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https://www.readbyqxmd.com/read/28332910/association-between-dietary-xanthophyll-lutein-and-zeaxanthin-intake-and-early-age-related-macular-degeneration-the-atherosclerosis-risk-in-communities-study
#1
Henry Lin, Julie A Mares, Michael J LaMonte, William E Brady, Michelle W Sahli, Ronald Klein, Barbara E K Klein, Jing Nie, Amy E Millen
PURPOSE: To examine the association between xanthophyll intake and prevalent early age-related macular degeneration (AMD) using data from the Atherosclerosis Risk in Communities Study (n = 10,295). Potential effect modification by genetic polymorphisms and biomarkers of high-density lipoprotein (HDL) metabolism was explored. METHODS: Xanthophyll intake was assessed at visit 1 (1987-1989) using food frequency questionnaires. Prevalent early AMD was assessed at visit 3 (1993-1995) via retinal photographs...
March 23, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28318359/zika-virus-and-eye
#2
Rupesh Agrawal, Hnin Hnin Oo, Praveen Kumar Balne, Lisa Ng, Louis Tong, Yee Sin Leo
Zika virus (ZIKV), a mosquito-borne flavivirus, is the latest global health concern. Transmission is mainly via Aedes mosquitoes and the infection can be diagnosed on molecular or serologic testings. It typically causes a mild self-remitting illness of low-grade fever, maculopapular rash, and myalgia, but when severe, it is associated with neurological deficits and congenital structural defects. Ocular manifestations are usually mild like nonpurulent conjunctivitis in adults, though it may be linked to uveitis, maculopathy, and hypertensive iridocyclitis...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28314832/features-of-the-choriocapillaris-in-myopic-maculopathy-identified-by-optical-coherence-tomography-angiography
#3
Kaori Sayanagi, Yasushi Ikuno, Sato Uematsu, Kohji Nishida
AIM: To describe the choriocapillaris features imaged by optical coherence tomography angiography (OCTA) in eyes with myopic maculopathy. METHODS: In this retrospective, non-invasive, observational case series, 26 eyes with myopic maculopathy and 12 age-matched healthy eyes underwent fluorescein angiography, indocyanine green angiography (ICGA) (highly myopic eyes only), OCT and OCTA, and the choriocapillaris features seen on OCTA and ICGA were compared. RESULTS: In all five (19%) eyes with patchy atrophy of the 26 highly myopic eyes, OCTA showed complete loss of the choriocapillaris and large choroidal vessels in the atrophic area...
March 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28303777/placental-up-regulation-of-leptin-and-arms2-is-associated-with-growth-discordance-in-monochorionic-diamniotic-twin-pregnancies
#4
Luming Sun, Jia Zhou, Kai Wang, Jian Wang, Ling Shang, Jianguang Zhang, Junqing Wu, David S Cram
Fetal growth discordance is a relatively common complication of monochorionic diamniotic (MCDA) twin pregnancies and is caused by a combination of maternal and placental factors. The aim of the study was to survey placental gene expression patterns and identify genes associated with growth discordance. Clinical samples comprised eight growth-discordant MCDA twin placentas (31+3-34+4 weeks gestational age) and six growth-concordant twin placentas (31+2-37 weeks gestational age). Gene expression libraries were constructed from placental biopsy samples and analyzed by RNA-sequencing...
April 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28301413/ophthalmic-findings-in-late-stage-sjogren-larsson-syndrome
#5
Tavish Nanda, Jaclyn L Kovach
PURPOSE: To report spectral domain optical coherence tomography and fundus autofluorescence documentation of late stage macular findings associated with Sjogren-Larsson Syndrome in three adult siblings. METHODS: Three adult siblings with Sjogren-Larsson Syndrome underwent ophthalmic examination and imaging. RESULTS: Crystalline maculopathy and subretinal deposits, presumably lipofuscin accumulation, with macular atrophy were present in varying degrees in all three adult siblings...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28297038/scleral-autograft-for-optic-nerve-head-pit-associated-chronic-maculopathy
#6
Parag K Shah, Smita S Karandikar, Venkatapathy Narendran
Chronic macular edema is a common finding seen in optic nerve head pits. There is no universally accepted modality present for this condition. Herein, the authors describe a novel surgical technique where a scleral autograft is used to plug the optic pit after microincision vitreous surgery. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:251-254.].
March 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28295944/paracentral-acute-middle-maculopathy-as-a-finding-in-patients-with-severe-vision-loss-following-phacoemulsification-cataract-surgery
#7
Katarina Creese, Daini Ong, Sukhpal S Sandhu, David Ware, C Alex Harper, Salmaan H Al-Qureshi, Sanjeewa S Wickremasinghe
IMPORTANCE: Paracentral acute middle maculopathy (PAMM) as diagnosed by spectral domain optical coherence tomography (SD-OCT) may be associated with "patch off" visual loss post cataract surgery. BACKGROUND: To report a case series of severe vision loss due to PAMM after cataract surgery DESIGN: Retrospective case series. PARTICIPANTS: Cases from five surgical centres (public and private) in Victoria, Australia. METHODS: Retrospective analysis of cases with unexplained "patch-off" vision loss post cataract surgery...
March 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28293432/diabetic-retinopathy-and-oct-angiography-clinical-findings-and-future-perspectives
#8
REVIEW
Jose Mauricio Botto de Barros Garcia, David Leonardo Cruvinel Isaac, Marcos Avila
In diabetic retinopathy (DR), macular involvement can present as either macular edema or ischemia. Fluorescein angiography remains the gold standard in the evaluation of retinal vascular perfusion and diagnosis of macular ischemia. However, it is a costly, time-consuming technique, it requires venipuncture, and reports of anaphylaxis and death related to fluorescein injections have been documented, despite their rarity. Optical coherence tomography (OCT) provides a fast and non-invasive method to assess retinal structures at a microscopic level...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28272283/dexamethasone-intravitreal-implant-vs-ranibizumab-in-the-treatment-of-macular-edema-secondary-to-brachytherapy-for-choroidal-melanoma
#9
Andrea Russo, Michele Reibaldi, Teresio Avitabile, Maurizio G Uva, Livio Marco Franco, Caterina Gagliano, Vincenza Bonfiglio, Corrado Spatola, Giuseppe Privitera, Antonio Longo
PURPOSE: To evaluate the efficacy of an intravitreal dexamethasone (Dex) implant 0.7 mg compared with intravitreal ranibizumab (Ra) for the treatment of radiation maculopathy with macular edema secondary to plaque brachytherapy in choroidal melanoma. METHODS: Eight patients were treated with intravitreal Ra, and eight patients received the Dex intravitreal implant. Visual acuity and foveal thickness were evaluated using spectral domain optical coherence tomography...
March 7, 2017: Retina
https://www.readbyqxmd.com/read/28255149/unusual-presentation-of-severe-dengue-dengue-maculopathy
#10
K H Chuah, C W K Ng, K Zabri, C L Wong
Dengue infection is epidemic but ocular complications of dengue are less reported. We report a case of dengueinfected patient with disturbing ocular symptoms. He was admitted for severe dengue. Subsequently, he presented with symptoms of bilateral central scotoma with metamorphosia. Fundus examination revealed cotton wool spots and flame-shaped haemorrhages at the macula, with dull foveal light reflex. He was diagnosed with bilateral dengue maculopathy. The patient was managed conservatively with surveillance...
February 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28248743/acute-idiopathic-maculopathy-7-year-follow-up-with-development-of-outer-retinal-tubulations
#11
Hans B Heymann, Daniel A Colon, Lee M Jampol
PURPOSE: To describe the development of outer retinal tubulations in a patient with acute idiopathic maculopathy. METHODS: Chart review was performed on a single patient to collect all relevant clinical information and diagnostic imaging. RESULTS: A case of outer retinal tubulations in a patient with idiopathic maculopathy is documented. CONCLUSION: Patients with acute idiopathic maculopathy may develop outer retinal tubulations similar to other entities that cause disturbance of retinal pigment epithelium or photoreceptors...
February 28, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28237427/three-dimensional-eye-shape-myopic-maculopathy-and-visual-acuity-the-zhongshan-ophthalmic-center-brien-holden-vision-institute-high-myopia-cohort-study
#12
Xinxing Guo, Ou Xiao, Yanxian Chen, Huawang Wu, Linxing Chen, Ian G Morgan, Mingguang He
PURPOSE: To investigate the relationship among eye shape, myopic maculopathy, and visual acuity in highly myopic eyes using 3-dimensional (3D) magnetic resonance imaging (MRI). DESIGN: Observational case series. PARTICIPANTS: The study included 190 eyes of 95 participants with bilateral high myopia from the Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study, with spherical power ≤-6.00 diopters (D) in both eyes...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28237415/en-face-oct-analysis-to-assess-the-spectrum-of-perivenular-ischemia-and-paracentral-acute-middle-maculopathy-in-retinal-vein-occlusion
#13
Khalil Ghasemi Falavarjani, Nopasak Phasukkijwatana, K Bailey Freund, Emmett T Cunningham, Ananda Kalevar, H Richard McDonald, Rosa Dolz Marco, Philipp K Roberts, Irena Tsui, Richard Rosen, Lee Merrill Jampol, Srinivas R Sadda, David Sarraf
PURPOSE: To assess the spectrum of perivenular ischemia in eyes with retinal vascular obstruction (typically central or hemicentral retinal vein obstruction) using en face optical coherence tomography (OCT). DESIGN: Retrospective observational case series. METHODS: Eyes with recent retinal vascular occlusion illustrating paracentral acute middle maculopathy (PAMM) in a perivenular fern-like pattern with en face OCT were evaluated in this study...
February 22, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28225723/characterization-of-macular-choroidal-thickness-in-ischemic-and-nonischemic-diabetic-maculopathy
#14
Jay U Sheth, Anantharaman Giridhar, Bindu Rajesh, Mahesh Gopalakrishnan
PURPOSE: To evaluate changes in macular choroidal thickness in eyes with ischemic and nonischemic diabetic maculopathy. METHODS: Cross-sectional study of enhanced depth imaging optical coherence tomography of patients with diabetes. The diabetic eyes were divided into 3 groups: 1) eyes with no diabetic retinopathy (NDR); 2) those with diabetic retinopathy without macular ischemia (DR/MI-); and 3) those with diabetic retinopathy and macular ischemia (DR/MI+). RESULTS: This analysis included 261 eyes of 160 patients...
March 2017: Retina
https://www.readbyqxmd.com/read/28225368/the-fundus-phenotype-associated-with-the-p-ala243val-best1-mutation
#15
Kamron N Khan, Farrah Islam, Anthony T Moore, Michel Michaelides
PURPOSE: To describe a highly recognizable and reproducible retinal phenotype associated with a specific BEST1 mutation-p.Ala243Val. METHODS: Retrospective review of consecutive cases where genetic testing has identified p.Ala243Val BEST1 as the cause of disease. Electronic patient records were used to extract demographic, as well as functional and anatomical data. These data were compared with those observed with the most common BEST1 genotype, p.Arg218Cys. RESULTS: Eight individuals (six families) were identified with the p...
February 20, 2017: Retina
https://www.readbyqxmd.com/read/28224275/the-english-national-screening-programme-for-diabetic-retinopathy-2003-2016
#16
Peter H Scanlon
The aim of the English NHS Diabetic Eye Screening Programme is to reduce the risk of sight loss amongst people with diabetes by the prompt identification and effective treatment if necessary of sight-threatening diabetic retinopathy, at the appropriate stage during the disease process. In order to achieve the delivery of evidence-based, population-based screening programmes, it was recognised that certain key components were required. It is necessary to identify the eligible population in order to deliver the programme to the maximum number of people with diabetes...
February 22, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28221332/sustained-resolution-of-macular-retinoschisis-after-trabeculectomy-in-a-patient-with-progressive-glaucoma
#17
Rany Woo, Handan Akil, Nicole Koulisis, Lisa C Olmos de Koo, James C H Tan
PURPOSE: To evaluate the clinical characteristics of a patient with primary open-angle glaucoma in whom macular retinoschisis resolved completely after trabeculectomy consistently lowered intraocular pressure (IOP). METHODS: A single case report. RESULTS: We report a case of retinoschisis involving the macula in a patient with primary open-angle glaucoma in the absence of myopic maculopathy, optic nerve anomaly, or x-linked retinoschisis. The patient's glaucoma was associated with progressive visual field loss in the setting of IOP fluctuations related to posture...
February 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28221261/zika-related-maculopathy
#18
Chee Wai Wong, Si Rui Ng, Chui Ming Gemmy Cheung, Tien Yin Wong, Ranjana Mathur
PURPOSE: To report a case of unilateral maculopathy associated with acute Zika virus infection. METHODS: Observational case report of one patient. RESULTS: A 22-year-old man presented with acute blurring of vision 10 days after symptoms of Zika virus infection. Findings resembling unilateral acute idiopathic maculopathy of the right eye were noted on ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and optical coherence tomography...
February 17, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28220890/clinical-investigation-of-the-posterior-scleral-contraction-to-treat-macular-traction-maculopathy-in-highly-myopic-eyes
#19
An-Peng Pan, Ting Wan, Shuang-Qian Zhu, Liang Dong, An-Quan Xue
Myopic traction maculopathy (MTM) can cause vision disabilities in highly myopic eyes. This retrospective case series investigated the clinical outcomes of posterior scleral contraction (PSC) using genipin-cross-linked sclera as the material to treat MTM in highly myopic eyes. In total, 32 eyes from 29 highly myopic patients who underwent PSC for MTM were recruited. The changes in best-corrected visual acuity (BCVA) and axial length were evaluated, macular reattachment and macular hole (MH) closure was assessed by optical coherence tomography, and complications were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28195622/optical-coherence-tomography-angiography-of-paracentral-acute-middle-maculopathy-associated-with-primary-antiphospholipid-syndrome
#20
Matthew G J Trese, Aristomenis Thanos, Yoshihiro Yonekawa, Sandeep Randhawa
The authors present the first case of paracentral acute middle maculopathy as a manifestation of primary antiphospholipid syndrome (APS) with multimodal imaging, including optical coherence tomography angiography (OCTA). The association between APS and ophthalmic sequela is well-known. Recent advances in multimodal imaging, specifically OCTA, allow for better characterization of the mechanism and extent by which retinal arterial thrombosis can cause vision loss. Using advanced imaging modalities, the authors provide a comprehensive assessment of retinal ischemia, which showed not only localized capillary occlusion, but also ischemia of the deep retinal capillary plexus...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
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