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https://www.readbyqxmd.com/read/28322780/reductive-metabolism-of-tiaprofenic-acid-by-the-human-liver-and-recombinant-carbonyl-reducing-enzymes
#1
Petra Malátková, Adam Skarka, Kateřina Musilová, Vladimír Wsól
Tiaprofenic acid is a widely used anti-inflammatory drug; however, the reductive metabolism of tiaprofenic acid is not yet well understood. Here, we compared the reduction of tiaprofenic acid in microsomes and cytosol from the human liver. The microsomes exhibited lower Km value toward tiaprofenic acid than the cytosol (Km = 164 ± 18 μM vs. 569 ± 74 μM, respectively), whereas the cytosol showed higher specific activity during reduction than the microsomes (Vmax = 728 ± 52 pmol mg of protein(-1)·min(-1) vs...
March 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28319005/prediction-of-treatment-response-in-patients-with-newly-diagnosed-type-2-diabetes-the-skaraborg-diabetes-register
#2
Miriam Pikkemaat, Olle Melander, Per Hjerpe, Kristina Bengtsson Boström
AIMS: Type 2 diabetes is associated with cardiovascular complications. It is largely unknown which patients have poor treatment response and high complication risk; biomarkers are studied for this purpose. The aim of the study was to investigate the association between clinical factors such as HbA1c, level of biomarkers (C-peptide, copeptin) at diagnosis and changes in HbA1c, blood pressure or body mass index (BMI) after five years. METHODS: Clinical data and blood samples from 460 newly diagnosed type 2 diabetes patients from the Skaraborg diabetes register (SDR) at diagnosis and after 5years and were analyzed with linear and logistic regressions...
March 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28287789/effects-of-adolescent-exposure-to-methylmercury-and-d-amphetamine-on-reversal-learning-and-an-extradimensional-shift-in-male-mice
#3
Steven R Boomhower, M Christopher Newland
Adolescence is associated with the continued maturation of dopamine neurotransmission and is implicated in the etiology of many psychiatric illnesses. Adolescent exposure to neurotoxicants that distort dopamine neurotransmission, such as methylmercury (MeHg), may modify the effects of chronic d-amphetamine (d-AMP) administration on reversal learning and attentional-set shifting. Male C57Bl/6n mice were randomly assigned to two MeHg-exposure groups (0 ppm and 3 ppm) and two d-AMP-exposure groups (saline and 1 mg/kg/day), producing four treatment groups (n = 10-12/group): control, MeHg, d-AMP, and MeHg + d-AMP...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28286207/virtual-screening-applications-in-short-chain-dehydrogenase-reductase-research
#4
REVIEW
Katharina R Beck, Teresa Kaserer, Daniela Schuster, Alex Odermatt
Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of steroids, oxysterols, bile acids, and retinoids in peripheral tissues, thereby controlling the local activation of their cognate receptors. Some of these SDRs are considered as promising therapeutic targets, for example to treat estrogen-/androgen-dependent and corticosteroid-related diseases, whereas others are considered as anti-targets as their inhibition may lead to disturbances of endocrine functions, thereby contributing to the development and progression of diseases...
March 9, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28275276/long-term-degree-of-conversion-of-two-bulk-fill-composites
#5
Matej Par, Matea Lapas-Barisic, Ozren Gamulin, Vlatko Panduric, Nika Spanovic, Zrinka Tarle
OBJECTIVES: To investigate the long-term development of the post-cure degree of conversion (DC) for two flowable bulk-fill composites. MATERIALS AND METHODS: Tetric EvoFlow Bulk Fill (TEFBF) and SDR were chosen due to their distinct compositional modifications that enable the decrease of translucency during polymerization and lower polymerization rate, respectively. DC was assessed using FT-Raman spectroscopy at the post-cure times of 0 h, 24 h, 7 d and 30 d. The post-cure behavior was analyzed by a mixed model ANOVA and partial eta-squared statistics...
December 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28265724/yll056c-from-saccharomyces-cerevisiae-encodes-a-novel-protein-with-aldehyde-reductase-activity
#6
Han-Yu Wang, Di-Fan Xiao, Chang Zhou, Lin-Lu Wang, Lan Wu, Ya-Ting Lu, Quan-Ju Xiang, Ke Zhao, Xi Li, Meng -Gen Ma
The short-chain dehydrogenase/reductase (SDR) family, the largest family in dehydrogenase/reductase superfamily, is divided into "classical," "extended," "intermediate," "divergent," "complex," and "atypical" groups. Recently, several open reading frames (ORFs) were characterized as intermediate SDR aldehyde reductase genes in Saccharomyces cerevisiae. However, no functional protein in the atypical group has been characterized in S. cerevisiae till now. Herein, we report that an uncharacterized ORF YLL056C from S...
March 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28260947/the-effect-of-curing-intensity-on-mechanical-properties-of-different-bulk-fill-composite-resins
#7
Fahad I Alkhudhairy
OBJECTIVE: The purpose of this study was to investigate the effects of two curing light intensities on the mechanical properties (Vickers microhardness, compressive strength, and diametral tensile strength) of bulk-fill resin-based composites (RBCs). MATERIALS AND METHODS: Four commercially available bulk-fill RBCs (Tetric(®) N-Ceram, SonicFill™, Smart Dentin Replacement (SDR™) Posterior Flowable Material, and Filtek™ Posterior Restorative) were used in this study...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/28257955/sex-hormones-reduce-nnk-detoxification-through-inhibition-of-short-chain-dehydrogenases-reductases-and-aldo-keto-reductases-in-vitro
#8
Claudia Stapelfeld, Edmund Maser
Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, nicotine-derived nitrosamine ketone) is classified as carcinogenic to humans (IARC, Group 1) and considered to play the most important role in tobacco-related lung carcinogenesis. Detoxification of NNK through carbonyl reduction is catalyzed by members of the AKR- and the SDR-superfamilies which include AKR1B10, AKR1C1, AKR1C2, AKR1C4, 11β-HSD1 and CBR1...
February 28, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28256700/clinical-relevance-of-antimicrobial-testing-results-for-dental-restorative-materials
#9
Cher Farrugia, Julie Haider, Liberato Camilleri, Josette Camilleri
BACKGROUND: The antimicrobial activity of restorative materials is clinically relevant because all dental materials are subject to an environment containing bacteria. This study aimed to investigate the use of 2 methodologies referred to in the literature to assess antimicrobial properties of restorative materials and investigate whether material properties alter results of these traditional methodologies. METHODS: A number of dental restorative materials - namely, Chemfil Superior®, Spectrum®, Heliobond®, Ionoseal®, Dyract Extra®, Smart Dentin Replacement (SDR®) and Biodentine® - were characterized by scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD) analysis, Fourier transform infrared (FT-IR) spectroscopy and pH analysis...
February 28, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28222209/effect-of-different-intermediary-bases-on-microleakage-of-a-restorative-material-in-class-ii-box-cavities-of-primary-teeth
#10
Faika Y Abdelmegid, Fouad S Salama, Waleed M Al-Mutairi, Saud K Al-Mutairi, Sultan O Baghazal
INTRODUCTION: The aim of this in vitro study was to assess and compare the effect of different intermediary bases on microleakage between tooth and a nanocomposite interface in Class II box cavities in primary teeth. METHODS: Standard Class II box cavities were prepared in 52 primary molars and randomly divided into 9 groups according to the intermediary base used (Multicore Flow, Fuji II LC, SDR, Smart Dentin Replacement, and Biodentine). All specimens were subjected to thermocycling and prepared for microleakage testing and evaluation...
February 21, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28217913/what-are-the-key-elements-of-cognitive-analytic-therapy-for-psychosis-a-delphi-study
#11
Peter J Taylor, Sarah Jones, Christopher D Huntley, Claire Seddon
OBJECTIVE: There has been growing interest in the use of cognitive analytic therapy (CAT) with those facing experiences of psychosis. However, there is little research on how CAT is best applied to working with psychosis. This study aimed to identify what the key aspects of CAT for psychosis are or whether this approach requires adaptation when applied to those with experiences of psychosis, drawing on expert opinion. METHOD: An adapted Delphi methodology was used...
February 20, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28214787/sparse-and-dense-hybrid-representation-via-subspace-modeling-for-dynamic-mri
#12
Qiegen Liu, Shanshan Wang, Dong Liang
Recent theoretical results on compressed sensing and low-rank matrix recovery have inspired significant interest in joint sparse and low rank modeling of dynamic magnetic resonance imaging (dMRI). Existing approaches usually describe these two respective prior information with different formulations. In this paper, we present a novel sparse and dense hybrid representation (SDR) model which describes the sparse plus low rank properties by a unified way. More specifically, under the learned dictionary consisting of temporal basis functions, SDR models the spatial coefficients in two subspaces with Laplacian and Gaussian prior distributions, respectively...
February 5, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28187883/enhancement-of-lung-sounds-based-on-empirical-mode-decomposition-and-fourier-transform-algorithm
#13
Ashok Mondal, Poulami Banerjee, Ajay Somkuwar
BACKGROUND AND OBJECTIVE: There is always heart sound (HS) signal interfering during the recording of lung sound (LS) signals. This obscures the features of LS signals and creates confusion on pathological states, if any, of the lungs. In this work, a new method is proposed for reduction of heart sound interference which is based on empirical mode decomposition (EMD) technique and prediction algorithm. METHOD: In this approach, first the mixed signal is split into several components in terms of intrinsic mode functions (IMFs)...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28179188/diacetyl-and-related-flavorant-%C3%AE-diketones-biotransformation-cellular-interactions-and-respiratory-tract-toxicity
#14
M W Anders
Exposure to diacetyl and related α-diketones causes respiratory-tract damage in humans and experimental animals. Chemical toxicity is often associated with covalent modification of cellular nucleophiles by electrophilic chemicals. Electrophilic α-diketones may covalently modify nucleophilic arginine residues in critical proteins and, thereby, produce the observed respiratory-tract pathology. The major pathway for the biotransformation of α-diketones is reduction to α-hydroxyketones (acyloins), which is catalyzed by NAD(P)H-dependent enzymes of the short-chain dehydrogenase/reductase (SDR) and the aldo-keto reductase (AKR) superfamilies...
February 5, 2017: Toxicology
https://www.readbyqxmd.com/read/28167628/exposure-to-a-social-stressor-induces-translocation-of-commensal-lactobacilli-to-the-spleen-and-priming-of-the-innate-immune-system
#15
William P Lafuse, Rachel Gearinger, Sydney Fisher, Connor Nealer, Amy R Mackos, Michael T Bailey
Studies have shown that exposure to psychological stressors leads to inflammation throughout the body. This has been widely studied using social disruption (SDR), a social stressor that involves repeated social defeat in subordinate mice. Exposure to SDR increases serum cytokine levels, results in accumulation of spleen CD11b(+) myeloid cells, and primes macrophages for increased cytokine and microbicidal activity. Our previous studies showed that intestinal microbes are necessary for SDR-enhancement of innate immunity...
March 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28158039/refractive-index-variance-of-cells-and-tissues-measured-by-quantitative-phase-imaging
#16
Mingguang Shan, Mikhail E Kandel, Gabriel Popescu
The refractive index distribution of cells and tissues governs their interaction with light and can report on morphological modifications associated with disease. Through intensity-based measurements, refractive index information can be extracted only via scattering models that approximate light propagation. As a result, current knowledge of refractive index distributions across various tissues and cell types remains limited. Here we use quantitative phase imaging and the statistical dispersion relation (SDR) to extract information about the refractive index variance in a variety of specimens...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28153571/providing-data-for-serrated-polyp-detection-rate-benchmarks-an-analysis-of-the-new-hampshire-colonoscopy-registry
#17
Joseph C Anderson, Lynn F Butterly, Julia E Weiss, Christina M Robinson
BACKGROUND AND AIMS: Similar to achieving adenoma detection rate (ADR) benchmarks to prevent colorectal cancer (CRC), achieving adequate serrated polyp detection rates (SDR) may be essential to the prevention of CRC associated with the serrated pathway. Previous studies have been based on data from high-volume endoscopists at single academic centers. Based on a hypothesis that ADR is correlated with SDR, we stratified a large, diverse group of endoscopists (n=77 practicing at 28 centers) into high and low performers based on ADR, to provide data for corresponding target SDR benchmarks...
January 30, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28144595/extraction-of-respiratory-signal-based-on-image-clustering-and-intensity-parameters-at-radiotherapy-with-external-beam-a-comparative-study
#18
P Samadi Miandoab, A Esmaili Torshabi, S Nankali
BACKGROUND: Since tumors located in thorax region of body mainly move due to respiration, in the modern radiotherapy, there have been many attempts such as; external markers, strain gage and spirometer represent for monitoring patients' breathing signal. With the advent of fluoroscopy technique, indirect methods were proposed as an alternative approach to extract patients' breathing signals. MATERIALS AND METHODS: The purpose of this study is to extract respiratory signals using two available methods based on clustering and intensity strategies on medical image dataset of XCAT phantom...
December 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/28128053/the-%C3%AE-sheet-core-is-the-favored-candidate-of-engineering-sdr-for-enhancing-thermostability-but-not-for-activity
#19
Deshuai Lou, Jun Tan, Liancai Zhu, Shunlin Ji, Bochu Wang
7α-Hydroxysteroid dehydrogenases (7α-HSDHs) can stereoselectively catalyze steroids, aromatic α-ketoesters, and benzaldehyde analogues playing a critical role in the biotransformation and poor thermostability that hinders their biomedical and industrial applications. Based on the three-dimensional structure of 7α-HSDH from Clostridium absonum (CA 7α-HSDH), recently reported program MAESTRO was used to compute the ΔΔG and predict the single-point mutants that could enhance its thermostability. Four mutants were selected and verified experimentally...
January 26, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28125217/functional-and-evolutionary-characterization-of-a-udp-xylose-synthase-gene-from-the-plant-pathogen-xylella-fastidiosa-involved-in-the-synthesis-of-bacterial-lipopolysaccharide
#20
Valquíria Campos Alencar, Daniela Leite Jabes, Fabiano Bezerra Menegidio, Guilherme Lanzi Sassaki, Lucas Rodrigo de Souza, Luciano Puzer, Maria Cecília Zorél Meneghetti, Marcelo Andrade Lima, Ivarne Luis Dos Santos Tersariol, Regina Costa de Oliveira, Luiz R Nunes
Xylella fastidiosa is a plant-infecting bacillus, responsible for many important crop diseases, such as Pierce's disease of vineyards, citrus variegated chlorosis, and coffee leaf scorch (CLS), among others. Recent genomic comparisons involving two CLS-related strains, belonging to X. fastidiosa subsp. pauca, revealed that one of them carries a frameshift mutation that inactivates a gene encoding an oxidoreductase of the short-chain dehydrogenase/reductase (SDR) superfamily, which may play important roles in determining structural variations in bacterial glycans and glycoconjugates...
January 26, 2017: Biochemistry
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