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https://www.readbyqxmd.com/read/29111539/external-validation-and-newly-development-of-a-nomogram-to-predict-overall-survival-of-abiraterone-treated-castration-resistant-patients-with-metastatic-prostate-cancer
#1
Yun-Jie Yang, Guo-Wen Lin, Gao-Xiang Li, Bo Dai, Ding-Wei Ye, Jun-Long Wu, Hu-Yang Xie, Yao Zhu
Abiraterone acetate is approved for the treatment of castration-resistant prostate cancer (CRPC); however, its effects vary. An accurate prediction model to identify patient groups that will benefit from abiraterone treatment is therefore urgently required. The Chi model exhibits a good profile for risk classification, although its utility for the chemotherapy-naive group is unclear. This study aimed to externally validate the Chi model and develop a new nomogram to predict overall survival (OS). We retrospectively analyzed a cohort of 110 patients...
November 7, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28795333/patient-characteristics-and-overall-survival-in-patients-with-post-docetaxel-metastatic-castration-resistant-prostate-cancer-in-the-community-setting
#2
William K Oh, Raymond Miao, Francis Vekeman, Jennifer Sung, Wendy Y Cheng, Marjolaine Gauthier-Loiselle, Ravinder Dhawan, Mei Sheng Duh
It is unclear how treatment sequencing for metastatic castration-resistant prostate cancer (mCRPC) affects real-world patient outcomes. We assessed treatment sequences, patient characteristics and overall survival (OS) in post-docetaxel mCRPC patients. mCRPC patients receiving second-line cabazitaxel or androgen receptor-targeted therapy (ART; abiraterone/enzalutamide) post-docetaxel were identified using electronic medical records. OS was assessed from second-line therapy initiation using Cox regressions adjusting for: metastases; prostate-specific antigen (PSA); hemoglobin; alkaline phosphatase (ALP); albumin; second-line therapy initiation year...
August 10, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28068151/prognostic-impact-of-pretreatment-neutrophil-to-lymphocyte-ratio-in-castration-resistant-prostate-cancer-patients-treated-with-first-line-docetaxel
#3
Consuelo Buttigliero, Chiara Pisano, Marcello Tucci, Francesca Vignani, Valentina Bertaglia, Davide Iaconis, Pamela Guglielmini, Gianmauro Numico, Giorgio V Scagliotti, Massimo Di Maio
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a measure of systemic inflammatory response, has been associated with poor outcome in several solid tumors, including prostate cancer. We retrospectively investigated the prognostic role of pretreatment NLR in metastatic castration-resistant prostate cancer (mCRPC) patients treated with first-line docetaxel. METHODS: All CRPC patients treated with first-line docetaxel at two Italian institutions, with available data about baseline neutrophil and lymphocyte values, were included in this retrospective analysis...
April 2017: Acta Oncologica
https://www.readbyqxmd.com/read/27613490/hematologic-safety-of-radium-223-dichloride-baseline-prognostic-factors-associated-with-myelosuppression-in-the-alsympca-trial
#4
RANDOMIZED CONTROLLED TRIAL
Nicholas J Vogelzang, Robert E Coleman, Jeff M Michalski, Sten Nilsson, Joe M O'Sullivan, Christopher Parker, Anders Widmark, Marcus Thuresson, Lei Xu, Joseph Germino, Oliver Sartor
BACKGROUND: Myelosuppression is common in patients with progressive castration-resistant prostate cancer and bone metastases. Radium-223 prolongs overall survival in these patients but may cause myelosuppression; understanding risk factors will improve clinical decision making. We describe hematologic safety of radium-223 in ALSYMPCA and post hoc analyses identifying patients at increased risk for hematologic toxicity. PATIENTS AND METHODS: Hematologic parameters and adverse events were analyzed...
February 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27586506/a-comparative-study-on-the-efficacies-of-gonadotropin-releasing-hormone-gnrh-agonist-and-gnrh-antagonist-in-neoadjuvant-androgen-deprivation-therapy-combined-with-transperineal-prostate-brachytherapy-for-localized-prostate-cancer
#5
RANDOMIZED CONTROLLED TRIAL
Kenta Miki, Hiroshi Sasaki, Masahito Kido, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa
BACKGROUND: Neoadjuvant androgen deprivation therapy (ADT) has been suggested to confer several clinical benefits in patients with prostate cancer (PCa) undergoing transperineal prostate brachytherapy (TPPB). Unlike gonadotropin-releasing hormone (GnRH) receptor agonists, a GnRH antagonist such as degarelix can achieve castrate levels of testosterone without testosterone flare. However, normalization of serum testosterone levels following completion of neoadjuvant ADT in either form of treatment has never been compared in clinical trials...
September 1, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27436076/effects-of-8-year-treatment-of-long-acting-testosterone-undecanoate-on-metabolic-parameters-urinary-symptoms-bone-mineral-density-and-sexual-function-in-men-with-late-onset-hypogonadism
#6
Sompol Permpongkosol, Kalayanee Khupulsup, Supatra Leelaphiwat, Sarawan Pavavattananusorn, Supranee Thongpradit, Thanom Petchthong
INTRODUCTION: The long-term effects of long-acting testosterone undecanoate (TU) and androgen receptor CAG repeat lengths in Thai men with late-onset hypogonadism (LOH) have not been reported. AIM: To analyze the 8-year follow-up effects of intramuscular TU therapy on metabolic parameters, urinary symptoms, bone mineral density, and sexual function and investigate CAG repeat lengths in men with LOH. METHODS: We reviewed the medical records of 428 men with LOH who had been treated with TU and 5 patients were diagnosed with prostate cancer during TU therapy...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27102406/predictors-of-chemotherapy-induced-toxicity-and-treatment-outcomes-in-elderly-versus-younger-patients-with-metastatic-castration-resistant-prostate-cancer
#7
COMPARATIVE STUDY
Per Kongsted, Inge Marie Svane, Henriette Lindberg, Lisa Sengeløv
BACKGROUND: In the present study, we examined possible predictors of chemotherapy-induced toxicity, treatment outcomes, and the consequences of dose reductions in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving standard docetaxel. PATIENTS AND METHODS: Medical records from 421 consecutive patients treated with first-line docetaxel (75 mg/m(2) every 3 weeks) and low-dose prednisolone from 2007 to 2013 at Herlev University Hospital were reviewed...
December 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27004570/chemotherapy-following-radium-223-dichloride-treatment-in-alsympca
#8
RANDOMIZED CONTROLLED TRIAL
Oliver Sartor, Peter Hoskin, Robert E Coleman, Sten Nilsson, Nicholas J Vogelzang, Oana Petrenciuc, Karin Staudacher, Marcus Thuresson, Christopher Parker
BACKGROUND: Radium-223 prolongs overall survival in patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases, regardless of prior docetaxel. Whether or not chemotherapy can be safely administered following radium-223 treatment is of clinical importance. An exploratory analysis of prospectively collected data, from the ALSYMPCA (ALpharadin in SYMptomatic Prostate CAncer) patient subgroup who received chemotherapy after radium-223 or placebo treatment, was conducted to evaluate the safety and efficacy of chemotherapy following radium-223...
July 2016: Prostate
https://www.readbyqxmd.com/read/26765317/predictors-of-early-androgen-deprivation-treatment-failure-in-prostate-cancer-with-bone-metastases
#9
RANDOMIZED CONTROLLED TRIAL
Eberhard Varenhorst, Rami Klaff, Anders Berglund, Per Olov Hedlund, Gabriel Sandblom
Approximately 15% of men with hormone naïve metastatic prostate cancer primarily fail to respond to androgen deprivation treatment (ADT). The reason why the response to ADT differs in this subgroup of men with prostate cancer remains unclear. The aim of this study was to describe the characteristics of these men and to thereby define predictors of early ADT failure in prostate cancer patients with bone metastases. The study was based on 915 men from the prospective randomized multicenter trial (no. 5) conducted by the Scandinavian Prostate Cancer Group comparing parenteral estrogen with total androgen blockade...
March 2016: Cancer Medicine
https://www.readbyqxmd.com/read/26503109/influence-of-1-year-of-androgen-deprivation-therapy-on-lipid-and-glucose-metabolism-and-fat-accumulation-in-japanese-patients-with-prostate-cancer
#10
K Mitsuzuka, A Kyan, T Sato, K Orikasa, M Miyazato, H Aoki, N Kakoi, S Narita, T Koie, T Namima, S Toyoda, Y Fukushi, T Habuchi, C Ohyama, Y Arai
BACKGROUND: We prospectively examined influence of androgen deprivation therapy (ADT) on lipid and glucose metabolisms in Japanese patients with prostate cancer. METHODS: Patients with prostate cancer who were hormone-naive and scheduled to receive long-term ADT were recruited between 2011 and 2013. Body weight, abdominal circumference and blood testing associated with lipid and glucose metabolism were recorded every 3 months during 1 year of ADT. Computed tomography (CT) was performed to measure areas of subcutaneous and visceral fat before and after 1 year of ADT...
March 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/26380014/platelet-to-lymphocyte-ratio-plays-an-important-role-in-prostate-cancer-s-diagnosis-and-prognosis
#11
Feng Li, Haibo Hu, Shuo Gu, Xin Chen, Qing Sun
OBJECTIVE: To compare the platelet to lymphocyte ratio (PLR) in normal people, benign prostatic hyperplasia (BPH) patients and prostate cancer (PCA) patients, and to explore the prognostic role of PLR in PCA. METHODS: 155 normal people, 168 BPH patients and 103 PCA patients were enrolled. PCA patients were divided into PLR low value group (PLR<150) and PLR high value group (PLR≥150), and the difference of patients' clinical characteristics between high value group and low value group was comparative studied...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26254696/low-dose-prednisolone-in-first-line-docetaxel-for-patients-with-metastatic-castration-resistant-prostate-cancer-is-there-a-clinical-benefit
#12
Per Kongsted, Inge Marie Svane, Henriette Lindberg, Gedske Daugaard, Lisa Sengeløv
BACKGROUND: Randomized studies have shown improved survival with the combination of docetaxel (D) and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC). We retrospectively investigated whether coadministration of low-dose glucocorticoids has clinical benefits. MATERIAL AND METHODS: Records from 358 patients with metastatic castration-resistant prostate cancer treated consecutively with either D 75mg/m(2) every 3 weeks (n = 124) (Rigshospitalet) or D and prednisolone (P) 10mg daily (n = 234) (Herlev Hospital) given as first-line chemotherapy were reviewed...
November 2015: Urologic Oncology
https://www.readbyqxmd.com/read/25771371/pharmacokinetic-dosimetry-and-toxicity-study-of-%C3%A2-%C3%A2-%C3%A2-lu-edtmp-in-patients-phase-0-i-study
#13
Chandrasekhar Bal, Geetanjali Arora, Praveen Kumar, Nishikant Damle, Tapas Das, Sudipta Chakraborty, Sharmila Banerjee, Meera Venkatesh, John J Zaknun, M R A Pillai
177Lu-EDTMP has been proposed as a potent bone pain palliation agent owing to theoretical advantage of reduced bone marrow suppression resulting from the low β(-) energy and a suitably long half-life facilitating its wider distribution with less loss from radioactive decay. Herein, we report the pharmacokinetics, dosimetry and toxicity analysis of 177Lu-EDTMP in patients (phase-0/I study). In a phase-0 study, the biokinetics of skeletal and non-skeletal uptake of 177Lu-EDTMP was assessed in 6 patients with metastatic prostate cancer using tracer doses (172...
2016: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/25595577/clinical-phenotypes-associated-with-circulating-tumor-cell-enumeration-in-metastatic-castration-resistant-prostate-cancer
#14
Rhonda L Bitting, Patrick Healy, Susan Halabi, Daniel J George, Michael Goodin, Andrew J Armstrong
BACKGROUND: The presence of ≥5 circulating tumor cells (CTCs) is prognostic for shorter survival in men with metastatic castration-resistant prostate cancer (mCRPC). However, some men have low CTCs despite widespread disease, suggesting heterogeneity in CTC phenotype or detection. The aim of this study was to evaluate the association of CTC enumeration with clinical disease characteristics and overall survival in men with mCRPC at our institution. DESIGN: CTCs were enumerated using the CellSearch method in a prospective correlative study in men with mCRPC starting a new systemic therapy...
March 2015: Urologic Oncology
https://www.readbyqxmd.com/read/25334285/acute-hemolysis-following-an-overdose-of-miracle-mineral-solution-in-a-patient-with-normal-glucose-6-phosphate-dehydrogenase-levels
#15
Daniel Burke, Bishoy Zakhary, Evgeny Pinelis
Critical Care Cases IISESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Tuesday, October 28, 2014 at 07:30 AM - 08:30 AMINTRODUCTION: Miracle Mineral Solution (MMS) is an alternative medicine that has been promoted to cure various diseases. It is an aqueous solution of 28% sodium chlorite that yields chlorine dioxide with the addition of citric acid. Prior case reports suggest MMS can cause hemolytic anemia in patients with glucose-6-phostphate dehydrogenase (G6PD) deficiency. We report a case of hemolytic anemia in a patient with normal levels of G6PD after the ingestion of a large quantity of MMS...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25292063/red-cell-distribution-width-as-a-predictor-of-prostate-cancer-progression
#16
COMPARATIVE STUDY
Sebahattin Albayrak, Kursad Zengin, Serhat Tanik, Hasan Bakirtas, Abdurrahim Imamoglu, Mesut Gurdal
BACKGROUND: The aims of this study were to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker in prostate cancer, as well as to evaluate RDW as a predictor of progression in prostate cancer patients. MATERIALS AND METHODS: We evaluated 62 newly diagnosed prostate cancer patients who underwent transrectal ultrasound (TRUS)-guided biopsy and 62 healthy controls of mean age 64 (range, 45-75) years at the Urology Clinic of Bozok University Hospital...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25277272/prognostic-factors-for-survival-in-noncastrate-metastatic-prostate-cancer-validation-of-the-glass-model-and-development-of-a-novel-simplified-prognostic-model
#17
RANDOMIZED CONTROLLED TRIAL
Gwenaelle Gravis, Jean-Marie Boher, Karim Fizazi, Florence Joly, Franck Priou, Patricia Marino, Igor Latorzeff, Remy Delva, Ivan Krakowski, Brigitte Laguerre, Jochen Walz, Fréderic Rolland, Christine Théodore, Gael Deplanque, Jean-Marc Ferrero, Damien Pouessel, Loïc Mourey, Philippe Beuzeboc, Sylvie Zanetta, Muriel Habibian, Jean-François Berdah, Jerome Dauba, Marjorie Baciuchka, Christian Platini, Claude Linassier, Jean-Luc Labourey, Jean Pascal Machiels, Claude El Kouri, Alain Ravaud, Etienne Suc, Jean-Christophe Eymard, Ali Hasbini, Guilhem Bousquet, Michel Soulie, Stéphane Oudard
BACKGROUND: The Glass model developed in 2003 uses prognostic factors for noncastrate metastatic prostate cancer (NCMPC) to define subgroups with good, intermediate, and poor prognosis. OBJECTIVE: To validate NCMPC risk groups in a more recently diagnosed population and to develop a more sensitive prognostic model. DESIGN, SETTING, AND PARTICIPANTS: NCMPC patients were randomized to receive continuous androgen deprivation therapy (ADT) with or without docetaxel in the GETUG-15 phase 3 trial...
August 2015: European Urology
https://www.readbyqxmd.com/read/25121948/predictive-clinical-indicators-of-biochemical-progression-in-advanced-prostate-cancer-patients-receiving-leuplin-depot-as-androgen-deprivation-therapy
#18
Chien-Hua Chen, Ju-Ton Hsieh, Kuo-How Huang, Yeong-Shiau Pu, Hong-Chiang Chang
Therapeutic planning and counseling for advanced prostate cancer patients receiving androgen deprivation therapy (ADT) is complicated because the prognoses are highly variable. The purpose of this study is to identify predictive clinical indicators of biochemical progression (BCP). In this retrospective analysis, data from 107 newly diagnosed patients (from November 1995 to April 2008) with advanced prostate adenocarcinoma receiving Leuprorelin acetate depot were analyzed. Data was collected from the computerized registry of two collaborating medical centers in Taiwan...
2014: PloS One
https://www.readbyqxmd.com/read/24761863/diabetes-mellitus-and-hba1c-levels-associated-with-high-grade-prostate-cancer
#19
Emin Ozbek, Alper Otunctemur, Murat Dursun, Suleyman Sahin, Huseyin Besiroglu, Ismail Koklu, Mustafa Erkoc, Eyyup Danis, Muammer Bozkurt
PURPOSE: The aim of this study to analyze the association between history of diabetes mellitus (DM) with risk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. MATERIALS AND METHODS: 50 patients with DM and 50 patients without DM who undervent radical prostatectomy (RP) were included in the study. Age at biopsy, height, weight, digital rectal examination (DRE), pre-biopsy PSA levels, prostate volume, histopathologic diagnosis after surgery and gleason scores were collected data from all patients...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/24578154/it-s-who-you-know-patient-sharing-quality-and-costs-of-cancer-survivorship-care
#20
Craig Evan Pollack, Kevin D Frick, Robert J Herbert, Amanda L Blackford, Bridget A Neville, Antonio C Wolff, Michael A Carducci, Craig C Earle, Claire F Snyder
PURPOSE: Cancer survivors frequently receive care from a large number of physicians, creating challenges for coordination. We sought to explore whether cancer survivors whose providers have more patients in common (e.g., shared patients) tend to have higher quality and lower cost care. METHODS: We performed a retrospective cohort study of 8,661 patients diagnosed with loco-regional breast, prostate, or colorectal cancer. We examined survivorship care from days 366 to 1,095 following their cancer diagnosis...
June 2014: Journal of Cancer Survivorship: Research and Practice
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