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Gastric electrical stimulation

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https://www.readbyqxmd.com/read/29160143/some-autonomic-deficits-of-acute-or-chronic-cervical-spinal-contusion-reversed-by-interim-brainstem-stimulation
#1
Alberto A Vitores, Stephanie S Sloley, Catalina Martinez, Melissa M Carballosa-Gautam, Ian D Hentall
Prolonged electrical stimulation of the hindbrain's nucleus raphe magnus (NRM) or its major midbrain input region, the periaqueductal gray (PAG), was previously found in rats to promote recovery from sensory-motor and histological deficits of acute thoracic spinal cord injury (SCI). Here, some visceral deficits of acute and chronic midline cervical (C5) contusion are similarly examined. Cranially implanted wireless stimulators delivered intermittent 8 Hz, 30-70 µA cathodal pulse trains to a brainstem microelectrode...
November 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29142468/glucagon-like-peptide-2-modulates-the-nitrergic-neurotransmission-in-strips-from-the-mouse-gastric-fundus
#2
Rachele Garella, Eglantina Idrizaj, Chiara Traini, Roberta Squecco, Maria Giuliana Vannucchi, Maria Caterina Baccari
AIM: To investigate whether glucagon-like peptide-2 (GLP-2) influences the neurally-induced responses in gastric strips from mice, since no data are available. METHODS: For functional experiments, gastric fundal strips were mounted in organ baths containing Krebs-Henseleit solution. Mechanical responses were recorded via force-displacement transducers, which were coupled to a polygraph for continuous recording of isometric tension. Electrical field stimulation (EFS) was applied via two platinum wire rings through which the preparation was threaded...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29093684/porcine-stomach-smooth-muscle-force-depends-on-history-effects
#3
André Tomalka, Mischa Borsdorf, Markus Böl, Tobias Siebert
The stomach serves as food reservoir, mixing organ and absorption area for certain substances, while continually varying its position and size. Large dimensional changes during ingestion and gastric emptying of the stomach are associated with large changes in smooth muscle length. These length changes might induce history-effects, namely force depression (FD) following active muscle shortening and force enhancement (FE) following active muscle stretch. Both effects have impact on the force generating capacity of the stomach, and thus functional relevance...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29067158/proof-of-concept-short-term-non-invasive-cervical-vagus-nerve-stimulation-in-patients-with-drug-refractory-gastroparesis
#4
Emma Paulon, Despoina Nastou, Francesca Jaboli, Juana Marin, Eric Liebler, Owen Epstein
BACKGROUND: Gastric electric stimulation (GES) is a treatment approach to refractory gastroparesis, possibly acting centrally via afferent vagus nerve stimulation (VNS). Non-invasive VNS (nVNS) is a potential alternative to GES that could eliminate the safety risks of or identify likely responders to implantable neurostimulators. OBJECTIVE: This open-label proof-of-concept study assessed the effects of nVNS in patients with severe drug-refractory gastroparesis. METHODS: Patients used the Gastroparesis Cardinal Symptom Index (GCSI) to grade symptoms in diaries daily for 2 weeks before treatment (baseline) and during ≥3 weeks of nVNS therapy...
October 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29060329/design-and-application-of-a-novel-gastric-pacemaker
#5
Saeed Alighaleh, Timothy R Angeli, Shameer Sathar, Gregory O'Grady, Leo K Cheng, Niranchan Paskaranandavadivel
Omnipresent bioelectrical events known as slow waves are responsible for coordinating motility in the gastrointestinal tract. Functional motility diseases, such as gastroparesis, are associated with slow wave dysrhythmias. Electrical stimulation is a potential therapy to correct abnormal slow wave patterns. We present the design and application of a new gastric pacemaker. Real-time changes to the stimulation parameters such as period, amplitude and pulse width were applied using a graphical user interface, which communicated with the microcontroller to deliver the stimulus...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059982/ambulatory-gastric-mucosal-slow-wave-recording-for-chronic-experimental-studies
#6
Niranchan Paskaranandavadivel, Timothy Angeli, Abigail Stocker, Lindsay McElmurray, Gregory O'Grady, Thomas Abell, Leo K Cheng
Dysrhythmic bioelectric slow wave activity have been implicated in major functional motility disorders such as gastroparesis and chronic unexplained nausea and vomiting, but its correlation to symptoms is still unclear. For patients with severe gastroparesis, high-frequency gastric stimulation is offered as a therapy in some centers. Temporary gastric electrical stimulation has also been proposed an approach to screen patients who would benefit from the implantation of a permanent stimulator. In this study we introduced novel methods for recording slow wave activity from the gastric mucosa during the entire temporary stimulation phase of 5 days, in 3 patients...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056361/compensatory-plasticity-in-diaphragm-and-intercostal-muscle-utilization-in-a-rat-model-of-als
#7
Yasin B Seven, Nicole L Nichols, Mia N Kelly, Orinda R Hobson, Irawan Satriotomo, Gordon S Mitchell
In SOD1(G93A) transgenic rat model of ALS, breathing capacity is preserved until late in disease progression despite profound respiratory motor neuron (MN) cell death. To explore mechanisms preserving breathing capacity, we assessed inspiratory EMG activity in diaphragm and external intercostal T2 (EIC2) and T5 (EIC5) muscles in anesthetized SOD1(G93A) rats at disease end-stage (20% decrease in body mass). We hypothesized that despite significant phrenic motor neuron loss and decreased phrenic nerve activity, diaphragm electrical activity and trans-diaphragmatic pressure (Pdi) are maintained to sustain ventilation...
October 19, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28985965/ghrelin-projection-from-the-lateral-hypothalamus-area-to-the-dorsal-vagal-complex-and-its-regulation-of-gastric-motility-in-cisplatin-treated-rats
#8
Yanling Gong, Yang Liu, Yaoyao Guo, Manqing Su, Yifan Zhong, Luo Xu, Feifei Guo, Shengli Gao
OBJECTIVE: To investigate ghrelin projection from the lateral hypothalamus area (LHA) to the dorsal vagal complex (DVC) and its regulation of gastric motility in cisplatin-treated rats. MATERIALS AND METHODS: In the present study, the protein and mRNA expression of ghrelin and its receptor GHSR-1a were measured by Western blot and PCR, respectively. The ghrelin fiber projections arising from the LHA and projecting to the DVC were investigated by retrograde tracing combined with fluoro-immunohistochemical staining...
September 28, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28984906/lateral-hypothalamic-orexin-a-ergic-projections-to-the-arcuate-nucleus-modulate-gastric-function-in-vivo
#9
Xiao Luan, Xiangrong Sun, Feifei Guo, Di Zhang, Cheng Wang, Li Ma, Luo Xu
It has been well-known that hypothalamic orexigenic neuropeptides, orexin-A and melanin-concentrating hormone (MCH), play important roles in regulation of gastric function. However, what neural pathway mediated by the two neuropeptides affects the gastric function remains unknown. In this study, by way of nucleic stimulation and extracellular recording of single unit electrophysiological properties, we found that electrically stimulating the lateral hypothalamic area (LH) or microinjection of orexin-A into the arcuate nucleus (ARC) excited most gastric distension-responsive neurons in the nuclei and enhanced the gastric function including motility, emptying and acid secretion of conscious rats...
October 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28918793/-workup-and-treatment-of-gastroparesis
#10
Mette Winther Klinge, Jan Bech Pedersen, Birgit Schelde, Sten Lund, Klaus Krogh
Gastroparesis is defined as impaired gastric emptying without mechanical obstruction and cardinal symptoms including vomiting, nausea, early satiety, and upper abdominal pain. Most cases of gastroparesis are diabetic, idiopathic or post-operative. The correlation between symptoms and objective measures of gastroparesis is poor. Basic treatment includes dietary advices and prokinetics. Selected patients not responding to basic treatment can be offered gastric electrical stimulation. In many cases, gastroparesis is present in combination with other motility disorders, especially constipation...
September 18, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28888796/laparoscopic-treatment-of-gastroparesis-a-single-center-experience
#11
Kotaro Wakamatsu, Federico Perez Quirante, Lisandro Montorfano, Emanuele Lo Menzo, Yasuyuki Seto, Raul J Rosenthal
BACKGROUND: Gastroparesis (GP) is a chronic disorder of gastric motility with delayed gastric emptying. Gastric electrical stimulator (GES) implantation and Roux-en-Y gastric bypass (RYGB) are surgical options for medically refractory GP. OBJECTIVE: Evaluate operational outcomes and symptom improvement of patients with diabetic (DM) and idiopathic (IP) GP. SETTING: University Hospital, United States. METHODS: A retrospective chart review was performed of all patients who underwent surgical treatment of GP from February 2003 to December 2014...
July 29, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28795473/gastrointestinal-peptides-during-chronic-gastric-electrical-stimulation-in-patients-with-intractable-vomiting
#12
Mathieu Meleine, Chloé Melchior, Philip Prinz, Alfred Penfornis, Benoît Coffin, Andreas Stengel, Philippe Ducrotté, Guillaume Gourcerol
OBJECTIVES: Gastric electrical stimulation (GES) is an alternative therapy to treat patients with intractable vomiting. A preclinical study has demonstrated the modulation of the gastrointestinal (GI) peptide ghrelin by GES but such mechanism has never been investigated in patients. The aim of this work was to assess the effect of GES on GI peptide levels in patients with intractable vomiting. MATERIALS AND METHODS: Twenty-one patients were randomized to receive either ON or OFF GES, 14 completed the study (10 ON, 4 OFF stimulation)...
August 10, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28752406/how-i-do-it-per-oral-pyloromyotomy-pop
#13
Matthew T Allemang, Andrew T Strong, Ivy N Haskins, John Rodriguez, Jeffrey L Ponsky, Matthew Kroh
INTRODUCTION: Several surgical treatments exist for treatment of gastroparesis, including gastric electrical stimulation, pyloroplasty, and gastrectomy. Division of the pylorus by means of endoscopy, Per-Oral Pyloromyotomy (POP), is a newer, endoluminal therapy that may offer a less invasive, interventional treatment option. METHODS: We describe and present a video of our step by step technique for POP using a lesser curvature approach. The following are technical steps to complete the POP procedure from the lesser curve approach...
November 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28725999/surgical-anti-reflux-options-beyond-fundoplication
#14
REVIEW
Dan Azagury, John Morton
PURPOSE OF REVIEW: This paper provides an overview of current and future surgical interventions available for the management of gastroesophageal reflux disease (GERD) beyond the well established and recognized fundoplication. Review the current indications and outcomes of these surgical procedures. RECENT FINDINGS: Fundoplication has been a cornerstone of the surgical management of GERD. However, other effective surgical options exist and can be considered based on prior interventions as well as patient, anatomical or other factors...
July 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28715324/electrical-impedance-tomography-tissue-properties-to-image-measures
#15
Andy Adler, Alistair Boyle
Electrical impedance tomography (EIT) uses electrical stimulation and measurement at the body surface to image the electrical properties of internal tissues. It has the advantage of noninvasiveness and high temporal resolution but suffers from poor spatial resolution and sensitivity to electrode movement and contact quality. EIT can be useful to applications, where there are conductive contrasts between tissues, fluids, or gasses, such as imaging of cancerous or ischemic tissue or functional monitoring of breathing, blood flow, gastric motility, and neural activity...
2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28684460/abdominal-surgery-induced-gastric-ileus-and-activation-of-m1-like-macrophages-in-the-gastric-myenteric-plexus-prevention-by-central-vagal-activation-in-rats
#16
Pu-Qing Yuan, Yvette Taché
Inflammation plays a role in abdominal surgery (AS)-induced intestinal ileus that is alleviated by electrical vagal stimulation. Intracisternal injection of RX-77368, the stable thyrotropin-releasing hormone agonist, activates dorsal motor nucleus neurons and gastric vagal efferent discharges. We investigated the gastric inflammation induced by AS and the modulation by intracisternal RX-77368 in rats. RX-77368 (50 ng/rat) or saline was injected followed, 1 h later, by laparotomy and small intestinal/cecal manipulation...
October 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28627584/gastric-electrical-stimulation-improves-enteric-neuronal-survival
#17
Nian Wang, Kun Li, Shuangning Song, Jie Chen
Research and clinical experience with vagotomy have confirmed that damage to the central nervous system severely affects physiological movement in the gastrointestinal system. The aim of this study was to investigate the effects of synchronized dual-pulse gastric electrical stimulation (SGES) on the apoptosis of enteric neurons and the possible pathways involved in these effects in vagotomized rats. For this purpose, Male Sprague-Dawley (SD) rats were randomized into a control group, an early subdiaphragmatic vagotomized group (ESDV group), an early subdiaphragmatic vagotomized group with short-term SGES (ESDV + SSGES group), a terminal subdiaphragmatic vagotomized group (TSDV group) and a terminal subdiaphragmatic vagotomized group with long-term SGES (TSDV + LSGES group)...
June 14, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28585346/ablation-of-tacr2-in-mice-leads-to-gastric-emptying-disturbance
#18
Y-L Mao, C-L Shen, T Zhou, B-T Ma, L-Y Tang, W-T Wu, H-X Zhang, H-L Lu, W-X Xu, Z-G Wang
BACKGROUND: Tacr2 is one of the G protein-coupled receptors(GPCRs) that mediate the biological actions of tachykinins. It is abundantly expressed in the gastrointestinal (GI) system and is thought to play an important role in GI motility, secretion, and visceral sensitivity. Previously, the physiological and pathophysiological functions of Tacr2 were mainly studied using Tacr2 selective agonists or antagonists. Here, we seek to investigate the effect of Tacr2 disruption in mice to provide further insights...
June 6, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28577248/pathological-findings-of-the-antral-and-pyloric-smooth-muscle-in-patients-with-gastroparesis-like-syndrome-compared-to-gastroparesis-similarities-and-differences
#19
COMPARATIVE STUDY
Mohammad Bashashati, Sharareh Moraveji, Alireza Torabi, Irene Sarosiek, Brian R Davis, Jesus Diaz, Richard W McCallum
BACKGROUND: Gastroparesis (GP)-like syndrome presents with the symptoms of GP but without delayed gastric emptying (GE). Whether GP-like syndrome is part of a spectrum of GP is not clear. This study aimed to compare the histopathological features of antral and pyloric smooth muscle tissue in GP and GP-like syndrome. METHODS: Full-thickness antral and/or pyloric biopsies were obtained from 37 GP and 18 GP-like syndrome patients who underwent abdominal surgery to place a gastric electrical stimulator or jejunal feeding tube and/or pyloroplasty...
October 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28547565/an-optimized-ies-method-and-its-inhibitory-effects-and-mechanisms-on-food-intake-and-body-weight-in-diet-induced-obese-rats-ies-for-obesity
#20
Xinyue Wan, Jieyun Yin, Robert Foreman, Jiande D Z Chen
PURPOSE: This paper aims to optimize stimulation parameters and durations for intestinal electrical stimulation (IES) and to explore the effects and mechanisms of chronic IES with optimized methodology in obesity rats. MATERIALS AND METHODS: Sixteen diet-induced obese (DIO) rats were tested for food intake with four different sets of IES parameters each lasting 1 week. Then, another 12 DIO rats were used to test the effect of IES on food intake with different stimulation durations...
May 25, 2017: Obesity Surgery
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