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https://www.readbyqxmd.com/read/28817705/cell-surface-dynamics-and-cellular-distribution-of-endogenous-fcrn
#1
Lena D'Hooghe, Andrew D Chalmers, Sam Heywood, Paul Whitley
A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH. This is important in maintaining high serum IgG and albumin levels and has the potential to be exploited to modulate the pharmacokinetics of antibody-based therapeutics. Although FcRn is responsible for the recycling of IgG, the dynamic behaviour of endogenous FcRn is not well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28817679/increased-half-life-and-enhanced-potency-of-fc-modified-human-pcsk9-monoclonal-antibodies-in-primates
#2
Yijun Shen, Hua Li, Li Zhao, Gang Li, Ben Chen, Qingsong Guo, Bei Gao, Jinsong Wu, Tong Yang, Li Jin, Yong Su
Blocking proprotein convertase subtilisin kexin type 9 (PCSK9) binding to low-density lipoprotein receptor (LDLR) can profoundly lower plasma LDL levels. Two anti-PCKS9 monoclonal antibodies (mAbs), alirocumab and evolocumab, were approved by the FDA in 2015. The recommended dose is 75 mg to 150 mg every two weeks for alirocumab and 140mg every two weeks or 420 mg once a month for evolocumab. This study attempted to improve the pharmacokinetic properties of F0016A, an IgG1 anti-PCKS9 mAb, to generate biologically superior molecules...
2017: PloS One
https://www.readbyqxmd.com/read/28817107/ag-nanorods-oxide-hybrid-array-substrates-synthesis-characterization-and-applications-in-surface-enhanced-raman-scattering
#3
REVIEW
Lingwei Ma, Jianghao Li, Sumeng Zou, Zhengjun Zhang
Over the last few decades, benefitting from the sufficient sensitivity, high specificity, nondestructive, and rapid detection capability of the surface-enhanced Raman scattering (SERS) technique, numerous nanostructures have been elaborately designed and successfully synthesized as high-performance SERS substrates, which have been extensively exploited for the identification of chemical and biological analytes. Among these, Ag nanorods coated with thin metal oxide layers (AgNRs-oxide hybrid array substrates) featuring many outstanding advantages have been proposed as fascinating SERS substrates, and are of particular research interest...
August 17, 2017: Sensors
https://www.readbyqxmd.com/read/28816448/metal-free-oxidative-c-c-coupling-of-arylamines-using-a-quinone-based-organic-oxidant
#4
Sudhakar Maddala, Sudesh Mallick, Parthasarathy Venkatakrishnan
A variety of arylamines are shown to undergo oxidative C-C bond formation using quinone-based chloranil/H(+) reagent as the recyclable organic (metal-free) oxidant system to afford benzidines/naphthidines. Arylamines (3°/2°) designed with various substituents were employed to understand the steric as well as electronic preferences of oxidative dimerization, and a mechanism involving amine radical cation has been proposed. The tetraphenylbenzidine derivative obtained via oxidative C-C coupling has been further converted to blue-emissive hole-transporting material via a simple chemical transformation...
August 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28815958/arabidopsis-exo70a1-recruits-patellin3-to-the-cell-membrane-independent-of-its-role-as-exocyst-subunit
#5
Chengyun Wu, Lu Tan, Max van Hooren, Xiaoyun Tan, Feng Liu, Yan Li, Yanxue Zhao, Bingxuan Li, Qingchen Rui, Teun Munnik, Yiqun Bao
The exocyst is a well-known complex to tether vesicles at the cell membrane before fusion. Whether an individual subunit can execute a unique function is largely unknown. Using yeast-two-hybrid (Y2H) analysis, we found that EXO70A1 interacted with the GOLD domain of Patellin3 (PATL3). The direct EXO70A1-PATL3 interaction was supported by in vitro and in vivo experiments. In Arabidopsis, PATL3-GFP colocalized with EXO70A1 predominantly at the cell membrane, and PATL3 localization was insensitive to BFA and TryA23...
August 16, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/28815903/rhenium-loaded-tio2-a-highly-versatile-and-chemoselective-catalyst-for-the-hydrogenation-of-carboxylic-acid-derivatives-and-the-n-methylation-of-amines-using-h2-and-co2
#6
Takashi Toyao, Hakim S M A Siddiki, Yoshitsugu Morita, Takashi Kamachi, Abeda S Touchy, Wataru Onodera, Kenichi Kon, Shinya Furukawa, Hiroko Ariga, Kiyotaka Asakura, Kazunari Yoshizawa, Ken-Ichi Shimizu
Herein, we report a heterogeneous TiO2-supported Re catalyst (Re/TiO2) that promotes various selective hydrogenation reactions, e.g. hydrogenation of esters to alcohols, hydrogenation of amides to amines, and N-methylation of amines using H2 and CO2. Initially, Re/TiO2 was evaluated in the context of the selective hydrogenation of 3-phenylpropionic acid methyl ester to afford 3-phenylpropanol (pH2 = 5 MPa, T = 180 ºC), where revealed a superior performance relative to other catalysts explored in this study...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815887/viologens-and-their-application-as-functional-materials
#7
Laura Striepe, Thomas Baumgartner
Organic materials have recently gained considerable attention for electronic applications, improving performance and sustainability to current technologies. Commercialized metal-based systems are generally expensive, toxic and difficult to recycle, however organic materials offer promising solutions. Viologens, N,N' di-quaternized bipyridyl salts, are a well-studied species exhibiting three reversible redox states, possessing valuable electrochromic and electron-accepting properties. These properties can be fine-tuned through synthesis by altering the nitrogen substituents and various counteranions...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815435/recent-trends-in-sustainable-textile-waste-recycling-methods-current-situation-and-future-prospects
#8
REVIEW
Nattha Pensupa, Shao-Yuan Leu, Yunzi Hu, Chenyu Du, Hao Liu, Houde Jing, Huaimin Wang, Carol Sze Ki Lin
In recent years, there have been increasing concerns in the disposal of textile waste around the globe. The growth of textile markets not only depends on population growth but also depends on economic and fashion cycles. The fast fashion cycle in the textile industry has led to a high level of consumption and waste generation. This can cause a negative environmental impact since the textile and clothing industry is one of the most polluting industries. Textile manufacturing is a chemical-intensive process and requires a high volume of water throughout its operations...
August 16, 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28815367/microplastic-pollution-a-threat-to-marine-ecosystem-and-human-health-a-short-review
#9
Shivika Sharma, Subhankar Chatterjee
Human populations are using oceans as their household dustbins, and microplastic is one of the components which are not only polluting shorelines but also freshwater bodies globally. Microplastics are generally referred to particles with a size lower than 5 mm. These microplastics are tiny plastic granules and used as scrubbers in cosmetics, hand cleansers, air-blasting. These contaminants are omnipresent within almost all marine environments at present. The durability of plastics makes it highly resistant to degradation and through indiscriminate disposal they enter in the aquatic environment...
August 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28815234/synthesis-of-mesoporous-iridium-nanosponge-a-highly-active-thermally-stable-and-efficient-olefin-hydrogenation-catalyst
#10
Sourav Ghosh, Balaji R Jagirdar
Three dimensional porous structures offer high specific surface areas and large pore volumes, which enhance substrate diffusion within the porous structures and provide a large number of surface active sites. Such types of structures find applications in catalysis. Herein, we report a simple synthetic strategy for the preparation of iridium nanosponges by the capping agent dissolution method. An Ir@BNHx nanocomposite was prepared starting from different iridium precursors by a solid state reduction method using ammonia borane wherein iridium(0) nanoparticles are embedded in a BNHx polymer...
August 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28815171/functional-analysis-of-na-h-exchanger-9-variants-identified-in-patients-with-autism-and-epilepsy
#11
Hari Prasad, James Osei-Owusu, Rajini Rao
Na(+)/H(+) exchanger isoform 9, NHE9, finely tunes the pH within the endosomal lumen to regulate cargo trafficking and turnover. In patients with autism, genetic approaches have revealed deletions, truncations and missense mutations in the gene encoding NHE9 (SLC9A9). To help establish causality, functional evaluation is needed to distinguish pathogenic mutations from harmless polymorphisms. Here, we evaluated three previously uncharacterized NHE9 variants, P117T, D496N, and Q609K reported in patients with autism and epilepsy...
April 2017: Matters (Zur)
https://www.readbyqxmd.com/read/28815060/defective-expression-of-atg4d-abrogates-autophagy-and-promotes-growth-in-human-uterine-fibroids
#12
Abdeljabar El Andaloussi, Samar Habib, Gizem Soylemes, Archana Laknaur, Heba Elhusseini, Ayman Al-Hendy, Nahed Ismail
Uterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were described in neoplasms; however, the contribution of autophagy to the pathogenesis of UF remains unknown. In this study, we demonstrate that autophagy is deregulated in human UF as evidenced by significant accumulation of autophagosome in human UF cells compared to normal myometrium cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28815017/autophagy-and-airway-fibrosis-is-there-a-link
#13
REVIEW
Anudeep Kota, Deepak Deshpande, Mehra Haghi, Brian Oliver, Pawan Sharma
In the past decade, an emerging process named "autophagy" has generated intense interest in many chronic lung diseases. Tissue remodeling and fibrosis is a common feature of many airway diseases, and current therapies do not prevent or reverse these structural changes. Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components to maintain basal cellular homeostasis and healthy organelle populations in the cell. Furthermore, autophagy serves as a cell survival mechanism and can also be induced by chemical and physical stress to the cell...
2017: F1000Research
https://www.readbyqxmd.com/read/28813417/cmtm6-maintains-the-expression-of-pd-l1-and-regulates-anti-tumour-immunity
#14
Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid Y N Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, Joseph A Trapani, Jonathan Cebon, Paul J Lehner, Mark A Dawson
Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to subvert T-cell-mediated immunosurveillance. The success of therapies that disrupt PD-L1-mediated tumour tolerance has highlighted the need to understand the molecular regulation of PD-L1 expression. Here we identify the uncharacterized protein CMTM6 as a critical regulator of PD-L1 in a broad range of cancer cells, by using a genome-wide CRISPR-Cas9 screen. CMTM6 is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression...
August 16, 2017: Nature
https://www.readbyqxmd.com/read/28812385/increased-acetaminophen-related-calls-to-finnish-pic-better-reflect-acetaminophen-sales-than-serious-poisonings
#15
Mikko J Parry, Helena Isoniemi, Anna-Maria Koivusalo, Kalle Hoppu
OBJECTIVE: Acetaminophen (APAP) or paracetamol is a commonly encountered medicine in poisonings. We studied the changes in APAP related calls to the Finnish poison information centre (FPIC), and serious intoxications, involving hepatotoxicity or death in 2001-2014. These data were compared with paracetamol sales in Finland. METHODS: This is a retrospective analysis of the FPIC database calls, national cause of death registry, registries of liver transplantations and molecular adsorbent recycling system (MARS)-treated patients from Helsinki University Hospital together with the National Institute of Health and Welfare registry of patients hospitalized...
August 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28811326/-10m-gift-supports-data-recycling-at-ucsf
#16
(no author information available yet)
The University of California, San Francisco's Institute for Computational Health Sciences has received a $10 million gift to support "data recycling" investigations. The approach to medical research involves mining existing data to potentially uncover new uses for existing drugs and help improve clinical care.
August 15, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28811147/neutralization-of-cement-asbestos-waste-by-melting-in-an-arc-resistance-furnace
#17
Jerzy Witek, Robert Kusiorowski
The paper presents the results of research on asbestos waste disposal by the melting process. The tests were carried out in a laboratory arc-resistance electric furnace. The obtained results showed that the fibrous structure of asbestos contained in cement-asbestos waste was completely destroyed. This led to the formation of new mineral phases without dangerous properties. The melting test was conducted on raw cement-asbestos samples without any additives and with a content of mineral compounds, the aim of which was to support the melting process...
August 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28810866/the-development-of-an-ivermectin-based-attractive-toxic-sugar-bait-atsb-to-target-anopheles-arabiensis
#18
Frank Chelestino Tenywa, Athumani Kambagha, Adam Saddler, Marta Ferreira Maia
BACKGROUND: An increasing number of countries in sub-Saharan Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns. However, elimination has proven challenging, resulting in the persistence of malaria transmission. It is now accepted that in order to eliminate malaria, new complementary vector control approaches must be developed. This study describes the development of a sugar-baited resting place containing a toxic dose of ivermectin for the control of Anopheles arabiensis...
August 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28809475/a-dna-fueled-and-catalytic-molecule-machine-lights-up-trace-under-expressed-micrornas-in-living-cells
#19
Daxiu Li, Wenjiao Zhou, Ruo Yuan, Yun Xiang
The detection of specific intracellular microRNAs (miRNAs) in living cells can potentially provide insight into the causal mechanism of cancer metastasis and invasion. However, due to the characteristic nature of miRNAs in terms of small sizes, low abundance and similarity among family members, it is of great challenge to monitor miRNAs in living cells, especially those with much lower expression levels. In this work, we describe the establishment of a DNA-fueled and catalytic molecule machinery in cell signal amplification approach for monitoring trace and under-expressed miRNAs in living cells...
August 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28808870/chest-circumference-and-birth-weight-are-good-predictors-of-lung-function-in-preschool-children-from-an-e-waste-recycling-area
#20
Xiang Zeng, Xijin Xu, Yuling Zhang, Weiqiu Li, Xia Huo
The purpose of this study was to investigate the associations between birth weight, chest circumference, and lung function in preschool children from e-waste exposure area. A total of 206 preschool children from Guiyu (an e-waste recycling area) and Haojiang and Xiashan (the reference areas) in China were recruited and required to undergo physical examination, blood tests, and lung function tests during the study period. Birth outcome such as birth weight and birth height were obtained by questionnaire. Children living in the e-waste-exposed area have a lower birth weight, chest circumference, height, and lung function when compare to their peers from the reference areas (all p value <0...
August 15, 2017: Environmental Science and Pollution Research International
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