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https://www.readbyqxmd.com/read/28811895/long-term-rearrangement-of-retinal-structures-in-a-novel-mutation-of-x-linked-retinoschisis
#1
Stefano Piermarocchi, Stefania Miotto, Davide Colavito, Elda Del Giudice, Alberta Leon, Veronica Maritan, Rita Piermarocchi, Alma Patrizia Tormene
The aim of the present study was to report a novel mutation in the retinoschisin 1 (RS1) gene in a Caucasian family affected by X-linked juvenile retinoschisis (XLRS) and to describe the long-term modification of retinal structure. Two brothers with an early onset maculopathy were diagnosed with XLRS. Fundus photography, fluorescein angiography, spectral domain optical coherence tomography and electroretinogram analyses were performed. Their sister was also examined. All subjects were screened for mutations in the RS1 gene...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28809763/persistent-placoid-maculopathy-complicated-by-cerebral-vasculitis
#2
Eva Lenassi, Maja Kojovic, Polona Jaki Mekjavić, Sasa Sega, Natasa Vidovič Valentinčič
Persistent placoid maculopathy (PPM) is a bilateral inflammatory chorioretinopathy characterized by long-standing plaque-like macular lesions. No systemic manifestations have been reported to date. We describe a case of PPM complicated by cerebral vasculitis, suggesting that neurological symptoms, including headache, should be enquired about in all PPM subjects.
September 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28808662/the-status-of-maculopathy-in-diabetes-and-prediabetes-patients-in-a-population-based-study-detected-by-optical-coherence-tomography-the-2011-health-examination-survey-in-beijing
#3
Xi Cao, Zhong Xin, Shiming Li, Yue Qi, Mingxia Yuan, Xiaorong Zhu, Jin-Kui Yang
OBJECTIVE: The aim of the study was to investigate the prevalence and the risk factors of maculopathy detected by optical coherence tomography (OCT) in a Chinese population with diabetes or prediabetes. Methods. 8,155 people were randomly selected to participate in the 2011 annual Health Examination Survey in Beijing. A 75 g oral glucose tolerance test (OGTT) was tested in 3760 subjects with fasting plasma glucose (FPG) ≥ 5.6 mmol/L. Of 3,760 subjects, 583 were also randomly selected to take OCT...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28806215/prevalence-of-vitreomacular-adhesion-in-patients-without-maculopathy-older-than-40-years
#4
Julie A Rodman, Diana Shechtman, Brad M Sutton, Joseph J Pizzimenti, Ava K Bittner
PURPOSE: To determine the prevalence and factors influencing vitreomacular adhesion (VMA) or vitreomacular traction (VMT) in subjects without maculopathy older than age 40 years. METHODS: In a prospective cross-sectional study, 1,950 eyes in 1,090 participants aged 40 to 89 years representing various ethnic groups from 14 centers in the United States underwent a comprehensive eye examination, including spectral domain optical coherence tomography. A team of independent, masked readers classified the presence or absence of VMA/VMT on spectral domain optical coherence tomography based on the International Vitreomacular Traction Study Group rubric...
August 10, 2017: Retina
https://www.readbyqxmd.com/read/28799637/facilitating-the-analysis-of-the-multifocal-electroretinogram-using-the-free-software-environment-r
#5
Richard Bergholz, Mirjam Rossel, Ralf M Dutescu, Klaas P Vöge, Daniel J Salchow
PURPOSE: The large amount of data rendered by the multifocal electroretinogram (mfERG) can be analyzed and visualized in various ways. The evaluation and comparison of more than one examination is time-consuming and prone to create errors. Using the free software environment R we developed a solution to average the data of multiple examinations and to allow a comparison of different patient groups. METHODS: Data of single mfERG recordings as exported in .csv format from a RETIport 21 system (version 7/03, Roland Consult) or manually compiled ...
August 7, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28791546/quantitative-analysis-of-photoreceptor-layer-reflectivity-on-en-face-optical-coherence-tomography-as-an-estimator-of-cone-density
#6
Maher Saleh, Mathieu Flores, Anne Sophie Gauthier, Emeric Elphege, Bernard Delbosc
BACKGROUND: To investigate whether outer retinal reflectivity on en-face Optical coherence tomography (OCT) can be considered as an estimator of cone density measured in the same area. METHODS: Forty-one points of comparisons were studied in 9 eyes (n = 6 patients) presenting maculopathies with various degrees of impairment of the photoreceptor layer. The inner segment ellipsoid zone (EZ), interdigitation zone (IZ), and retinal pigment epithelium (RPE) reflectivity were measured on coronal reconstruction of the photoreceptor layer using homemade dedicated software (Matlab, MathWorks Inc...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28781803/cystoid-macular-edema-secondary-to-paclitaxel-therapy-for-ovarian-cancer-a-case-report
#7
Emma Bassi, Vera Loizzi, Claudio Furino, Rosa Martino, Giovanni Alessio, Cicinelli Ettore, Gennaro Cormio
Paclitaxel is a member of the taxane agents that has demonstrated efficacy in ovarian cancer, both in first- and in second-line therapy. Counted among the side-effects of this drug are neurological disorders. In the present study, a rare case of a non-neuropathic ocular disorder, known as cystoid macular edema (CME), due to paclitaxel in patients treated for ovarian cancer is described. Macular edema, or CME, is a common cause of visual impairment that has been classically demonstrated by fluorescein angiograms, showing capillary leakage...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28775091/limbal-cyst-following-blunt-trauma-in-an-operated-case-of-congenital-cataract-a-rare-scenario
#8
Amar Pujari, Deepa R Swamy, Harathy Selvan, Rohan Chawla
A 15-year-old male patient with the history of bilateral operated congenital cataract surgery 5 years back now presents with gradual painless diminution of visual acuity in left eye following a blunt trauma with a fist. Ocular examination showed a well-defined slightly bluish-tinged limbal-based conjunctival cyst without any irregularities in the anterior chamber/pupil. Intraocular pressures were 16 mm Hg in the right eye and 10 mm Hg in the left eye; retinal examination showed findings consistent with hypotonic maculopathy...
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28763558/radiation-maculopathy-after-proton-beam-therapy-for-uveal-melanoma-optical-coherence-tomography-angiography-alterations-influencing-visual-acuity
#9
Alexandre Matet, Alejandra Daruich, Leonidas Zografos
Purpose: To analyze microvascular and structural changes in radiation maculopathy and their influence on visual acuity (VA), using optical coherence tomography (OCT) and OCT angiography (OCTA). Methods: This was a retrospective analysis of consecutive patients with radiation maculopathy, 12 months or more after proton-beam irradiation for uveal melanoma, imaged with fluorescein angiography, OCT, and OCTA. Clinical parameters potentially affecting VA were recorded, including OCTA-derived metrics: foveal avascular zone (FAZ) area, vascular density, and local fractal dimension of the superficial (SCP) and deep capillary plexuses (DCP)...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28763557/c2orf71-mutations-as-a-frequent-cause-of-autosomal-recessive-retinitis-pigmentosa-clinical-analysis-and-presentation-of-8-novel-mutations
#10
MULTICENTER STUDY
Christina Gerth-Kahlert, Amit Tiwari, James V M Hanson, Vaishnavi Batmanabane, Elias Traboulsi, Mark E Pennesi, Abdullah A Al-Qahtani, Byron L Lam, John Heckenlively, Sandrine A Zweifel, Ajoy Vincent, Fabienne Fierz, Daniel Barthelmes, Kari Branham, Naheed Khan, Angela Bahr, Luzy Baehr, István Magyar, Samuel Koller, Silvia Azzarello-Burri, Dunja Niedrist, Elise Heon, Wolfgang Berger
Purpose: To define the phenotype of C2orf71 associated retinopathy and to present novel mutations in this gene. Methods: A retrospective multicenter study of patients with retinopathy and identified C2orf71 mutations was performed. Ocular function (visual acuity, visual fields, electroretinogram [ERG] responses); retinal morphology (fundus, optical coherence tomography); and underlying mutations were analyzed. Results: Thirteen patients from 11 families, who were aged 7 to 63 years (mean: 32...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28761324/arms2-variants-may-predict-the-3-year-outcome-of-photodynamic-therapy-for-wet-age-related-macular-degeneration
#11
Shunichiro Nakai, Shigeru Honda, Wataru Matsumiya, Akiko Miki, Makoto Nakamura
PURPOSE: To determine the association of age-related maculopathy susceptibility2 (ARMS2) gene polymorphisms with the 3-year outcomes of photodynamic therapy (PDT) in wet age-related macular degeneration (wet AMD). METHODS: The single nucleotide polymorphism (SNP) at rs10490924 in the ARMS2 gene of 65 patients with wet AMD who underwent PDT was genotyped using the TaqMan assay. The clinical characteristics and the outcomes of PDT were compared among the three genotypes at rs10490924...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28756498/post-transplant-erythrocytosis-related-maculopathy-successful-management-of-hyperviscosity-with-phlebotomy
#12
Sumeet Khanduja, Brijesh Takkar, Neha Khanduja, Pradeep Venkatesh
PURPOSE: To report clinical features in a case of hyperviscosity retinopathy following post-renal transplant erythrocytosis (PTE) and its outcome after phlebotomy. METHODS: Fundus fluorescein angiography and optical coherence tomography (OCT) were carried out for a 29-year-old renal allograft recipient who presented with acute unilateral visual loss. RESULT: There was mild retinal vascular dilation in both eyes with retinal hemorrhages and retinal opaqueness in left eye...
July 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28755024/concentration-of-acute-phase-factors-in-vitreous-fluid-in-diabetic-macular-edema
#13
Kazuhiro Kimura, Tomoko Orita, Yuka Kobayashi, Shigeo Matsuyama, Kazushi Fujimoto, Kazuhiko Yamauchi
PURPOSE: Diabetic retinal maculopathy is associated with acute and chronic local inflammation. We measured the concentrations of acute phase factors in vitreous fluid of patients with diabetic macular edema (DME) and examined their relations to visual acuity and central retinal thickness (CRT) both before and after vitrectomy. STUDY DESIGN: Retrospective. METHODS: Vitreous fluid was collected during vitreoretinal surgery from 19 patients with DME and 12 control subjects with epiretinal membrane...
July 28, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28752370/post-hypoxic-constriction-of-retinal-arterioles-is-impaired-during-nitric-oxide-and-cyclo-oxygenase-inhibition-and-in-diabetic-patients-without-retinopathy
#14
Line Petersen, Toke Bek
Occlusion of retinal vessels leads to retinal ischaemia and hypoxia, which induces vasodilatation in adjacent retinal areas in order to normalize retinal oxygenation. Previous studies have shown that NO and COX products are involved in hypoxia-induced dilatation of retinal arterioles in vitro and in vivo, and that this response is disturbed in patients with diabetes mellitus. However, it is unknown to what extent post-hypoxic recovery of the diameter of retinal arterioles depends on NO and COX products in normal persons and in diabetic patients...
July 27, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28750218/insulin-resistance-correlates-with-maculopathy-and-severity-of-retinopathy-in-young-adults-with-type-1-diabetes-mellitus
#15
C W Rowe, A S Haider, D Viswanathan, M Jones, J Attia, K Wynne, S Acharya
AIMS: To assess the relationship between insulin resistance (IR), retinopathy and maculopathy in young adults with Type 1 diabetes mellitus. METHODS: A cross-sectional study at a regional Australian tertiary hospital. Retinal pathology, assessed by colour fundus photography, was correlated with two surrogate measures of IR: estimated Glucose Disposal Rate (eGDR) and Insulin Sensitivity Score (ISS), where lower scores reflect greater IR. RESULTS: 107 patients were recruited, with mean age 24...
June 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28750115/association-of-c-reactive-protein-genetic-polymorphisms-with-late-age-related-macular-degeneration
#16
Valentina Cipriani, Ruth E Hogg, Reecha Sofat, Anthony T Moore, Andrew R Webster, John R W Yates, Astrid E Fletcher
Importance: C-reactive protein (CRP) is a circulating inflammatory marker associated with late age-related macular degeneration (AMD). It remains uncertain whether the association between CRP concentrations and AMD is causal. Objective: To assess whether CRP (OMIM 123260) single-nucleotide polymorphisms that influence circulating CRP concentrations are associated with late AMD. Design, Setting, and Participants: Participants in 2 UK, hospital-based, case-control studies (Cambridge AMD study and Moorfields Eye Hospital AMD study) and 1 pan-European, cross-sectional, population-based study (the European Eye [EUREYE] Study) were recruited between November 6, 2000, and April 30, 2007...
July 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28739278/p38mapk-plays-a-critical-role-in-induction-of-a-pro-inflammatory-phenotype-of-retinal-m%C3%A3-ller-cells-following-zika-virus-infection
#17
Shuang Zhu, Huanle Luo, Hua Liu, Yonju Ha, Elizabeth R Mays, Ryan E Lawrence, Evandro Winkelmann, Alan D Barrett, Sylvia B Smith, Min Wang, Tian Wang, Wenbo Zhang
Zika virus (ZIKV) infection has been associated with ocular abnormalities such as chorioretinal atrophy, optic nerve abnormalities, posterior uveitis and idiopathic maculopathy. Yet our knowledge about ZIKV infection in retinal cells and its potential contribution to retinal pathology is still very limited. Here we found that primary Müller cells, the principal glial cells in the retina, expressed a high level of ZIKV entry cofactor AXL gene and were highly permissive to ZIKV infection. In addition, ZIKV-infected Müller cells exhibited a pro-inflammatory phenotype and produced many inflammatory and growth factors...
July 21, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28733050/the-optical-imaging-of-an-idiopathic-paracentral-acute-middle-maculopathy-chinese-young-man-and-review-of-the-literatures
#18
REVIEW
Yanyan Chen, Yuedong Hu
We report a case of idiopathic paracentral acute middle maculopathy with typical optical imaging and clinical features. A 26-year-old Chinese policeman presented with a 20-day history of paracentral scotoma in the left eye after early wake-up and long-time working in front of computer the day before. He experienced sudden-onset strong flash in his left eye. Paracentral scotoma appeared in his left eye after 6hours of rest. The general history was negative. His best-corrected visual acuity was 20/20 OU. Anterior segment, dilated fundus examination, papillary evaluation and intraocular pressure were normal...
July 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28731058/multicenter-study-of-pars-plana-vitrectomy-for-optic-disc-pit-maculopathy-macpit-study
#19
R Avci, Z Kapran, Ş Ozdek, M Y Teke, O Oz, D Guven, S Yilmaz, B Kaderli, A H Durukan, G Sobaci, Y B Unver, L Akduman, S Kaynak, I Dogan, U U Inan
PurposeTo evaluate surgical intervention with pars plana vitrectomy (PPV) for correction of optic disc pit maculopathy (ODP-M).Patients and methodsRetrospective chart review from 13 centres of 51 eyes of 50 patients with ODP-M who underwent PPV between 2002-2014. Anatomic and final best-corrected visual acuity (BCVA) outcomes were evaluated for all cases with different adjuvant techniques.ResultsThere were 23 males and 27 females with median age 25.5 (6-68) years. Preoperative median foveal thickness was 694...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28724375/bilateral-idiopathic-retinal-vasculitis-following-coxsackievirus-a4-infection-a-case-report
#20
Izumi Mine, Manzo Taguchi, Yutaka Sakurai, Masaru Takeuchi
BACKGROUND: Coxsackieviruses are members of a group of viruses called the enteroviruses, which may cause respiratory and gastrointestinal symptoms, erythema, meningoencephalitis, myocarditis, pericarditis, and myositis. Unilateral acute idiopathic maculopathy caused by coxsackievirus A16 has been associated with hand, foot, and mouth disease, but only a few reports describe retinitis associated with coxsackievirus serotype B3 or B4. We report a case of bilateral multifocal obstructive retinal vasculitis that developed after coxsackievirus A4 infection...
July 19, 2017: BMC Ophthalmology
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