keyword
MENU ▼
Read by QxMD icon Read
search

per1

keyword
https://www.readbyqxmd.com/read/29669984/circadian-rhythms-of-micturition-during-jet-lag
#1
Kakeru Ito, Miho Yasuda, Yuki Maeda, Jean-Michel Fustin, Yoshiaki Yamaguchi, Yuka Kono, Hiromitsu Negoro, Akihiro Kanematsu, Osamu Ogawa, Masao Doi, Hitoshi Okamura
Micturition behavior follows regular day/night fluctuations, and unwanted increase in micturition could occur during night in jet lag condition. To clarify the effect of jet lag on micturition behavior, we simultaneously detected circadian micturition patterns and locomotor activity rhythms of mice under experimental jet lag conditions, by applying the improved automated Voided Stain on Paper (aVSOP) method. When wild-type (WT) mice were phase-advanced for 8 hours, day-night variation of micturition was disrupted suddenly, and this irregular daily micturition continued until 8 days, although their activity rhythms entrained gradually day by day until 8 days...
2018: Biomedical Research
https://www.readbyqxmd.com/read/29659895/identification-of-differential-transcriptional-patterns-in-primary-and-secondary-hyperparathyroidism
#2
Samira M Sadowski, Marc Pusztaszeri, Marie-Claude Brulhart-Meynet, Volodymyr Petrenko, Claudio De Vito, Jonathan Sobel, Céline Delucinge-Vivier, Electron Kebebew, Romano Regazzi, Jacques Philippe, Frédéric Triponez, Charna Dibner
Context: Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion. However, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PG) in sporadic primary and secondary hyperparathyroidism (HPT1, 2). Objective: To evaluate dynamic alterations in molecular patterns as a function of the type of PG pathology, a comparative transcript analysis was conducted in subgroups of healthy samples, sporadic HPT1 adenoma and hyperplasia, and HPT2...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29626648/abnormal-circadian-locomotor-rhythms-and-per-gene-expression-in-six-month-old-triple-transgenic-mice-model-of-alzheimer-s-disease
#3
Meina Wu, Fang Zhou, Xiuli Cao, Junting Yang, Yu Bai, Xudong Yan, Jimin Cao, Jinshun Qi
Circadian rhythm disturbance (CRD) is one of the iconic manifestations in Alzheimer's disease (AD), a disease tightly associated with age, but the characteristics and gender difference of CRD occurred in AD have not been well demonstrated. Using 6-month-old triple transgenic AD mouse model (3xTg-AD) without obvious brain pathological changes, we demonstrated the gender difference of CRD at this age. We further showed abnormal Per gene expression in the central clock suprachiasmatic nucleus (SCN) of the 3xTg-AD mice...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29599751/circadian-rhythms-and-clock-genes-in-reproduction-insights-from-behavior-and-the-female-rabbit-s-brain
#4
REVIEW
Mario Caba, Gabriela González-Mariscal, Enrique Meza
Clock gene oscillations are necessary for a successful pregnancy and parturition, but little is known about their function during lactation, a period demanding from the mother multiple physiological and behavioral adaptations to fulfill the requirements of the offspring. First, we will focus on circadian rhythms and clock genes in reproductive tissues mainly in rodents. Disruption of circadian rhythms or proper rhythmic oscillations of clock genes provoke reproductive problems, as found in clock gene knockout mice...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29588368/clock-phosphorylation-by-akt-regulates-its-nuclear-accumulation-and-circadian-gene-expression-in-peripheral-tissues
#5
Amelia K Luciano, Wenping Zhou, Jeans M Santana, Cleo Kyriakides, Heino Velazquez, William C Sessa
Circadian locomotor output cycles kaput (CLOCK) is a transcription factor which activates transcription of clock-controlled genes (CCG) by heterodimerizing with BMAL1 and binding to E-box elements on DNA. While several phosphorylation sites on CLOCK have already been identified, this study characterizes a novel phosphorylation site at Serine 845 (S836 in humans). Here we show that CLOCK is a novel AKT substrate in vitro and in cells, and this phosphorylation site is a negative regulator of CLOCK nuclear localization by acting as a binding site for 14-3-3 proteins...
March 27, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29581861/the-circadian-clock-regulates-cisplatin-induced-toxicity-and-tumor-regression-in-melanoma-mouse-and-human-models
#6
Panshak P Dakup, Kenneth I Porter, Alexander A Little, Rajendra P Gajula, Hui Zhang, Elena Skornyakov, Michael G Kemp, Hans P A Van Dongen, Shobhan Gaddameedhi
Cisplatin is one of the most commonly used chemotherapeutic drugs; however, toxicity and tumor resistance limit its use. Studies using murine models and human subjects have shown that the time of day of cisplatin treatment influences renal and blood toxicities. We hypothesized that the mechanisms responsible for these outcomes are driven by the circadian clock. We conducted experiments using wild-type and circadian disrupted Per1/2-/- mice treated with cisplatin at selected morning (AM) and evening (PM) times...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29577261/clock-genes-alterations-and-endocrine-disorders
#7
REVIEW
Anna Angelousi, Eva Kassi, Narjes Nasiri-Ansari, Martin O Weickert, Harpal Randeva, Gregory Kaltsas
BACKGROUND: Various endocrine signals oscillate over the 24-hour period and so does the responsiveness of target tissues. These daily oscillations do not occur solely in response to external stimuli but are also under the control of an intrinsic circadian clock. DESIGN: We searched the PubMed database to identify studies describing the associations of clock genes with endocrine diseases. RESULTS: Various human single nucleotide polymorphisms of BMAL1 and CLOCK genes exhibited significant associations with type 2 diabetes mellitus...
March 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29556064/an-evolutionary-hotspot-defines-functional-differences-between-cryptochromes
#8
Clark Rosensweig, Kimberly A Reynolds, Peng Gao, Isara Laothamatas, Yongli Shan, Rama Ranganathan, Joseph S Takahashi, Carla B Green
Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME 1/2 (CRY1/2) and PER1/2). To understand the structural principles of regulation, we used evolutionary sequence analysis to identify co-evolving residues within the CRY/PHL protein family. Here we report the identification of an ancestral secondary cofactor-binding pocket as an interface in repressive CRYs, mediating regulation through direct interaction with CLOCK and BMAL1...
March 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29541184/a-role-for-the-clock-period-circadian-regulator-2-gene-in-regulating-the-clock-gene-network-in-human-oral-squamous-cell-carcinoma-cells
#9
Yiran Ao, Qin Zhao, Kai Yang, Gang Zheng, Xiaoqing Lv, Xiaoli Su
Clock genes are the core of the circadian rhythms in the human body and are important in regulating normal physiological functions. To date, research has indicated that the clock gene, period circadian clock 2 ( PER2 ), is downregulated in numerous types of cancer, and that it is associated with cancer occurrence and progression via the regulation of various downstream cell cycle genes. However, it remains unclear whether the decreased expression of PER2 influences the expression of other clock genes in cancer cells...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29534090/asymmetric-expression-level-of-clock-genes-in-left-vs-right-nasal-mucosa-in-humans-with-and-without-allergies-and-in-rats-circadian-characteristics-and-possible-contribution-to-nasal-cycle
#10
Ha Kyun Kim, Hyun Jung Kim, Jae Hyung Kim, Tae Hoon Kim, Sang Hag Lee
Numerous peripheral tissues possess self-sustaining daily biologic rhythms that are regulated at the molecular level by clock genes such as PER1, PER2, CLOCK, and BMAL1. Physiological function of nasal mucosa exhibits rhythmic variability to a day-night environmental cycle. Nevertheless, little is known of the expression and distribution pattern of clock genes in nasal mucosa. The present study investigates the expression level and distribution pattern of PER1, PER2, CLOCK, and BMAL1 genes in nasal mucosa of healthy controls, allergic rhinitis patients, and normal rats...
2018: PloS One
https://www.readbyqxmd.com/read/29524919/placental-circadian-pathway-methylation-and-in-utero-exposure-to-fine-particle-air-pollution
#11
Tim S Nawrot, Nelly D Saenen, Julie Schenk, Bram G Janssen, Valeria Motta, Letizia Tarantini, Bianca Cox, Wouter Lefebvre, Charlotte Vanpoucke, Cristina Maggioni, Valentina Bollati
In mammals, a central clock maintains the daily rhythm in accordance with the external environment. At the molecular level, the circadian rhythm is maintained by epigenetic regulation of the Circadian pathway. Here, we tested the role of particulate matter with an aerodynamic diameter ≤ 2.5 μm (PM2.5 ) exposure during gestational life on human placental Circadian pathway methylation, as an important molecular target for healthy development. In 407 newborns, we quantified placental methylation of CpG sites within the promoter regions of the following genes: CLOCK, BMAL1, NPAS2, CRY1-2 and PER1-3 using bisulfite-PCR-pyrosequencing...
March 7, 2018: Environment International
https://www.readbyqxmd.com/read/29518531/entrainment-of-the-circadian-clock-in-neural-stem-cells-by-epidermal-growth-factor-is-closely-associated-with-erk1-2-mediated-induction-of-multiple-clock-related-genes
#12
Asuka Mogi, Ryo Yomoda, Syunya Kimura, Chisato Tsushima, Jun Takouda, Miho Sawauchi, Tomoko Maekawa, Hidenobu Ohta, Satoshi Nishino, Masatake Kurita, Nariyasu Mano, Noriko Osumi, Takahiro Moriya
The mitotic activity of certain tissues in the body is closely associated with circadian clock function. However, the effects of growth factors on the molecular clockwork are not fully understood. Stimulation of neural stem cells (NSCs) with epidermal growth factor (EGF), a well-known mitogen, is known to cause synchronized cell cycle progression with a period of approximately 24 h, closely associated with the Per2 gene expression rhythm. Here, we examined the effects of EGF on the molecular clockwork of NSCs...
March 5, 2018: Neuroscience
https://www.readbyqxmd.com/read/29500314/postnatal-ontogenesis-of-the-islet-circadian-clock-plays-a-contributory-role-in-%C3%AE-cell-maturation-process
#13
Kuntol Rakshit, Jingyi Qian, Krutika Satish Gaonkar, Sangeeta Dhawan, Christopher S Colwell, Aleksey V Matveyenko
Development of cell replacement therapies in diabetes requires understanding of the molecular underpinnings of β-cell maturation. Circadian clock regulates diverse cellular functions important for regulation of β-cell function and turnover. However postnatal ontogenesis of the islet circadian clock and its potential role in β-cell maturation remain unknown. To address this, we studied wild type Sprague Dawley as well as Period1 luciferase transgenic rats ( Per1 :LUC) to determine circadian clock function, clock protein expression and diurnal insulin secretion during islet development and maturation process...
March 2, 2018: Diabetes
https://www.readbyqxmd.com/read/29499429/time-does-matter-acute-copper-exposure-abolishes-rhythmicity-of-clock-gene-in-danio-rerio
#14
Halina Binde Doria, Marianna Boia Ferreira, Silvia Daniele Rodrigues, Sze Mei Lo, Cinthia Eloise Domingues, Lia Sumie Nakao, Sandro Xavier de Campos, Ciro Alberto de Oliveira Ribeiro, Marco Antonio Ferreira Randi
The circadian clock is a key cellular timing system that coordinates physiology and behavior. Light is a key regulator of the clock mechanism via its activation of Per and Cry clock gene expression. Evidence points to a key role of reactive oxygen species (ROS) in resetting this process. In this context, the aim of the present study was to explore copper as a ROS generator, using an innovative approach investigating its effects on circadian timing. Liver and brain from Danio rerio specimens exposed to 0, 5, 25 and 45 μg/L copper concentrations were obtained...
February 27, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29481900/biochemical-markers-of-striatal-desensitization-in-cortical-limbic-hyperglutamatergic-ts-ocd-like-transgenic-mice
#15
Kylie B O'Brien, Anjail Z Sharrief, Eric J Nordstrom, Anthony J Travanty, Mailee Huynh, Megan P Romero, Katie C Bittner, Michael T Bowser, Frank H Burton
Tics and compulsions in comorbid Tourette's syndrome (TS) and obsessive-compulsive disorder (OCD) are associated with chronic hyperactivity of parallel cortico/amygdalo-striato-thalamo-cortical (CSTC) loop circuits. Comorbid TS- & OCD-like behaviors have likewise been observed in D1CT-7 mice, in which an artificial neuropotentiating transgene encoding the cAMP-elevating intracellular subunit of cholera toxin (CT) is chronically expressed selectively in somatosensory cortical & amygdalar dopamine (DA) D1 receptor-expressing neurons that activate cortico/amygdalo-striatal glutamate (GLU) output...
February 23, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29479318/circadian-clock-proteins-and-melatonin-receptors-in-neurons-and-glia-of-the-sapajus-apella-cerebellum
#16
Leila M Guissoni Campos, Alessandre Hataka, Isis Z Vieira, Rogério L Buchaim, Isadora F Robalinho, Giovanna E P S Arantes, Joyce S Viégas, Henrique Bosso, Rafael M Bravos, Luciana Pinato
Oscillations of brain proteins in circadian rhythms are important for determining several cellular and physiological processes in anticipation of daily and seasonal environmental rhythms. In addition to the suprachiasmatic nucleus, the primary central oscillator, the cerebellum shows oscillations in gene and protein expression. The variety of local circuit rhythms that the cerebellar cortex contains influences functions such as motivational processes, regulation of feeding, food anticipation, language, and working memory...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29455641/circadian-pathway-genetic-variation-and-cancer-risk-evidence-from-genome-wide-association-studies
#17
Simone Mocellin, Saveria Tropea, Clara Benna, Carlo Riccardo Rossi
BACKGROUND: Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent. We aimed to investigate the association between circadian pathway genetic variation and risk of developing common cancers based on the findings of genome-wide association studies (GWASs). METHODS: Single nucleotide polymorphisms (SNPs) of 17 circadian genes reported by three GWAS meta-analyses dedicated to breast (Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Consortium; cases, n = 15,748; controls, n = 18,084), prostate (Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium; cases, n = 14,160; controls, n = 12,724) and lung carcinoma (Transdisciplinary Research In Cancer of the Lung (TRICL) Consortium; cases, n = 12,160; controls, n = 16,838) in patients of European ancestry were utilized to perform pathway analysis by means of the adaptive rank truncated product (ARTP) method...
February 19, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29435282/circadian-clock-and-oral-cancer
#18
Minou Nirvani, Cuong Khuu, Tor Paaske Utheim, Lars Peter Sand, Amer Sehic
The circadian clock is comprised of a master component situated in the hypothalamic suprachiasmatic nucleus and subordinate clock genes in almost every cell of the body. The circadian clock genes and their encoded proteins govern the organism to follow the natural signals of time, and adapt to external changes in the environment. The majority of physiological processes in mammals exhibit variable circadian rhythms, which are generated and coordinated by an oscillation in the expression of the clock genes. A number of studies have reported that alteration in the expression level of clock genes is correlated with several pathological conditions, including cancer...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29393895/glycosylphosphatidylinositol-anchors-from-galactomannan-and-gpi-anchored-protein-are-synthesized-by-distinct-pathways-in-aspergillus-fumigatus
#19
Jizhou Li, Isabelle Mouyna, Christine Henry, Frédérique Moyrand, Christian Malosse, Julia Chamot-Rooke, Guilhem Janbon, Jean-Paul Latgé, Thierry Fontaine
Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall polymers. GPIs follow a specific biosynthetic pathway in the endoplasmic reticulum. After the transfer of the protein onto the GPI-anchor, a lipid remodeling occurs to substitute the diacylglycerol moiety by a ceramide. In addition to GPI-APs, A. fumigatus produces a GPI-anchored polysaccharide, the galactomannan (GM), that remains unique in the fungal kingdom...
February 2, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29377895/the-non-classical-nuclear-import-carrier-transportin-1-modulates-circadian-rhythms-through-its-effect-on-per1-nuclear-localization
#20
Sandra Korge, Bert Maier, Franziska Brüning, Lea Ehrhardt, Thomas Korte, Matthias Mann, Andreas Herrmann, Maria S Robles, Achim Kramer
Circadian clocks are molecular timekeeping mechanisms that allow organisms to anticipate daily changes in their environment. The fundamental cellular basis of these clocks is delayed negative feedback gene regulation with PERIOD and CRYPTOCHROME containing protein complexes as main inhibitory elements. For a correct circadian period, it is essential that such clock protein complexes accumulate in the nucleus in a precisely timed manner, a mechanism that is poorly understood. We performed a systematic RNAi-mediated screen in human cells and identified 15 genes associated with the nucleo-cytoplasmic translocation machinery, whose expression is important for circadian clock dynamics...
January 2018: PLoS Genetics
keyword
keyword
82502
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"