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Diabetes nephropathy

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https://www.readbyqxmd.com/read/29222368/novel-lncrna-erbb4-ir-promotes-diabetic-kidney-injury-in-db-db-mice-by-targeting-mir-29b
#1
Si F Sun, Patrick Mk Tang, Min Feng, Xiao Jun, Xiao R Huang, Ping Li, Ronal Cw Ma, Hui Y Lan
TGF-β/Smad signaling plays an important role in diabetic nephropathy. The present study identified a novel Smad3-dependent long non-coding RNA (lncRNA) Erbb4-IR in the development of type-2 diabetic nephropathy (T2DN) in db/db mice. We found that Erbb4-IR was highly expressed in T2DN of db/db mice and was specifically induced by AGE via a Smad3-dependent mechanism. The functional role of Erbb4-IR in T2DN was revealed by kidney-specific silencing of Erbb4-IR to protect against the development of T2DN such as elevated microalbuminuria, serum creatinine and progressive renal fibrosis in db/db mice, and to block AGE-induced collagen I and IV expression in mouse mesangial cells (mMCs) and mouse tubular epithelial cells (mTECs)...
December 8, 2017: Diabetes
https://www.readbyqxmd.com/read/29221422/total-flavones-of-abelmoschus-manihot-improve-diabetic-nephropathy-by-inhibiting-the-irhom2-tace-signalling-pathway-activity-in-rats
#2
Su Liu, Lifang Ye, Jing Tao, Chao Ge, Liji Huang, Jiangyi Yu
CONTEXT: Total flavones extracted from Abelmoschus manihot L. (Malvaceae) medic (TFA) have been proven clinically effective at improving renal inflammation and glomerular injury in chronic kidney disease (CKD). OBJECTIVE: This study evaluated the function of TFA as an inhibitor of iRhom2/TACE (tumour necrosis factor-α converting enzyme) signalling and investigated its anti-DN (diabetic nephropathy) effects in a DN rat model. MATERIALS AND METHODS: In vitro, cells were treated with 200 μg/mL advanced glycation end products (AGEs), and then co-cultured with 20 μg/mL TFA for 24 h...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29218029/microvascular-complications-in-type-1-diabetes-a-comparative-analysis-of-patients-treated-with-autologous-nonmyeloablative-hematopoietic-stem-cell-transplantation-and-conventional-medical-therapy
#3
Jaquellyne G Penaforte-Saboia, Renan M Montenegro, Carlos E Couri, Livia A Batista, Ana Paula D R Montenegro, Virginia O Fernandes, Hussain Akhtar, Carlos A Negrato, Kelen Cristina Ribeiro Malmegrim, Daniela Aparecida Moraes, Juliana B E Dias, Belinda P Simões, Marilia Brito Gomes, Maria Carolina Oliveira
Objective: To explore the impact on microvascular complications, long-term preservation of residual B-cell function and glycemic control of patients with type 1 diabetes treated with autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST) compared with conventional medical therapy (CT). Research design and methods: Cross-sectional data of patients treated with AHST were compared with patients who received conventional therapy from the Brazilian Type 1 Diabetes Study Group, the largest multicenter observational study in type 1 diabetes mellitus in Brazil...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29216336/managing-diabetic-kidney-disease
#4
Sagen Zac-Varghese, Peter Winocour
Introduction: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). This review covers the pillars of care essential for the management of diabetic kidney disease (DKD) including (1) early diagnosis, (2) improved glycaemic control, (3) treatment of hypertension, (4) identification and treatment of associated metabolic bone disease and (5) identification and effective management of dyslipidaemia and additional cardiovascular risk factors. Sources of data: We searched PubMed for articles using search terms: diabetic nephropathy, diabetic kidney disease, diabetes and chronic kidney disease...
December 5, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29214987/influence-of-c-reactive-protein-on-the-occurrence-and-assessing-of-albuminuria-severity-in-diabetics
#5
Lamija Pojskić, Sabaheta Hasić, Ema Tahto, Vildana Arnautović-Torlak, Belma Pojskić
Aim To asses relation of serum high sensitive C-reactive protein (hsCRP) level with albumin concentration in daily urine in patients with diabetes mellitus type 2 (T2DM). Methods The prospective study included 69 patients with T2DM, both sexes (24 males, 45 females), aged 30-82 years. They were divided into two groups: patients with T2DM and normoalbuminuria(T2DM-NA; n=40) and patients with T2DM and microalbuminuria (T2DM-MA; n=29). Patients were hospitalized at the Department of Internal Medicine, Cantonal Hospital Zenica, in the period January-April 2014...
February 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29214163/protective-effects-of-pyridoxamine-supplementation-in-the-early-stages-of-diet-induced-kidney-dysfunction
#6
F Chiazza, A S Cento, D Collotta, D Nigro, G Rosa, F Baratta, V Bitonto, J C Cutrin, M Aragno, R Mastrocola, M Collino
Pyridoxamine, a structural analog of vitamin B6 that exerts antiglycative effects, has been proposed as supplementary approach in patients with initial diabetic nephropathy. However, the molecular mechanism(s) underlying its protective role has been so far slightly examined. C57Bl/6J mice were fed with a standard diet (SD) or a diet enriched in fat and fructose (HD) for 12 weeks. After 3 weeks, two subgroups of SD and HD mice started pyridoxamine supplementation (150 mg/kg/day) in the drinking water. HD fed mice showed increased body weight and impaired glucose tolerance, whereas pyridoxamine administration significantly improved insulin sensitivity, but not body weight, and reduced diet-induced increase in serum creatinine and urine albumin...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29214160/mir-217-is-a-useful-diagnostic-biomarker-and-regulates-human-podocyte-cells-apoptosis-via-targeting-tnfsf11-in-membranous-nephropathy
#7
Jing Li, Bin Liu, Hen Xue, Qiao Qiao Zhou, Ling Peng
Background: MicroRNAs have recently been verified as useful diagnostic biomarkers in various diseases. In this study, we investigated whether miR-217 is a useful diagnostic biomarker and the possible pathological mechanism of miR-217 in this disease. Methods: Patients with focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and diabetic nephropathy (DN) and control patients were enrolled in this study. The miR-217 inhibitor and mimics were transfected into human podocyte cells to investigate the pathological mechanism of miR-217 in this disease...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29212780/excitatory-gabaergic-action-and-increased-vasopressin-synthesis-in-hypothalamic-magnocellular-neurosecretory-cells-underlie-the-high-plasma-level-of-vasopressin-in-diabetic-rat
#8
Young-Beom Kim, Woong Bin Kim, Won Woo Jung, Xiangyan Jin, Yoon Sik Kim, Byoungjae Kim, Hee Chul Han, Gene D Block, Christopher S Colwell, Yang In Kim
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP) which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in the supraoptic nucleus (SON) slices from streptozotocin-induced DM model (STZ) rats and vehicle-treated control rats revealed that GABA functions generally as an excitatory neurotransmitter in the AVP neurons of STZ rats, whereas it evoked usually inhibitory responses in the cells of control animals...
December 6, 2017: Diabetes
https://www.readbyqxmd.com/read/29211853/nrf2-deficiency-upregulates-intrarenal-angiotensin-converting-enzyme-2-and-angiotensin-1-7-receptor-expression-and-attenuates-hypertension-and-nephropathy-in-diabetic-mice
#9
Shuiling Zhao, Anindya Ghosh, Chao-Sheng Lo, Isabelle Chenier, James W Scholey, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Chan
We investigated the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in renin-angiotensin system (RAS) gene expression in renal proximal tubule cells (RPTCs) and in the development of systemic hypertension and kidney injury in diabetic Akita mice. We used adult male Akita Nrf2 knockout (KO) mice and Akita mice treated with trigonelline (an Nrf2 inhibitor) or oltipraz (an Nrf2 activator). We also examined immortalized rat RPTCs (IRPTCs) stably transfected with control plasmids or plasmids containing rat angiotensinogen (Agt), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (Ace2) or angiotensin 1-7 receptor (MasR) gene promoters...
December 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/29210634/preventive-and-therapeutic-potentials-of-anthocyanins-in-diabetes-and-associated-complications
#10
Swathi Putta, Nagendra Sastry Yarla, Eswar K Kumar, Dhananjaya Bhadrapura Lakkappa, Mohammad A Kamal, Luciana Scotti, Marcus T Scotti, Ghulam Md Ashraf, George E Barreto, B Sasi Bhusana Rao, D Sarala Kumari, Gorla V Reddy, Vadim V Tarasov, Sarat Babu Imandi, Gjumrakch Aliev
Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, it is to be considering the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29210632/role-of-matrix-metalloproteinases-in-degenerative-kidney-disorders
#11
Shifa Narula, Chanderdeep Tandon, Simran Tandon
Matrix metalloproteinases (MMPs) are members of calcium dependent-zinc containing endopeptidases that play a pivotal role in extracellular matrix (ECM) remodeling. MMPs are also known to cleave non-matrix proteins, including cell surface receptors, TNF-α, angiotensin-II, growth factors, (especially transforming growth factor-β1, ΤGF-β1) plasminogen, endothelin and other bioactive molecules. The tissue inhibitors of metalloproteinases (TIMPs) inhibit the activity of MMPs and decrease ECM degradation. Various patho-physiological conditions have been linked with the imbalance of ECM synthesis and degradation...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29209813/fsp1-specific-smad2-knockout-in-renal-tubular-endothelial-and-interstitial-cells-reduces-fibrosis-and-epithelial-to-mesenchymal-transition-in-murine-stz-induced-diabetic-nephropathy
#12
Ivonne Loeffler, Marita Liebisch, Stefanie Allert, Elke Kunisch, Raimund W Kinne, Gunter Wolf
Extracellular matrix deposition during tubulointerstitial fibrosis (TIF), a central pathological process in patients with diabetic nephropathy (DN), is driven by locally activated, disease-relevant myofibroblasts. Myofibroblasts can arise from various cellular sources, e.g., tubular epithelial cells via a process named epithelial-to-mesenchymal transition (EMT). Transforming growth factor beta 1 (TGF-β1) and its downstream Smad signaling play a critical role in both TIF and EMT. Whereas Smad3 is one central mediator, the role of the other prominently expressed variant, Smad2, is not completely understood...
December 6, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29209216/effects-of-intensive-control-of-glycemia-on-clinical-kidney-outcomes-in-type-2-diabetes-patients-compared-with-standard-control-a-meta-analysis
#13
Francisco Herrera-Gómez, María Asensio-González, Anunciación González-López, F Javier Álvarez
Background: Association between poor control of glycemia and the onset of microvascular complications in type 2 diabetes mellitus (T2DM) patients is a hard issue. However, it seems that the impact of pharmacological treatment is important only in early stages of diabetic nephropathy. We sought to examine whether intensive glycemic control is associated with improvement of clinical Chronic Kidney Disease (CKD) outcomes compared to standard glycemic control. Methods: Meta-analysis of published and unpublished randomized controlled trials (RCT) and post-hoc analysis of RCTs comparing anti-diabetic drugs and/or insulin (intensive control) vs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29208861/etiology-of-early-renal-allograft-dysfunction-and-comparison-between-dysfunction-and-function-group-a-single-center-study
#14
K M Hadiuzzaman, S F Islam, M O Faroque, R M Hossain, M Munirunnessa, S I Selim, M Morshed
Over a period of two years thirty five renal allograft recipients & donors were evaluated to find out the aetiology of early renal allograft dysfunction, in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from March 2010 to February 2012. A comparison was made between dysfunction & functioning graft group. Mean age of recipients were (36.4±9.4) years, mean age of donors were (41.7±8.3) years, with a male and female ratio of 3:1. Fifty percent recipients showed one heliotype match, ninety percent recipients were anti CMV antibody IgG positive, few were anti CMV antibody IgM positive...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208058/low-protein-diet-supplemented-with-ketoacids-delays-the-progression-of-diabetic-nephropathy-by-inhibiting-oxidative-stress-in-the-kkay-mice-model
#15
Dongmei Liu, Ming Wu, Lin Li, Xiang Gao, Bo Yang, Shuqin Mei, Lili Fu, Changlin Mei
Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone...
December 6, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29207691/a-comparative-study-of-high-sensitivity-c-reactive-protein-and-metabolic-variables-in-type-2-diabetes-mellitus-with-and-without-nephropathy
#16
Abid K Shaheer, Jithesh K Tharayil, Parvathi W Krishna
Introduction: Diabetic nephropathy is a serious chronic complication of Type 2 Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased morbidity and mortality. The high sensitivity C-reactive protein (hs-CRP) is an acute phase reactant which acts as a non-specific systemic marker of inflammation. Aim: To find out the relationship between serum hs-CRP and metabolic variables in Type 2 diabetic patients with and without nephropathy. Materials and Methods: The study group consists of 96 subjects that include non-diabetic healthy controls, Type 2 diabetic patients without any complications and patients with diabetic nephropathy...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207635/socs2-overexpression-alleviates-diabetic-nephropathy-in-rats-by-inhibiting-the-tlr4-nf-%C3%AE%C2%BAb-pathway
#17
Suxia Yang, Junwei Zhang, Shiying Wang, Xinxin Zhao, Jun Shi
Suppressor of cytokine signaling 2 (SOCS2) was reported to be involved in the development of Diabetic Nephropathy (DN). However, its underlying mechanism remains undefined. Western blot was carried out to determine the expressions of SOCS2, Toll-like receptors 4 (TLR4) and nuclear factor kappa B (NF-κB) pathway-related proteins in DN patients, streptozotocin (STZ)-induced DN rats and high glucose (HG)-stimulated podocytes. The effects of SOCS2 overexpression on renal injury, the inflammatory cytokines production, renal pathological changes, apoptosis and the TLR4/NF-κB pathway in DN rats or HG-stimulated podocytes were investigated...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207397/relationship-of-serum-fetuin-a-with-metabolic-and-clinical-parameters-in-german-children-and-adolescents-with-type-1-diabetes
#18
Christina Reinauer, Thomas Reinehr, Christina Baechle, Beate Karges, Julia Seyfarth, Katharina Foertsch, Martin Schebek, Joachim Woelfle, Michael Roden, Reinhard W Holl, Joachim Rosenbauer, Thomas Meissner
BACKGROUND AND AIM: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. METHODS: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Pa-tienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D...
December 5, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29207384/slc2a1-tag-snps-in-greek-patients-with-diabetic-retinopathy-and-nephropathy
#19
Vasileios Siokas, Anatoli Fotiadou, Efthimios Dardiotis, Maria G Kotoula, Sophia V Tachmitzi, Dimitrios Z Chatzoulis, Elias Zintzaras, Ioannis Stefanidis, Evangelia E Tsironi
Backround: Genetic variants are implicated in the development of diabetic retinopathy (DR) and nephropathy (DN). The role of solute carrier family 2-facilitated glucose transporter member 1 (SLC2A1), also known as glucose transporter (GLUT1), on DR and DN remain controversial. OBJECTIVE: Examination of the influence of tag SLC2A1 single-nucleotide polymorphisms (SNPs) on the development of DR and DN during the course of type 2 diabetes mellitus (T2DM). METHODS: A total of 169 patients with DR or DN, 107 uncomplicated T2DM patients, and 315 controls were recruited and genotyped for 14 SLC2A1 tag SNPs...
December 6, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29207360/oridonin-protects-against-the-inflammatory-response-in-diabetic-nephropathy-by-inhibiting-the-tlr4-p38-mapk-and-tlr4-nf-%C3%AE%C2%BAb-signaling-pathways
#20
Jushuang Li, Liping Bao, Dongqing Zha, Lian Zhang, Ping Gao, Juan Zhang, Xiaoyan Wu
Inflammation plays a pivotal role in the development and progression of diabetic nephropathy (DN). Oridonin (Ori), a component isolated from Rabdosia rubescens, possesses remarkable anti-inflammatory, immunoregulatory and antitumor properties. However, the renoprotective effects of Ori and the underlying molecular mechanisms have not been explored in DN. In this study, we aimed to investigate the protective effects and potential mechanisms responsible for the anti-inflammatory effects of Ori in diabetes-induced renal injury in vivo and in vitro...
December 2, 2017: International Immunopharmacology
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