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Gastric electrical stimulation

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https://www.readbyqxmd.com/read/29748143/the-investigation-and-treatment-of-diabetic-gastroparesis
#1
REVIEW
Mohit Kumar, Adam Chapman, Saad Javed, Uazman Alam, Rayaz A Malik, Shazli Azmi
PURPOSE: This review provides an update on the investigations and treatment options for gastroparesis. METHODS: A comprehensive literature search of Medline, PubMed, Embase and OVID was conducted which included all systematic reviews and research articles that focused on the diagnosis, investigations and management diabetic gastroparesis. FINDINGS: Dietary modifications and pharmacologic treatment with prokinetics to increase gastric motility form the mainstay of treatment...
May 7, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29739973/impaired-neural-pathway-in-gastric-muscles-of-patients-with-diabetes
#2
Yang Won Min, Eun-Ju Ko, Ji-Yeon Lee, Poong-Lyul Rhee
To explore the pathogenic mechanism of diabetic gastropathy, we investigated differences in response to electrical field stimulation (EFS) of gastric muscles from diabetic and non-diabetic (control) patients. Gastric specimens were obtained from 34 patients and 45 controls who underwent gastrectomy for early gastric cancer. Using organ bath techniques, we examined peak and nadir values of contraction under EFS. To examine responses to purinergic and nitrergic inhibition without cholinergic innervation, atropine, MRS2500, and N-nitro-L-arginine (L-NNA) were added sequentially to the organ bath...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29712933/effect-of-electroacupuncture-on-99m-tc-sodium-pertechnetate-uptake-and-extracellular-fluid-free-molecules-in-the-stomach-in-acupoint-st36-and-st39
#3
Rui Gao, Shan Gao, Jinteng Feng, Hongying Cui, Yanchao Cui, Junke Fu, Guangjian Zhang
Electroacupuncture (EA) is a therapeutic modality in which the electrical stimulation is integrated with concepts of acupuncture to treat diseases. This study was designed to evaluate the connection between the electro-acupuncture induced increase in Na99m TcO4 uptake in the stomach wall, and the ionic molecule levels in the extracellular fluid in the acupoints. Wistar rats were treated by 2 or 100 Hz EA at Zusanli (ST 36) and Xiajuxu (ST 39) bilaterally for 60 minutes. The accumulation of Na99m TcO4 in the gastric wall and the free ions, including Ca2+ , K+ , Na+ , and Cl- , in the acupoints were measured every 60 minutes...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29672439/cajal-cell-counts-are-important-predictors-of-outcomes-in-drug-refractory-gastroparesis-patients-with-neurostimulation
#4
Endashaw Omer, Archana Kedar, Harsha S Nagarajarao, Yana Nikitina, Vetta Vedanarayanan, Charu Subramony, Christopher J Lahr, Thomas L Abell
BACKGROUND AND AIMS: Cajal cells serve as the pacemaker cells of the gastrointestinal tract and regulates peristalsis. On the baisis of that fact, it has been hypothesized that a decrease in Cajal cells can lead to gastroparesis and other motility issues. Treatment with medications has a limited efficacy and most resort to gastric electrical stimulation (GES) devices for symptomatic relief. We believe that the number of Cajal cells present is directly proportional to symptomatic relief with GES...
April 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29652029/evaluation-of-a-modified-rat-model-for-functional-dyspepsia
#5
Qiankun Liang, Yuan Yan, Lanfang Mao, Xiaojuan Du, Jingjing Liang, Junhong Liu, Longde Wang, Hongfang Li
Background/Aim: The purpose of this study was to establish a modified rat model with functional dyspepsia (FD) and analyze the changes in gastrointestinal motility and brain-gut peptide levels in serum and brain-gut axis. Materials and Methods: Male Wistar rats were divided into control group (Con) and FD model group. FD model was established by stimulating semi-starvation rats via tail damping, provocation, and forced exercise fatigue until gastrointestinal motility disorder appeared, and then levels of motilin, leptin, cholecystokinin (CCK), and vasoactive intestinal peptide (VIP) were detected in serum by enzyme linked immunosorbent assay and in duodenum, antrum, and hypothalamus by immunohistochemistry, reverse transcriptase-polymerase chain reaction, and Western blot...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29567054/electrical-stimulation-of-the-lower-esophageal-sphincter-to-address-gastroesophageal-reflux-disease-after-sleeve-gastrectomy
#6
Yves Borbély, Nicole Bouvy, Henning G Schulz, Leonardo Antonio Rodriguez, Camilo Ortiz, Alejandro Nieponice
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) can result in de novo and worsen preexisting gastroesophageal reflux disease (GERD). Post-LSG patients with GERD refractory to proton pump inhibitors (PPI) usually undergo more invasive, anatomy-altering Roux-en-Y gastric bypass surgery. Lower esophageal sphincter (LES) electrical stimulation (ES) preserves the anatomy and has been shown to improve outcomes in GERD patients. OBJECTIVE: To evaluate the safety and efficacy of LES-ES in post-LSG patients with GERD not controlled with maximal PPI therapy...
February 26, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29528115/a-role-for-focal-adhesion-kinase-in-facilitating-the-contractile-responses-of-murine-gastric-fundus-smooth-muscles
#7
Yeming Xie, Koon Hee Han, Nathan Grainger, Wen Li, Robert D Corrigan, Brian A Perrino
Smooth muscle contraction involves regulating myosin light chain phosphorylation and dephosphorylation by myosin light chain kinase and myosin light chain phosphatase. CPI-17 and MYPT1 are crucial for regulating gastrointestinal smooth muscle contraction by inhibiting myosin light chain phosphatase. Integrin signalling involves the dynamic recruitment of several proteins, including FAK, to focal adhesions. FAK tyrosine kinase activation is involved in cell adhesion to the extracellular matrix via integrin signalling...
March 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29410956/effect-of-hyperglycemia-on-purinergic-and-nitrergic-inhibitory-neuromuscular-transmission-in-the-antrum-of-the-stomach-implications-for-fast-gastric-emptying
#8
Xue-Dao He, Yan-Mei Guo, Raj K Goyal
Background: Hyperglycemia has been reported to enhance vagovagal reflex that causes the release of inhibitory neurotransmitter, nitric oxide (NO), at the neuromuscular junction in the antrum to relax the antrum and slow gastric emptying by stimulating glucose-sensitive afferent neurons. However, hyperglycemia has also been reported to cause fast gastric emptying that may be due to suppression of the inhibitory motor neurons. Aims: The purpose of the present study was to investigate changes in inhibitory neuromuscular transmission in the gastric antrum due to hyperglycemia...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29354988/-effect-of-transcutaneous-electrical-acupoint-stimulation-on-gastric-emptying-in-patients-undergoing-surgery
#9
Yunchang Mo, Anqi Zhang, Bo Zheng, Chengyu Chen, Yelong Ren, Xixi Wang, Haifeng Fu, Lingmin Lin, Junlu Wang
OBJECTIVE: To observe the effects of transcutaneous electrical acupoint stimulation (TEAS) on gastric emptying in patients undergoing selective surgery based on velocity of gastric emptying by ultrasonography. METHODS: A total of 75 patients with selective operation of subarachnoid block at lower limb in the afternoon were randomly assigned to a TEAS group, a sham group and a control group, 25 patients in each one. All the patients were provided with semi-fluid diet at 8 a...
December 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29333595/implanted-closed-loop-gastric-electrical-stimulation-clges-system-with-sensor-based-feedback-safely-limits-weight-regain-at-24-months
#10
S Morales-Conde, I Alarcón Del Agua, L Busetto, F Favretti, M Anselmino, G M Rovera, M Socas-Macias, A Barranco-Moreno, R Province-Azalde, A J Torres
BACKGROUND: Weight regain following bariatric surgery is not uncommon. Safe, effective weight loss treatment up to 1 year has been reported with the closed-loop gastric electrical stimulation (CLGES) system. Continuous recording of eating and activity behavior by onboard sensors is one of the novel features of this closed-loop electrical stimulation therapy, and may provide improved long-term weight maintenance by enhancing aftercare. METHODS: Four centers participating in a 12-month prospective multicenter randomized study monitored all implanted participants (n = 47) up to 24 months after laparoscopic implantation of a CLGES system...
January 15, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29234370/electroacupuncture-improves-gastric-emptying-in-critically-ill-neurosurgical-patients-a-pilot-study
#11
Man-Ling Kao, Yao-Li Chen, Shu-Ching Lee, Sung-Yen Huang, Ping-Yi Lin
Objective: To compare the efficacy of combined electroacupuncture and metoclopramide treatment with that of metoclopramide only in improving gastric emptying in critically ill neurosurgical patients. Methods: In this prospective case-control pilot study, a total of 16 adult critically ill mechanically ventilated patients who were treated in the surgical intensive care unit were enrolled. Electrical stimulation was applied to 4 pairs of points (maximum intensity < 9...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29219123/chronic-cuffing-of-cervical-vagus-nerve-inhibits-efferent-fiber-integrity-in-rat-model
#12
Jesse Paul Somann, Gabriel Albors, Kaitlyn Neihouser, Kun-Han Lu, Zhongming Liu, Matthew Peter Ward, Abigail Durkes, J Paul Robinson, Terry Powley, Pedro Irazoqui
Numerous studies of vagal nerve stimulation (VNS) have been published showing it to be a potential treatment for chronic inflammation and other related diseases and disorders. Studies in recent years have shown that electrical stimulation of the vagal efferent fibers can artificially modulate cytokine levels and reduce systematic inflammation. Most VNS research in the treatment of inflammation have been acute studies on rodent subjects. Our study tested VNS on freely moving animals by stimulating and recording from the cervical vagus with nerve cuff electrodes over an extended period of time...
December 8, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29177486/glucagon-like-peptide-1-inhibits-prandial-gastrointestinal-motility-through-myenteric-neuronal-mechanisms-in-humans
#13
Md Abdul Halim, Marie Degerblad, Magnus Sundbom, Urban Karlbom, Jens Juul Holst, Dominic-Luc Webb, Per M Hellström
Context: Glucagon-like peptide-1 (GLP-1) secretion from l-cells and postprandial inhibition of gastrointestinal motility. Objective: Investigate whether physiological plasma concentrations of GLP-1 inhibit human postprandial motility and determine mechanism of action of GLP-1 and analog ROSE-010 action. Design: Single-blind parallel study. Setting: University hospital laboratory. Participants: Healthy volunteers investigated with antroduodenal manometry...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29164818/home-based-transabdominal-interferential-electrical-stimulation-for-six-months-improves-paediatric-slow-transit-constipation-stc
#14
Yee Ian Yik, John Hutson, Bridget Southwell
BACKGROUND: Transcutaneous electrical stimulation (TES) for one to two months has produced some improvement in treatment-resistant slow-transit constipation (STC) in children. Optimal parameters for treatment are not known. It is possible that more improvement would occur with stimulation for longer. This study examined the effectiveness of stimulation for six months. METHODS: Children with STC confirmed by nuclear transit study (NTS) were enrolled prospectively...
November 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29160143/some-autonomic-deficits-of-acute-or-chronic-cervical-spinal-contusion-reversed-by-interim-brainstem-stimulation
#15
Alberto A Vitores, Stephanie S Sloley, Catalina Martinez, Melissa M Carballosa-Gautam, Ian D Hentall
Prolonged electrical stimulation of the hindbrain's nucleus raphe magnus (NRM) or of its major midbrain input region, the periaqueductal gray (PAG), was previously found in rats to promote recovery from sensory-motor and histological deficits of acute thoracic spinal cord injury (SCI). Here, some visceral deficits of acute and chronic midline cervical (C5) contusion are similarly examined. Cranially implanted wireless stimulators delivered intermittent 8 Hz, 30-70 μA cathodal pulse trains to a brainstem microelectrode...
February 1, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29142468/glucagon-like-peptide-2-modulates-the-nitrergic-neurotransmission-in-strips-from-the-mouse-gastric-fundus
#16
Rachele Garella, Eglantina Idrizaj, Chiara Traini, Roberta Squecco, Maria Giuliana Vannucchi, Maria Caterina Baccari
AIM: To investigate whether glucagon-like peptide-2 (GLP-2) influences the neurally-induced responses in gastric strips from mice, since no data are available. METHODS: For functional experiments, gastric fundal strips were mounted in organ baths containing Krebs-Henseleit solution. Mechanical responses were recorded via force-displacement transducers, which were coupled to a polygraph for continuous recording of isometric tension. Electrical field stimulation (EFS) was applied via two platinum wire rings through which the preparation was threaded...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29093684/porcine-stomach-smooth-muscle-force-depends-on-history-effects
#17
André Tomalka, Mischa Borsdorf, Markus Böl, Tobias Siebert
The stomach serves as food reservoir, mixing organ and absorption area for certain substances, while continually varying its position and size. Large dimensional changes during ingestion and gastric emptying of the stomach are associated with large changes in smooth muscle length. These length changes might induce history-effects, namely force depression (FD) following active muscle shortening and force enhancement (FE) following active muscle stretch. Both effects have impact on the force generating capacity of the stomach, and thus functional relevance...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29067158/proof-of-concept-short-term-non-invasive-cervical-vagus-nerve-stimulation-in-patients-with-drug-refractory-gastroparesis
#18
Emma Paulon, Despoina Nastou, Francesca Jaboli, Juana Marin, Eric Liebler, Owen Epstein
BACKGROUND: Gastric electric stimulation (GES) is a treatment approach to refractory gastroparesis, possibly acting centrally via afferent vagus nerve stimulation (VNS). Non-invasive VNS (nVNS) is a potential alternative to GES that could eliminate the safety risks of or identify likely responders to implantable neurostimulators. OBJECTIVE: This open-label proof-of-concept study assessed the effects of nVNS in patients with severe drug-refractory gastroparesis. METHODS: Patients used the Gastroparesis Cardinal Symptom Index (GCSI) to grade symptoms in diaries daily for 2 weeks before treatment (baseline) and during ≥3 weeks of nVNS therapy...
October 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29060329/design-and-application-of-a-novel-gastric-pacemaker
#19
Saeed Alighaleh, Timothy R Angeli, Shameer Sathar, Gregory O'Grady, Leo K Cheng, Niranchan Paskaranandavadivel
Omnipresent bioelectrical events known as slow waves are responsible for coordinating motility in the gastrointestinal tract. Functional motility diseases, such as gastroparesis, are associated with slow wave dysrhythmias. Electrical stimulation is a potential therapy to correct abnormal slow wave patterns. We present the design and application of a new gastric pacemaker. Real-time changes to the stimulation parameters such as period, amplitude and pulse width were applied using a graphical user interface, which communicated with the microcontroller to deliver the stimulus...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059982/ambulatory-gastric-mucosal-slow-wave-recording-for-chronic-experimental-studies
#20
Niranchan Paskaranandavadivel, Timothy Angeli, Abigail Stocker, Lindsay McElmurray, Gregory O'Grady, Thomas Abell, Leo K Cheng
Dysrhythmic bioelectric slow wave activity have been implicated in major functional motility disorders such as gastroparesis and chronic unexplained nausea and vomiting, but its correlation to symptoms is still unclear. For patients with severe gastroparesis, high-frequency gastric stimulation is offered as a therapy in some centers. Temporary gastric electrical stimulation has also been proposed an approach to screen patients who would benefit from the implantation of a permanent stimulator. In this study we introduced novel methods for recording slow wave activity from the gastric mucosa during the entire temporary stimulation phase of 5 days, in 3 patients...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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