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https://www.readbyqxmd.com/read/28806856/direct-cell-labeling-to-image-transplanted-stem-cells-in-real-time-using-a-dual-contrast-mri-technique
#1
Ethel J Ngen, Yoshinori Kato, Dmitri Artemov
Exogenous direct cell labeling with superparamagnetic iron oxide nanoparticles (SPIONs) is currently the most employed cell-labeling technique for tracking transplanted cells using magnetic resonance imaging (MRI). Although SPION-based cell labeling is effective for monitoring cell delivery and migration, monitoring cell survival is still a challenge. This unit describes an MRI technique that permits detection of the delivery, migration, and death of transplanted cells. This dual-contrast technique involves labeling cells with two different classes of MRI contrast agents, possessing different diffusion coefficients: SPIONs (T2 /T2(*) contrast agents, with lower diffusion coefficients) and gadolinium chelates (T1 contrast agents, with higher diffusion coefficients)...
August 14, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/28806842/clowns-in-paediatric-surgery-less-anxiety-and-more-oxytocin-a-pilot-study
#2
Tabea Scheel, Dorothea Hoeppner, Anne Grotevendt, Winfried Barthlen
Background Hospital stays and medical interventions are accompanied by worries and anxiety in children and parents. Recent studies show that hospital clowns may reduce anxiety and enhance well-being. However, so far studies are based solely on subjective measures and clowns are usually not integrated in medical routine. With this pilot study, we aim to provide both psychological and physiological evidence of positive effects of clowns' interventions in hospitalized children. Patients/Method In a consecutive randomized intervention-control group design with 31 children aged 4 to 13 years, 17 patients were accompanied by a clown prior to surgery or during ward round (intervention group) and 14 were not (control group)...
August 14, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28806585/relationship-between-craving-and-plasma-leptin-concentrations-in-patients-with-cocaine-addiction
#3
Giovanni Martinotti, Chiara Montemitro, Gaia Baroni, Sara Andreoli, Flaminia Alimonti, Marco Di Nicola, Federico Tonioni, Lorenzo Leggio, Massimo di Giannantonio, Luigi Janiri
BACKGROUND: There is robust evidence indicating an overlap between neurobiological circuitry and pathways that regulate addictions and those that regulate appetite and food intake. Rodent work suggests a role of the appetitive peptide leptin in cocaine-seeking behaviours. The goal of this study was to investigate the possible relationship between plasma leptin concentrations and cocaine craving and use in patients seeking treatment for cocaine dependence. METHODS: Patients (N=43) with a DSM-IV diagnosis of cocaine dependence were studied before starting detoxification (baseline; T0) and then again 14days after (T1; only those patients who abstained from cocaine during the study)...
August 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28806257/orbital-hemangiopericytoma-in-68ga-prostate-specific-membrane-antigen-hbed-cc-pet-ct
#4
Jochen Hammes, Carsten Kobe, Ute Hilgenberg, Wolfgang E Lieb, Alexander Drzezga
A 76-year-old man with biochemical relapse of prostate cancer underwent Ga-prostate-specific membrane antigen PET/CT. Besides a local lymph node metastasis, a nodular structure inside the left orbit caudal to the optic nerve showed increased uptake. A metastasis in this location is unlikely. The subsequently performed MRI showed the structure being T1 hypointense, T2 indifferent, and strongly gadolinium contrast agent enhancing. Histopathologic examination after surgical removal identified the tumor as hemangiopericytoma, which rarely occurs in the orbit...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28806111/-effectiveness-of-mindfulness-based-cancer-recovery-mbcr-program-among-hungarian-cancer-patients
#5
Magda Rohánszky, Károly Berényi, Dóra Fridrik, Henriette Pusztafalvi
INTRODUCTION AND AIM: Employment of mindfulness-based programs and techniques in the treatment of cancer patients have spread exponentially in the past decade. A large number of studies have proved the effectiveness of the program in the reduction of stress symptoms, depression and anxiety, and the improvement of sleep and mood patterns. The present study was done at Firebird Foundation and examines the effectiveness of the complex, MBCR (mindfulness-based cancer recovery)-based psycho-social intervention in the treatment of cancer patients...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28805936/characterizing-hypoxia-in-human-glioma-a-simultaneous-multimodal-mri-and-pet-study
#6
Christine Preibisch, Kuangyu Shi, Anne Kluge, Mathias Lukas, Benedikt Wiestler, Jens Göttler, Jens Gempt, Florian Ringel, Mohamed Al Jaberi, Jürgen Schlegel, Bernhard Meyer, Claus Zimmer, Thomas Pyka, Stefan Förster
Hypoxia plays an important role for the prognosis and therapy response of cancer. Thus, hypoxia imaging would be a valuable tool for pre-therapeutic assessment of tumor malignancy. However, there is no standard validated technique for clinical application available yet. Therefore, we performed a study in 12 patients with high-grade glioma, where we directly compared the two currently most promising techniques, namely the MR-based relative oxygen extraction fraction (MR-rOEF) and the PET hypoxia marker H-1-(3-[(18) F]-fluoro-2-hydroxypropyl)-2-nitroimidazole ([(18) F]-FMISO)...
August 14, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28805609/efficacy-of-pet-ct-to-exclude-leiomyoma-in-patients-with-lesions-suspicious-for-uterine-sarcoma-on-mri
#7
Soshi Kusunoki, Yasuhisa Terao, Takafumi Ujihira, Kazunari Fujino, Hiroshi Kaneda, Miki Kimura, Tsuyoshi Ota, Satoru Takeda
OBJECTIVE: To analyze the efficacy of positron emission tomography/computed tomography (PET/CT) for the diagnosis of uterine sarcoma. MATERIALS AND METHODS: Thirty-four patients evaluated between January 2010 and March 2015 were retrospectively enrolled. All patients in whom uterine sarcoma was suspected based on contrast-enhanced magnetic resonance imaging (MRI) findings (heterogeneous, high signal intensity on T2-weighted images and/or high intensity on T1-weighted images) underwent PET/CT for further assessment...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28805546/air-pollution-is-associated-to-the-multiple-sclerosis-inflammatory-activity-as-measured-by-brain-mri
#8
Roberto Bergamaschi, Andrea Cortese, Anna Pichiecchio, Francesca Gigli Berzolari, Paola Borrelli, Giulia Mallucci, Valentina Bollati, Alfredo Romani, Guido Nosari, Silvia Villa, Cristina Montomoli
BACKGROUND: Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional factors might play a role. OBJECTIVE: To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters with diameter less than 10 μm (PM10). METHODS: We analyzed from 52 remitting MS patients 226 brain MRIs, 34% with (Gd+MRI) and 66% without (Gd-MRI) T1-Gd-enhancing lesions...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28805053/heterogeneous-photochemistry-of-agrochemicals-at-leaf-surface-a-case-study-of-plant-activator-acibenzolar-s-methyl
#9
Mohamad Sleiman, Pascal de Sainte Claire, Claire Richard
The photoreactivity of plant activator benzo-(1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) commonly named acibenzolar-S-methyl was studied on surfaces of glass, paraffinic wax films and apple leaves. Experiments were carried out in a solar simulator using pure and formulated BTH (BION®). Surface photoproducts were identified using liquid chromatography coupled with electrospray ionization and high resolution Orbitrap mass spectrometer, while volatile photoproducts were characterized using an online thermal desorption system coupled to gas chromatography-mass spectrometry (GC-MS)...
August 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28804918/low-rank-approximation-methods-for-mr-fingerprinting-with-large-scale-dictionaries
#10
Mingrui Yang, Dan Ma, Yun Jiang, Jesse Hamilton, Nicole Seiberlich, Mark A Griswold, Debra McGivney
PURPOSE: This work proposes new low rank approximation approaches with significant memory savings for large scale MR fingerprinting (MRF) problems. THEORY AND METHODS: We introduce a compressed MRF with randomized singular value decomposition method to significantly reduce the memory requirement for calculating a low rank approximation of large sized MRF dictionaries. We further relax this requirement by exploiting the structures of MRF dictionaries in the randomized singular value decomposition space and fitting them to low-degree polynomials to generate high resolution MRF parameter maps...
August 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28804643/local-staging-of-sigmoid-colon-cancer-using-mri
#11
Claus Dam, Jan Lindebjerg, Anders Jakobsen, Lars Henrik Jensen, Hans Rahr, Søren Rafael Rafaelsen
BACKGROUND: An accurate radiological staging of colon cancer is crucial to select patients who may benefit from neoadjuvant chemotherapy. PURPOSE: To evaluate the diagnostic accuracy of preoperative magnetic resonance imaging (MRI) in identifying locally advanced sigmoid colon cancer, poor prognostic factors, and the inter-observer variation of the tumor apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI). MATERIAL AND METHODS: Using 1...
July 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28804463/effect-of-oral-docosahexaenoic-acid-dha-supplementation-on-dha-levels-and-omega-3-index-in-red-blood-cell-membranes-of-breast-cancer-patients
#12
Alessio Molfino, Maria I Amabile, Sara Mazzucco, Gianni Biolo, Alessio Farcomeni, Cesarina Ramaccini, Simonetta Antonaroli, Massimo Monti, Maurizio Muscaritoli
Rationale: Docosahexaenoic acid (DHA) in cell membrane may influence breast cancer (BC) patients' prognosis, affecting tumor cells sensitivity to chemo- and radio-therapy and likely modulating inflammation. The possibility of identifying BC patients presenting with low DHA levels and/or low ability of DHA incorporation into cell membrane might help to treat this condition. Methods: We enrolled BC patients and healthy controls, recording their seafood dietary intake. DHA in form of algal oil was administered for 10 consecutive days (2 g/day)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28804390/relations-between-views-on-ageing-and-perceived-age-discrimination-a-domain-specific-perspective
#13
Peggy Voss, Julia K Wolff, Klaus Rothermund
This study investigates the relation between age stereotypes and perceived age discrimination. Existing evidence for such a relation is notoriously ambiguous with regard to its direction-age stereotypes can predict (perceived) discrimination, but experiencing discrimination may also change views on ageing-which is why we used a dataset with two waves to disentangle the direction of the associations. Considering research on the multi-dimensionality of views on ageing and perceived age discrimination, we addressed this question from a domain- and age group-specific perspective...
March 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28803352/breast-cancer-in-elderly-women-and-altered-clinico-pathological-characteristics-a-systematic-review
#14
REVIEW
M Lodi, L Scheer, N Reix, D Heitz, A-J Carin, N Thiébaut, K Neuberger, C Tomasetto, C Mathelin
PURPOSE: Breast cancer is the most common malignancy in women in terms of incidence and mortality. Age is undoubtedly the biggest breast cancer risk factor. In this study we examined clinical, histological, and biological characteristics and mortality of breast cancer in elderly women along with their changes with advancing age. METHODS: We reviewed 63 original articles published between 2006 and 2016 concerning women over 70 years with breast cancer. RESULTS: Compared to patients 70-79 years, patients aged 80 and over had larger tumor size with fewer T1 (42...
August 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28803247/potential-gender-related-aging-processes-occur-earlier-and-faster-in-the-vermis-of-patients-with-bipolar-disorder-an-mri-study
#15
Marta Serati, Giuseppe Delvecchio, Giulia Orsenigo, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, Alfredo Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: In the last decades, there has been increasing interest in investigating the role of the vermis in bipolar disorder (BD), especially because of its involvement in cognitive processes. The main aims of this study were to explore the integrity of the vermis and elucidate the role of demographic and clinical variables on vermis volumes in BD patients, stratified according to gender. METHODS: T1-weighted images were obtained for 38 BD patients and 38 healthy controls using a 1...
August 12, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28802959/a-combined-tract-based-spatial-statistics-and-voxel-based-morphometry-study-of-the-first-mri-scan-after-diagnosis-of-amyotrophic-lateral-sclerosis-with-subgroup-analysis
#16
A R Alruwaili, K Pannek, A Coulthard, R Henderson, N D Kurniawan, P McCombe
BACKGROUND AND PURPOSE: This study aims to compare the cortical and subcortical deep gray matter (GM) and white matter (WM) of ALS subjects and controls and to compare ALS subjects with (ALScog) and without (ALSnon-cog) cognitive impairment. MATERIALS AND METHODS: The study was performed in 30 ALS subjects, and 19 healthy controls. Structural T1- and diffusion-weighted MRI data were analyzed using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS)...
August 9, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28802891/time-to-second-line-treatment-and-subsequent-relative-survival-in-older-patients-with-relapsed-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#17
Eric M Ammann, Tait D Shanafelt, Melissa C Larson, Kara B Wright, Bradley D McDowell, Brian K Link, Elizabeth A Chrischilles
BACKGROUND: Novel targeted therapies offer excellent short-term outcomes in patients with chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL). However, there is disagreement over how widely these therapies should be used in place of standard chemo-immunotherapy (CIT). We investigated whether stratification on the length of the interval between first-line (T1) and second-line (T2) treatments could identify a subgroup of older patients with relapsed CLL/SLL with an expectation of normal overall survival, and for whom CIT could be an acceptable treatment choice...
July 19, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28802887/clinical-outcomes-of-patients-with-t1-nested-variant-of-urothelial-carcinoma-compared-to-pure-urothelial-carcinoma-of-the-bladder
#18
Abhijith D Mally, Amy L Tin, Justin K Lee, Prassannah Satasivam, Eugene K Cha, S Michele Donat, Harry W Herr, Bernard H Bochner, Daniel D Sjoberg, Guido Dalbagni
PURPOSE: Evaluate oncologic outcomes of patients with cT1 nested variant (NV) of urothelial carcinoma (UC) and compare with cases of pure UC of the bladder. MATERIALS AND METHODS: We retrospectively identified 30 patients with NV who, between 1997 and 2012, underwent transurethral resection with T1 tumor stage, followed by restaging transurethral resection within 3 months confirming non-muscle-invasive disease. Radical cystectomy within 3 months of restaging transurethral resection was considered "early" treatment...
July 14, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28802798/most-common-sites-on-mri-of-intracranial-neoplastic-leptomeningeal-disease
#19
J Matthew Debnam, Rory R Mayer, T Linda Chi, Leena Ketonen, Jeffrey S Weinberg, Wei Wei, Morris D Groves, Nandita Guha-Thakurta
Neoplastic leptomeningeal disease (LMD) represents infiltration of the leptomeninges by tumor cells. Knowledge of the frequencies of locations of LMD on MRI may assist in early detection, help elucidate the process of leptomeningeal spread of cancer and understand how LMD affects the central nervous system. Our goal was to identify intracranial sites of neoplastic LMD predilection on MRI in patients with cytologically-proven LMD. The presence of FLAIR signal hyperintensity and T1-weighted post-contrast enhancement in the sulci of the supratentorial compartment and cerebellum and enhancement of the cranial nerves (CNs), basal cisterns, pituitary stalk, and ependymal surface of the lateral ventricles, as well as the presence of parenchymal metastasis were recorded...
August 9, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28802729/predictors-of-pathologic-upstaging-in-early-esophageal-adenocarcinoma-results-from-the-national-cancer-database
#20
Craig S Brown, Natalie Gwilliam, Alex Kyrillos, Waseem Lutfi, Brittany Lapin, Ki Wan Kim, Seth B Krantz, John A Howington, Katherine Yao, Michael B Ujiki
BACKGROUND: Upstaging in early esophageal adenocarcinoma (EAC) patients happens at a high rate and has implications for treatment. We sought to identify risk factors predicting upstaging. STUDY DESIGN: The National Cancer Database (2010-2013) was queried for all patients with clinical T1/T2 and N0 EAC who underwent esophagectomy without neoadjuvant therapy. Logistic regression models were developed to investigate risk factors for upstaging. RESULTS: A total of 1120 patients were included...
July 18, 2017: American Journal of Surgery
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