Katharina O Sandström, Olga B Baltzersen, Anouk Marsman, Cecilie K Lemvigh, Vincent O Boer, Kirsten B Bojesen, Mette Ø Nielsen, Henrik Lundell, Daban K Sulaiman, Mikkel E Sørensen, Birgitte Fagerlund, Adrienne C Lahti, Warda T Syeda, Christos Pantelis, Esben T Petersen, Birte Y Glenthøj, Hartwig R Siebner, Bjørn H Ebdrup
Background: Antipsychotic drugs are primarily efficacious in treating positive symptoms by blocking the dopamine D2 receptor, but they fail to substantially improve negative symptoms and cognitive deficits. The limited efficacy may be attributed to the fact that the pathophysiology of psychosis involves multiple neurotransmitter systems. In patients with chronic schizophrenia, memantine, a non-competitive glutamatergic NMDA receptor antagonist, shows promise for ameliorating negative symptoms and improving cognition...
2022: Frontiers in Psychiatry