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JOURNAL ARTICLE
Hao Peng, Shan Xin, Susanne Pfeiffer, Constanze Müller, Juliane Merl-Pham, Stefanie M Hauck, Patrick N Harter, Daniel Spitzer, Kavi Devraj, Borys Varynskyi, Thomas Arzberger, Stefan Momma, Joel A Schick
The progression of human degenerative and hypoxic/ischemic diseases is accompanied by widespread cell death. One death process linking iron-catalyzed reactive species with lipid peroxidation is ferroptosis, which shows hallmarks of both programmed and necrotic death in vitro. While evidence of ferroptosis in neurodegenerative disease is indicated by iron accumulation and involvement of lipids, a stable marker for ferroptosis has not been identified. Its prevalence is thus undetermined in human pathophysiology, impeding recognition of disease areas and clinical investigations with candidate drugs...
April 23, 2024: Cell Death & Disease
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JOURNAL ARTICLE
Alireza Saeedi, Kun Wang, Ghazaleh Nikpourian, Andreas Bartels, Nikos K Logothetis, Nelson K Totah, Masataka Watanabe
Brightness illusions are a powerful tool in studying vision, yet their neural correlates are poorly understood. Based on a human paradigm, we presented illusory drifting gratings to mice. Primary visual cortex (V1) neurons responded to illusory gratings, matching their direction selectivity for real gratings, and they tracked the spatial phase offset between illusory and real gratings. Illusion responses were delayed compared to real gratings, in line with the theory that processing illusions requires feedback from higher visual areas (HVAs)...
April 23, 2024: Nature Communications
#23
JOURNAL ARTICLE
Amila Cizmic, Frida Häberle, Philipp A Wise, Felix Müller, Felix Gabel, Pietro Mascagni, Babak Namazi, Martin Wagner, Daniel A Hashimoto, Amin Madani, Adnan Alseidi, Thilo Hackert, Beat P Müller-Stich, Felix Nickel
BACKGROUND: The learning curve in minimally invasive surgery (MIS) is lengthened compared to open surgery. It has been reported that structured feedback and training in teams of two trainees improves MIS training and MIS performance. Annotation of surgical images and videos may prove beneficial for surgical training. This study investigated whether structured feedback and video debriefing, including annotation of critical view of safety (CVS), have beneficial learning effects in a predefined, multi-modal MIS training curriculum in teams of two trainees...
April 23, 2024: Surgical Endoscopy
#24
JOURNAL ARTICLE
Christoph Buchta, Stephan W Aberle, Irene Görzer, Andrea Griesmacher, Mathias M Müller, Erich Neuwirth, Elisabeth Puchhammer-Stöckl, Lukas Weseslindtner, Jeremy V Camp
BACKGROUND: External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are particularly important during pandemics as they also assess the reliability of individual test results and show opportunities to improve test strategies. With the end of the COVID-19 pandemic, the testing frequency significantly decreased in Austria. Here, we analyzed whether this decrease had an effect on participation and/or performance in SARS-CoV‑2 virus detection EQAs, as compared to the pandemic era...
April 23, 2024: Wiener Klinische Wochenschrift
#25
JOURNAL ARTICLE
Margarita Grammatikopoulou, Martha Zachariadou, Maria Zande, Georgios Giannios, Achilleas Chytas, Haralampos Karanikas, Spiros Georgakopoulos, Dimitrios Karanikas, George Nikolaidis, Pantelis Natsiavas, Thanos G Stavropoulos, Spiros Nikolopoulos, Ioannis Kompatsiaris
BACKGROUND: Health Care Professionals (HCPs) are the main end-users of digital clinical tools such as electronic prescription systems. For this reason, it is of high importance to include HCPs throughout the design, development and evaluation of a newly introduced system to ensure its usefulness, as well as confirm that it tends to their needs and can be integrated in their everyday clinical practice. METHODS: In the context of the PrescIT project, an electronic prescription platform with three services was developed (i...
April 17, 2024: Research in Social & Administrative Pharmacy: RSAP
#26
JOURNAL ARTICLE
Zoe Grabinski, Kar-Mun Woo, Olumide Akindutire, Cassidy Dahn, Lauren Nash, Inna Leybell, Yelan Wang, Danielle Bayer, Jordan Swartz, Catherine Jamin, Silas W Smith
BACKGROUND: Review of emergency department (ED) revisits with admission allows the identification of improvement opportunities. Applying a health equity lens to revisits may highlight potential disparities in care transitions. Universal definitions or practicable frameworks for these assessments are lacking. The authors aimed to develop a structured methodology for this quality assurance (QA) process, with a layered equity analysis. METHODS: The authors developed a classification instrument to identify potentially preventable 72-hour returns with admission (PPRA-72), accounting for directed, unrelated, unanticipated, or disease progression returns...
March 15, 2024: Joint Commission Journal on Quality and Patient Safety
#27
JOURNAL ARTICLE
Pengyu Zhang, Saskia von Ungern-Sternberg, Luisa Hastenplug, Fiorella Solari, Albert Sickmann, Marijke Kuijpers, Johan Wm Heemskerk, Ulrich Walter, Kerstin Jurk
BACKGROUND: Platelet glycoprotein VI (GPVI) stimulation activates the tyrosine kinases Syk and Btk, and the effector proteins phospholipase Cγ 2 (PLCγ2) and protein kinase C (PKC). Here, the activation sequence, crosstalk and downstream effects of this Syk-Btk-PKC signalosome in human platelets was analyzed. METHODS AND RESULTS: Using immunoblotting, we quantified 14 regulated phospho-sites in platelets stimulated by convulxin with and without inhibition of Syk, Btk or PKC...
April 23, 2024: Thrombosis and Haemostasis
#28
JOURNAL ARTICLE
Erica Berlin, Christopher Lourenço, Stephen Poyer
Despite global recommendations that surveillance systems should capture malaria case data from both private and public sectors, the integration of private sector data into national systems remains a challenge for national malaria programs in high-burden settings. The WHO's Malaria Surveillance, Monitoring & Evaluation: A Reference Manual suggests eight general guidelines for conducting private sector surveillance. Practical operational guidance is needed to implement private sector surveillance and service delivery interventions...
April 23, 2024: American Journal of Tropical Medicine and Hygiene
#29
JOURNAL ARTICLE
Nikhil Tej Kantu, Ryan Osswald, Amit Kandel, Jiyeon Kang
Individuals with neurological disorders often exhibit altered manual dexterity and muscle weakness in their upper limbs. These motor impairments with tremor lead to severe difficulties in performing Activities of Daily Living (ADL). There is a critical need for ADL-focused robotic training that improves individual's strength when engaging with dexterous ADL tasks. This research introduces a new approach to training ADLs by employing a novel robotic rehabilitation system, Spherical Parallel INstrument for Daily Living Emulation (SPINDLE), which incorporates Virtual Reality (VR) to simulate ADL tasks...
April 23, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
#30
JOURNAL ARTICLE
Ziming Liu, Jian Wu, Lili Wang, Xiangyu Li, Sio Kei Im
In virtual reality applications, in addition to visual feedback, real objects can be used as props for virtual objects to provide passive haptic feedback, which greatly enhances user immersion. Usually, real object props are not one-to-one correspondence with virtual objects. Haptic retargeting technique is proposed to establish the virtual-real correspondence by introducing an offset between the virtual hand and the real hand. Sometimes, the offset is too large to cause user discomfort, and it is necessary to introduce a reset between two haptic retargeting operations to force the virtual hand and the real hand to coincide in order to eliminate the offset...
April 23, 2024: IEEE Transactions on Visualization and Computer Graphics
#31
JOURNAL ARTICLE
Liqi Cheng, Dazhen Deng, Xiao Xie, Rihong Qiu, Mingliang Xu, Yingcai Wu
To enhance the appeal and informativeness of data news, there is an increasing reliance on data analysis techniques and visualizations, which poses a high demand for journalists' abilities. While numerous visual analytics systems have been developed for deriving insights, few tools specifically support and disseminate viewpoints for journalism. Thus, this work aims to facilitate the automatic creation of sports news from natural language insights. To achieve this, we conducted an extensive preliminary study on the published sports articles...
April 23, 2024: IEEE Transactions on Visualization and Computer Graphics
#32
JOURNAL ARTICLE
Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Michihiro Kono, Mitsuki Sugihara, Yosuke Kawai, Minae Kawashima, Seik-Soon Khor, Kazuhiro Sugi, Hirotaka Kouno, Hiroshi Kouno, Atsushi Naganuma, Satoru Iwamoto, Shinji Katsushima, Kiyoshi Furuta, Toshiki Nikami, Tomohiko Mannami, Tsutomu Yamashita, Keisuke Ario, Tatsuji Komatsu, Fujio Makita, Masaaki Shimada, Noboru Hirashima, Shiro Yokohama, Hideo Nishimura, Rie Sugimoto, Takuya Komura, Hajime Ota, Motoyuki Kojima, Makoto Nakamuta, Naoyuki Fujimori, Kaname Yoshizawa, Yutaka Mano, Hironao Takahashi, Kana Hirooka, Satoru Tsuruta, Takeaki Sato, Kazumi Yamasaki, Yuki Kugiyama, Yasuhide Motoyoshi, Tomoyuki Suehiro, Akira Saeki, Kosuke Matsumoto, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Masahiro Ito, Kazuhito Kawata, Akinobu Takaki, Kuniaki Arai, Teruko Arinaga, Masanori Abe, Masaru Harada, Makiko Taniai, Mikio Zeniya, Hiromasa Ohira, Shinji Shimoda, Atsumasa Komori, Atsushi Tanaka, Kazuyoshi Ishigaki, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
BACKGROUND AIMS: Previous genome-wide association studies (GWAS) have indicated the involvement of shared (population-non-specific) and non-shared (population-specific) susceptibility genes in the pathogenesis of primary biliary cholangitis (PBC) among European and East-Asian populations. Although a meta-analysis of these distinct populations has recently identified more than 20 novel PBC susceptibility loci, analyses of population-specific genetic architecture are still needed for a more comprehensive search for genetic factors in PBC...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#33
JOURNAL ARTICLE
Michał Pawłowski, Joseph M Ricotta, Sayan D De, Mark L Latash
We explored unintentional drifts of finger forces during force production and matching task. Based on earlier studies, we predicted that force matching with the other hand would reduce or stop the force drift in instructed fingers while uninstructed (enslaved) fingers remain unaffected. Twelve young, healthy, right-handed participants performed two types of tasks with both hands (task hand and match hand). The task hand produced constant force at 20% of MVC level with the Index and Ring fingers pressing in parallel on strain gauge force sensors...
April 23, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
#34
JOURNAL ARTICLE
Marina Frietsch, Manuel Pacheco-Romero, Vicky M Temperton, Beth A Kaplin, Joern Fischer
Expanding in both scope and scale, ecosystem restoration needs to embrace complex social-ecological dynamics. To help scientists and practitioners navigate ever new demands on restoration, we propose the "social-ecological ladder of restoration ambition" as a conceptual model to approach dynamically shifting social and ecological restoration goals. The model focuses on three dynamic aspects of restoration, namely degrading processes, restoration goals and remedial actions. As these three change through time, new reinforcing and balancing feedback mechanisms characterize the restoration process...
April 23, 2024: Ambio
#35
JOURNAL ARTICLE
Katsuhiro Kawaai, Yumiko Oishi, Yukiko Kuroda, Ryota Tamura, Masahiro Toda, Koichi Matsuo
PURPOSE: Chordomas are malignant tumors that destroy bones, compress surrounding nerve tissues and exhibit phenotypes that recapitulate notochordal differentiation in the axial skeleton. Chordomas recur frequently, as they resist radio-chemotherapy and are difficult to completely resect, leading to repeated bone destruction and local expansion via unknown mechanisms. Here, using chordoma specimens and JHC7 chordoma cells, we asked whether chordoma cells possess bone-dissolving activity...
April 23, 2024: Cellular Oncology (Dordrecht)
#36
JOURNAL ARTICLE
Alan M Hall, Adam Gray, John W Ragsdale
BACKGROUND: Narrative written feedback given to students by faculty often fails to identify areas for improvement and recommended actions to lead to this improvement. When these elements are missing, it is challenging for students to improve and for medical schools to use narrative feedback in promotion decisions, to guide coaching plans and to pass on meaningful information to residency programs. Large-group faculty development has improved narrative written feedback, but less is known about individualised faculty development to supplement large-group sessions...
April 23, 2024: Clinical Teacher
#37
JOURNAL ARTICLE
Maria Teresa Moreira, Andreia Lima, Carla Sílvia Fernandes, Ariana Pereira, Dulce Lemos, Lúcia Pereira, Raquel Delgado, Sandra Rodrigues, Francisco Sampaio
This study delves into how motivational sessions and brief interventions impact students' alcohol consumption, highlighting the vital role of nurses in fostering positive behavioural changes. The study aims to discern the effects of these interventions, starting with a pre-and post-intervention setup involving 62 students from a private school in northern Portugal. The intervention comprised a session delivered by school and mental health nurses, utilizing the motivational intervention and FRAMES method and a poster offering feedback on alcohol consumption scores...
March 25, 2024: Nursing Reports
#38
JOURNAL ARTICLE
Xin-Yu Li, Ni Yan, Ye-Yang Wu, Ren-Jiang Kong, Zi-Wen Qiu, Shu-Peng Liu, De-Hua Wu, Hong Cheng
Antiangiogenic therapy is an effective way to disrupt nutrient supply and starve tumors, but it is restricted by poor efficacy and negative feedback-induced tumor relapse. In this study, a neuropilin-1 (NRP-1)-targeted nanomedicine (designated as FPPT@Axi) is reported for spatiotemporal tumor suppression by combining photodynamic therapy (PDT) with antiangiogenesis. In brief, FPPT@Axi is prepared by utilizing an NRP-1-targeting chimeric peptide (Fmoc-K(PpIX)-PEG8 -TKPRR) to encapsulate the antiangiogenic drug Axitinib (Axi)...
April 23, 2024: ACS Applied Materials & Interfaces
#39
JOURNAL ARTICLE
Jennifer M Knight, Melissa K Ward, Sofia Fernandez, Becky L Genberg, Mary Catherine Beach, Robert A Ladner, Mary Jo Trepka
Background: Patient-centered care (PCC) improves HIV adherence and retention, though lack of consensus on its conceptualization and understanding how it is interpreted has hindered implementation. Methods: We recruited 20 HIV providers at Ryan White Programs in FL for in-depth interviews. Thematic analysis identified core consistencies pertaining to: 1) provider perceptions, 2) current practices promoting PCC. Results: Provider perceptions of PCC emerged under four domains: 1) holistic, 2) individualized care, 3) respect for comfort and security, and 4) patient engagement and partnership...
2024: Journal of the International Association of Providers of AIDS Care
#40
JOURNAL ARTICLE
Sabra L Katz-Wise, Snehal N Shah, Patrice Melvin, Elizabeth R Boskey, Amanda W Grice, Susan Kornetsky, Tina Young Poussaint, Melicia Y Whitley, Anne M Stack, S Jean Emans, Benjamin Hoerner, James J Horgan, Valerie L Ward
Equity, diversity, and inclusion (EDI) research is increasing, and there is a need for a more standardized approach for methodological and ethical review of this research. A supplemental review process for EDI-related human subject research protocols was developed and implemented at a pediatric academic medical center (AMC). The goal was to ensure that current EDI research principles are consistently used and that the research aligns with the AMC's declaration on EDI. The EDI Research Review Committee, established in January 2022, reviewed EDI protocols and provided recommendations and requirements for addressing EDI-related components of research studies...
April 23, 2024: Pediatrics
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