Inoue, Hideo Okamura, Takashi Noda, Takeshi Aiba, Shiro Kamakura, Wataru Shimizu, Satoshi Yasuda, Takashi Akasaka, Kengo Kusano
Previous studies showed that continuous anticoagulation or single antiplatelet therapy during implantations of cardiac implantable electronic devices (CIED) was relatively safe. However, the safety of continuous multi antithrombotic therapy (AT) in patients undergoing CIED interventions has not been clearly defined. We sought to evaluate the safety of this therapy during CIED implantations. A total of 300 consecutive patients (mean 69 years old, 171 males) with CIED implantations were enrolled in this study...
July 28, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27390966/drug-induced-aortic-valve-stenosis-an-under-recognized-entity
#18
Pierre-Vladimir Ennezat, Patrick Bruneval, Daniel Czitrom, Jean-Pierre Gueffet, Nicolas Piriou, Jean Noël Trochu, Odile Patra, Bénédicte Blanchard-Lemoine, Xavier Halna du Fretay, Pierre Nazeyrollas, Bernard Assoun, Yannick Jobic, Eric Brochet, Emmanuel Bogino, Raymond Roudaut, Caroline Augier, Lorraine Greffe, Hélène Petit-Eisenmann, Camille Dambrin, Olivier Chavanon, Louis Guillou, Dominique Grisoli, Pierre Morera, Carlo Banfi, Jean Paul Remadi, Olivier Fabre, André Vincentelli, Sylvie Lantuejoul, Jean-Fortuné Ikoli, Marie-Christine Copin, Marie-Christine Malergue, Sylvestre Maréchaux, Christophe Tribouilloy
BACKGROUND: We have been intrigued by the observation that aortic stenosis (AS) may be associated with characteristic features of mitral drug-induced valvular heart disease (DI-VHD) in patients exposed to valvulopathic drugs, thus suggesting that beyond restrictive heart valve regurgitation, valvulopathic drugs may be involved in the pathogenesis of AS. METHODS: Herein are reported echocardiographic features, and pathological findings encountered in a series of patients suffering from both AS (mean gradient >15mmHg) and mitral DI-VHD after valvulopathic drugs exposure...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27354049/large-scale-community-echocardiographic-screening-reveals-a-major-burden-of-undiagnosed-valvular-heart-disease-in-older-people-the-oxvalve-population-cohort-study
#19
Joanna L d'Arcy, Sean Coffey, Margaret A Loudon, Andrew Kennedy, Jonathan Pearson-Stuttard, Jacqueline Birks, Eleni Frangou, Andrew J Farmer, David Mant, Jo Wilson, Saul G Myerson, Bernard D Prendergast
BACKGROUND: Valvular heart disease (VHD) is expected to become more common as the population ages. However, current estimates of its natural history and prevalence are based on historical studies with potential sources of bias. We conducted a cross-sectional analysis of the clinical and epidemiological characteristics of VHD identified at recruitment of a large cohort of older people. METHODS AND RESULTS: We enrolled 2500 individuals aged ≥65 years from a primary care population and screened for undiagnosed VHD using transthoracic echocardiography...
December 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27184870/the-immunosuppressive-effect-of-ctla4-immunoglobulin-is-dependent-on-regulatory-t-cells-at-low-but-not-high-doses
#20
C Schwarz, L Unger, B Mahr, K Aumayr, H Regele, A M Farkas, K Hock, N Pilat, T Wekerle
B7.1/2-targeted costimulation blockade (CTLA4 immunoglobulin [CTLA4-Ig]) is available for immunosuppression after kidney transplantation, but its potentially detrimental impact on regulatory T cells (Tregs) is of concern. We investigated the effects of CTLA4-Ig monotherapy in a fully mismatched heart transplant model (BALB/c onto C57BL/6). CTLA4-Ig was injected chronically (on days 0, 4, 14, and 28 and every 4 weeks thereafter) in dosing regimens paralleling clinical use, shown per mouse: low dose (LD), 0.25 mg (≈10 mg/kg body weight); high dose (HD), 1...
May 17, 2016: American Journal of Transplantation
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