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Andrew W Shih, Vinai C Bhagirath, Nancy M Heddle, Jason P Acker, Yang Liu, John W Eikelboom, Patricia C Liaw
Background. Whole blood donations in Canada are processed by either the red cell filtration (RCF) or whole blood filtration (WBF) methods, where leukoreduction is potentially delayed in WBF. Fresh WBF red blood cells (RBCs) have been associated with increased in-hospital mortality after transfusion. Cell-free DNA (cfDNA) is released by neutrophils prior to leukoreduction, degraded during RBC storage, and is associated with adverse patient outcomes. We explored cfDNA levels in RBCs prepared by RCF and WBF and different storage durations...
2016: Journal of Blood Transfusion
Mark Lucock, Emma Beckett, Charlotte Martin, Patrice Jones, John Furst, Zoe Yates, Nina G Jablonski, George Chaplin, Martin Veysey
OBJECTIVES: The purpose of this study was to examine whether UV exposure alters folate status according to C677T-MTHFR genotype, and to consider the relevance of this to human health and the evolutionary model of skin pigmentation. METHODS: Total Ozone Mapping Spectrometer (TOMS) satellite data were used to examine surface UV-irradiance, as a marker of UV exposure, in a large (n = 649) Australian cross-sectional study population. PCR/RFLP analysis was used to genotype C677T-MTHFR...
October 22, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
Rayna B Hirst, Kaitlyn R Young, Louise M Sodos, Robert E Wickham, Mitch Earleywine
INTRODUCTION: While many studies suggest that regular cannabis use leads to deficits in cognitive functioning, particularly in memory, few have measured effort put forth during testing, and none have examined this as a potential mediator. Both age of onset of regular cannabis use and frequency of use have been linked to increased risk of memory deficits. The present study sought to determine whether effort mediated the relationship between frequency or age of onset of cannabis use and learning and memory performance...
October 18, 2016: Journal of Clinical and Experimental Neuropsychology
Thom Vreven, Brian G Pierce, Tyler M Borrman, Zhiping Weng
We report the performance of our protein-protein docking pipeline, including the ZDOCK rigid-body docking algorithm, on 19 targets in CAPRI rounds 28-34. Following the docking step, we reranked the ZDOCK predictions using the IRAD scoring function, pruned redundant predictions, performed energy landscape analysis, and utilized our interface prediction approach RCF. In addition, we applied constraints to the search space based on biological information that we culled from the literature, which increased the chance of making a correct prediction...
October 7, 2016: Proteins
Katharina Roempler, Tobias Mueller, Lisa Juris, Mirjam Wissel, Milena Vukotic, Kay Hofmann, Markus Deckers
The mitochondrial electron transport chain (ETC) consists of individual protein complexes arranged into large macromolecular structures, termed respiratory chain supercomplexes or respirasomes. In the yeast Saccharomyces cerevisiae respiratory chain supercomplexes form by association of the bc1-complex with the cytochrome c oxidase. Formation and maintenance of these assemblies are promoted by specific respiratory supercomplex factors, the Rcf proteins. For these proteins a regulatory function in bridging the electron transfer within supercomplexes has been proposed...
September 23, 2016: Journal of Biological Chemistry
P Madhan Mohan, V Nagarajan, J C Vignesh
Due to increasing health consciousness among people, it is imperative to have low-cost health care devices to measure the vital parameters like heart rate and arterial oxygen saturation (SpO2). In this paper, an efficient heart rate monitoring algorithm based on the morphology of photoplethysmography (PPG) signals to measure the spot heart rate (HR) and its real-time implementation is proposed. The algorithm does pre-processing and detects the onsets and systolic peaks of the PPG signal to estimate the heart rate of the subject...
September 9, 2016: Journal of Medical Engineering & Technology
Rasike De Silva, Xungai Wang, Nolene Byrne
By blending cellulose and duck feather in the common solvent 1-allyl-3-methylimidazoloium chloride, a regenerated composite fibre has been developed with improved fibres over regenerated cellulose fibres (RCF). The mechanical properties of composite fibre was shown to be better than RCF with a 63.7% improvement in tensile strain. Here, we thoroughly characterise the composite fibre and show that the composite fibre has many advantages over RCFs both from a spinning perspective and as a regenerated fibre.
November 20, 2016: Carbohydrate Polymers
M B Fauzi, Y Lokanathan, B S Aminuddin, B H I Ruszymah, S R Chowdhury
Collagen is the most abundant extracellular matrix (ECM) protein in the human body, thus widely used in tissue engineering and subsequent clinical applications. This study aimed to extract collagen from ovine (Ovis aries) Achilles tendon (OTC), and to evaluate its physicochemical properties and its potential to fabricate thin film with collagen fibrils in a random or aligned orientation. Acid-solubilized protein was extracted from ovine Achilles tendon using 0.35M acetic acid, and 80% of extracted protein was measured as collagen...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
E Warchol-Celinska, M Gosk-Przybylek, J Harazny, E Binczyk, K Szymanek, K Hanus, K Jozwik-Plebanek, E Florczak, A Prejbisz, I Cendrowska-Demkow, P Dobrowolski, A Klisiewicz, I Kurkowska-Jastrzebska, B Blazejewska-Hyzorek, M Januszewicz, I Michalowska, J P Szaflik, R E Schmieder, J Szaflik, A Januszewicz
OBJECTIVE: To compare retinal microperfusion and arteriolal structure between patients with fibromuscular dysplasia (FMD) enrolled to the ARCADIA-POL registry and patients with essential hypertension (EHT). DESIGN AND METHOD: From the first 84 patients with confirmed FMD in any vascular bed enrolled in the ARCADIA-POL registry in 2015 (instituted on the basis of as Polish-French collaboration), we analyzed data regarding retinal microperfusion and arteriolar structure available from 70 patients (51F, 19 M, mean age: 41...
September 2016: Journal of Hypertension
S N Chen, M Gauthier, M Bazalova-Carter, S Bolanos, S Glenzer, R Riquier, G Revet, P Antici, A Morabito, A Propp, M Starodubtsev, J Fuchs
Radiochromic films (RCF) are commonly used in dosimetry for a wide range of radiation sources (electrons, protons, and photons) for medical, industrial, and scientific applications. They are multi-layered, which includes plastic substrate layers and sensitive layers that incorporate a radiation-sensitive dye. Quantitative dose can be retrieved by digitizing the film, provided that a prior calibration exists. Here, to calibrate the newly developed EBT3 and HDv2 RCFs from Gafchromic™, we used the Stanford Medical LINAC to deposit in the films various doses of 10 MeV photons, and by scanning the films using three independent EPSON Precision 2450 scanners, three independent EPSON V750 scanners, and two independent EPSON 11000XL scanners...
July 2016: Review of Scientific Instruments
Akiyo Matsumoto, Kaida Arita
BACKGROUND: The gold standard of rectal surgery is TME and DST anastomosis.1 (-) 6 The division of mesorectum in tumor-specific mesorectal and total mesorectal excisions is one of the most difficult procedures of anterior dissection. We have developed a laparoscopic-assisted anterior dissection technique using the simple Rectum Catcher device (RC) with an intraoperative colonoscopy (CF).7 (,) 8 METHODS: Surgical and oncological outcomes were compared between 99 patients undergoing a laparoscopic approach with the RC and a CF (RCF) and 104 patients undergoing the laparoscopic approach without the RC and without a CF (NRCF)...
November 2016: Annals of Surgical Oncology
Camilla Rydström Lundin, Christoph von Ballmoos, Martin Ott, Pia Ädelroth, Peter Brzezinski
The respiratory supercomplex factors (Rcf) 1 and 2 mediate supramolecular interactions between mitochondrial complexes III (ubiquinol-cytochrome c reductase; cyt. bc1) and IV (cytochrome c oxidase; CytcO). In addition, removal of these polypeptides results in decreased activity of CytcO, but not of cyt. bc1 In the present study, we have investigated the kinetics of ligand binding, the single-turnover reaction of CytcO with O2, and the linked cyt. bc1-CytcO quinol oxidation-oxygen-reduction activities in mitochondria in which Rcf1 or Rcf2 were removed genetically (strains rcf1Δ and rcf2Δ, respectively)...
August 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
Sina Stock, Michael Scharfschwerdt, Roza Meyer-Saraei, Doreen Richardt, Efstratios I Charitos, Hans-Hinrich Sievers, Thorsten Hanke
Background The transcatheter aortic valve-in-valve implantation (TAViVI) is an evolving treatment strategy for degenerated surgical aortic valve bioprostheses (SAVBs) in patients with high operative risk. Although hemodynamics is excellent, there is some concern regarding coronary obstruction, especially in SAVB with externally mounted leaflet tissue, such as the Trifecta (St. Jude Medical Inc., St. Paul, Minnesota, United States). We investigated coronary flow and hydrodynamics before and after TAViVI in a SAVB with externally mounted leaflet tissue (St...
June 15, 2016: Thoracic and Cardiovascular Surgeon
Feng M Sun, Guang Y Shi, Hui W Wang
Consumers prefer natural and healthy food, but artificial pigments are often abused in egg products. The study aimed at differentiating the origin of pigments in eggs by applying the technique of carbon ((13)C/(12)C) and nitrogen ((15)N/(14)N) stable isotope analysis. Five hundred sixty laying hens were randomly distributed into 14 treatments, which were divided into four groups: maize, carophyll red pigment, carophyll yellow pigment, and a mixture of carophyll red and yellow pigments. Eggs were collected and pretreated to determe the values of the Roche Yolk Color Fan (RCF), δ(13)C, and δ(15)N...
July 2016: Journal of AOAC International
Junlang Qiu, Guosheng Chen, Jianqiao Xu, Erlun Luo, Yan Liu, Fuxin Wang, Hong Zhou, Yuan Liu, Fang Zhu, Gangfeng Ouyang
An in vivo uptake and elimination tracing study based on solid phase microextraction (SPME) was conducted to investigate the accumulation, persistence and distribution of organochloride pesticides (OCPs) and organophosphorus pesticides (OPPs) in malabar spinach (Basella alba L.) plants. Uptake and elimination of the pesticides were traced in leaves, stems and roots of living malabar spinach plants. Root concentration factor (RCF), distribution concentration factor (DCF) and transpiration stream concentration factor (TSCF) were calculated based on the in vivo tracing data...
October 5, 2016: Journal of Hazardous Materials
Shaorui Wang, Yan Wang, Chunling Luo, Jun Li, Hua Yin, Gan Zhang
The concentrations and homolog patterns of halogenated flame retardants (HFRs) in vegetables grown at an e-waste contaminated site were investigated. Polybrominated diphenyl ethers (PBDEs) were the dominant HFRs in vegetable tissues, with concentrations ranging from 10.3 to 164 ng g(-1) and 1.16-107 ng g(-1) in shoots and roots, respectively, followed by novel brominated flame retardants (NBFRs) and dechlorane plus (DPs). This is an indication that PBDE contamination in vegetables grown around e-waste recycling sites may pose a risk to the local terrestrial ecosystem and residents...
July 2016: Environmental Pollution
Rcf Sinclair, M Navidi, S M Griffin, K Sumpter
Introduction Operable oesophagogastric adenocarcinoma management in the UK includes three cycles of neoadjuvant chemotherapy (NAC) followed by resection. Determination of oxygen uptake at the anaerobic threshold (AT) with cardiopulmonary exercise testing (CPET) is used to objectively measure cardiorespiratory reserve. Oxygen uptake at AT predicts perioperative risk, with low values associated with increased morbidity. Previous studies indicate NAC may have a detrimental impact on cardiorespiratory reserve. Methods CPET was completed by 30 patients before and after a standardised NAC protocol...
July 2016: Annals of the Royal College of Surgeons of England
Davide Cittaro, Valentina Lampis, Alessandra Luchetti, Roberto Coccurello, Alessandro Guffanti, Armando Felsani, Anna Moles, Elia Stupka, Francesca R D' Amato, Marco Battaglia
Hyperventilation following transient, CO2-induced acidosis is ubiquitous in mammals and heritable. In humans, respiratory and emotional hypersensitivity to CO2 marks separation anxiety and panic disorders, and is enhanced by early-life adversities. Mice exposed to the repeated cross-fostering paradigm (RCF) of interference with maternal environment show heightened separation anxiety and hyperventilation to 6% CO2-enriched air. Gene-environment interactions affect CO2 hypersensitivity in both humans and mice...
2016: Scientific Reports
Rakesh Gupta, Vinit Verma, Pankaj Mathur
Quitline activity in Rajasthan, India is a voluntary activity of Rajasthan Cancer Foundation (RCF) since April 2013. To kick-off, it took the benefit of the State Government- PIRAMAL SWASTHYA (PS)1 collaborative 104 Health Information Helpline that existed already in public-private partnership. It is a reactive quitline that helps callers through the counselors and nursing staff trained specifically through the weekly sessions held by the first author, the RCF resource on quitline. Besides structuring of the scripts for primary intervention and follow-ups after 1 week, 1 month, 6 months and a year, he also monitors calls, advices and coordinates with the supervisors to manage and analyze the data base, and reports to the PS lead at the Jaipur Center on overall performance and to plan strategic communication with the State Government on its outcomes...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Samuel D Towne, Jinmyoung Cho, Matthew Lee Smith, Marcia G Ory
OBJECTIVE: Despite a growing literature on the epidemiology of falls, little is known about injurious falls in residential care facilities (RCFs). Addressing this gap, this study examined demographic, interpersonal, institutional, and community factors associated with injurious falls in RCFs. METHOD: We conducted analyses using a nationally representative sample (n = 733,309) of RCF residents (2010) examining whether or not a resident experienced a fall that resulted in any injury (past year)...
April 22, 2016: Journal of Aging and Health
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