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https://www.readbyqxmd.com/read/28732039/abnormal-meiosis-in-an-intersectional-allotriploid-of-populus-l-and-segregation-of-ploidy-levels-in-2x-%C3%A3-3x-progeny
#1
Jun Wang, Beibei Huo, Wanting Liu, Daili Li, Ling Liao
Triploid plants are usually highly aborted owing to unbalanced meiotic chromosome segregation, but limited viable gametes can participate in the transition to different ploidy levels. In this study, numerous meiotic abnormalities were found with high frequency in an intersectional allotriploid poplar (Populus alba × P. berolinensis 'Yinzhong'), including univalents, precocious chromosome migration, lagging chromosomes, chromosome bridges, micronuclei, and precocious cytokinesis, indicating high genetic imbalance in this allotriploid...
2017: PloS One
https://www.readbyqxmd.com/read/28727412/a-novel-host-guest-recognition-assisted-electrochemical-release-its-reusable-sensing-application-based-on-dna-cross-configuration-fueled-target-cycling-and-sdr-amplification
#2
Yuanyuan Chang, Ying Zhuo, Yaqin Chai, Ruo Yuan
In this work, an elegantly designed host-guest recognition-assisted electrochemical release was established and applied in a reusable electrochemical biosensor for the detection of microRNA-182-5p (miRNA-182-5p), a prostate cancer biomarker in prostate cancer, based on the DNA cross configuration-fueled target cycling and strand displacement reaction (SDR) amplification. With such design, the single target miRNA input could be converted to large numbers of single-stranded DNA (S1-Trp and S2-Trp) output which could be trapped by cucurbit[8]uril-methyl viologen (CB-8-MV2+) based on the host-guest recognition, significantly enhancing the sensitivity for miRNA detection...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28721100/shear-bond-strength-of-different-surface-treatments-in-bulk-fill-microhybrid-and-nanoparticle-repair-resins
#3
Rudys Rodolfo de Jesus Tavarez, Lauber Jose Dos Santos Almeida Júnior, Tayanne Christine Gomes Guará, Izabella Santos Ribeiro, Etevaldo Matos Maia Filho, Leily Macedo Firoozmand
OBJECTIVES: The purpose of this study was to evaluate the influence of surface treatment and different types of composite resin on the microshear bond strength of repairs. MATERIALS AND METHODS: Seventy-two specimens (n=72) were prepared using a nanoparticle resin and stored in artificial saliva at 37 ± 1°C for 24 h. After this period, the specimens (n=24) were restored with microhybrid resin P60 (3M ESPE), nanoparticle resin Filtek Z350 (3M ESPE), and Bulk Fill Surefil SDR Flow (Dentsply) composite resins...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/28711622/prolonged-low-level-noise-induced-plasticity-in-the-peripheral-and-central-auditory-system-of-rats
#4
Adam M Sheppard, Guang-Di Chen, Senthilvelan Manohar, Dalian Ding, Bo-Hua Hu, Wei Sun, Jiwie Zhao, Richard Salvi
Prolonged low-level noise exposure alters loudness perception in humans, presumably by decreasing the gain of the central auditory system. Here we test the central gain hypothesis by measuring the acute and chronic physiologic changes at the level of the cochlea and inferior colliculus (IC) after a 75-dB SPL, 10-20-kHz noise exposure for 5weeks. The compound action potential (CAP) and summating potential (SP) were used to assess the functional status of the cochlea and 16 channel electrodes were used to measure the local field potentials (LFP) and multi-unit spike discharge rates (SDR) from the IC immediately after and one-week post-exposure...
July 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28694726/a-nationwide-multicentre-study-in-turkey-for-establishing-reference-intervals-of-haematological-parameters-with-novel-use-of-a-panel-of-whole-blood
#5
Yesim Ozarda, Kiyoshi Ichihara, Ebubekir Bakan, Harun Polat, Nurinnisa Ozturk, Nurcan K Baygutalp, Fatma Taneli, Yesim Guvenc, Murat Ormen, Zubeyde Erbayraktar, Nurten Aksoy, Hatice Sezen, Meltem Demir, Gulcin Eskandari, Gurbuz Polat, Nuriye Mete, Hatice Yuksel, Husamettin Vatansev, Fatma Gun, Okhan Akin, Ozlem Ceylan, Tevfik Noyan, Ozgul Gozlukaya, Yuksel Aliyazicioglu, Sevim Kahraman, Melahat Dirican, Gul Ozlem Tuncer, Shogo Kimura, Pinar Eker
INTRODUCTION: A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). MATERIALS AND METHODS: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28649479/functional-outcomes-of-childhood-selective-dorsal-rhizotomy-20-to-28-years-later
#6
T S Park, Jenny L Liu, Caleb Edwards, Deanna M Walter, Matthew B Dobbs
BACKGROUND: Selective dorsal rhizotomy (SDR) is a surgical method used to treat childhood spastic cerebral palsy (CP). However, the effects of early SDR on functional outcomes and quality of life decades later in adulthood remains to be elucidated. OBJECTIVES: To evaluate the long-term outcomes in terms of satisfaction and mobility of adult patients who received childhood SDR. METHODS: Adult patients who received SDR in childhood were surveyed...
May 17, 2017: Curēus
https://www.readbyqxmd.com/read/28628659/wave-intensity-of-aortic-root-pressure-as-diagnostic-marker-of-left-ventricular-systolic-dysfunction
#7
Bernhard Hametner, Stephanie Parragh, Thomas Weber, Siegfried Wassertheurer
BACKGROUND: Systolic left ventricular function strongly influences the blood pressure waveform. Therefore, pressure-derived parameters might potentially be used as non-invasive, diagnostic markers of left ventricular impairment. The aim of this study was to investigate the performance of pressure-based parameters in combination with electrocardiography (ECG) for the detection of left ventricular systolic dysfunction defined as severely reduced ejection fraction (EF). METHODS AND RESULTS: Two populations, each comprising patients with reduced EF and pressure-matched controls, were included for the main analysis (51/102 patients) and model testing (44/88 patients)...
2017: PloS One
https://www.readbyqxmd.com/read/28623564/an-nadph-dependent-lactobacillus-composti-short-chain-dehydrogenase-reductase-characterization-and-application-to-r-1-phenylethanol-synthesis
#8
Ya-Jun Wang, Bin-Bin Ying, Min Chen, Wei Shen, Zhi-Qiang Liu, Yu-Guo Zheng
A new anti-Prelog short-chain dehydrogenase/reductase (SDR) encoding gene lcsdr was cloned from Lactobacillus composti DSM 18527, and heterologously expressed in Escherichia coli. LcSDR is nicotinamide adenine dinucleotide phosphate (NADPH)-dependent and has a molecular weight of approximately 30 kDa. The optimal pH and temperature were 6.5 and 30 °C, respectively. The maximal reaction rate Vmax was 133.9 U mg(-1); the Michaelis-Menten constant K m of LcSDR were 0.345 mM for acetophenone (1a), and 0.085 mM for NADPH...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28623123/screening-mutations-in-drug-resistant-mycobacterium-tuberculosis-strains-in-yunnan-china
#9
Daoqun Li, Yuzhu Song, Cheng-Lin Zhang, Xiaofei Li, Xueshan Xia, A-Mei Zhang
Drug-resistant tuberculosis (DR-TB), especially multidrug-resistant tuberculosis (MDR-TB), is a serious medical and societal problem in China. The purpose of this study was to evaluate the mutation characteristics of drug-resistant Mycobacterium tuberculosis (M. tuberculosis) isolates in Yunnan, China. Drug susceptibility testing (DST) was performed in 523 clinical M. tuberculosis isolates. Six drug resistance genes (katG, inhA, rpoB, rpsL, embB, and pncA) were selected to screen for mutations. In total, 54 clinical M...
June 13, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28619386/a-novel-17%C3%AE-hydroxysteroid-dehydrogenase-in-rhodococcus-sp-p14-for-transforming-17%C3%AE-estradiol-to-estrone
#10
Xueying Ye, Hui Wang, Jie Kan, Jin Li, Tongwang Huang, Guangming Xiong, Zhong Hu
17β-hydroxysteroid dehydrogenases (17β-HSD) are a group of oxidoreductase enzymes that exhibit high specificity for 17C reduction/oxidation. However, the mechanism of 17β-HSD in oxidizing steroid hormone 17β-estradiol to estrone in bacterium is still unclear. In this work, a functional bacterium Rhodococcus sp. P14 was identified having rapid ability to oxidize estradiol into estrone in mineral salt medium (MSM) within 6 h. The functional genes encoding NADH-dependent oxidoreductase were successfully detected with the help of bioinformatics, and it was identified that it contained two consensus regions affiliated to the short-chain dehydrogenase/reductase (SDR) superfamily...
June 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28617943/long-term-impact-of-childhood-selective-dorsal-rhizotomy-on-pain-fatigue-and-function-a-case-control-study
#11
Alecia K Daunter, Anna L Kratz, Edward A Hurvitz
AIM: Selective dorsal rhizotomy (SDR) is a surgical treatment for spasticity in children with cerebral palsy (CP). Studies suggest long-lasting effects of SDR on spasticity; long-term effects on symptoms and function are not clear. This study tested whether adults with CP (average 22y after SDR) report less pain, fatigue, and functional decline than a retrospectively assessed non-surgical comparison group. METHOD: This was a case-control study. Eighty-eight adults with CP (mean age 27y; SDR=38 male/female/missing=20/16/2; non-surgical [comparison]=50, male/female=19/31) recruited from a tertiary care center and the community completed a battery of self-reported outcome measures...
June 15, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28614783/effectiveness-and-safety-of-pd-1-pd-l1-inhibitors-in-the-treatment-of-solid-tumors-a-systematic-review-and-meta-analysis
#12
REVIEW
Xiaohui Wang, Zhengqiang Bao, Xiaoju Zhang, Fei Li, Tianwen Lai, Chao Cao, Zhihua Chen, Wen Li, Huahao Shen, Songmin Ying
BACKGROUND: PD-1/PD-L1 inhibitors have been implicated as potentially effective anti-cancer therapies. Some clinical randomized controlled trials (RCTs) have been completed for a variety of PD-1/PD-L1 inhibitors to treat various malignancies, and more RCTs are still under way. We carried out this systematic meta-analysis to evaluate the efficacy and safety of PD-1/PD-L1 inhibitors in the treatment of solid tumors. METHODS: We searched PubMed, EMBASE, clinical trial registers, conference reports, and related reviews...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28613173/large-scale-crowdsourced-study-for-tone-mapped-hdr-pictures
#13
Debarati Kundu, Deepti Ghadiyaram, Alan C Bovik, Brian L Evans
Measuring digital picture quality, as perceived by human observers, is increasingly important in many applications in which humans are the ultimate consumers of visual information. Standard dynamic range (SDR) images provide 8 b/color/pixel. High dynamic range (HDR) images, usually created from multiple exposures of the same scene, can provide 16 or 32 b/color/pixel, but need to be tonemapped to SDR for display on standard monitors. Multiexposure fusion (MEF) techniques bypass HDR creation by fusing an exposure stack directly to SDR images to achieve aesthetically pleasing luminance and color distributions...
October 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28595587/multiple-gene-movements-into-and-out-of-haploid-sex-chromosomes
#14
Agnieszka P Lipinska, Nicholas R T Toda, Svenja Heesch, Akira F Peters, J Mark Cock, Susana M Coelho
BACKGROUND: Long-term evolution of sex chromosomes is a dynamic process shaped by gene gain and gene loss. Sex chromosome gene traffic has been studied in XY and ZW systems but no detailed analyses have been carried out for haploid phase UV sex chromosomes. Here, we explore sex-specific sequences of seven brown algal species to understand the dynamics of the sex-determining region (SDR) gene content across 100 million years of evolution. RESULTS: A core set of sex-linked genes is conserved across all the species investigated, but we also identify modifications of both the U and the V SDRs that occurred in a lineage-specific fashion...
June 8, 2017: Genome Biology
https://www.readbyqxmd.com/read/28595002/diacetyl-l-xylulose-reductase-mediates-chemical-redox-cycling-in-lung-epithelial-cells
#15
Shaojun Yang, Yi-Hua Jan, Vladimir Mishin, Diane E Heck, Debra L Laskin, Jeffrey D Laskin
Reactive carbonyls such as diacetyl (2,3-butanedione) and 2,3-pentanedione in tobacco and many food and consumer products are known to cause severe respiratory diseases. Many of these chemicals are detoxified by carbonyl reductases in the lung, in particular, dicarbonyl/l-xylulose reductase (DCXR), a multifunctional enzyme important in glucose metabolism. DCXR is a member of the short-chain dehydrogenase/reductase (SDR) superfamily. Using recombinant human enzyme, we discovered that DCXR mediates redox cycling of a variety of quinones generating superoxide anion, hydrogen peroxide, and, in the presence of transition metals, hydroxyl radicals...
June 26, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28590748/huygens-metasurfaces-enabled-by-magnetic-dipole-resonance-tuning-in-split-dielectric-nanoresonators
#16
Sheng Liu, Aleksandr Vaskin, Salvatore Campione, Omri Wolf, Michael B Sinclair, John Reno, Gordon A Keeler, Isabelle Staude, Igal Brener
Dielectric metasurfaces that exploit the different Mie resonances of nanoscale dielectric resonators are a powerful platform for manipulating electromagnetic fields and can provide novel optical behavior. In this work, we experimentally demonstrate independent tuning of the magnetic dipole resonances relative to the electric dipole resonances of split dielectric resonators (SDRs). By increasing the split dimension, we observe a blue shift of the magnetic dipole resonance toward the electric dipole resonance...
June 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28587722/comparative-evaluation-of-topographical-data-of-dental-implant-surfaces-applying-optical-interferometry-and-scanning-electron-microscopy
#17
N Kournetas, S Spintzyk, E Schweizer, T Sawada, F Said, P Schmid, J Geis-Gerstorfer, G Eliades, F Rupp
OBJECTIVE: Comparability of topographical data of implant surfaces in literature is low and their clinical relevance often equivocal. The aim of this study was to investigate the ability of scanning electron microscopy and optical interferometry to assess statistically similar 3-dimensional roughness parameter results and to evaluate these data based on predefined criteria regarded relevant for a favorable biological response. METHODS: Four different commercial dental screw-type implants (NanoTite Certain Prevail, TiUnite Brånemark Mk III, XiVE S Plus and SLA Standard Plus) were analyzed by stereo scanning electron microscopy and white light interferometry...
June 3, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28577399/a-parsimonious-approach-to-estimate-pah-concentrations-in-river-sediments-of-anthropogenically-impacted-watersheds
#18
Marc Schwientek, Hermann Rügner, Ulrike Scherer, Michael Rode, Peter Grathwohl
The contamination of riverine sediments and suspended matter with hydrophobic pollutants is typically associated with urban land use. However, it is rarely related to the sediment supply of the watershed, because sediment yield data are often missing. We show for a suite of watersheds in two regions of Germany with contrasting land use and geology that the contamination of suspended particles with polycyclic aromatic hydrocarbons (PAH) can be explained by the ratio of inhabitants residing within the watershed and the watershed's sediment yield...
May 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28571830/effect-of-bulk-fill-base-material-on-fracture-strength-of-root-filled-teeth-restored-with-laminate-resin-composite-restorations
#19
N A Taha, G A Maghaireh, A S Ghannam, J E Palamara
OBJECTIVES: To evaluate the effect of using a bulk-fill flowable base material on fracture strength and fracture patterns of root-filled maxillary premolars with MOD preparations restored with laminate restorations. METHODS: Fifty extracted maxillary premolars were selected for the study. Standardized MOD cavities with endodontic treatment were prepared for all teeth, except for intact control. The teeth were divided randomly into five groups (n=10); (Group 1) sound teeth, (Group 2) unrestored teeth; (Group 3) MOD cavities with Vitrebond base and resin-based composite (Ceram...
May 29, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28552510/post-marketing-safety-surveillance-for-inactivated-and-live-attenuated-japanese-encephalitis-vaccines-in-china-2008-2013
#20
Wendi Wu, Dawei Liu, Keli Li, J Pekka Nuorti, Hanna M Nohynek, Disha Xu, Jiakai Ye, Jingshan Zheng, Huaqing Wang
INTRODUCTION: Two types of Japanese encephalitis (JE) vaccines, inactivated JE vaccine (JE-I) and live-attenuated JE vaccine (JE-L), are available and used in China. In particular, one JE-L, produced by a domestic manufacturer in China, was prequalified by WHO in 2013. We assessed the safety of JE vaccines in China during 2008-2013 using the Chinese National Adverse Events Following Immunization Information System (CNAEFIS) data. METHODS: We retrieved AEFI reporting data about JE vaccines from CNAEFIS, 2008-2013, examined demographic characteristics of AEFI cases, and used administrative data on vaccine doses as denominator to calculate and compare crude reporting rates...
June 22, 2017: Vaccine
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