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David Graham, Kristian Aquilina, Stephanie Cawker, Simon Paget, Neil Wimalasundera
The management of cerebral palsy (CP) is complex and requires a multidisciplinary approach. Selective dorsal rhizotomy (SDR) is a neurosurgical technique that aims to reduce spasticity in the lower limbs. A minimally invasive approach to SDR involves a single level laminectomy at the conus and utilises intraoperative electromyography (EMG). When combined with physiotherapy, SDR is effective in selected children and has minimal complications. This review discusses the epidemiology of CP and the management using SDR within an integrated multidisciplinary centre...
September 2016: J Spine Surg
Yuehong Tong, Tal Ben Ami, Sungmin Hong, Rainer Heintzmann, Guido Gerig, Zsolt Ablonczy, Christine A Curcio, Thomas Ach, R Theodore Smith
PURPOSE: To elucidate the molecular pathogenesis of age-related macular degeneration (AMD) and interpretation of fundus autofluorescence imaging, the authors identified spectral autofluorescence characteristics of drusen and retinal pigment epithelium (RPE) in donor eyes with AMD. METHODS: Macular RPE/Bruch membrane flat mounts were prepared from 5 donor eyes with AMD. In 12 locations (1-3 per eye), hyperspectral autofluorescence images in 10-nm-wavelength steps were acquired at 2 excitation wavelengths (λex 436, 480 nm)...
September 30, 2016: Retina
Pawel Zagozdzon, Bartosz Goyke, Magdalena Wrotkowska
BACKGROUND: The role of antipsychotics in influencing mortality of patients with mental disorders is still unexplained. OBJECTIVE: The aim of this study was to determine mortality rates of patients treated with atypical and typical antipsychotics and to compare these data with the mortality rates for the general population. METHODS: The study was based on the 2008-2012 prescription drug reimbursement data from the Polish National Health Fund in Gdansk and mortality data from the death registry...
September 2016: Drugs—Real World Outcomes
Faika Abdelmegid, Fouad Salama, Nawaf Albogami, Muhannad Albabtain, Abdulkareem Alqahtani
This in vitro investigation compared the shear bond strength (SBS) of four dentin substitute/replacement materials to caries-affected dentin of primary teeth. Dentin surfaces were randomly divided into four groups of 12 each according to the material used as follows: SDR/Smart Dentin Replacement, Biodentine, Multicore Flow, and Fuji II LC. The SBS was measured and failure modes were determined. There was a statistically significant difference in the mean values of SBS among the four materials (F=741.523, p<0...
2016: Dental Materials Journal
Leily Macedo Firoozmand, Mariana Gonçalves Cordeiro, Marcos André Dos Santos Da Silva, Rudys Rodolfo De Jesus Tavarez, Etevaldo Matos Maia Filho
The aim of this study was to evaluate the radiopacity of silorane and methacrylate resin composites, comparing them to the enamel, dentin, and aluminum penetrometer using a digital image. From six resin composites (Filtek™ P90, Filtek Z350, Filtek Z350 XT flow, Tetric Ceram, TPH Spectrum, and SureFil SDR flow) cylindrical disks (5 × 1 mm) were made and radiographed by a digital method, together with a 15-step aluminum step-wedge and a 1 mm slice of human tooth. The degree of radiopacity of each image was quantified using digital image processing...
2016: TheScientificWorldJournal
Lingling Chang, Ying An, Shuling Yang, Xiaosu Zhang
PURPOSE: A meta-analysis of published data was conducted to investigate the therapeutic effects in patients with renal cell carcinoma (RCC) who were receiving antiangiogenic drugs. METHODS: A computerized search through electronic databases, including PubMed (until February 2016), was performed to obtain eligible randomized controlled trials that compared the effectiveness of antiangiogenic with control groups (everolimus, placebo, and interferon [IFN] alfa) in patients with RCC...
October 2016: Journal of Cancer Research and Therapeutics
Denyse Cavalcante Lago, Fernanda Carvalho Humann, Angel Roberto Barchuk, Kuruvilla Joseph Abraham, Klaus Hartfelder
Adult honey bee queens and workers drastically differ in ovary size. This adult ovary phenotype difference becomes established during the final larval instar, when massive programmed cell death leads to the degeneration of 95-99% of the ovariole anlagen in workers. The higher juvenile hormone (JH) levels in queen larvae protect the ovaries against such degeneration. To gain insights into the molecular architecture underlying this divergence critical for adult caste fate and worker sterility, we performed a microarray analysis on fourth and early fifth instar queen and worker ovaries...
October 5, 2016: Insect Biochemistry and Molecular Biology
Maria Michela Gianino, Jacopo Lenzi, Aida Muça, Maria Pia Fantini, Roberta Siliquini, Walter Ricciardi, Gianfranco Damiani
OBJECTIVE: To update amenable mortality in 32 OECD countries at 2013 (or last available year), to describe the time trends during 2000-2013, and to evaluate the association of these trends with various geographic areas. DATA SOURCES: Secondary data from 32 countries during 2000-2013, gathered from the World Health Organization Mortality Database. STUDY DESIGN: Time trend analysis. DATA COLLECTION: Using Nolte and McKee's list, age-standardized amenable mortality rates (SDRs) were calculated as the annual number of deaths over the population aged 0-74 years per 100,000 inhabitants...
October 5, 2016: Health Services Research
Joachim Ruther, Åsa K Hagström, Birgit Brandstetter, John Hofferberth, Astrid Bruckmann, Florian Semmelmann, Michaela Fink, Helena Lowack, Sabine Laberer, Oliver Niehuis, Rainer Deutzmann, Christer Löfstedt, Reinhard Sterner
Males of all species of the parasitic wasp genus Nasonia use (4R,5S)-5-hydroxy-4-decanolide (RS) as component of their sex pheromone while only N. vitripennis (Nv), employs additionally (4R,5R)-5-hydroxy-4-decanolide (RR). Three genes coding for the NAD(+)-dependent short-chain dehydrogenases/reductases (SDRs) NV10127, NV10128, and NV10129 are linked to the ability of Nv to produce RR. Here we show by assaying recombinant enzymes that SDRs from both Nv and N. giraulti (Ng), the latter a species with only RS in the pheromone, epimerise RS into RR and vice versa with (4R)-5-oxo-4-decanolide as an intermediate...
October 5, 2016: Scientific Reports
Ambrose J Melson, Rebecca Louise Monk, Derek Heim
BACKGROUND: Data-driven student drinking norms interventions are based on reported normative overestimation of the extent and approval of an average student's drinking. Self-reported differences between personal and perceived normative drinking behaviors and attitudes are taken at face value as evidence of actual levels of overestimation. This study investigates whether commonly used data collection methods and socially desirable responding (SDR) may inadvertently impede establishing "objective" drinking norms...
October 4, 2016: Alcoholism, Clinical and Experimental Research
C S Sampaio, K-J Chiu, E Farrokhmanesh, M Janal, R M Puppin-Rontani, M Giannini, E A Bonfante, P G Coelho, R Hirata
The present study aimed to characterize the pattern and volume of polymerization shrinkage of flowable resin composites, including one conventional, two bulk fill, and one self-adhesive. Standardized class I preparations (2.5 mm depth × 4 mm length × 4 mm wide) were performed in 24 caries-free human third molars that were randomly divided in four groups, according to the resin composite and adhesive system used: group 1 = Permaflo + Peak Universal Bond (PP); group 2 = Filtek Bulk Fill + Scotchbond Universal (FS); group 3 = Surefil SDR + XP Bond (SX); and group 4 = Vertise flow self-adhering (VE) (n=6)...
September 30, 2016: Operative Dentistry
Małgorzata Pikala, Monika Burzyn Ska, Robert Pikala, Marek Bryła, Irena Maniecka-Bryła
BACKGROUND: The aim of the study is to evaluate the differences in premature mortality between educational groups of Polish inhabitants in 2002 and 2011. METHODS: The analysis included all deaths among inhabitants of Poland, aged 25-64 years, which occurred in 2002 (N=97 004) and 2011 (N=104 598). We calculated age-standardised death rates (SDRs) and summary measures on inequalities. The relative index of inequality (RII) was calculated with Poisson regression...
2016: BMJ Open
Noor-Ul-Ain Jawaed, Syed Yawar Ali Abidi, Fazal-Ur-Rehman Qazi, Shahbaz Ahmed
OBJECTIVE: To evaluate the coronal microleakage of packable composite using conventional incremental and posterior bulk fill flowable composite using Smart Dentine Replacement Single Step technique in the cervical margins of class II cavities in dentine using the dye penetration method. STUDY DESIGN: In-vitroInterventional study. PLACE AND DURATION OF STUDY: Department of Operative Dentistry, Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Karachi, from November 2012 to April 2013...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Reyhan Şişman, Ayça Aksoy, Muhammet Yalçın, Erdal Karaöz
Five bulk fill composite resins, including SDR, Tetric EvoCeram Bulk Fill (TEC), X-trafil (XTF), Sonic Fill (SF), Filtek Bulk Fill (FBF), were used in this study. Human dental pulp stem cells were cultured in 12-well culture dishes (3 × 104 cells per cm(2)) and stored in an incubator at 37°C and 5% CO2 for 1 day. On days 1, 7, 14, and 21 of co-culture, viable cells were measured using a WST-1 assay. Lower cell viability was observed with XTF and SDR bulk fill composite resins compared to the control group during the WST-1 assay...
2016: Journal of Oral Science
Yang Liu, Francesca Chiaromonte, Bing Li
In many scientific and engineering fields, advanced experimental and computing technologies are producing data that are not just high dimensional, but also internally structured. For instance, statistical units may have heterogeneous origins from distinct studies or subpopulations, and features may be naturally partitioned based on experimental platforms generating them, or on information available about their roles in a given phenomenon. In a regression analysis, exploiting this known structure in the predictor dimension reduction stage that precedes modeling can be an effective way to integrate diverse data...
September 20, 2016: Biometrics
Makbule Bilge Akbulut, Pembegul Uyar Arpaci, Ayce Unverdi Eldeniz
The aim of this study was to evaluate the adhesion of periodontal ligament fibroblasts (PDLs) on newly proposed root repair materials [Biodentine, MM-MTA, polymethylmethacrylate (PMMA) bone cement, and SDR], in comparison with contemporary root repair materials [IRM, Dyract compomer, ProRoot MTA (PMTA), and Vitrebond]. Five discs from each material were fabricated in sterile Teflon molds, and the specimens were aged and prewetted in cell culture media for 96 hours. Three material discs were used for scanning electron microscopy (SEM) for the assessment of the attachment, density, and morphological changes in the PDLs, while two samples were used for energy dispersive x-ray spectroscopy (SEM-EDX) to determine the elemental composition of the materials...
September 20, 2016: Microscopy Research and Technique
Martin Schäfer, Clare E M Stevenson, Barrie Wilkinson, David M Lawson, Mark J Buttner
SimC7 is a polyketide ketoreductase involved in biosynthesis of the angucyclinone moiety of the gyrase inhibitor simocyclinone D8 (SD8). SimC7, which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily, catalyzes reduction of the C-7 carbonyl of the angucyclinone, and the resulting hydroxyl is essential for antibiotic activity. SimC7 shares little sequence similarity with characterized ketoreductases, suggesting it might have a distinct mechanism. To investigate this possibility, we determined the structures of SimC7 alone, with NADP(+), and with NADP(+) and the substrate 7-oxo-SD8...
September 22, 2016: Cell Chemical Biology
Tarek A Omran, Sufyan Garoushi, Aous A Abdulmajeed, Lippo V Lassila, Pekka K Vallittu
OBJECTIVES: Bulk-fill resin composites (BFCs) are gaining popularity in restorative dentistry due to the reduced chair time and ease of application. This study aimed to evaluate the influence of increment thickness on dentin bond strength and light transmission of different BFCs and a new discontinuous fiber-reinforced composite. MATERIALS AND METHODS: One hundred eighty extracted sound human molars were prepared for a shear bond strength (SBS) test. The teeth were divided into four groups (n = 45) according to the resin composite used: regular particulate filler resin composite: (1) G-ænial Anterior [GA] (control); bulk-fill resin composites: (2) Tetric EvoCeram Bulk Fill [TEBF] and (3) SDR; and discontinuous fiber-reinforced composite: (4) everX Posterior [EXP]...
September 10, 2016: Clinical Oral Investigations
Huan Zhang, Meng-Long Zhang, Li-Hong Qiu, Jing-Tao Yu, Fu-Liang Zhan
PURPOSE: To compare the abrasion resistance and flexure strength of three bulk-fill resin composites with an universal nano-hybrid composite resins. METHODS: The specimens were prepared with three kinds of bulk fill composites (SDR , sonicfill, Tetric N-Ceram Bulk Fill) and an universal nano-hybrid composite resins(Herculite Precis). 10 mm in diameter × 2mm in height specimens were prepared for abrasion resistance, while 2 mm in width × 2 mm in depth×25 mm in length specimens were prepared for flexure strength...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Daniel Malafaia, Beatriz Oliveira, Pedro Ferreira, Tiago Varum, José Vieira, Ana Tomé
In this article we discuss a novel approach to Bio-Radar, contactless measurement of bio-signals, called Cognitive Bio-Radar. This new approach implements the Bio-Radar in a Software Defined Radio (SDR) platform in order to obtain awareness of the environment where it operates. Due to this, the Cognitive Bio-Radar can adapt to its surroundings in order to have an intelligent usage of the radio frequency spectrum to improve its performance. In order to study the feasibility of such implementation, a SDR based Bio-Radar testbench was developed and evaluated...
October 2016: Journal of Medical Systems
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