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https://www.readbyqxmd.com/read/28938678/the-response-of-the-oxford-classification-to-steroid-in-iga-nephropathy-a-systematic-review-and-meta-analysis
#1
Pingping Yang, Xi Chen, Lei Zeng, Hua Hao, Gaosi Xu
BACKGROUND: The present review is aimed to evaluate the correlation between pathological features and the response to steroid in the patients with IgA nephropathy according to the Oxford classification, mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental glomerulosclerosis (S), tubular atrophy and interstitial fibrosis (T). METHODS: We searched Chinese Biomedical Database, EMBASE, Cochrane Library, PubMed and MEDLINE with all spellings of "IgA nephropathy", "Oxford Classification", and "steroid"...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938651/positive-transcription-elongation-factor-b-p-tefb-is-a-therapeutic-target-in-human-multiple-myeloma
#2
Yu Zhang, Liang Zhou, Yun Leng, Yun Dai, Robert Z Orlowski, Steven Grant
The role of the positive RNA Pol II regulator, P-TEFb (positive transcription elongation factor b), in maintenance of the anti-apoptotic protein Mcl-1 and bortezomib (btz) resistance was investigated in human multiple myeloma (MM) cells. Mcl-1 was up-regulated in all MM lines tested, including bortezomib-resistant lines, human MM xenograft mouse models, and primary CD138(+) MM cells. Mcl-1 over-expression significantly reduced bortezomib lethality, indicating a functional role for Mcl-1 in bortezomib resistance...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938276/anesthesia-with-dexmedetomidine-and-low-dose-isoflurane-increases-solute-transport-via-the-glymphatic-pathway-in-rat-brain-when-compared-with-high-dose-isoflurane
#3
Helene Benveniste, Hedok Lee, Fengfei Ding, Qian Sun, Ehab Al-Bizri, Rany Makaryus, Stephen Probst, Maiken Nedergaard, Elliot A Stein, Hanbing Lu
BACKGROUND: The glymphatic pathway transports cerebrospinal fluid through the brain, thereby facilitating waste removal. A unique aspect of this pathway is that its function depends on the state of consciousness of the brain and is associated with norepinephrine activity. A current view is that all anesthetics will increase glymphatic transport by inducing unconsciousness. This view implies that the effect of anesthetics on glymphatic transport should be independent of their mechanism of action, as long as they induce unconsciousness...
September 22, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28937532/prevalence-risk-factors-and-characteristics-of-the-adding-on-phenomenon-in-idiopathic-scoliosis-after-correction-surgery-a-systematic-review-and-meta-analysis
#4
Mingyuan Yang, Yuechao Zhao, Xin Yin, Ziqiang Chen, Changwei Yang, Li Li, Ming Li
STUDY DESIGN: A systematic review and meta-analysis OBJECTIVE.: To discuss the prevalence, risk factors and characteristics of the 'adding-on' phenomenon in idiopathic scoliosis (IS). SUMMARY OF BACKGROUND DATA: There are controversies on the prevalence and risk factors of the 'adding-on' phenomenon. In addition, there is no comprehensive study to describe the characteristics of 'adding-on' in IS patients. METHODS: We performed a systematic online search using PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library to identify eligible studies...
September 20, 2017: Spine
https://www.readbyqxmd.com/read/28937484/diagnostic-accuracy-of-qualitative-and-quantitative-computed-tomography-analysis-for-diagnosis-of-pathological-grade-and-stage-in-upper-tract-urothelial-cell-carcinoma
#5
Suraj Mammen, Satheesh Krishna, Matthew Quon, Wael M Shabana, Shaheed W Hakim, Trevor A Flood, Nicola Schieda
OBJECTIVE: The aim of this study was to compare grade and stage of upper tract urothelial cell carcinoma (UCC) using computed tomography. MATERIALS AND METHODS: With institutional review board approval, 48 patients with 49 UCC (44 high grade and 5 low grade, 26 ≤ T1 and 23 ≥ T2) underwent nephroureterectomy and preoperative computed tomography between 2013 and 2015. Two blinded radiologists assessed for tumor appearance (filling defect/mass or wall thickening/stricture), margin (smooth or spiculated/irregular), texture (homogeneous, heterogeneous), hydronephrosis, and calcification...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937466/compressive-myelopathy-in-congenital-kyphosis-of-the-upper-thoracic-spine-a-retrospective-study-of-6-cases
#6
Zhengfeng Zhang, Honggang Wang, Wenjie Zheng
STUDY DESIGN: A retrospective study. OBJECTIVE: The goal of this retrospective study was to describe the uncommon presentation of neurological deficits in patients with congenital kyphosis of the upper thoracic spine (T1-T4). SUMMARY OF BACKGROUND DATA: Congenital kyphosis is an uncommon deformity but can potentially lead to spinal cord compression and paraplegia, particularly in type I (failure of formation) deformities. Few reports have described compressive myelopathy associated with congenital kyphosis of the upper thoracic spine...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937322/diffusion-tensor-imaging-reveals-morphological-alterations-of-the-lateral-pterygoid-muscle-in-patients-with-mandibular-asymmetry
#7
Enrico Nastro, Lilla Bonanno, Luciano Catalfamo, Michele Runci, Alessia Bramanti, Giuseppe Anastasi, Silvia Marino, Francesco Saverio De Ponte
OBJECTIVES: To evaluate non-invasively the morphological features of both lateral pterygoid (LPM) and masseter muscles by using Diffusion Tensor Imaging on two patients affected by mandibular asymmetry. METHODS: Two female patients with mandibular excess and asymmetry who underwent Le Fort I osteotomy and bilateral sagittal split osteotomy were recruited for this study. Morphological (T1-weighted) and diffusion weighted images were acquired with a 3T scanner one week before (T0) and one month after the surgery (T1)...
September 20, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28937288/pain-and-side-effects-associated-with-4-dimensional-hysterosalpingo-contrast-sonography-for-evaluating-of-the-fallopian-tubes-patency
#8
Hongbo Li, MeiMei Zhang, Ye Qiang, YunFei Ma, ShuXia Mao, Hao Zhang
4-Dimensional hysterosalpingo-contrast sonography (4 D HyCoSy) using SonoVue is regarded as a really good option available for evaluating fallopian tubal patency. This study was designed to assess the pain and adverse effects incurred by women undergoing 4 D HyCoSy. Through evaluating the pelvic pain immediately after 4 D HyCoSy and 30 min after 4 D HyCoSy, the circumstances of the pain relief was also observed. The predictive factors of pain were assessed simultaneously. 827 consecutive women as part of infertility evaluation were included...
September 22, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/28936607/time-of-flight-mr-angiography-in-cerebral-venous-sinus-thrombosis
#9
Dimitri Renard, Emmanuelle Le Bars, Caroline Arquizan, Nicolas Gaillard, Nicolas Menjot de Champfleur, Isabelle Mourand
Recently, time-of-flight (TOF) and gadolinium-enhanced MR angiography (MRA) imaging have been used to demonstrate subacute intramural hematoma in cervical artery dissection and to detect intraplaque haemorrhage. Our aim was to perform an exploratory study to analyse if venous thrombus-related signal changes (potentially showing iso- or hyperintensity) in cerebral venous sinus thrombosis (CVST) could be observed on 3D-TOF MRA imaging. We analysed retrospectively MRIs of CVST patients in whom both contrast-enhanced MR venography (CEMRV) and 3D-TOF sequences were performed in the acute/subacute phase (i...
September 21, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28936295/dentoskeletal-modifications-in-class-ii-deep-bite-malocclusion-treatment-with-anterior-bite-plane-functional-appliance
#10
Domenico Ciavarella, Michele Laurenziello, Laura Guida, Graziano Montaruli, Crescenzio Gallo, Michele Tepedino, Lorenzo Lo Muzio
BACKGROUND: A treatment modality for Class II division 1 malocclusion is discussed. Orthodontic treatment of patients with deep bite and Class II malocclusion is an important challenge in clinical practice. The aim of this work is to compare the efficacy of anterior bite plane functional appliance (ABPFA) by assessing the changes in different times with untreated patients by literature. MATERIAL AND METHODS: The study group comprised 22 subjects with Class II division 1 malocclusion and hypo-divergent...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28935762/effect-of-different-anesthetic-methods-on-cellular-immune-functioning-and-the-prognosis-of-patients-with-ovarian-cancer-undergoing-oophorectomy
#11
Xin-Rui Han, Xin Wen, Yan-Yi Li, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Xing-Feng Sun, Gui-Qi Geng, Shen Sun, Shao-Qiang Huang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aimed to explore the effects of different anesthetic methods on cellular immune function and prognosis of patients with ovarian cancer (OC) undergoing oophorectomy. A total of 167 patients who received general anesthesia (GA) treatment (GA group) and 154 patients who received combined general/epidural anesthesia (GEA) treatment (GEA group) were collected retrospectively. Each group selected 124 patients that met the inclusion and exclusion criteria for further study. ELISA and radioimmunoassay were employed to detect levels of IL-2, TNF-α and CA-125...
September 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28935625/topographic-diagnosis-of-craniopharyngiomas-the-accuracy-of-mri-findings-observed-on-conventional-t1-and-t2-images
#12
R Prieto, J M Pascual, L Barrios
BACKGROUND AND PURPOSE: The topography of craniopharyngiomas has proved fundamental in predicting the involvement of vital brain structures and the possibility of achieving a safe radical resection. Beyond the imprecise term "suprasellar," indiscriminately used for craniopharyngiomas, an accurate definition of craniopharyngioma topography should be assessed by preoperative MR imaging. The objective of this study was to investigate the MRI findings that help define craniopharyngioma topography...
September 21, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28935487/clinical-prognostic-factors-of-salivary-adenoid-cystic-carcinoma-a%C3%A2-single-center-analysis-of-61-patients
#13
Robert Cordesmeyer, Henning Schliephake, Philipp Kauffmann, Markus Tröltzsch, Rainer Laskawi, Philipp Ströbel, Felix Bremmer
PURPOSE: Adenoid cystic carcinomas are rare malignant tumors of the salivary glands. They are characterized by a high rate of local recurrence, late distant metastasis and a poor disease-free survival. In this study, we analyzed a series of 61 patients who were all treated at the University of Göttingen over a period of 21.0 years. MATERIALS AND METHODS: In all 61 patients with salivary adenoid cystic carcinoma, clinical data, demographic data, risk factors, tumor location, tumor stage, status of surgical margin, surgical treatment, postoperative radiotherapy and follow-up interval were assessed...
August 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28935460/myocardial-fibrosis-detected-by-magnetic-resonance-in-systemic-sclerosis-patients-relationship-with-biochemical-and-echocardiography-parameters
#14
Milan Hromádka, Jitka Seidlerová, David Suchý, Daniel Rajdl, Jan Lhotský, Jaroslav Ludvík, Richard Rokyta, Jan Baxa
OBJECTIVES: Systemic scleroderma (SSc) is a rare connective tissue disease presenting with fibrosis affecting skin and internal organs. Cardiovascular magnetic resonance (CMR) with quantification of extracellular volume (ECV) and T1 mapping might help to detect heart involvement. We aimed to evaluate whether myocardial involvement correlates with functional and laboratory parameters. METHODS: Thirty-three asymptomatic SSc patients (29 women, aged 56.6±12.2years) and 20 controls (10 women, 53...
September 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28934962/age-and-sex-corrected-normal-reference-values-of-t1-t2%C3%A2-t2-and-ecv-in-healthy-subjects-at-3t-cmr
#15
Clotilde Roy, Alisson Slimani, Christophe de Meester, Mihaela Amzulescu, Agnès Pasquet, David Vancraeynest, Jean-Louis Vanoverschelde, Anne-Catherine Pouleur, Bernhard L Gerber
BACKGROUND: Myocardial T1, T2 and T2* imaging techniques become increasingly used in clinical practice. While normal values for T1, T2 and T2* times are well established for 1.5 Tesla (T) cardiovascular magnetic resonance (CMR), data for 3T remain scarce. Therefore we sought to determine normal reference values relative to gender and age and day to day reproducibility for native T1, T2, T2* mapping and extracellular volume (ECV) at 3T in healthy subjects. METHODS: After careful exclusion of cardiovascular abnormality, 75 healthy subjects aged 20 to 90 years old (mean 56 ± 19 years, 47% women) underwent left-ventricular T1 (3-(3)-3-(3)-5 MOLLI)), T2 (8 echo- spin echo-imaging) and T2 * (8 echo gradient echo imaging) mapping at 3T CMR (Philips Ingenia 3T and computation of extracellular volume after administration of 0...
September 21, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28934866/initial-experience-with-synthetic-mri-of-the-knee-at-3t-comparison-with-conventional-t-1-weighted-imaging-and-t2-mapping
#16
Sunghoon Park, Kyu-Sung Kwack, Young Ju Lee, Sung-Min Gho, Hyun Young Lee
OBJECTIVE: To assess the feasibility and accuracy of synthetic magnetic resonance imaging (MRI) compared to conventional T1-weighted and multi-echo spin-echo (MESE) sequences for obtaining T2 values in the knee joint at 3 Tesla. METHODS: This retrospective study included 19 patients with normal findings in the knee joint who underwent both synthetic MRI and MESE pulse sequences for T2 quantification. T2 values of the two sequences at the articular cartilage, bone marrow, and muscle were measured...
September 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28934529/traveling-slow-oscillations-during-sleep-a-marker-of-brain-connectivity-in-childhood
#17
Salome Kurth, Brady A Riedner, Douglas C Dean, Jonathan O'Muircheartaigh, Reto Huber, Oskar G Jenni, Sean C L Deoni, Monique K LeBourgeois
Slow oscillations, a defining characteristic of the nonrapid eye movement sleep electroencephalogram (EEG), proliferate across the scalp in highly reproducible patterns. In adults, the propagation of slow oscillations is a recognized fingerprint of brain connectivity and excitability. In this study, we (1) describe for the first time maturational features of sleep slow oscillation propagation in children (n = 23; 2-13 years) using high-density (hd) EEG and (2) examine associations between sleep slow oscillatory propagation characteristics (ie, distance, traveling speed, cortical involvement) and white matter myelin microstructure as measured with multicomponent Driven Equilibrium Single Pulse Observation of T1 and T2-magnetic resonance imaging (mcDESPOT-MRI)...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28934137/evidence-for-involvement-of-il-9-and-il-22-in-cows-milk-allergy-in-infants
#18
Karina V Barros, Vera L Flor Silveira, Marisa S Laranjeira, Neusa F Wandalsen, Susana Passeti, Roberta de Oliveira, Regina V Munekata, Paul S Noakes, Elizabeth A Miles, Philip C Calder
Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20)...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28934001/imazethapyr-persistence-in-sandy-loam-detected-using-white-mustard-bioassay
#19
Katarina Jovanović-Radovanov
Field experiments were conducted during two years at Srem region to investigate the influence of meteorological conditions, time and rate of application on soil persistence of imazethapyr in sandy loam type of soil. Imazethapyr was applied PRE- and POST-EM and in both cases in three application rates: 80, 120 and 160 g a.i./ha. Soil samples were collected from the day of herbicide application in predetermined intervals up to one year after application and residual concentrations were determined with a white mustard root bioassay...
September 21, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28933918/pharmacokinetics-of-a-new-amphetamine-extended-release-oral-suspension-in-children-with-attention-deficit-hyperactivity-disorder
#20
Carolyn R Sikes, Russ L McMahen, Jeffrey G Stark, Dorothy Engelking
OBJECTIVE: An extended-release amphetamine (AMP) oral suspension has been developed to facilitate medication ingestion and dose titration. This study sought to determine the pharmacokinetic (PK) profile of this new formulation in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: This was an open-label, single-period, PK study in 29 pediatric participants with ADHD. Participants were stratified into age groups 1 (6-7 years), 2 (8-9 years), and 3 (10-12 years), and dosed with 15 mL extended-release AMP liquid suspension (equivalent to 30 mg mixed AMP salts) after an overnight fast...
September 21, 2017: Journal of Child and Adolescent Psychopharmacology
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