Ken Okamura, Yuko Abe, Izumi Naka, Jun Ohashi, Akiko Yagami, Kayoko Matsunaga, Yui Kobayashi, Kazuyoshi Fukai, Atsushi Tanemura, Ichiro Katayama, Yukiko Masui, Akiko Ito, Toshiharu Yamashita, Hiroshi Nagai, Chikako Nishigori, Naoki Oiso, Yumi Aoyama, Yuta Araki, Toru Saito, Masahiro Hayashi, Yutaka Hozumi, Tamio Suzuki
Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin-lightening cosmetics, was unexpectedly reported in Japan to induce leukoderma or vitiligo called RD-induced leukoderma (RIL) after repeated application. To our knowledge, no studies have investigated chemical-induced vitiligo pathogenesis on a genome-wide scale. Here, we conducted a genome-wide association study (GWAS) for 147 cases and 112 controls. CDH13, encoding a glycosylphosphatidylinositol-anchored protein called T-cadherin (T-cad), was identified as the strongest RIL susceptibility gene...
November 2020: Pigment Cell & Melanoma Research