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https://www.readbyqxmd.com/read/28120081/functional-reconstruction-of-motor-and-language-pathways-based-on-navigated-transcranial-magnetic-stimulation-and-dti-fiber-tracking-for-the-preoperative-planning-of-low-grade-glioma-surgery-a-new-tool-for-preservation-and-restoration-of-eloquent-networks
#1
Giovanni Raffa, Alfredo Conti, Antonino Scibilia, Carmela Sindorio, Maria Catena Quattropani, Massimiliano Visocchi, Antonino Germanò, Francesco Tomasello
BACKGROUND: Surgery of low-grade gliomas (LGGs) in eloquent areas still presents a challenge. New technologies have been introduced to enable the performance of "functional", customized preoperative planning aimed at maximal resection, while reducing the risk of postoperative deficits. We describe our experience in the surgery of LGGs in eloquent areas using preoperative planning based on navigated transcranial magnetic stimulation (nTMS) and diffusion tensor imaging (DTI) tractography...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28106500/cortical-plasticity-of-motor-eloquent-areas-measured-by-navigated-transcranial-magnetic-stimulation-in-patients-with-glioma
#2
Neal Conway, Noémie Wildschuetz, Tobias Moser, Lucia Bulubas, Nico Sollmann, Noriko Tanigawa, Bernhard Meyer, Sandro M Krieg
OBJECTIVE The goal of this study was to obtain a better understanding of the mechanisms underlying cerebral plasticity. Coupled with noninvasive detection of its occurrence, such an understanding has huge potential to improve glioma therapy. The authors aimed to demonstrate the frequency of plastic reshaping, find clues to the patterns behind it, and prove that it can be recognized noninvasively using navigated transcranial magnetic stimulation (nTMS). METHODS The authors used nTMS to map cortical motor representation in 22 patients with gliomas affecting the precentral gyrus, preoperatively and 3-42 months postoperatively...
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28059664/navigated-transcranial-magnetic-stimulation-for-glioma-removal-prognostic-value-in-motor-function-recovery-from-postsurgical-neurological-deficits
#3
Tomokazu Takakura, Yoshihiro Muragaki, Manabu Tamura, Takashi Maruyama, Masayuki Nitta, Chiharu Niki, Takakazu Kawamata
OBJECTIVE The aim of the present study was to evaluate the usefulness of navigated transcranial magnetic stimulation (nTMS) as a prognostic predictor for upper-extremity motor functional recovery from postsurgical neurological deficits. METHODS Preoperative and postoperative nTMS studies were prospectively applied in 14 patients (mean age 39 ± 12 years) who had intraparenchymal brain neoplasms located within or adjacent to the motor eloquent area in the cerebral hemisphere. Mapping by nTMS was done 3 times, i...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28050345/functional-mri-vs-navigated-tms-to-optimize-m1-seed-volume-delineation-for-dti-tractography-a-prospective-study-in-patients-with-brain-tumours-adjacent-to-the-corticospinal-tract
#4
Carolin Weiss Lucas, Irada Tursunova, Volker Neuschmelting, Charlotte Nettekoven, Ana-Maria Oros-Peusquens, Gabriele Stoffels, Andrea Maria Faymonville, Shah N Jon, Karl Josef Langen, Hannah Lockau, Roland Goldbrunner, Christian Grefkes
BACKGROUND: DTI-based tractography is an increasingly important tool for planning brain surgery in patients suffering from brain tumours. However, there is an ongoing debate which tracking approaches yield the most valid results. Especially the use of functional localizer data such as navigated transcranial magnetic stimulation (nTMS) or functional magnetic resonance imaging (fMRI) seem to improve fibre tracking data in conditions where anatomical landmarks are less informative due to tumour-induced distortions of the gyral anatomy...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28049425/the-variability-of-motor-evoked-potential-latencies-in-neurosurgical-motor-mapping-by-preoperative-navigated-transcranial-magnetic-stimulation
#5
Nico Sollmann, Lucia Bulubas, Noriko Tanigawa, Claus Zimmer, Bernhard Meyer, Sandro M Krieg
BACKGROUND: Recording of motor evoked potentials (MEPs) is used during navigated transcranial magnetic stimulation (nTMS) motor mapping to locate motor function in the human brain. However, factors potentially underlying MEP latency variability in neurosurgical motor mapping are vastly unknown. In the context of this study, one hundred brain tumor patients underwent preoperative nTMS-based motor mapping of the tumor hemisphere between 2010 and 2013. Fourteen predefined predictor variables were recorded, and MEP latencies of abductor pollicis brevis muscle (APB), abductor digiti minimi muscle (ADM), and flexor carpi radialis muscle (FCR) were analyzed using linear mixed-effect multiple regression analysis with the forward step-wise model comparison approach...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28003422/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-for-combined-species-identification-and-drug-sensitivity-testing-in-mycobacteria
#6
Pieter-Jan Ceyssens, Karine Soetaert, Markus Timke, An Van den Bossche, Katrin Sparbier, Koen De Cremer, Markus Kostrzewa, Marijke Hendrickx, Vanessa Mathys
Species identification and drug susceptibility testing (DST) of mycobacteria are important yet complex processes traditionally reserved for reference laboratories. Recent technical improvements in matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has started to facilitate routine mycobacterial identifications in clinical laboratories. In this paper, we investigate the possibility of performing phenotypic MALDI-based DST in mycobacteriology using the recently described MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA)...
February 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27994536/a-novel-technique-for-region-and-linguistic-specific-ntms-based-dti-fiber-tracking-of-language-pathways-in-brain-tumor-patients
#7
Giovanni Raffa, Ina Bährend, Heike Schneider, Katharina Faust, Antonino Germanò, Peter Vajkoczy, Thomas Picht
Navigated transcranial magnetic stimulation (nTMS) has recently been introduced as a non-invasive tool for functional mapping of cortical language areas prior to surgery. It correlates well with intraoperative neurophysiological monitoring (IONM) findings, allowing defining the best surgical strategy to preserve cortical language areas during surgery for language-eloquent tumors. Nevertheless, nTMS allows only for cortical mapping and postoperative language deficits are often caused by injury to subcortical language pathways...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27974980/differential-impairment-of-interferon-%C3%AE-responses-in-two-cases-of-pulmonary-nontuberculous-mycobacterial-disease
#8
William Rae, Yifang Gao, Efrem Eren, Rainer Döffinger, Ben Marshall, Anthony P Williams
Nontuberculous mycobacteria (NTMs) are weakly virulent intracellular pathogens that are common in food and water supplies. The persistent culture of these organisms in the setting of clinical infection warrants investigation of immune function. In cases of isolated pulmonary NTM (PNTM) disease, underlying immune defects have not been clearly identified. We present two patients with isolated PNTM infection who demonstrated differentially impaired IFN-γ production across a range of stimuli. These cases show that cellular IFN-γ responses may be defective in a proportion of patient suffering PNTM disease and that when assessing responses, the stimulant used in the testing is important to delineate defective cell populations...
2016: Case Reports in Immunology
https://www.readbyqxmd.com/read/27904603/prevalence-of-nontuberculous-mycobacteria-isolated-from-environmental-samples-in-iran-a-meta-analysis
#9
REVIEW
Azad Khaledi, Abbas Bahador, Davood Esmaeili, Alireza Tafazoli, Kiarash Ghazvini, Davood Mansury
BACKGROUND: While the most nontuberculous mycobacteria (NTMs) species are considered as opportunistic pathogens, some of them are related to several human infections. It is believed that environment is the main source for these infections. Distribution and scattering pattern of NTMs has not been well studied in Iran and a few studies about this subject have been done, so the aim of this study was to determine prevalence of NTMs in environmental samples from Iran. MATERIALS AND METHODS: Data about prevalence of NTMs in environmental samples from Iran were obtained by searching databases...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27866220/molecular-basis-of-mycobacterial-survival-in-macrophages
#10
REVIEW
Jane Atesoh Awuh, Trude Helen Flo
Macrophages play an essential role in the immune system by ingesting and degrading invading pathogens, initiating an inflammatory response and instructing adaptive immune cells, and resolving inflammation to restore homeostasis. More interesting is the fact that some bacteria have evolved to use macrophages as a natural habitat and tools of spread in the host, e.g., Mycobacterium tuberculosis (Mtb) and some non-tuberculous mycobacteria (NTM). Mtb is considered one of humanity's most successful pathogens and is the causal agent of tuberculosis, while NTMs cause opportunistic infections all of which are of significant public health concern...
November 19, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27815647/clinical-factors-underlying-the-inter-individual-variability-of-the-resting-motor-threshold-in-navigated-transcranial-magnetic-stimulation-motor-mapping
#11
Nico Sollmann, Noriko Tanigawa, Lucia Bulubas, Jamil Sabih, Claus Zimmer, Florian Ringel, Bernhard Meyer, Sandro M Krieg
Correctly determining individual's resting motor threshold (rMT) is crucial for accurate and reliable mapping by navigated transcranial magnetic stimulation (nTMS), which is especially true for preoperative motor mapping in brain tumor patients. However, systematic data analysis on clinical factors underlying inter-individual rMT variability in neurosurgical motor mapping is sparse. The present study examined 14 preselected clinical factors that may underlie inter-individual rMT variability by performing multiple regression analysis (backward, followed by forward model comparisons) on the nTMS motor mapping data of 100 brain tumor patients...
January 2017: Brain Topography
https://www.readbyqxmd.com/read/27808247/clinical-significance-of-nontuberculous-mycobacteria-isolated-from-respiratory-specimens-in-a-chinese-tuberculosis-tertiary-care-center
#12
Hongfei Duan, Xiqin Han, Qingfeng Wang, Jing Wang, Jun Wang, Naihui Chu, Hairong Huang
The clinical relevance of non-tuberculous mycobacteria (NTM) has been reported to be different dramatically by species or by regions, however, no such evaluation has been performed in China.A retrospective study was performed in Beijing Chest Hospital. All the NTM strains isolated from respiratory specimens in the past 5 years, and patients' clinical records (symptoms and radiographic information etc.) were investigated. The clinical relevance was evaluated according to the criteria recommended by the American Thoracic society...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27681202/increasing-prevalence-rate-of-nontuberculous-mycobacteria-infections-in-five-states-2008-2013
#13
Maura J Donohue, Larry Wymer
RATIONALE: Many nontuberculous mycobacteria (NTM) are clinically significant pathogens that cause disease in a variety of different human organs and tissues. OBJECTIVES: A population-based study was undertaken to investigate the prevalence of patients with a positive specimen for NTM within five states of the United States. METHODS: We determined the case and age distribution of patients with at least one specimen positive for NTM, using data submitted to the disease surveillance systems of five states (Maryland, Mississippi, Missouri, Ohio, and Wisconsin) between 2008 and 2013...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27615740/localization-of-cortical-primary-motor-area-of-the-hand-using-navigated-transcranial-magnetic-stimulation-bold-and-arterial-spin-labeling-fmri
#14
Elisa Kallioniemi, Minna Pitkänen, Mervi Könönen, Ritva Vanninen, Petro Julkunen
BACKGROUND: Although the relationship between neuronavigated transcranial magnetic stimulation (nTMS) and functional magnetic resonance imaging (fMRI) has been widely studied in motor mapping, it is unknown how the motor response type or the choice of motor task affect this relationship. NEW METHOD: Centers of gravity (CoGs) and response maxima were measured with blood-oxygen-level dependent (BOLD) and arterial spin labeling (ASL) fMRI during motor tasks against nTMS CoGs and response maxima, which were mapped with motor evoked potentials (MEPs) and silent periods (SPs)...
September 8, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27595773/on-the-interplay-between-neoclassical-tearing-modes-and-nonlocal-transport-in-toroidal-plasmas
#15
X Q Ji, Y Xu, C Hidalgo, P H Diamond, Yi Liu, O Pan, Z B Shi, D L Yu
This Letter presents the first observation on the interplay between nonlocal transport and neoclassical tearing modes (NTMs) during transient nonlocal heat transport events in the HL-2A tokamak. The nonlocality is triggered by edge cooling and large-scale, inward propagating avalanches. These lead to a locally enhanced pressure gradient at the q = 3/2 (or 2/1) rational surface and hence the onset of the NTM in relatively low β plasmas (βN < 1). The NTM, in return, regulates the nonlocal transport by truncation of avalanches by local sheared toroidal flows which develop near the magnetic island...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27501333/preoperative-navigated-transcranial-magnetic-stimulation-in-patients-with-motor-eloquent-lesions-with-emphasis-on-metastasis
#16
Philipp Hendrix, Sebastian Senger, Christoph J Griessenauer, Andreas Simgen, Karsten Schwerdtfeger, Joachim Oertel
Navigated transcranial magnetic stimulation (nTMS) is a frequently used, non-invasive method to map the motor cortex. It is of great value in the preoperative workup of patients that suffer from motor eloquent brain lesions. Here, we present a single-center experience using preoperative nTMS in cortical motor eloquent lesions with emphasis on metastasis. All patients that underwent preoperative nTMS between June 2013 and January 2016 were evaluated. A total of 61 patients underwent nTMS before undergoing surgery for a motor eloquent brain lesion...
October 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/27399560/363%C3%A2-cortical-plasticity-of-motor-eloquent-areas-measured-by-navigated-transcranial-magnetic-stimulation-in-glioma-patients
#17
Neal Conway, Noriko Tanigawa, Bernhard Meyer, Sandro M Krieg
INTRODUCTION: Better understanding of the mechanisms behind cerebral plasticity, coupled with noninvasive detection of its presence, harbors a huge potential to improve glioma therapy. Our aim was to demonstrate the frequency of plastic reshaping, find the patterns behind it, and prove that it can be recognized noninvasively using navigated transcranial stimulation (nTMS). METHODS: We used nTMS to map cortical motor representation in 22 patients with gliomas affecting the precentral gyrus immediately preoperatively, and 3 to 42 months postoperatively...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27387550/impact-of-the-mycobaterium-africanum-west-africa-2-lineage-on-tb-diagnostics-in-west-africa-decreased-sensitivity-of-rapid-identification-tests-in-the-gambia
#18
Boatema Ofori-Anyinam, Fatoumatta Kanuteh, Schadrac C Agbla, Ifedayo Adetifa, Catherine Okoi, Gregory Dolganov, Gary Schoolnik, Ousman Secka, Martin Antonio, Bouke C de Jong, Florian Gehre
BACKGROUND: MPT64 rapid speciation tests are increasingly being used in diagnosis of tuberculosis (TB). Mycobacterium africanum West Africa 2 (Maf 2) remains an important cause of TB in West Africa and causes one third of disease in The Gambia. Since the introduction of MPT64 antigen tests, a higher than expected rate of suspected non-tuberculous mycobacteria (NTM) was seen among AFB smear positive TB suspects, which led us to prospectively assess sensitivity of the MPT64 antigen test in our setting...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27336882/clinical-manifestations-course-and-outcome-of-patients-with-neutralizing-anti-interferon-%C3%AE-autoantibodies-and-disseminated-nontuberculous-mycobacterial-infections
#19
Chih-Yu Chi, Chia-Hao Lin, Mao-Wang Ho, Jing-Ya Ding, Wen-Chi Huang, Han-Po Shih, Chun-Fu Yeh, Chang-Phone Fung, Hsin-Yun Sun, Ching-Tai Huang, Ting-Shu Wu, Chih-Yen Chang, Yuag-Meng Liu, Jia-Yih Feng, Wei-Kai Wu, Lih-Shinn Wang, Chung-Hao Tsai, Cheng-Mao Ho, Huang-Shen Lin, Hung-Jen Chen, Po-Chang Lin, Wei-Chin Liao, Wei-Ting Chen, Chia-Chi Lo, Shang-Yu Wang, Chen-Yen Kuo, Chen-Hsiang Lee, Cheng-Lung Ku
Neutralizing anti-interferon-γ autoantibody (nAIGA)-associated immunodeficiency is an emerging medical issue worldwide. In the present study, we describe and discuss the clinical features and outcomes of patients with nAIGAs and disseminated infections by nontuberculous mycobacteria (dNTM).We thoroughly reviewed the medical records of all patients. Microorganisms and nAIGAs were identified using previously described methods with modifications. All data were calculated and analyzed using SPSS software.Among 46 adult patients with dNTM infections, we identified 45 cases (97...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27284662/modulation-of-core-turbulent-density-fluctuations-by-large-scale-neoclassical-tearing-mode-islands-in-the-diii-d-tokamak
#20
L Bardóczi, T L Rhodes, T A Carter, A Bañón Navarro, W A Peebles, F Jenko, G McKee
We report the first observation of localized modulation of turbulent density fluctuations n[over ˜] (via beam emission spectroscopy) by neoclassical tearing modes (NTMs) in the core of the DIII-D tokamak. NTMs are important as they often lead to severe degradation of plasma confinement and disruptions in high-confinement fusion experiments. Magnetic islands associated with NTMs significantly modify the profiles and turbulence drives. In this experiment n[over ˜] was found to be modulated by 14% across the island...
May 27, 2016: Physical Review Letters
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