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Gastric electrical stimulation

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https://www.readbyqxmd.com/read/28213202/determinants-of-cough-effectiveness-in-patients-with-respiratory-muscle-weakness
#1
Franco Laghi, Veeranna Maddipati, Timothy Schnell, W Edwin Langbein, Martin J Tobin
Experiments were undertaken to mechanistically define expiratory-muscle contribution to effectiveness of cough while controlling glottic movement. We hypothesized that electrical abdominal-muscle stimulation in patients with respiratory-muscle weakness produces effective coughs only when glottic closure accompanies coughs. In ten spinal-cord-injury patients, esophago-gastric pressure and airflow were recorded during solicited-coughs, coughs augmented by abdominal-muscle stimulation, and passive open-glottis exhalations...
February 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28164463/impact-of-the-feedback-provided-by-a-gastric-electrical-stimulation-system-on-eating-behavior-and-physical-activity-levels
#2
Luca Busetto, Antonio J Torres, Salvador Morales-Conde, Isaias Alarcón Del Agua, Carlo Moretto, Paola Fierabracci, Giuseppe Rovera, Gianni Segato, Miguel A Rubio, Franco Favretti
OBJECTIVE: The closed-loop gastric electrical stimulation (CLGES) abiliti(®) system provides tailored gastric electrical stimulation activated by food entry into the stomach and sensor-based data to medical professionals. The aim of this study was to analyze behavior changes using sensor-based food intake and activity data in participants treated with the CLGES system. METHODS: Food intake and activity data (3D accelerometer) were downloaded at baseline and monthly/bimonthly for 12 months in a subset of patients with obesity (N = 45) participating in a multicenter trial with CLGES...
February 6, 2017: Obesity
https://www.readbyqxmd.com/read/28163260/central-and-peripheral-effects-of-transcutaneous-acupuncture-treatment-for-nausea-in-patients-with-diabetic-gastroparesis
#3
Irene Sarosiek, Gengqing Song, Yan Sun, Hugo Sandoval, Stephen Sands, Jiande Chen, Richard W McCallum
Background/Aims: Nausea, an unpleasant symptom of diabetic gastroparesis (DMGP), has been reported to be alleviated by needleless transcutaneous electrical acupuncture (TEA). Our study was designed to utilize electroencephalography (EEG) and electrogastrography (EGG) recordings to investigate the central and peripheral responses of TEA in the treatment of nausea in DMGP patients. Methods: Eleven DMGP subjects underwent simultaneous EEG and EGG testing while grading the severity of nausea following 30-minute intervals of: (1) baseline, (2) visual stimulation (VS) to provoke more nausea, (3) active VS together with TEA, and (4) TEA alone, and a final 15-minute recording without any intervention...
February 5, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28147471/recent-trends-in-endoscopic-bariatric-therapies
#4
REVIEW
Hyuk Soon Choi, Hoon Jai Chun
Obesity and its associated metabolic diseases including diabetes mellitus are severe medical problems that are increasing in prevalence worldwide and result in significant healthcare expenses. While behavioral and pharmacological treatment approaches are partly effective in the short term, their effects are not long-lasting. Although previous studies have described bariatric surgery as the most effective treatment for obesity, it is associated with morbidity, mortality, and economic burden. Endoluminal interventions performed entirely using gastrointestinal flexible endoscopy offer alternative approaches to the treatment of obesity that are safer and more cost-effective than current surgical approaches...
January 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28066619/clinical-management-of-chronic-obstructive-pulmonary-disease-patients-with-muscle-dysfunction
#5
REVIEW
Joaquim Gea, Carme Casadevall, Sergi Pascual, Mauricio Orozco-Levi, Esther Barreiro
Muscle dysfunction is frequently observed in chronic obstructive pulmonary disease (COPD) patients, contributing to their exercise limitation and a worsening prognosis. The main factor leading to limb muscle dysfunction is deconditioning, whereas respiratory muscle dysfunction is mostly the result of pulmonary hyperinflation. However, both limb and respiratory muscles are also influenced by other negative factors, including smoking, systemic inflammation, nutritional abnormalities, exacerbations and some drugs...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28013450/post-implant-analysis-of-epidemiologic-and-eating-behavior-data-related-to-weight-loss-effectiveness-in-obese-patients-treated-with-gastric-electrical-stimulation
#6
I Alarcón Del Agua, M Socas-Macias, L Busetto, A Torres-Garcia, A Barranco-Moreno, P P Garcia de Luna, S Morales-Conde
OBJECTIVE: To determine possible preoperative predictors for obtaining clinically meaningful weight loss with gastric electrical stimulation (GES) using the "Three-Factor Eating Questionnaire" (TFEQ) as well as epidemiological data. METHODS: Ninety-seven obese participants in a prospective multicenter randomized study conducted in nine European centers were implanted laparoscopically with the abiliti® closed-loop GES system (CLGES). Five clinical variables and three preoperative TFEQ factor scores (F1-cognitive-restraint, F2-disinhibition, and F3-hunger) were analyzed in order to determine predictors of weight loss success defined as excess weight loss (EWL) > 30% and failure defined as EWL < 20% at 12 months post-surgery...
December 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27982684/nesfatin-1-influences-the-excitability-of-gastric-distension-responsive-neurons-in-the-ventromedial-hypothalamic-nucleus-of-rats
#7
Hongzhen Feng, Qiaoling Wang, Feifei Guo, Xiaohua Han, Mingjie Pang, Xiangrong Sun, Yanling Gong, Luo Xu
The present study investigated the effects of nesfatin-1 on gastric distension (GD)- responsive neurons via an interaction with corticotropin-releasing factor (CRF) receptor signaling in the ventromedial hypothalamic nucleus (VMH), and the potential regulation of these effects by hippocampal projections to VMH. Extracellular single-unit discharges were recorded in VHM following administration of nesfatin-1. The projection of nerve fibers and expression of nesfatin-1 were assessed by retrograde tracing and fluoro-immunohistochemical staining, respectively...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27896652/the-long-term-efficacy-and-safety-of-pyloroplasty-combined-with-gastric-electrical-stimulation-therapy-in-gastroparesis
#8
Brian R Davis, Irene Sarosiek, Mohammad Bashashati, Ben Alvarado, Richard W McCallum
INTRODUCTION: Gastroparesis is delayed gastric emptying without mechanical obstruction. Symptomatic improvement can be 50-60% with gastric electrical stimulation. To address delayed gastric emptying, pyloroplasty was added. This study examines the long-term efficacy and safety of simultaneous gastric electrical stimulator implantation and pyloroplasty. METHODS: In this prospective single-arm trial conducted from 2012 to 2015, 27 [23 females; mean age 43 (22-63)] gastroparesis patients who underwent simultaneous gastric electrical stimulator implantation with Heineke-Mikulicz pyloroplasty were studied...
November 28, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27816547/overexpression-of-na-ca-2-exchanger-1-display-enhanced-relaxation-in-the-gastric-fundus
#9
Yasuyuki Fujimoto, Satomi Hayashi, Yasu-Taka Azuma, Kazunori Mukai, Kazuhiro Nishiyama, Satomi Kita, Ai Morioka, Hidemitsu Nakajima, Takahiro Iwamoto, Tadayoshi Takeuchi
In gastric smooth muscles, the released Ca(2+) activates the contractile proteins and Ca(2+) taken up from the cytosol cause relaxation. The Na(+)/Ca(2+) exchanger (NCX) is an antiporter membrane protein that controls Ca(2+) influx and efflux across the membrane. However, the possible relation of NCX in gastric fundus motility is largely unknown. Here, we investigated electric field stimulation (EFS)-induced relaxations in the circular muscles of the gastric fundus in smooth muscle-specific NCX1 transgenic mice (Tg)...
November 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27785318/autonomic-evaluation-of-patients-with-gastroparesis-and-neurostimulation-comparisons-of-direct-systemic-and-indirect-cardiac-measures
#10
Abigail Stocker, Thomas L Abell, Hani Rashed, Archana Kedar, Ben Boatright, Jiande Chen
BACKGROUND: Disorders of nausea, vomiting, abdominal pain, and related problems often are manifestations of gastrointestinal, neuromuscular, and/or autonomic dysfunction. Many of these patients respond to neurostimulation, either gastric electrical stimulation or electroacupuncture. Both of these therapeutic techniques appear to influence the autonomic nervous system which can be evaluated directly by traditional testing and indirectly by heart rate variability. METHODS: We studied patients undergoing gastric neuromodulation by both systemic autonomic testing (39 patients, six males and 33 females, mean age 38 years) and systemic autonomic testing and heart rate variability (35 patients, seven males and 28 females, mean age 37 years) testing before and after gastric neuromodulation...
February 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27723668/vagus-nerve-stimulation-an-evolving-adjunctive-treatment-for-cardiac-disease
#11
Barış Akdemir, David G Benditt
The vagus nerve is a major component of the autonomic nervous system and plays a critical role in many body functions including for example, speech, swallowing, heart rate and respiratory control, gastric secretion, and intestinal motility. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, with electrical stimulation being the most important. Implantable devices for VNS are approved therapy for refractory epilepsy and for treatment-resistant depression. In the case of heart disease applications, implantable VNS has been shown to be beneficial for treating heart failure in both preclinical and clinical studies...
October 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27678506/gastric-electrical-stimulation-for-gastroparesis-and-chronic-unexplained-nausea-and-vomiting
#12
REVIEW
John M Wo, Thomas V Nowak, Shamaila Waseem, Matthew P Ward
Gastroparesis is a heterogeneous clinical syndrome. Some patients have debilitating vomiting, weight loss, and dehydration, while others have effortless regurgitation of undigested foods or postprandial distress suggestive of functional dyspepsia. Gastric electrical stimulation (GES) has been proposed as an effective treatment option for patients with gastroparesis refractory to medical therapy. Evidence suggests that the clinically available device, a low-energy high-frequency GES, activates the vagal afferent pathways to influence the central control mechanisms for nausea and vomiting...
December 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/27634009/convergence-of-inhibitory-neural-inputs-regulate-motor-activity-in-the-murine-and-monkey-stomach
#13
Lara A Shaylor, Sung Jin Hwang, Kenton M Sanders, Sean M Ward
Inhibitory motor neurons regulate several gastric motility patterns including receptive relaxation, gastric peristaltic motor patterns, and pyloric sphincter opening. Nitric oxide (NO) and purines have been identified as likely candidates that mediate inhibitory neural responses. However, the contribution from each neurotransmitter has received little attention in the distal stomach. The aims of this study were to identify the roles played by NO and purines in inhibitory motor responses in the antrums of mice and monkeys...
November 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27633147/closed-loop-gastric-electrical-stimulation-versus-laparoscopic-adjustable-gastric-band-for-the-treatment-of-obesity-a-randomized-12-month-multicenter-study
#14
T Horbach, G Meyer, S Morales-Conde, I Alarcón, F Favretti, M Anselmino, G M Rovera, J Dargent, C Stroh, M Susewind, A J Torres
OBJECTIVE: To compare the weight loss, change in quality of life (QOL) and safety of closed-loop gastric electrical stimulation (CLGES) versus adjustable gastric band (LAGB) in the treatment of obesity. METHODS: This multicenter, randomized, non-inferiority trial randomly assigned the patients in a 2:1 ratio to laparoscopic CLGES versus LAGB and followed them for 1 year. We enrolled 210 patients, of whom 50 were withdrawn preoperatively. Among 160 remaining patients (mean age=39±11 years; 75% women; mean body mass index=43±6 kg m(-)(2)) 106 received CLGES and 54 received LAGB...
December 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27589594/nitrergic-pathway-is-the-main-contributing-mechanism-in-the-human-gastric-fundus-relaxation-an-in-vitro-study
#15
Yang Won Min, Yun Soo Hong, Eun-Ju Ko, Ji-Yeon Lee, Ki Duck Ahn, Je Moon Bae, Poong-Lyul Rhee
BACKGROUND: Human gastric fundus relaxation is mediated by intrinsic inhibitory pathway. We investigated the roles of nitrergic and purinergic pathways, two known inhibitory factors in gastric motility, on spontaneous and nerve-evoked contractions in human gastric fundus muscles. METHODS: Gastric fundus muscle strips (12 circular and 13 longitudinal) were obtained from patients without previous gastrointestinal motility disorder who underwent gastrectomy for stomach cancer...
2016: PloS One
https://www.readbyqxmd.com/read/27583411/neurostimulation-of-the-gastrointestinal-tract-in-children-is-it-time-to-shock-the-gut
#16
Peter L Lu, Carlo Di Lorenzo
PURPOSE OF REVIEW: The use of neurostimulation for treatment of gastrointestinal disorders has been growing over the past two to three decades. Our objective is to review current applications of neurostimulation in the treatment of gastrointestinal disorders with an emphasis on the use of these treatment modalities in children. RECENT FINDINGS: Gastric electrical stimulation can lead to symptomatic improvement in children with chronic nausea and vomiting refractory to conventional treatment, and a recent report of long-term outcomes is encouraging...
October 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27534962/treating-an-oft-unrecognized-and-troublesome-entity-using-gastric-electrical-stimulation-to-reduce-symptoms-of-malignancy-associated-gastroparesis
#17
Hamza Shah, Gregg Wendorf, Shifat Ahmed, Lindsay McElmurray, Chris Lahr, Michael Hughes, Brian Beauerle, Ed Miller, Abigail Stocker, Thomas L Abell
PURPOSE: Malignancy-associated gastroparesis (MAG) is a cause of morbidity in cancer patients but therapies are lacking. Gastric electrical stimulation (GES) is a novel treatment for MAG. Here, we describe 19 patients with MAG who underwent temporary GES placement. PATIENTS AND METHODS: Nineteen patients (6 males, 13 females) with various malignancies were reviewed for symptom scores and physiologic measures at baseline and after temporary GES placement. Symptoms were scored by three variables: nausea (N), vomiting (V), and GI total symptom score (TSS)...
January 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27417243/functional-nausea-in-children-a-review-of-the-literature-and-need-for-diagnostic-criteria
#18
REVIEW
Alexandra C Russell, Amanda L Stone, Lynn S Walker
Nausea is common amongst children with functional gastrointestinal disorders and is associated with a high burden of somatic and psychosocial comorbidities in both the short and long-term. Current treatments including medications, phytotherapy, stress-reduction techniques, and gastric electrical stimulation for recalcitrant cases, are reviewed. Functional nausea merits its own diagnostic criteria as a pediatric functional gastrointestinal disorder.
2016: Children
https://www.readbyqxmd.com/read/27405482/laparoscopic-duodenojejunostomy-for-superior-mesenteric-artery-syndrome-intermediate-follow-up-results-and-a-review-of-the-literature
#19
Julietta Chang, Mena Boules, John Rodriguez, Matthew Walsh, Raul Rosenthal, Matthew Kroh
BACKGROUND: Superior mesenteric artery syndrome (SMAS) is a rare condition caused by partial obstruction of the third portion of the duodenum by the SMA anteriorly and aorta posteriorly. Laparoscopic duodenojejunostomy has been described as a safe and feasible surgical intervention with favorable short-term outcomes. However, descriptions of intermediate outcomes are lacking in the literature. METHODS: A retrospective chart review was performed on patients who underwent minimally invasive duodenojejunostomy from March 2005 to August 2015 at our healthcare system with greater than 6-month follow-up...
March 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27342113/medial-cerebellar-nucleus-projects-to-feeding-related-neurons-in-the-ventromedial-hypothalamic-nucleus-in-rats
#20
Bin Li, Qian-Xing Zhuang, He-Ren Gao, Jian-Jun Wang, Jing-Ning Zhu
The cerebellum, a hindbrain motor center, also participates in regulating nonsomatic visceral activities such as feeding control. However, the underlying neural mechanism is largely unknown. Here, we investigate whether the cerebellar medial nucleus (MN), one of the final outputs of the cerebellum, could directly project to and modulate the feeding-related neurons in the ventromedial hypothalamic nucleus (VMN), which has been traditionally implicated in feeding behavior, energy balance, and body weight regulation...
June 24, 2016: Brain Structure & Function
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