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TUBULOINTERSTITIAL

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https://www.readbyqxmd.com/read/28433070/effects-of-nicorandil-on-renal-function-and-histopathology-in-rats-with-partial-unilateral-ureteral-obstruction
#1
Hayrettin Ozturk, Tulin Firat, Buket Kin Tekce, Fahri Yilmaz, Hulya Ozturk
To evaluate the effects of nicorandil in a rat kidney model of partial unilateral ureteral obstruction (PUUO). Thirty male rats were randomly divided into three groups as follows: (1) Group 1 (Sham-control), ureters of the rats were manipulated but not ligated; (2) Group 2 (PUUO-untreated), PUUO was performed with two-thirds of the left ureter embedded in the psoas muscle; and (3) Group 3 (PUUO-nicorandil treated). After PUUO was established, nicorandil (15 mg/kg/day) was administered by gastric lavage for 21 days to determine its effects on PUUO-induced histopathological-, functional-, and oxidative stress-induced changes...
May 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28420760/novel-lnc-rna-regulated-by-hif-1-inhibits-apoptotic-cell-death-in-the-renal-tubular-epithelial-cells-under-hypoxia
#2
Imari Mimura, Yosuke Hirakawa, Yasuharu Kanki, Natsuki Kushida, Ryo Nakaki, Yutaka Suzuki, Tetsuhiro Tanaka, Hiroyuki Aburatani, Masaomi Nangaku
Chronic tubulointerstitial hypoxia plays an important role as the final common pathway to end-stage renal disease. HIF-1 (hypoxia-inducible factor-1) is a master transcriptional factor under hypoxia, regulating downstream target genes. Genome-wide analysis of HIF-1 binding sites using high-throughput sequencers has clarified various kinds of downstream targets and made it possible to demonstrate the novel roles of HIF-1. Our aim of this study is to identify novel HIF-1 downstream epigenetic targets which may play important roles in the kidney...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28414804/cyclosporine-a-alters-expression-of-renal-micrornas-new-insights-into-calcineurin-inhibitor-nephrotoxicity
#3
Jennifer L Gooch, Clayton King, Cynthia E Francis, Paul S Garcia, Yun Bai
Calcineurin inhibitors are powerful immunosuppressants that revolutionized organ transplantation. However, non-immune effects of the calcineurin inhibitor, such as cyclosporine A (CsA), have significantly hindered their use. Specifically, nephrotoxicity, which is associated with tubulointerstitial fibrosis, inflammation, and podocyte damage, affects up to half of all transplant patients. Calcineurin is involved in many aspects of kidney development and function; therefore, mechanisms of CsA-induced nephrotoxicity are complex and not yet fully understood...
2017: PloS One
https://www.readbyqxmd.com/read/28413644/reduction-in-mirna-125b-5p-levels-is-associated-with-obstructive-renal-injury
#4
Silu Wang, Lianfeng Wu, Linyong Du, Hong Lu, Bicheng Chen, Yongheng Bai
Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of renal function. MicroRNAs (miRNAs/miRs) are small non-coding molecules that may be involved in the progression of many renal diseases. The aim of the present study was to investigate the roles of miRNAs, including miR-125b, miR-326 and miR-324p, in obstructive renal injury. Blood samples were collected from 91 patients with ureteral obstruction and 76 controls to examine renal function...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28409352/epithelial-to-mesenchymal-transition-emt-and-endothelial-to-mesenchymal-transition-endmt-role-and-implications-in-kidney-fibrosis
#5
Ana S Cruz-Solbes, Keith Youker
Tubulointerstitial injury is one of the hallmarks of renal disease. In particular, interstitial fibrosis has a prominent role in the development and progression of kidney injury. Collagen-producing fibroblasts are responsible for the ECM deposition. However, the origin of those activated fibroblasts is not clear. This chapter will discuss in detail the concept of epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT) in the context of fibrosis and kidney disease. In short, EMT and EndMT involve a change in cell shape, loss of polarity and increased motility associated with increased collagen production...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28408246/renal-protective-effect-and-action-mechanism-of-huangkui-capsule-and-its-main-five-flavonoids
#6
Hong-Die Cai, Shu-Lan Su, Da-Wei Qian, Sheng Guo, Wei-Wei Tao, Xu Dong Cong, Renmao Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: The flower of Abelmoschus manihot (Linn.) Medicus (A. manihot), as a traditional Chinese Herbal medicine, was used widely in China with efficacy of inducing diuresis for treating strangurtia, and subdhing swelling and detoxicating. It has been reported that Huangkui capsule, prepared by the extract of the flower of A. manihot, can reduce the content of urinary protein, serum creatinine and serum urea nitrogen in nephropathy rats and processes renoprotective activity, while the action mechanism need to illuminate deeply...
April 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28407133/con-mesoamerican-nephropathy-is-the-problem-dehydration-or-rehydration
#7
Vito M Campese
In recent years, an increasing number of inhabitants of Central America have developed a form of chronic kidney disease, now named Mesoamerican nephropathy. This disease is characterized by minimal proteinuria, hyperuricemia, hypokalemia and reduced glomerular filtration rate. Histologically the kidneys manifest tubulointerstitial nephritis. The cause(s) of this disease remain unknown. Some have proposed that dehydration, in combination with hyperuricemia, may be primarily responsible for Mesoamerican nephropathy...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28405610/btk-specific-inhibition-blocks-pathogenic-plasma-cell-signatures-and-myeloid-cell-associated-damage-in-ifn%C3%AE-driven-lupus-nephritis
#8
Arna Katewa, Yugang Wang, Jason A Hackney, Tao Huang, Eric Suto, Nandhini Ramamoorthi, Cary D Austin, Meire Bremer, Jacob Zhi Chen, James J Crawford, Kevin S Currie, Peter Blomgren, Jason DeVoss, Julie A DiPaolo, Jonathan Hau, Adam Johnson, Justin Lesch, Laura E DeForge, Zhonghua Lin, Marya Liimatta, Joseph W Lubach, Sami McVay, Zora Modrusan, Allen Nguyen, Chungkee Poon, Jianyong Wang, Lichuan Liu, Wyne P Lee, Harvey Wong, Wendy B Young, Michael J Townsend, Karin Reif
Systemic lupus erythematosus (SLE) is often associated with exaggerated B cell activation promoting plasma cell generation, immune-complex deposition in the kidney, renal infiltration of myeloid cells, and glomerular nephritis. Type-I IFNs amplify these autoimmune processes and promote severe disease. Bruton's tyrosine kinase (Btk) inhibitors are considered novel therapies for SLE. We describe the characterization of a highly selective reversible Btk inhibitor, G-744. G-744 is efficacious, and superior to blocking BAFF and Syk, in ameliorating severe lupus nephritis in both spontaneous and IFNα-accelerated lupus in NZB/W_F1 mice in therapeutic regimens...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28400046/atgl-gene-deletion-predisposes-to-proximal-tubule-damage-by-impairing-the-fatty-acid-metabolism
#9
Wen Chen, Qiong Zhang, Shiwu Cheng, Jie Huang, Ge Diao, Jian Han
Fibrosis is the final common pathway of chronic kidney disease (CKD). Normal lipid metabolism is integral to renal physiology, and disturbances of renal lipid metabolism are increasingly being linked with CKD, including the fibrosis. Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis. In the present study, we used Atgl(-/-) mice to investigate whether ATGL played a role in the regulation of proximal convoluted tubule (PCT) lipid metabolism and renal fibrosis development. ATGL deficiency led to lipid vacuolation of PCT and tubulointerstitial fibrosis, accompanied by massive albuminuria and decreased creatinine clearance rate (Ccr)...
April 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28397074/plasma-neutrophil-gelatinase-associated-lipocalin-ngal-is-an-indicator-of-interstitial-damage-and-a-predictor-of-kidney-function-worsening-of-chronic-kidney-disease-in-the-early-stage-a-pilot-study
#10
Hidekazu Moriya, Yasuhiro Mochida, Kunihiko Ishioka, Machiko Oka, Kyoko Maesato, Sumi Hidaka, Takayasu Ohtake, Shuzo Kobayashi
BACKGROUND: The aim of this study was to examine whether plasma neutrophil gelatinase-associated lipocalin (NGAL) levels predict the outcome of kidney function and correlate with the severity of tubulointerstitial damages in patients with chronic kidney disease (CKD). METHODS: In this prospective 18-month cohort study of 112 patients with CKD between 2010 and 2011, associations between plasma NGAL levels and estimated glomerular filtration ratio (eGFR), further worsening of kidney function and histological lesion on kidney biopsy were investigated...
April 10, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28396119/interferon-%C3%AE-production-by-tubulointerstitial-human-cd56-bright-natural-killer-cells-contributes-to-renal-fibrosis-and-chronic-kidney-disease-progression
#11
Becker M P Law, Ray Wilkinson, Xiangju Wang, Katrina Kildey, Mae Lindner, Melissa J Rist, Kenneth Beagley, Helen Healy, Andrew J Kassianos
Natural killer (NK) cells are a population of lymphoid cells that play a significant role in mediating innate immune responses. Studies in mice suggest a pathological role for NK cells in models of kidney disease. In this study, we characterized the NK cell subsets present in native kidneys of patients with tubulointerstitial fibrosis, the pathological hallmark of chronic kidney disease. Significantly higher numbers of total NK cells (CD3(-)CD56(+)) were detected in renal biopsies with tubulointerstitial fibrosis compared with diseased biopsies without fibrosis and healthy kidney tissue using multi-color flow cytometry...
April 8, 2017: Kidney International
https://www.readbyqxmd.com/read/28390067/tubulointerstitial-expression-and-urinary-excretion-of-connective-tissue-growth-factor-3-months-after-renal-transplantation-predict-interstitial-fibrosis-and-tubular-atrophy-at-5-years-in-a-retrospective-cohort-analysis
#12
Thomas Vanhove, Hiroshi Kinashi, Tri Q Nguyen, Christoph Metalidis, Koen Poesen, Maarten Naesens, Evelyne Lerut, Roel Goldschmeding, Dirk R J Kuypers
BACKGROUND: Connective tissue growth factor (CTGF) is an important mediator of renal allograft fibrosis and urinary CTGF (CTGFu) levels correlate with the development of human allograft interstitial fibrosis. METHODS: We evaluated the predictive value of CTGF protein expression in 160 kidney transplant recipients with paired protocol biopsies at 3 months and 5 years after transplantation. At month 3 and year 1, CTGFu was measured using ELISA and biopsies were immunohistochemically stained for CTGF, with semiquantitative scoring of tubulointerstitial CTGF positive area (CTGFti)...
April 8, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28386316/energy-intake-correlates-with-the-levels-of-fatty-acid-synthase-and-insulin-like-growth-factor-1-in-male-and-female-c57bl-6-mice
#13
Anup S Ramdhave, Shreesh Ojha, Mukesh Nandave
Emerging evidence suggests that, dysregulation of fatty acid synthase (FASN) and insulin-like growth factor-1 (IGF-1) could play a vital role in pathology of various diseases. Our aim was to determine the changes in FASN and IGF-1 levels concomitant to long term feeding of HFD in either sex. Male and female mice were fed either HFD or LFD for a period of 16 weeks. During this period, physiological, biochemical, and histological parameters were evaluated. Mice fed with HFD showed a significant gain in body weight, body mass index, energy intake, and abdominal circumference...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28382855/natural-infections-with-pigeon-paramyxovirus-serotype-1-pathologic-changes-in-eurasian-collared-doves-streptopelia-decaocto-and-rock-pigeons-columba-livia-in-the-united-states
#14
M Isidoro-Ayza, C L Afonso, J B Stanton, S Knowles, H S Ip, C L White, H Fenton, M G Ruder, A C Dolinski, J Lankton
Pigeon paramyxovirus serotype 1 (PPMV-1) is a globally distributed, virulent member of the avian paramyxovirus serotype 1 serogroup that causes mortality in columbiformes and poultry. Following introduction into the United States in the mid-1980s, PPMV-1 rapidly spread causing numerous mortality events in Eurasian collared-doves ( Streptopelia decaocto) (ECDOs) and rock pigeons ( Columba livia) (ROPIs). The investigators reviewed pathological findings of 70 naturally infected, free-ranging columbiforms from 25 different mortality events in the United States...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28378840/alpha-lipoic-acid-ameliorates-the-epithelial-mesenchymal-transition-induced-by-unilateral-ureteral-obstruction-in-mice
#15
Hyun Seop Cho, Jin Hyun Kim, Ha Nee Jang, Tae Won Lee, Myeong Hee Jung, Tae Ho Kim, Se-Ho Chang, Dong Jun Park
The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in renal fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) is a natural compound with antioxidant properties. Studies for ALA are performed in acute kidney injury with renal tubular apoptosis, renal inflammation, and oxidative stress. We investigated the effects of ALA on EMT-mediated renal interstitial fibrosis in mice with unilateral ureteral obstruction (UUO)...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28378548/effect-of-coenzyme-q10-on-radiation-nephropathy-in-rats
#16
Yongkan Ki, Wontaek Kim, Yong Ho Kim, Donghyun Kim, Jin Sook Bae, Dahl Park, Hosang Jeon, Ju Hye Lee, Jayoung Lee, Jiho Nam
The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28375181/dietary-metabolites-and-chronic-kidney-disease
#17
REVIEW
Sho Hasegawa, Tzu-Ming Jao, Reiko Inagi
Dietary contents and their metabolites are closely related to chronic kidney disease (CKD) progression. Advanced glycated end products (AGEs) are a type of uremic toxin produced by glycation. AGE accumulation is not only the result of elevated glucose levels or reduced renal clearance capacity, but it also promotes CKD progression. Indoxyl sulfate, another uremic toxin derived from amino acid metabolism, accumulates as CKD progresses and induces tubulointerstitial fibrosis and glomerular sclerosis. Specific types of amino acids (d-serine) or fatty acids (palmitate) are reported to be closely associated with CKD progression...
April 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28371433/urinary-markers-of-fibrosis-and-risk-of-cardiovascular-events-and-death-in-kidney-transplant-recipients-the-favorit-trial
#18
M Park, R Katz, M G Shlipak, D Weiner, R Tracy, V Jotwani, J Hughes-Austin, F Gabbai, C Y Hsu, M Pfeffer, N Bansal, A Bostom, O Gutierrez, M Sarnak, A Levey, J H Ix
Cardiovascular risk remains high in kidney transplant recipients (KTRs) despite improved kidney function after transplant. Urinary markers of kidney fibrosis and injury may help to reveal mechanisms of this risk. In a case-cohort study among stable KTRs who participated in the FAVORIT trial, we measured 4 urinary proteins known to correlate with kidney tubulointerstitial fibrosis on biopsy (urine alpha 1 microglobulin [α1m], monocyte chemoattractant protein-1 [MCP-1], procollagen type I [PINP] and type III [PIIINP] N-terminal amino peptide) and evaluated associations with cardiovascular disease (CVD) events (N=300) and death (N=371)...
March 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28364255/microrna-184-is-a-downstream-effector-of-albuminuria-driving-renal-fibrosis-in-rats-with-diabetic-nephropathy
#19
Cristina Zanchi, Daniela Macconi, Piera Trionfini, Susanna Tomasoni, Daniela Rottoli, Monica Locatelli, Michael Rudnicki, Jo Vandesompele, Pieter Mestdagh, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja
AIMS/HYPOTHESIS: Renal fibrosis is a common complication of diabetic nephropathy and is a major cause of end-stage renal disease. Despite the suggested link between renal fibrosis and microRNA (miRNA) dysregulation in diabetic nephropathy, the identification of the specific miRNAs involved is still incomplete. The aim of this study was to investigate miRNA profiles in the diabetic kidney and to identify potential downstream targets implicated in renal fibrosis. METHODS: miRNA expression profiling was investigated in the kidneys of 8-month-old Zucker diabetic fatty (ZDF) rats during overt nephropathy...
March 31, 2017: Diabetologia
https://www.readbyqxmd.com/read/28356293/urinary-dcr2-is-a-novel-biomarker-for-tubulointerstitial-injury-in-patients-with-diabetic-nephropathy
#20
Jia Chen, Wei-Wei Zhang, Ke-Hong Chen, Li-Rong Lin, Huan-Zi Dai, Kai-Long Li, Jian-Guo Zhang, Lu-Quan Zheng, Bi-Qiong Fu, Ya-Ni He
Tubulointerstitial injury (TII) plays a crucial role in the progression of diabetic nephropathy (DN), but lack of specific and sensitive biomarkers for monitoring TII in DN management. This study is to investigate whether urinary decoy receptor 2 (uDcR2) could serve as a novel noninvasive biomarker for assessing TII in DN. We recruited 311 type 2 diabetics and 139 DN patients which diagnosed by renal biopsy. uDcR2 levels were measured by ELISA and renal DcR2 expression was detected immunohistochemically. Associations between uDcR2 and renal DcR2, renal functional parameters were evaluated...
March 29, 2017: American Journal of Physiology. Renal Physiology
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