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https://www.readbyqxmd.com/read/29776403/rostral-cranial-fossa-as-a-site-for-cerebrospinal-fluid-drainage-volumetric-studies-in-dog-breeds-of-different-size-and-morphotype
#1
Wojciech Sokołowski, Norbert Czubaj, Michał Skibniewski, Karolina Barszcz, Marta Kupczyńska, Wojciech Kinda, Zdzisław Kiełbowicz
BACKGROUND: Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the cribriform plate located in the rostral cranial fossa (RCF) is a site of cerebrospinal fluid (CSF) drainage, the RCF has not been studied extensively. Literature reports indicate that a decreased caudal cranial fossa (CCF) volume in the course of the Chiari-like malformation may obstruct CSF circulation...
May 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29746825/structural-and-functional-heterogeneity-of-cytochrome-c-oxidase-in-s-cerevisiae
#2
Jacob Schäfer, Hannah Dawitz, Martin Ott, Pia Ädelroth, Peter Brzezinski
Respiration in Saccharomyces cerevisiae is regulated by small proteins such as the respiratory supercomplex factors (Rcf). One of these factors (Rcf1) has been shown to interact with complexes III (cyt. bc1 ) and IV (cytochrome c oxidase, CytcO) of the respiratory chain and to modulate the activity of the latter. Here, we investigated the effect of Rcf1 deletion on the functionality of CytcO, purified using a protein C-tag on core subunit 1 (Cox1). Specifically, we measured the kinetics of ligand binding to the CytcO catalytic site, the O2 -reduction activity and changes in light absorption spectra...
May 7, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29745840/hierarchical-combinatorial-deep-learning-architecture-for-pancreas-segmentation-of-medical-computed-tomography-cancer-images
#3
Min Fu, Wenming Wu, Xiafei Hong, Qiuhua Liu, Jialin Jiang, Yaobin Ou, Yupei Zhao, Xinqi Gong
BACKGROUND: Efficient computational recognition and segmentation of target organ from medical images are foundational in diagnosis and treatment, especially about pancreas cancer. In practice, the diversity in appearance of pancreas and organs in abdomen, makes detailed texture information of objects important in segmentation algorithm. According to our observations, however, the structures of previous networks, such as the Richer Feature Convolutional Network (RCF), are too coarse to segment the object (pancreas) accurately, especially the edge...
April 24, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29714344/frequency-stability-of-a-pulsed-optically-pumped-atomic-clock-with-narrow-ramsey-linewidth
#4
Haixiao Lin, Jianliao Deng, Jinda Lin, Song Zhang, Yuzhu Wang
In general, the linewidth of the Ramsey central fringe (RCF) is equal to 1/(2T), where T is the Ramsey free-evolution time. We demonstrate that the RCF linewidth of a pulsed optically pumped (POP) atomic clock with orthogonal polarization detection based on the magneto-optical rotation effect can be narrowed down to 1/(4T). The Allan deviation of the POP atomic clock decreases from 2.4×10-13 τ-1/2 to 1.4×10-13 τ-1/2 . This corresponds to an improvement in the frequency stability by about 60%. We also estimate the main noise sources that limit the short-term frequency stability of the POP atomic clock...
April 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29621938/does-strategy-instruction-on-the-rey-osterrieth-complex-figure-task-lead-to-transferred-performance-improvement-on-the-modified-taylor-complex-figure-task-a-randomized-controlled-trial-in-school-aged-children
#5
Christine Resch, Esther Keulers, Rosa Martens, Caroline van Heugten, Petra Hurks
OBJECTIVE: Providing children with organizational strategy instruction on the Rey Osterrieth Complex Figure (ROCF) has previously been found to improve organizational and accuracy performance on this task. It is unknown whether strategy instruction on the ROCF would also transfer to performance improvement on copying and the recall of another complex figure. METHODS: Participants were 98 typically developing children (aged 9.5-12.6 years, M = 10.6). Children completed the ROCF (copy and recall) as a pretest...
April 5, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29609221/accuracy-of-medication-information-sources-compared-to-the-best-possible-medication-history-for-patients-presenting-to-the-emergency-department
#6
Hayley H Chen, Simone E Taylor, Andrew M Harding, David McD Taylor
OBJECTIVE: To assess the accuracy of medication information sources available for adult patients presenting to the ED, compared to a best possible medication history (BPMH). METHODS: This prospective observational study was undertaken in the ED of a major tertiary-referral teaching hospital. A convenience sample of consecutive adult patients taking one or more regular medications was included. A BPMH was ascertained using patient/carer interviews, where available, and confirmed with one or more other sources...
April 2, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29600621/-feasibility-study-of-qams-for-quantitative-analysis-of-multiple-structural-types-of-ingredients-in-atractylodis-rhizome-by-gc
#7
Wen-Ting Chen, Yang Chen, Bo Cui, Xiao-Qi Li, Yan-Hao Fan, Xin-Hong Wang, Rui An
In this study, quantitative analysis of multi-components with single marker(QAMS) was established and validated to simultaneously determine four sesquiterpenoids(β-eudesmol, atractylon, atractylolideⅠ, atractylolide Ⅱ) in Atractylodis Rhizome based on the gas chromatographic method(GC). Using β-eudesmol as the contrast, the relative correctionfactors(RCF) of the other three sesquiterpenoids were determined by GC. Within the line arranges,the values of RCF of β-eudesmol to atractylon, atractylolideⅠand atractylolide Ⅱ were 0...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29572752/development-of-a-smart-mobile-data-module-for-fetal-monitoring-in-e-healthcare
#8
Agathe Houzé de l'Aulnoit, Samuel Boudet, Michaël Génin, Pierre-François Gautier, Jessica Schiro, Denis Houzé de l'Aulnoit, Régis Beuscart
The fetal heart rate (FHR) is a marker of fetal well-being in utero (when monitoring maternal and/or fetal pathologies) and during labor. Here, we developed a smart mobile data module for the remote acquisition and transmission (via a Wi-Fi or 4G connection) of FHR recordings, together with a web-based viewer for displaying the FHR datasets on a computer, smartphone or tablet. In order to define the features required by users, we modelled the fetal monitoring procedure (in home and hospital settings) via semi-structured interviews with midwives and obstetricians...
March 23, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29564943/review-of-refractory-ceramic-fiber-rcf-toxicity-epidemiology-and-occupational-exposure
#9
L Daniel Maxim, Mark J Utell
This literature review on refractory ceramic fibers (RCF) summarizes relevant information on manufacturing, processing, applications, occupational exposure, toxicology and epidemiology studies. Rodent toxicology studies conducted in the 1980s showed that RCF caused fibrosis, lung cancer and mesothelioma. Interpretation of these studies was difficult for various reasons (e.g. overload in chronic inhalation bioassays), but spurred the development of a comprehensive product stewardship program under EPA and later OSHA oversight...
March 22, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29509050/a-low-speed-centrifugation-concept-leads-to-cell-accumulation-and-vascularization-of-solid-platelet-rich-fibrin-an-experimental-study-in-vivo
#10
Alica Kubesch, Mike Barbeck, Sarah Al-Maawi, Anna Orlowska, Patrick F Booms, Robert A Sader, Richard J Miron, Charles J Kirkpatrick, Joseph Choukroun, Shahram Ghanaati
Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the relative centrifugal force (RCF) and mildly increasing the centrifugation time, resulted in modified solid and liquid PRF-matrices with increased number of platelets, leukocytes, and growth factors' concentrations...
March 6, 2018: Platelets
https://www.readbyqxmd.com/read/29421383/latrunculin-b-and-substratum-stiffness-regulate-corneal-fibroblast-to-myofibroblast-transformation
#11
Sara M Thomasy, Vijay Krishna Raghunathan, Hidetaka Miyagi, Alexander T Evashenk, Jasmyne C Sermeno, Geneva K Tripp, Joshua T Morgan, Christopher J Murphy
The transformation of keratocytes and fibroblasts to myofibroblasts is important to corneal wound healing as well as formation of stromal haze. The purpose of this study was to determine the effect of latrunculin B, an actin cytoskeleton disruptor in conjunction with a fundamental biophysical cue, substrate stiffness, on myofibroblast transformation in vitro and in vivo. Rabbit corneal fibroblasts were cultured on substrates of differing compliance (1.5, 22, and 71 kPa) and tissue culture plastic (TCP; > 1 GPa) in media containing 0 or 10 ng/ml TGFβ1 for 72 h...
May 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29396481/conserved-dna-methylation-signatures-in-early-maternal-separation-and-in-twins-discordant-for-co-2-sensitivity
#12
Francesca Giannese, Alessandra Luchetti, Giulia Barbiera, Valentina Lampis, Claudio Zanettini, Gun Peggy Knudsen, Simona Scaini, Dejan Lazarevic, Davide Cittaro, Francesca R D'Amato, Marco Battaglia
Respiratory and emotional responses to blood-acidifying inhalation of CO2 are markers of some human anxiety disorders, and can be enhanced by repeatedly cross-fostering (RCF) mouse pups from their biological mother to unrelated lactating females. Yet, these dynamics remain poorly understood. We show RCF-associated intergenerational transmission of CO2 sensitivity in normally-reared mice descending from RCF-exposed females, and describe the accompanying alterations in brain DNA methylation patterns. These epigenetic signatures were compared to DNA methylation profiles of monozygotic twins discordant for emotional reactivity to a CO2 challenge...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29341858/respiratory-assessment-of-refractory-ceramic-fibers-in-a-heating-technician-population
#13
David Lucas, Vincent Clamagirand, Pascale Capellmann, Agnès Hervé, Gilles Mauguen, Yannik Le Mer, Dominique Jegaden
Refractory ceramic fibers (RCF) have been extensively used for insulation in condensing boilers. The aim of this study was to evaluate the respiratory exposure to these fibers among maintenance heating technicians. We first created a working group (Carsat Brittany and Finistère Occupational Health Services) and carried out a sampling strategy. Atmospheric measurements were done during work tasks, and filters were analyzed by phase contrast microscopy (PCM) and scanning electron microscopy (SEM) in French approved laboratories...
January 17, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29315669/guillain-barr%C3%A3-syndrome-subtype-diagnosis-a-prospective-multicentric-european-study
#14
Peter Y K Van den Bergh, Françoise Piéret, John L Woodard, Shahram Attarian, Aude-Marie Grapperon, Guillaume Nicolas, Marion Brisset, Julien Cassereau, Yusuf A Rajabally, Vinciane Van Parijs, Donatienne Verougstraete, Philippe Jacquerye, Jean-Marc Raymackers, Céline Redant, Claure Michel, Emilien Delmont
INTRODUCTION: There is uncertainty as to whether the Guillain-Barré syndrome (GBS) subtypes, acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), can be diagnosed electrophysiologically. METHODS: We prospectively included 58 GBS patients. Electrodiagnostic testing (EDX) was performed at means of 5 and 33 days after disease onset. Two traditional and one recent criteria sets were used to classify studies as demyelinating or axonal...
January 5, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29249067/detection-of-angiographically-significant-coronary-obstruction-using-resting-transthoracic-coronary-doppler-echocardiography
#15
Alberto Cozzarin, Gerardo Manuel Marambio, Daniel Ernesto Ferreiro, Maria Fernanda Gonda, Lorena Romina Balletti, Martin Hernán Medawar, Juan Alberto Gagliardi, Tomás Francisco Cianciulli
BACKGROUND: Transesophageal Doppler echocardiography has shown that significant stenosis can be detected based on the presence of aliasing with color Doppler in the stenotic area. The study aimed to assess the detection of angiographically significant coronary stenosis (ASCS) by analyzing the characteristics and velocities of resting coronary artery flow (RCF) using transthoracic coronary Doppler echocardiography (TCDE). METHODS: TCDE was performed before diagnostic coronary angiography (CA)...
December 16, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/29198225/a-pilot-study-exploring-staff-acceptability-of-a-socially-assistive-robot-in-a-residential-care-facility-that-accommodates-people-under-65-years-old
#16
Samantha M Loi, Alice Bennett, Marta Pearce, Khanh Nguyen, Nicola T Lautenschlager, Rajiv Khosla, Dennis Velakoulis
Socially assistive robots have successfully been trialed in residential care facilities (RCFs) for older adults. These robots may have potential for younger adults (i.e. under 65 years old) who also live in RCFs. However, it is important to investigate staff acceptability and ease-of-use of these robots. This pilot study used the Technology Acceptance Model to investigate how staff working in a specialized RCF for younger adults accept Betty, a socially assistive robot who was introduced in the facility for 12 weeks...
December 4, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29185815/2016-annual-report-of-the-american-association-of-poison-control-centers-national-poison-data-system-npds-34th-annual-report
#17
David D Gummin, James B Mowry, Daniel A Spyker, Daniel E Brooks, Michael O Fraser, William Banner
INTRODUCTION: This is the 34th Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of 1 January 2016, 55 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 9.50 [7.33, 14.6] (median [25%, 75%]) min, facilitating a near real-time national exposure and information database and surveillance system. METHODS: We analyzed the case data tabulating specific indices from NPDS...
December 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29146510/relative-contributions-of-the-midcarpal-and-radiocarpal-joints-to-dart-thrower-s-motion-at-the-wrist
#18
Patrick M Kane, Bryan G Vopat, P Kaveh Mansuripur, Michael P Gaspar, Scott W Wolfe, Joseph J Crisco, Christopher Got
PURPOSE: To identify the relative contributions of the radiocarpal (RC) and midcarpal (MC) joints to dart-thrower's motion (DTM) of the wrist. METHODS: Six cadaveric upper extremities were fixed to a custom-designed loading jig allowing for pure moment-rotation analysis in 24 different directions of wrist motion. Each specimen was tested in 3 states: intact, simulated radiocarpal fusion (sRCF) and simulated pancarpal fusion (sPCF). Moments of ± 1.5 Nm were applied at each of 24 directions for each state and the resulting wrist rotation recorded...
March 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29124996/a-30-year-mortality-and-respiratory-morbidity-study-of-refractory-ceramic-fiber-workers
#19
Grace LeMasters, James E Lockey, Timothy J Hilbert, Linda S Levin, Jeff W Burkle, Ralph Shipley, Charles Perme, Cristopher A Meyer, Carol H Rice
AIM: Report mortality (n = 1119), cancer incidence (n = 1207) and radiographic (n = 1451) findings from a 30-year investigation of current and former refractory ceramic fiber (RCF) workers. METHODS: Cause of death, health and work histories, radiographs and spirometry were collected. Mortality and cancer incidence were analyzed. Logistic regression analysis investigated the associations of latency and cumulative fiber exposure (CFE) on radiographic changes...
August 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29091588/the-incidence-of-the-different-sources-of-noise-on-the-uncertainty-in-radiochromic-film-dosimetry-using-single-channel-and-multichannel-methods
#20
Antonio González-López, Juan Antonio Vera-Sánchez, Carmen Ruiz-Morales
The influence of the various sources of noise on the uncertainty in radiochromic film (RCF) dosimetry using single channel and multichannel methods is investigated in this work. These sources of noise are extracted from pixel value (PV) readings and dose maps. Pieces of an RCF were each irradiated to different uniform doses, ranging from 0 to 1092 cGy. Then, the pieces were read at two resolutions (72 and 150 ppp) with two flatbed scanners: Epson 10000XL and Epson V800, representing two states of technology...
November 1, 2017: Physics in Medicine and Biology
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