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https://www.readbyqxmd.com/read/29036451/genetic-mapping-and-phylogenetic-analysis-reveal-intraspecific-variation-in-sex-chromosomes-of-the-virginian-strawberry
#1
Na Wei, Rajanikanth Govindarajulu, Jacob A Tennessen, Aaron Liston, Tia-Lynn Ashman
With their extraordinary diversity in sexual systems, flowering plants offer unparalleled opportunities to understand sex determination and to reveal generalities in the evolution of sex chromosomes. Comparative genetic mapping of related taxa with good phylogenetic resolution can delineate the extent of sex chromosome diversity within plant groups, and lead the way to understanding the evolutionary drivers of such diversity. The North American octoploid wild strawberries provide such an opportunity. We performed linkage mapping using targeted sequence capture for the subdioecious western Fragaria virginiana ssp...
September 27, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29034597/effect-of-composite-type-and-placement-technique-on-cuspal-strain
#2
Vilhelm G Ólafsson, André V Ritter, Edward J Swift, Lee W Boushell, Ching-Chang Ko, Gabrielle R Jackson, Sumitha N Ahmed, Terence E Donovan
OBJECTIVE: To compare the cuspal strain in Class II restorations made with bulk-fill and conventional composite resins. MATERIALS AND METHODS: Fifty extracted maxillary premolars were mounted into phenolic rings and divided into five groups (n = 10). Specimens received standardized MOD preparations. A two-step self-etch adhesive was applied and the preparations were restored using a custom matrix as follows: Filtek Supreme Ultra in eight 2-mm increments (FSUI); Filtek Supreme Ultra in bulk (FSUB); SonicFill in bulk (SF); SureFil SDR flow in bulk, covered with a 2-mm occlusal layer of Filtek Supreme Ultra (SDR/FSU); Tetric EvoCeram Bulk Fill in bulk (TEBF)...
October 16, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29034432/ykl071w-from-saccharomyces-cerevisiae-encodes-a-novel-aldehyde-reductase-for-detoxification-of-glycolaldehyde-and-furfural-derived-from-lignocellulose
#3
Hanyu Wang, Yidan Ouyang, Chang Zhou, Difan Xiao, Yaping Guo, Lan Wu, Xi Li, Yunfu Gu, Quanju Xiang, Ke Zhao, Xiumei Yu, Likou Zou, Menggen Ma
Aldehydes generated as by-products during the pretreatment of lignocellulose are the key inhibitors to Saccharomyces cerevisiae, which is considered as the most promising microorganism for industrial production of biofuel, xylitol as well as other special chemicals from lignocellulose. S. cerevisiae has the inherent ability to in situ detoxify aldehydes to corresponding alcohols by multiple aldehyde reductases. Herein, we report that an uncharacterized open reading frame YKL071W from S. cerevisiae encodes a novel "classical" short-chain dehydrogenase/reductase (SDR) protein with NADH-dependent enzymatic activities for reduction of furfural (FF), glycolaldehyde (GA), formaldehyde (FA), and benzaldehyde (BZA)...
October 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29022160/a-catalyst-from-burkholderia-cenocepacia-for-efficient-anti-prelog-s-bioreduction-of-3-5-bis-trifluoromethyl-acetophenone
#4
Songzhu Yu, Hongxia Li, Yan Lu, Guojun Zheng
(R)-3, 5-Bis(trifluoromethyl)phenyl ethanol is a key chiral intermediate for the synthesis of aprepitant. Through a genome mining approach, an NADPH-dependent short-chain dehydrogenases derived from Burkholderia cenocepacia (Bc-SDR) was discovered with excellent anti-Prelog's stereoselectivity of reducing 3, 5-bis(trifluoromethyl) acetophenone. The enzyme with 247 amino acids was successfully expressed in Escherichia coli and the molecular weight was about 26 kDa. Optimization of reaction conditions showed that the optimum temperature and pH of the enzyme was 25 °C and pH 7...
October 12, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29020934/transcriptome-analyses-reveal-sr45-to-be-a-neutral-splicing-regulator-and-a-suppressor-of-innate-immunity-in-arabidopsis-thaliana
#5
Xiao-Ning Zhang, Yifei Shi, Jordan J Powers, Nikhil B Gowda, Chong Zhang, Heba M M Ibrahim, Hannah B Ball, Samuel L Chen, Hua Lu, Stephen M Mount
BACKGROUND: Regulation of pre-mRNA splicing diversifies protein products and affects many biological processes. Arabidopsis thaliana Serine/Arginine-rich 45 (SR45), regulates pre-mRNA splicing by interacting with other regulatory proteins and spliceosomal subunits. Although SR45 has orthologs in diverse eukaryotes, including human RNPS1, the sr45-1 null mutant is viable. Narrow flower petals and reduced seed formation suggest that SR45 regulates genes involved in diverse processes, including reproduction...
October 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29018182/role-of-nitric-oxide-pathway-in-development-and-progression-of-chronic-kidney-disease-in-rats-sensitive-and-resistant-to-its-occurrence-in-an-experimental-model-of-5-6-nephrectomy
#6
Marek Saracyn, Katarzyna Czarzasta, Marek Brytan, Piotr Murawski, Sławomir Lewicki, Tomasz Ząbkowski, Robert Zdanowski, Agnieszka Cudnoch-Jędrzejewska, Grzegorz Wiktor Kamiński, Zofia Wańkowicz
BACKGROUND Understanding the mechanisms conditioning development of chronic kidney disease (CKD) is still a challenge. The aim of this study was to evaluate the activity of the intrarenal nitric oxide (NO) pathway in the context of sensitivity or resistance of different animal strains to the development and degree of renal failure. MATERIAL AND METHODS Two rat strains were used: Wistar (WR) and Sprague-Dawley rats (SDR) in a model of CKD - 5/6 nephrectomy. We assessed parameters of renal failure and expression of nitric oxide synthase (NOS) isoforms in renal cortex and medulla...
October 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28992410/product-release-mechanism-associated-with-structural-changes-in-monomeric-l-threonine-3-dehydrogenase
#7
Tomoharu Motoyama, Shogo Nakano, Yuta Yamamoto, Hiroaki Tokiwa, Yasuhisa Asano, Sohei Ito
A short-chain dehydrogenase like L-threonine 3-dehydrogenase (SDR-TDH) from metagenome data (mtTDH) was identified by database mining. Its enzymatic properties suggested that mtTDH has unique characteristics relative to other SDR-TDHs, including two mesophilic and thermophilic SDR-TDHs identified in this study. The activation energy of mtTDH was the lowest (29.6 kJ/mol) among SDR-TDHs, indicating that it is a psychrophilic enzyme. Size-exclusion chromatography analysis revealed mtTDH is monomer. Crystal structures of mtTDH in apo, binary, and two ternary complexes (L-Ser and L-Thr soaked forms) were determined at resolutions of 1...
October 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/28991307/an-enzyme-free-electrochemical-biosensor-for-sensitive-detection-of-mirna-with-a-high-discrimination-factor-by-coupling-the-strand-displacement-reaction-and-catalytic-hairpin-assembly-recycling
#8
Juan Yao, Zhang Zhang, Zhenghua Deng, Youqiang Wang, Yongcan Guo
An isothermal, enzyme free, ultra-specific and ultra-sensitive protocol for electrochemical detection of miRNAs is proposed based on the toehold-mediated strand displacement reaction (SDR) and non-enzymatic catalytic hairpin reaction (CHA) recycling. The SDR was first triggered only in the presence of target miRNA and this process also affects other miRNA interferences having similar target sequences, thus guaranteeing a high discrimination factor and could be used in rare content miRNA detection with various amounts of interferences having similar target sequences...
October 9, 2017: Analyst
https://www.readbyqxmd.com/read/28984817/robust-weighted-sum-harvested-energy-maximization-for-swipt-cognitive-radio-networks-based-on-particle-swarm-optimization
#9
Pham Viet Tuan, Insoo Koo
In this paper, we consider multiuser simultaneous wireless information and power transfer (SWIPT) for cognitive radio systems where a secondary transmitter (ST) with an antenna array provides information and energy to multiple single-antenna secondary receivers (SRs) equipped with a power splitting (PS) receiving scheme when multiple primary users (PUs) exist. The main objective of the paper is to maximize weighted sum harvested energy for SRs while satisfying their minimum required signal-to-interference-plus-noise ratio (SINR), the limited transmission power at the ST, and the interference threshold of each PU...
October 6, 2017: Sensors
https://www.readbyqxmd.com/read/28976845/radiopacity-and-porosity-of-bulk-fill-and-conventional-composite-posterior-restorations-digital-x-ray-analysis
#10
C J Soares, Cmp Rosatto, V F Carvalho, A A Bicalho, Jcg Henriques, A L Faria-E-Silva
OBJECTIVES: To compare radiopacity and porosity as expressed by the presence of voids in restorations carried out using bulk-fill and incremental filling techniques to restore large mesio-occlusal-distal (MOD) cavities. METHODS: Fifty-five molars with MOD preparations were incrementally filled with Filtek Z-350XT (Z350XT) or bulk-fill composite: Filtek Bulk Fill/Z-350XT (FBF/Z350XT), Venus Bulk Fill/Charisma Diamond (VBF/CHA), SDR/Esthet-X HD (SDR/EST-X), Tetric EvoCeram Bulk Fill (TEC)...
October 4, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28976838/bulk-fill-composites-effectiveness-of-cure-with-poly-and-monowave-curing-lights-and-modes
#11
J K Gan, A U Yap, J W Cheong, N Arista, Cbk Tan
This study compared the effectiveness of cure of bulk-fill composites using polywave light-emitting diode (LED; with various curing modes), monowave LED, and conventional halogen curing lights. The bulk-fill composites evaluated were Tetric N-Ceram bulk-fill (TNC), which contained a novel germanium photoinitiator (Ivocerin), and Smart Dentin Replacement (SDR). The composites were placed into black polyvinyl molds with cylindrical recesses of 4-mm height and 3-mm diameter and photopolymerized as follows: Bluephase N Polywave High (NH), 1200 mW/cm(2) (10 seconds); Bluephase N Polywave Low (NL), 650 mW/cm(2) (18...
October 4, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28969281/comparative-evaluation-of-the-depth-of-cure-and-degree-of-conversion-of-two-bulk-fill-flowable-composites
#12
Ca Anand Yokesh, P Hemalatha, M Muthalagu, M Robert Justin
INTRODUCTION: Since the development of resin based composites, several improvements have been made to improve their physical and chemical properties. In an attempt to fasten and simplify the restoration process, a new class of resin based composite materials, called the bulk fill resin based composites have been introduced, which has been claimed to achieve a depth of cure of 4 mm without affecting the properties of the material. AIM: To comparatively evaluate the depth of cure of two different bulk fill flowable composite resins by ISO 4049 method and to evaluate the degree of conversion of the same composite resins with Fourier Transform Infrared (FTIR) spectroscopy method...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28962564/introducing-leprosy-post-exposure-prophylaxis-into-the-health-systems-of-india-nepal-and-indonesia-a-case-study
#13
A Tiwari, L Mieras, K Dhakal, M Arif, S Dandel, J H Richardus
BACKGROUND: Leprosy has a wide range of clinical and socio-economic consequences. India, Indonesia and Nepal contribute significantly to the global leprosy burden. After integration, the health systems are pivotal in leprosy service delivery. The Leprosy Post Exposure Prophylaxis (LPEP) program is ongoing to investigate the feasibility of providing single dose rifampicin (SDR) as post-exposure prophylaxis (PEP) to the contacts of leprosy cases in various health systems. We aim to compare national leprosy control programs, and adapted LPEP strategies in India, Nepal and Indonesia...
September 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28954496/territorial-variation-in-mortality-from-causes-amenable-to-medical-care-in-poland
#14
Wiktoria Wróblewska
INTRODUCTION AND OBJECTIVE: This study examines the geographical variation of amenable mortality in Poland, focusing primarily on the role of health care resources at the level of administrative districts and regions, and selected area socioeconomic characteristics as explanatory factors. The concept was used of amenable mortality, based on the assumption that deaths from certain causes should not occur in the presence of timely and effective health care. MATERIAL AND METHODS: Standardized death rates (SDR) from causes considered amenable to health care and, separately, for ischaemic heart disease (IHD), were calculated for each of 379 districts (NUTS 4 level) in Poland in 1991-1995 and 2006-2010, using unit mortality data from the National Causes of Death Register...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28945882/extensive-genetic-differentiation-between-homomorphic-sex-chromosomes-in-the-mosquito-vector-aedes-aegypti
#15
Albin Fontaine, Igor Filipovic, Thanyalak Fansiri, Ary A Hoffmann, Changde Cheng, Mark Kirkpatrick, Gordana Rašic, Louis Lambrechts
Mechanisms and evolutionary dynamics of sex-determination systems are of particular interest in insect vectors of human pathogens like mosquitoes because novel control strategies aim to convert pathogen-transmitting females into nonbiting males, or rely on accurate sexing for the release of sterile males. In Aedes aegypti, the main vector of dengue and Zika viruses, sex determination is governed by a dominant male-determining locus, previously thought to reside within a small, nonrecombining, sex-determining region (SDR) of an otherwise homomorphic sex chromosome...
September 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28938692/effectiveness-and-safety-of-pd-1-pd-l1-inhibitors-in-the-treatment-of-solid-tumors-a-systematic-review-and-meta-analysis
#16
REVIEW
Xiaohui Wang, Zhengqiang Bao, Xiaoju Zhang, Fei Li, Tianwen Lai, Chao Cao, Zhihua Chen, Wen Li, Huahao Shen, Songmin Ying
BACKGROUND: PD-1/PD-L1 inhibitors have been implicated as potentially effective anti-cancer therapies. Some clinical randomized controlled trials (RCTs) have been completed for a variety of PD-1/PD-L1 inhibitors to treat various malignancies, and more RCTs are still under way. We carried out this systematic meta-analysis to evaluate the efficacy and safety of PD-1/PD-L1 inhibitors in the treatment of solid tumors. METHODS: We searched PubMed, EMBASE, clinical trial registers, conference reports, and related reviews...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28931873/characterization-of-methane-excess-and-absolute-adsorption-in-various-clay-nanopores-from-molecular-simulation
#17
Yuanyuan Tian, Changhui Yan, Zhehui Jin
In this work, we use grand canonical Monte Carlo (GCMC) simulation to study methane adsorption in various clay nanopores and analyze different approaches to characterize the absolute adsorption. As an important constituent of shale, clay minerals can have significant amount of nanopores, which greatly contribute to the gas-in-place in shale. In previous works, absolute adsorption is often calculated from the excess adsorption and bulk liquid phase density of absorbate. We find that methane adsorbed phase density keeps increasing with pressure up to 80 MPa...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927979/enlarging-vascular-stents-after-pediatric-liver-transplantation
#18
Yi-Ting Yeh, Cheng-Yen Chen, Hsiou-Shan Tseng, Hsin-Kai Wang, Hsin-Lin Tsai, Niang-Cheng Lin, Chou-Fu Wei, Chinsu Liu
BACKGROUND: Endovascular intervention with stent placement to treat portal vein (PV) and hepatic vein (HV) stenosis after pediatric liver transplantation (LT) is still controversial in small children owing to the potential risk of functional stenosis after growth. The aim of this study is to evaluate the safety and efficacy of stent placement in this population. METHODS: Between 2004 and 2016, 6 children (all <3 years) received HV (n = 2) and PV (n = 4) stents placement among 46 pediatric LT patients at our institution...
September 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28923777/an-improved-method-for-permeability-estimation-of-the-bioclastic-limestone-reservoir-based-on-nmr-data
#19
Xinmin Ge, Yiren Fan, Jianyu Liu, Li Zhang, Yujiao Han, Donghui Xing
Permeability is an important parameter in formation evaluation since it controls the fluid transportation of porous rocks. However, it is challengeable to compute the permeability of bioclastic limestone reservoirs by conventional methods linking petrophysical and geophysical data, due to the complex pore distributions. A new method is presented to estimate the permeability based on laboratory and downhole nuclear magnetic resonance (NMR) measurements. We divide the pore space into four intervals by the inflection points between the pore radius and the transversal relaxation time...
October 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28920167/comparison-of-efficacy-between-dorsal-root-entry-zone-lesioning-and-selective-dorsal-rhizotomy-for-spasticity-of-cerebral-origin
#20
Bunpot Sitthinamsuwan, Luckchai Phonwijit, Inthira Khampalikit, Akkapong Nitising, Sarun Nunta-Aree, Sirilak Suksompong
BACKGROUND: Severe spasticity adversely affects patient functional status and caregiving. No previous study has compared efficacy between dorsal root entry zone lesioning (DREZL) and selective dorsal rhizotomy (SDR) for reduction of spasticity. This study aimed to investigate the efficacy of DREZL and SDR for attenuating spasticity, and to compare efficacy between these two methods. METHODS: All patients who underwent DREZL, SDR, or both for treatment of intractable spasticity caused by cerebral pathology at Siriraj Hospital during 2009 to 2016 were recruited...
September 17, 2017: Acta Neurochirurgica
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