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optic coherence tomography

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https://www.readbyqxmd.com/read/28637033/quantitative-swept-source-optical-coherence-tomography-of-early-enamel-erosion-in-vivo
#1
Rupert S Austin, Maisalamah Haji Taha, Frederic Festy, Richard Cook, Manoharan Andiappan, Juliana Gomez, Iain A Pretty, Rebecca Moazzez
Swept-source optical coherence tomography (SS-OCT) shows potential for the in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralization. This randomized controlled single-blind cross-over clinical study aimed to evaluate the use of SS-OCT for detecting optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states...
June 22, 2017: Caries Research
https://www.readbyqxmd.com/read/28636406/protective-effect-of-intravitreal-administration-of-exosomes-derived-from-mesenchymal-stem-cells-on-retinal-ischemia
#2
Elad Moisseiev, Johnathon D Anderson, Sharon Oltjen, Mayank Goswami, Robert J Zawadzki, Jan A Nolta, Susanna S Park
PURPOSE: Exosomes derived from human mesenchymal stem cells (hMSCs) cultured under hypoxic conditions contain proteins and growth factors that promote angiogenesis. This study investigated the effect of intravitreal administration of these exosomes on retinal ischemia using a murine model. METHODS: Oxygen-induced retinopathy (OIR) was induced by exposing one-week-old male C57BL/6J mice to 5 days of 75% hyperoxic conditioning, and returning to room air. After hyperoxic conditioning, the right eye of each mouse was injected intravitreally with 1 µl saline or exosomes derived from hMSCs and compared to control mice of the same age raised in room air without OIR injected intravitreally with saline...
June 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28636255/recombinant-human-serum-albumin-for-corneal-preservation
#3
Mohit Parekh, Hossein Elbadawy, Gianni Salvalaio, Marie-Claude Amoureux, Enzo Di Iorio, Denis Fortier, Diego Ponzin, Stefano Ferrari, Alessandro Ruzza
PURPOSE: To study the performance of a completely synthetic organ culture (OC) preservation system containing recombinant human serum albumin (rHSA) for preservation of human donor corneas. METHODS: Twenty-four paired donor corneas were randomly collected, and one cornea from each donor was preserved in synthetic (experimental) and serum-based media (control). The tissues were assessed at day 0; after 6 days of preservation at room temperature (RT) in Cornea Trans(®) and Cornea Prep II(®) ; after 28 days at 31°C in Cornea Syn(®) [with rHSA] and Cornea Max(®) [with foetal calf serum (FCS)] and; 4-day post deswelling in Cornea Trans(®) and Cornea Jet(®) ...
June 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28636065/automatic-motion-correction-for-in-vivo-human-skin-optical-coherence-tomography-angiography-through-combined-rigid-and-nonrigid-registration
#4
David Wei Wei, Anthony J Deegan, Ruikang K Wang
No abstract text is available yet for this article.
June 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28635425/multimodal-imaging-in-cabp4-related-retinopathy
#5
Patrik Schatz, Maram E A Abdalla Elsayed, Arif O Khan
PURPOSE: Multimodal imaging has not been documented for CABP4-related retinopathy. In this study, we describe optical coherence tomography (OCT) and fundus autofluorescence findings for five genetically confirmed cases. METHODS: Retrospective case series. RESULTS: Four patients with the previously described homozygous Saudi CABP4 founder mutation c.81_82insA (p.Pro28ThrfsX44) and one patient with the homozygous mutation c.1A>G (p.Met1?) in CABP4 were examined...
March 1, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28635311/type-d-personality-but-not-type-a-behavior-pattern-is-associated-with-coronary-plaque-vulnerability
#6
Ping Lin, Ling Li, Yini Wang, Zhenjuan Zhao, Guojie Liu, Wei Chen, Hui Tao, Xueqin Gao
Personality traits are associated with major adverse coronary events (MACE) in patients with coronary artery disease (CAD). However, the link between personality traits and intravascular morphology in CAD patients is poorly understood. This study investigated the relationship between personality traits, specifically Type A behavior pattern and Type D personality, and plaque vulnerability. After adjustment for demographic and clinical factors, multivariable regression analysis showed no association between Type A and optical coherence tomography indices...
June 21, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28635138/snake-spectacle-vessel-permeability-to-sodium-fluorescein
#7
Roy W Bellhorn, Ann R Strom, Monica J Motta, John Doval, Michelle G Hawkins, Joanne Paul-Murphy
OBJECTIVE: Assess vascular permeability of the snake spectacle to sodium fluorescein during resting and shedding phases of the ecdysis cycle. ANIMAL STUDIED: Ball python (Python regius). PROCEDURES: The snake was anesthetized, and spectral domain optic coherence tomography was performed prior to angiographic procedures. An electronically controlled digital single-lens reflex camera with a dual-head flash equipped with filters suitable for fluorescein angiography was used to make images...
June 20, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28635102/ratiometric-analysis-of-optical-coherence-tomography-measured-in%C3%A2-vivo-retinal-layer-thicknesses-for-the-detection-of-early-diabetic-retinopathy
#8
Basanta Bhaduri, Ryan L Shelton, Ryan M Nolan, Lucas Hendren, Alexandra Almasov, Leanne T Labriola, Stephen A Boppart
Influence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral-domain optical coherence tomography images using open-source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one-way analyses of variance (ANOVA) between adjacent study groups (i. e...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28633153/association-between-visual-function-and-subretinal-drusenoid-deposits-in-normal-and-early-age-related-macular-degeneration-eyes
#9
David Neely, Anna V Zarubina, Mark E Clark, Carrie E Huisingh, Gregory R Jackson, Yuhua Zhang, Gerald McGwin, Christine A Curcio, Cynthia Owsley
PURPOSE: To examine the association between subretinal drusenoid deposits (SDDs) identified by multimodal retinal imaging and visual function in older eyes with normal macular health or in the earliest phases of age-related macular degeneration (AMD). METHODS: Age-related macular degeneration status for each eye was defined according to the Age-Related Eye Disease Study (AREDS) 9-step classification system (normal = Step 1, early AMD = Steps 2-4) based on color fundus photographs...
July 2017: Retina
https://www.readbyqxmd.com/read/28632847/pattern-recognition-analysis-of-age-related-retinal-ganglion-cell-signatures-in-the-human-eye
#10
Nayuta Yoshioka, Barbara Zangerl, Lisa Nivison-Smith, Sieu K Khuu, Bryan W Jones, Rebecca L Pfeiffer, Robert E Marc, Michael Kalloniatis
Purpose: To characterize macular ganglion cell layer (GCL) changes with age and provide a framework to assess changes in ocular disease. This study used data clustering to analyze macular GCL patterns from optical coherence tomography (OCT) in a large cohort of subjects without ocular disease. Methods: Single eyes of 201 patients evaluated at the Centre for Eye Health (Sydney, Australia) were retrospectively enrolled (age range, 20-85); 8 × 8 grid locations obtained from Spectralis OCT macular scans were analyzed with unsupervised classification into statistically separable classes sharing common GCL thickness and change with age...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28632845/iris-malformation-and-anterior-segment-dysgenesis-in-mice-and-humans-with-a-mutation-in-pi-3-kinase
#11
Marie H Solheim, Allen C Clermont, Jonathon N Winnay, Erlend Hallstensen, Anders Molven, Pål R Njølstad, Eyvind Rødahl, C Ronald Kahn
Purpose: To determine the ocular consequences of a dominant-negative mutation in the p85α subunit of phosphatidylinositol 3-kinase (PIK3R1) using a knock-in mouse model of SHORT syndrome, a syndrome associated with short stature, lipodystrophy, diabetes, and Rieger anomaly in humans. Methods: We investigated knock-in mice heterozygous for the SHORT syndrome mutation changing arginine 649 to tryptophan in p85α (PIK3R1) using physical examination, optical coherence tomography (OCT), tonometry, and histopathologic sections from paraffin-embedded eyes, and compared the findings to similar investigations in two human subjects with SHORT syndrome heterozygous for the same mutation...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28632734/choroidal-thickness-in-patients-with-coronary-artery-disease
#12
Meleha Ahmad, Patrick A Kaszubski, Lucy Cobbs, Harmony Reynolds, Roland Theodore Smith
PURPOSE: To evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls. DESIGN: Cross-sectional. METHODS: Setting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure...
2017: PloS One
https://www.readbyqxmd.com/read/28632411/the-effect-of-dexamethasone-intravitreal-implant-on-retinal-nerve-fiber-layer-in-patients-diagnosed-with-branch-retinal-vein-occlusion
#13
Orhan Ayar, Atilla Alpay, Yaran Koban, Mehmet Orcun Akdemir, Serpil Yazgan, Sılay Canturk Ugurbas, Suat Hayri Ugurbas
PURPOSE: To evaluate the effect of a single dose of intravitreal dexamethasone (DEX) implant on retinal nerve fiber layer (RNFL) thickness in patients with branch retinal vein occlusion (BRVO) in a 6-month period. MATERIALS AND METHODS: This retrospective observational study included the patients with BRVO who received intravitreal DEX implant and whose assessment included the baseline RNFL thickness measurements. The data of 26 eyes of 24 patients were retrospectively analyzed...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28632403/effect-of-amblyopia-treatment-on-choroidal-thickness-in-children-with-hyperopic-anisometropic-amblyopia
#14
Seray Aslan Bayhan, Hasan Ali Bayhan
PURPOSE: To evaluate choroidal thickness (CT) in the eyes of children with hyperopic anisometropic amblyopia and to assess changes in CT during amblyopia treatment using spectral-domain optical coherence tomography (SD-OCT). METHODS: This longitudinal study, initially enrolled 40 patients, aged 3-9 years with hyperopic anisometropic amblyopia. Patients underwent treatment with refractive correction alone for 16 weeks and if needed, with refractive correction and patching treatment thereafter (6 months)...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28632205/speckle-modulating-optical-coherence-tomography-in-living-mice-and-humans
#15
Orly Liba, Matthew D Lew, Elliott D SoRelle, Rebecca Dutta, Debasish Sen, Darius M Moshfeghi, Steven Chu, Adam de la Zerda
Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo. As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by creating and averaging an unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution...
June 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28632031/mr-imaging-of-the-anterior-visual-pathway-in-primary-open-angle-glaucoma-correlation-with-octopus-101-perimetry-and-spectralis-optical-coherence-tomography-findings
#16
Mehmet Giray Ersoz, Yeliz Pekcevik, Emre Ayintap, İrfan Botan Gunes, Duygu Kunak Mart, Ersin Yucel, Gamze Türe
PURPOSE: To investigate structural changes in the visual pathway measured by magnetic resonance imaging (MRI) and its relationship with the clinical severity of glaucoma in primary open-angle glaucoma (POAG) patients. MATERIALS AND METHODS: The study included 28 patients with POAG and 26 age- and sex-matched healthy volunteers. All the subjects underwent spectral domain optical coherence tomography (OCT) of the peripapillary retina nerve fiber layer (RNFL). The optic nerve diameter (OND), chiasma height (Ch), and lateral geniculate nucleus height (LGNh) were measured bilaterally using a 1...
February 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28632029/longitudinal-evaluation-of-wound-healing-after-penetrating-corneal-injury-anterior-segment-optical-coherence-tomography-study
#17
Kang Keng Zheng, Jianhao Cai, Shi Song Rong, Kun Peng, Honghe Xia, Chuan Jin, Xuehui Lu, Xinyu Liu, Haoyu Chen, Vishal Jhanji
PURPOSE: Ocular imaging can enhance our understanding of wound healing. We report anterior segment optical coherence tomography (ASOCT) findings in penetrating corneal injury. METHODS: Serial ASOCT was performed after repair of penetrating corneal injury. Internal aberrations of wound edges were labeled as "steps" or "gaps" on ASOCT images. The wound type was characterized as: type 1: continuous inner wound edge or step height ≤ 80 µm; type 2: step height > 80 µm; type 3: gap between wound edges; and type 4: intraocular tissue adherent to wound...
February 26, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28631244/optical-coherence-tomography-angiography-in-pre-perimetric-open-angle-glaucoma
#18
Gilda Cennamo, Daniela Montorio, Nunzio Velotti, Federica Sparnelli, Michele Reibaldi, Giovanni Cennamo
PURPOSE: To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma. METHODS: Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated...
June 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28631180/microvascular-changes-after-vitrectomy-with-internal-limiting-membrane-peeling-an-optical-coherence-tomography-angiography-study
#19
Leonardo Mastropasqua, Enrico Borrelli, Paolo Carpineto, Lisa Toto, Luca Di Antonio, Peter A Mattei, Rodolfo Mastropasqua
PURPOSE: To evaluate superficial capillary plexus (SCP) changes occurring after internal limiting membrane (ILM) peeling for the treatment of idiopathic epiretinal membrane (ERM). METHODS: A total of 15 eyes of 15 patients affected by idiopathic ERM (eight males and seven females; mean age 59.8 ± 9.6 years) were enrolled in the study. Patients were treated with pars plana vitrectomy followed by ERM and ILM peeling. Subjects were evaluated at baseline and at the week-1 and month-1 follow-up visits...
June 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28630947/evolution-of-geographic-atrophy-in-participants-treated-with-ranibizumab-for-neovascular-age-related-macular-degeneration
#20
Alisa T Thavikulwat, Naima Jacobs-El, Jane S Kim, Elvira Agrón, Jesia Hasan, Catherine B Meyerle, David Valent, Catherine A Cukras, Henry E Wiley, Wai T Wong, Emily Y Chew
PURPOSE: To evaluate the risk factors, incidence, and rate of progression of geographic atrophy (GA) in eyes with neovascular age-related macular degeneration (nAMD) treated with ranibizumab. DESIGN: Post-hoc analysis of a prospective clinical study. PARTICIPANTS: 69 participants with nAMD in at least one eye. METHODS: Participants were prospectively treated in the study eye with 0.5 mg intravitreal ranibizumab. Study eyes received 4 monthly injections followed by pro re nata injections until a fluid-free macula was achieved on optical coherence tomography...
January 2017: Ophthalmology retina
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