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https://www.readbyqxmd.com/read/28091437/radiopacity-of-bulk-fill-flowable-resin-composite-materials
#1
T Yildirim, M K Ayar, M S Akdag, C Yesilyurt
OBJECTIVES: The purpose of this study was to evaluate the radiopacity of currently marketed bulk fill flowable dental composite materials (Beautifil Bulk Flowable, SDR Flow, Filtek Bulk Fill Flow, and x-tra Base Bulk Fill). MATERIALS AND METHODS: Six specimens of each material with a thickness of 1 mm were prepared, and digital radiographs were taken, using a CCD sensor along with an aluminum stepwedge and 1 mm-thick tooth slice. The mean gray level of each aluminum stepwedge and selected materials was measured, using the equal-density area tool of Kodak Dental Imaging software...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28088459/strain-development-in-bulk-filled-cavities-of-different-depths-characterized-using-a-non-destructive-acoustic-emission-approach
#2
Annelies Van Ende, Diogo Pedrollo Lise, Jan De Munck, Johan Vanhulst, Martine Wevers, Bart Van Meerbeek
OBJECTIVES: (1) To evaluate the effect of cavity depth and composite type on the interfacial debonding in bulk-filled cavities. (2) To correlate the theoretical shrinkage stress and the level of interfacial debonding determined by acoustic emission (AE). METHODS: 80 sound molars were divided in two groups to receive a Class-I cavity (3.5×3.5mm) with 2.5- or 4.0-mm depth. The cavities were restored with either a conventional paste-like (Filtek Z100, 3M ESPE), a conventional flowable (G-ænial Universal Flo, GC), a bulk-fill paste-like (Tetric EvoCeram Bulk Fill, Ivoclar Vivadent) or a bulk-fill flowable (SDR, Dentsply) composite (n=10)...
January 11, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28076679/molecular-dynamics-simulations-for-deciphering-structural-basis-of-recognition-of-pre-let-7-mirnas-by-lin28
#3
Chhaya Sharma, Debasisa Mohanty
LIN28 protein inhibits biogenesis of miRNAs belonging to let-7 family by binding to precursor forms of miRNAs. Over expression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells. We have performed multiple explicit solvent molecular dynamics simulations ranging from 200 to 500 ns in length on different isoforms of preE-let7 in complex with LIN28 and also in isolation to identify structural features and key specificity determining residues (SDR) important for inhibitory role of LIN28...
January 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/28075345/software-defined-doppler-radar-as-a-contactless-multipurpose-microwave-sensor-for-vibrations-monitoring
#4
Antonio Raffo, Sandra Costanzo, Giuseppe Di Massa
A vibration sensor based on the use of a Software-Defined Radio (SDR) platform is adopted in this work to provide a contactless and multipurpose solution for low-cost real-time vibrations monitoring. In order to test the vibration detection ability of the proposed non-contact method, a 1 GHz Doppler radar sensor is simulated and successfully assessed on targets at various distances, with various oscillation frequencies and amplitudes. Furthermore, an SDR Doppler platform is practically realized, and preliminary experimental validations on a device able to produce a harmonic motion are illustrated to prove the effectiveness of the proposed approach...
January 8, 2017: Sensors
https://www.readbyqxmd.com/read/28059941/adenoma-detection-rates-for-screening-colonoscopies-in-smokers-and-obese-adults-data-from-the-new-hampshire-colonoscopy-registry
#5
Joseph C Anderson, Julia E Weiss, Christina M Robinson, Lynn F Butterly
GOAL: To examine screening adenoma detection rates (ADR) and serrated detection rates (SDR) among smokers and obese adults in the New Hampshire Colonoscopy Registry. BACKGROUND: ADR, a quality measure for screening colonoscopies, is associated with protection from interval colorectal cancer. Currently, only sex-specific ADR benchmarks are reported. However, obesity and smoking ≥20 pack-years are strong predictors for colorectal neoplasia, as highlighted by the 2009 American College of Gastroenterology CRC Screening Guidelines...
January 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28033498/a-robust-approach-to-apodization-design-in-phased-arrays-for-ultrasound-imaging
#6
Amir Gholampour, Sayed Mahmoud Sakhaei, Seyed Mehdi Hosseini Andargoli
Apodization is a common way to control the sidelobe level of the beampattern. To design the apodization, it is usually assumed that the medium is homogenous with a fixed value of sound speed, despite the fact that the speed may vary by a great value in practical situations. On the other hand, the beamforming performance is highly affected by the speed value. In this paper, the beampattern sensitivity to the speed variations is firstly investigated through both mathematical representations and simulation results showing that the speed errors lead to a sever degradation of the beampattern in terms of both mainlobe width and sidelobe level...
December 16, 2016: Ultrasonics
https://www.readbyqxmd.com/read/28007336/the-combined-frequency-of-igf-and-myostatin-polymorphism-among-track-field-athletes-and-swimmers
#7
Sigal Ben-Zaken, Yoav Meckel, Dan Nemet, Alon Eliakim
OBJECTIVE: The IGF C-1245T (rs35767) and the myostatin (MSTN) Lys(K)-153Arg(R) genetic polymorphism may influence skeletal muscle phenotypes and athletic performance. Carrying the minor IGF T allele and the myostatin rare R allele was associated with higher circulating IGF-I levels, greater muscle mass and improved performance. The aim of the present study was to assess the combined frequency of the IGF 1245T (rs35767) and MSTN 153Arg(R) polymorphism among Israeli track and field athletes (n=111) and swimmers (n=80)...
December 15, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28005671/hyperspectral-autofluorescence-imaging-of-drusen-and-retinal-pigment-epithelium-in-donor-eyes-with-age-related-macular-degeneration
#8
Yuehong Tong, Tal Ben Ami, Sungmin Hong, Rainer Heintzmann, Guido Gerig, Zsolt Ablonczy, Christine A Curcio, Thomas Ach, R Theodore Smith
PURPOSE: To elucidate the molecular pathogenesis of age-related macular degeneration (AMD) and interpretation of fundus autofluorescence imaging, the authors identified spectral autofluorescence characteristics of drusen and retinal pigment epithelium (RPE) in donor eyes with AMD. METHODS: Macular RPE/Bruch membrane flat mounts were prepared from 5 donor eyes with AMD. In 12 locations (1-3 per eye), hyperspectral autofluorescence images in 10-nm-wavelength steps were acquired at 2 excitation wavelengths (λex 436, 480 nm)...
December 2016: Retina
https://www.readbyqxmd.com/read/28002693/degree-of-conversion-and-polymerization-shrinkage-of-bulk-fill-resin-based-composites
#9
P Yu, Auj Yap, X Y Wang
This study evaluated the degree of conversion (DC) and polymerization shrinkage (PS) of contemporary bulk-fill resin-based composites (RBCs) including giomer materials. Two giomer bulk-fill (Beautifil Bulk Restorative [BBR], Beautifil Bulk Flowable [BBF]), two nongiomer bulk-fill (Tetric N-Ceram Bulk-fill [TNB], Smart Dentin Replacement [SDR]), and three conventional non-bulk-fill (Beautifil II [BT], Beautifil Flow Plus [BF], Tetric N-Ceram [TN]) RBCs were selected for the study. To evaluate the DC, disc-shaped specimens of 5-mm diameter and 2-mm, 4-mm, and 6-mm thickness were fabricated using customized Teflon molds...
January 2017: Operative Dentistry
https://www.readbyqxmd.com/read/27998499/study-of-factors-influencing-response-and-outcome-of-cat-iv-regimen-in-mdrtb-patients
#10
Arun Kumar Yadav, Ashok Kumar Mehrotra, S P Agnihotri, Shivani Swami
BACKGROUND: CAT IV regimen or the standardized drug regimen (SDR) under the Revised National Control Program (RNTCP) uses six second-line anti-tubercular drugs in the initial intensive phase (IP). These drugs have many side effects and toxicity; they are less efficacious and have poor acceptability. The present study was conducted to evaluate the efficacy and outcome of Cat-IV regimen and the factors which influence the treatment outcome in MDR TB patients. METHODS: It was a prospective observational study, which was done in the CAT II treatment failure, LPA proven MDR TB patients, above the age of 18 years, who were referred to DOTS Plus center for treatment...
October 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27995418/the-effects-of-sildenafil-citrate-on-urinary-podocin-and-nephrin-mrna-expression-in-an-l-name-model-of-pre-eclampsia
#11
Sooraj Baijnath, Saravanakumar Murugesan, Irene Mackraj, Prem Gathiram, Jagidesa Moodley
We investigated the effects of sildenafil citrate (SC) on podocyturia in N (ω)-nitro-L-arginine methyl ester hydrochloride (L-NAME) model of pre-eclampsia (PE). One hundred and twenty Sprague-Dawley rats (SDR) were divided into five groups like pregnant control (PC), early-onset PE (EOPE), late-onset PE(LOPE), early and late-onset PE with SC-treated groups [EOPE (SC); LOPE (SC)]. PE was induced in SDR by oral administration of L-NAME in drinking water for 4-8 days for EOPE and 8-14 day for LOPE. The blood pressure, urine volume and total urine protein were increased in EOPE and LOPE groups when compared to PC, and all the above parameters decreased in EOPE (SC) and LOPE (SC) groups when compared to EOPE and LOPE groups, respectively...
December 19, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27994310/clinical-performance-of-class-i-nanohybrid-composite-restorations-with-resin-modified-glass-ionomer-liner-and-flowable-composite-liner-a-randomized-clinical-trial
#12
Krishtipati Suhasini, Koppolu Madhusudhana, Chinni Suneelkumar, Anumula Lavanya, K S Chandrababu, Perisetty Dinesh Kumar
BACKGROUND: Liners play a vital role in minimizing polymerization shrinkage stress by elastic bonding concept and increase the longevity and favorable outcome for composite restorations. AIMS: The aim of this study was to evaluate the clinical performance of nanohybrid composite restorations using resin-modified glass-ionomer and flowable composite liners. SETTINGS AND DESIGN: A single-centered, double-blinded randomized clinical trial, with split-mouth design and equal allocation ratio that was conducted in the Department of Conservative Dentistry and Endodontics...
November 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27983671/enzymatic-metabolism-of-vitamin-a-in-developing-vertebrate-embryos
#13
REVIEW
Melissa A Metzler, Lisa L Sandell
Embryonic development is orchestrated by a small number of signaling pathways, one of which is the retinoic acid (RA) signaling pathway. Vitamin A is essential for vertebrate embryonic development because it is the molecular precursor of the essential signaling molecule RA. The level and distribution of RA signaling within a developing embryo must be tightly regulated; too much, or too little, or abnormal distribution, all disrupt embryonic development. Precise regulation of RA signaling during embryogenesis is achieved by proteins involved in vitamin A metabolism, retinoid transport, nuclear signaling, and RA catabolism...
December 15, 2016: Nutrients
https://www.readbyqxmd.com/read/27979183/rapid-determination-of-total-protein-and-wet-gluten-in-commercial-wheat-flour-using-sisvr-nir
#14
Jia Chen, Shipin Zhu, Guohua Zhao
The determination of total protein and wet gluten is of critical importance when screening commercial flour for desired processing suitability. To this end, a near-infrared spectroscopy (NIR) method with support vector regression was developed in the present study. The effects of spectral preprocessing and the synergy interval on model performance were investigated. The results showed that the models from raw spectra were not acceptable, but they were substantially improved by properly applying spectral preprocessing methods...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27965486/comparison-of-shear-bond-strength-and-microleakage-of-various-bulk-fill-bioactive-dentin-substitutes-an-in-vitro-study
#15
Fahad I Alkhudhairy, Zeeshan H Ahmad
INTRODUCTION: Various bulk-fill materials depending on their composition, viscosity, and flow ability have different physical and mechanical properties. The aim of this in vitro study was to determine and compare the shear bond strength and microleakage properties of activa restorative with other bulk-fill restorative materials surefil (SDR), Biodentine, ever X posterior. MATERIALS AND METHODS: Forty permanent premolars were selected for shear bond strength, and 20 permanent premolars were selected with class II cavities on mesial and distal side for microleakage...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27964938/high-dose-metformin-may-increase-the-concentration-of-atorvastatin-in-the-liver-by-inhibition-of-multidrug-resistance-associated-protein-2
#16
Eunjung Shin, Naree Shin, Ju-Hee Oh, Young-Joo Lee
In this study, we evaluated the effect of coadministered metformin on the biliary excretion and liver concentration of atorvastatin. To investigate the inhibitory effect of metformin on biliary efflux transporters, the transport of atorvastatin in MDCKII-MDR1, BCRP, and MRP2 was evaluated. The effects of metformin on the steady state liver concentration and biliary excretion of atorvastatin and 2-hydroxyatorvastatin were evaluated in SDR and Mrp2-deficient EHBR. Metformin did not inhibit the transport of atorvastatin via BCRP and MDR1...
December 11, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27933965/first-structure-activity-relationship-of-17%C3%AE-hydroxysteroid-dehydrogenase-type-14-nonsteroidal-inhibitors-and-crystal-structures-in-complex-with-the-enzyme
#17
Florian Braun, Nicole Bertoletti, Gabriele Möller, Jerzy Adamski, Torsten Steinmetzer, Mohamed Salah, Ahmed S Abdelsamie, Chris J van Koppen, Andreas Heine, Gerhard Klebe, Sandrine Marchais-Oberwinkler
17β-HSD14 belongs to the SDR family and oxidizes the hydroxyl group at position 17 of estradiol and 5-androstenediol using NAD(+) as cofactor. The goal of this study was to identify and optimize 17β-HSD14 nonsteroidal inhibitors as well as to disclose their structure-activity relationship. In a first screen, a library of 17β-HSD1 and 17β-HSD2 inhibitors, selected with respect to scaffold diversity, was tested for 17β-HSD14 inhibition. The most interesting hit was taken as starting point for chemical modification applying a ligand-based approach...
December 8, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27927843/risk-of-childhood-mortality-in-family-members-of-men-with-poor-semen-quality
#18
Heidi A Hanson, Erik N Mayer, Ross E Anderson, Kenneth I Aston, Douglas T Carrell, Justin Berger, William T Lowrance, Ken R Smith, James M Hotaling
STUDY QUESTION: What is the familial childhood mortality in first-degree (FDR) and second-degree relatives (SDR) of patients undergoing semen analysis (SA)? SUMMARY ANSWER: The relationship between infertility and congenital malformations (CM) in offspring is complex, with an increased risk of death due to CM in FDR, but not SDR, of men with lower semen parameters. WHAT IS KNOWN ALREADY: Semen quality is an established predictor of men's somatic health...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27925387/microcomputed-tomography-evaluation-of-volumetric-shrinkage-of-bulk-fill-composites-in-class-ii-cavities
#19
Hamad Algamaiah, Camila S Sampaio, Lindiane C Rigo, Malvin N Janal, Marcelo Giannini, Estevam A Bonfante, Paulo G Coelho, Andre F Reis, Ronaldo Hirata
PURPOSE: This study aimed to quantify polymerization shrinkage of one conventional and three bulk-fill composites, under bonded and unbonded conditions, in Class II preparations using 3D microcomputed tomography (μCT) and report its location. MATERIALS AND METHODS: Preparations (2.5 mm occlusal depth × 4 mm wide × 4 mm mesial box and 1 mm beyond the CEJ distal box depth) were made in 48 human extracted molars (n = 6). Four composites were tested, one regular (Vitalescence/VIT) and three bulk-fill: SureFil SDR Flow (SDR), Tetric EvoCeram Bulk Fill (TET), and Filtek flowable Bulk Fill (FIL)...
December 7, 2016: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/27908676/effect-of-selective-dorsal-rhizotomy-on-daily-care-and-comfort-in-non-walking-children-and-adolescents-with-severe-spasticity
#20
A I Buizer, P E M van Schie, E A M Bolster, W J van Ouwerkerk, R L Strijers, L A van de Pol, A Stadhouder, J G Becher, R J Vermeulen
BACKGROUND: In non-walking children with severe spasticity, daily care can be difficult and many patients suffer from pain. Selective dorsal rhizotomy (SDR) reduces spasticity in the legs, and therefore has the potential to improve daily care and comfort. AIM: To examine effects of SDR on daily care and comfort in non-walking children with severe spasticity due to different underlying neurological conditions. METHODS: Medical history, changes in daily care and comfort and satisfaction with outcome were assessed retrospectively in non-walking children who underwent SDR in our center, with a mean follow-up of 1y 7m (range 11m-4y 3m)...
October 22, 2016: European Journal of Paediatric Neurology: EJPN
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