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Dominique Silva Silveira, Luis Filipe Gomes Barbosa Ferreira Lemos, Rafael Miranda Tassitano, Maria Teresa Cattuzzo, Anderson Henry Pereira Feitoza, Luisa Maria Seara Moreira Carneiro Aires, Jorge Augusto Pinto Silva Mota, Clarice Maria de Lucena Martins
This study evaluated the effect of a multi-component intervention on motor performance (MP) and metabolic risk markers (MRM) in overweight/obese youth. A secondary aim was to examine whether changes in MP are associated to changes in MRM. A 3-month multi-component intervention was performed, consisting of physical exercise sessions (twice/week;1h), nutritional education sessions (once/month), and parental support (twice/week). The sample included 35 volunteers (7-13 y.o), allocated to intervention (INT, n = 17) and control (CONT, n = 18) group...
March 20, 2018: Journal of Sports Sciences
Jean-Marc Idée, Philippe Robert, Jean-Sébastien Raynaud, Marlène Rasschaert, Nathalie Fretellier, Cécile Factor, Claire Corot
No abstract text is available yet for this article.
April 2018: Radiology
Ga Ram Kim, Ji Soo Choi, Boo-Kyung Han, Jeong Eon Lee, Seok Jin Nam, Eun Young Ko, Eun Sook Ko, Se Kyung Lee
Purpose To evaluate the value of preoperative axillary ultrasonography (US) for preventing unnecessary axillary lymph node dissection after sentinel lymph node (SLN) biopsy in a large series of patients with early-stage breast cancers treated with both breast-conserving surgery and SLN biopsy. Materials and Methods From March 2009 to February 2013, 1802 patients who underwent breast-conserving surgery for clinical T1-2/N0 cancers and SLN biopsy with or without axillary lymph node dissection were included. Preoperative axillary US results and clinical-pathologic variables were compared according to the status of non-SLN metastasis...
March 20, 2018: Radiology
Laurie Cook, Michelle Tensley, Wm Tod Drost, Christopher Koivisto, Michael Oglesbee
A 4 yr old border collie presenting for mydriasis and decreased mentation and a 7 yr old Boston terrier presenting for obtundation, head tilt, and paraparesis were both evaluated using MRI. Findings in both included mass lesions of the thalamus and brainstem that were hypo- to isointense on T1-weighted images and hyperintense on T2-weighted images with regions of hypointensity, and robust contrast enhancement and displacement of adjacent structures. Postmortem histopathology findings, tumor location, and a mixed pattern of epithelial cell differentiation were consistent with germ cell tumor in both cases...
March 20, 2018: Journal of the American Animal Hospital Association
Marco Scardino, Tiziana D'Amato, Federica Martorelli, Giorgia Fenocchio, Vincenzo Simili, Berardo Di Matteo, Dario Bugada, Elizaveta Kon
BACKGROUND: Currently many TKA protocols rely on multimodal analgesic protocols with patient-controlled analgesia systems that administer opioids through a patient controlled IV infusion pump, in addition to concomitant peripheral nerve blocks and local anesthetics. Although effective, PCA IV opioids do not provide optimal results with fast track rehabilitation protocols. METHODS: The present is a retrospective study comparing the novel sublingual sufentanil PCA system (SSTS) to our standard of care foreseeing continuous femoral nerve block (cFNB) within a multimodal analgesic in a TKA fast-track protocol...
March 20, 2018: Journal of Experimental Orthopaedics
Chris Yin Wei Chan, Chee Kidd Chiu, Xin Yi Ler, Yun Hui Ng, Xue Han Chian, Pheng Hian Tan, Mun Keong Kwan
STUDY DESIGN: Retrospective study. OBJECTIVE: To investigate the association between postoperative upper instrumented vertebra (UIV) Tilt Angle with postoperative medial shoulder and neck imbalance. SUMMARY OF BACKGROUND DATA: Studies had found that current recommendations for UIV selection were not predictive of good postoperative shoulder balance. METHODS: 98 AIS patients with Lenke 1/2 curves who underwent posterior spinal fusion between 2013 and 2014 with minimum follow up of 2 years were recruited...
March 19, 2018: Spine
Valentina O Puntmann, Andreas M Zeiher, Eike Nagel
Myocarditis and its sequelae remain an unconquered clinical problem, disproportionately affecting the young. Several hurdles beset myocarditis, including nonspecific symptoms, heterogeneous clinical presentation, dynamic disease stages, underscored by an absence of an easy diagnostic test or a specific treatment. Areas covered: The current diagnostic means are poorly equipped to counter the challenge; the gold standard by invasive endomyocardial biopsy relies on availability of expert procedural and reading skill...
March 20, 2018: Expert Review of Cardiovascular Therapy
Xin Dai, Gayan Bowatte, Adrian J Lowe, Melanie C Matheson, Lyle C Gurrin, John A Burgess, Shyamali C Dharmage, Caroline J Lodge
PURPOSE OF REVIEW: Glutathione S-transferase (GST) genes are involved in oxidative stress management and may modify the impact of indoor air pollution. We aimed to assess the influence of GST genes on the relationship between indoor air pollution and allergy/lung function. RECENT FINDINGS: Our systematic review identified 22 eligible studies, with 15 supporting a gene-environment interaction. Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits...
March 20, 2018: Current Allergy and Asthma Reports
Qing Tu, Jianhui Gan, Jinlin Shi, Hong Yu, Shuangliang He, Jian Zhang
Transcutaneous electrical acupoint stimulation (TEAS) is an effective analgesic measure. We studied the analgesic effect of TEAS by applying it alone after ureteroscopic lithotripsy, rather than applying it as a supplementary analgesic measure. Participants (n = 120) scheduled to undergo ureteroscopic holmium laser lithotripsy, were enrolled and randomly assigned into Group T (TEAS n = 60) and Group C (Control, n = 60). The participants in Group T were treated with TEAS for postoperative analgesia...
March 20, 2018: Urolithiasis
Defne Alfandari, Chris Vriend, Dirk J Heslenfeld, Niek J Versfeld, Sophia E Kramer, Adriana A Zekveld
Speech comprehension depends on the successful operation of a network of brain regions. Processing of degraded speech is associated with different patterns of brain activity in comparison with that of high-quality speech. In this exploratory study, we studied whether processing degraded auditory input in daily life because of hearing impairment is associated with differences in brain volume. We compared T1-weighted structural magnetic resonance images of 17 hearing-impaired (HI) adults with those of 17 normal-hearing (NH) controls using a voxel-based morphometry analysis...
January 2018: Trends in Hearing
W Gregory Hundley
PURPOSE OF REVIEW: This article reviews the utility of cardiovascular magnetic resonance imaging (CMR) to detect abnormalities of the cardiovascular system that may result from cancer or its treatment. RECENT FINDINGS: With CMR, one may assess cardiac anatomy, function, myocardial perfusion, tissue composition, and blood flow. For those with cancer, these capabilities allow one to differentiate myocardial masses that may relate to the presence of cancer and evaluate diseases of the pericardium...
March 20, 2018: Current Treatment Options in Cardiovascular Medicine
Sumit S Sood, Christopher McClinton, Rajeev Badkul, Nathan Aguilera, Fen Wang, Allen M Chen
Purpose: The treatment of apical lung tumors with stereotactic body radiation therapy (SBRT) is challenging due to the proximity of the brachial plexus and the concern for nerve damage. Methods and materials: Between June 2009 and February 2017, a total of 75 consecutive patients underwent SBRT for T1-T3N0 non-small cell lung cancer involving the upper lobe of the lung. All patients were treated with 4-dimensional computed tomography (CT)-based image guided SBRT to a dose of 40 to 60 Gy in 3 to 5 fractions...
January 2018: Advances in Radiation Oncology
Günseli Kurt-Gür, Emel Ordu
NAD+ -dependent formate dehydrogenases (FDH, EC, providing energy to the cell in methylotrophic microorganisms, are stress proteins in higher plants and the level of FDH expression increases under several abiotic and biotic stress conditions. They are biotechnologically important enzymes in NAD(P)H regeneration as well as CO2 reduction. Here, the truncated form of the Gossypium hirsutum fdh1 cDNA was cloned into pQE-2 vector, and overexpressed in Escherichia coli DH5α-T1 cells. Recombinant GhFDH1 was purified 26...
March 2018: 3 Biotech
Liang Zhang, Danli Sheng, Dong Wang, Yuanzhi Yao, Ke Yang, Zhigang Wang, Liming Deng, Yu Chen
Background: The construction of theranostic nanosystems with concurrently high biosafety and therapeutic performance is a challenge but has great significance for the clinical translation of nanomedicine for combating cancer. Methods: Bio-inspired melanin-based nanoliposomes (Lip-Mel) as theranostic agents were constructed for simultaneous photoacoustic (PA) imaging- and T1 -weighted magnetic resonance (MR) imaging-guided photothermal ablation of tumors, which was demonstrated both in vitro and in vivo . The high biosafety of Lip-Mel was also systematically evaluated...
2018: Theranostics
Joshua J Todd, Muslima S Razaqyar, Jessica W Witherspoon, Tokunbor A Lawal, Ami Mankodi, Irene C Chrismer, Carolyn Allen, Mary D Meyer, Anna Kuo, Monique S Shelton, Kim Amburgey, Dmitriy Niyazov, Pierre Fequiere, Carsten G Bönnemann, James J Dowling, Katherine G Meilleur
The ryanodine receptor 1-related congenital myopathies ( RYR1 -RM) comprise a spectrum of slow, rare neuromuscular diseases. Affected individuals present with a mild-to-severe symptomatology ranging from proximal muscle weakness, hypotonia and joint contractures to scoliosis, ophthalmoplegia, and respiratory involvement. Although there is currently no FDA-approved treatment for RYR1- RM, our group recently conducted the first clinical trial in this patient population (NCT02362425). This study aimed to characterize novel RYR1 variants with regard to genetic, laboratory, muscle magnetic resonance imaging (MRI), and clinical findings...
2018: Frontiers in Neurology
Yoshiko Ariji, Hisataka Kondo, Ken Miyazawa, Masako Tabuchi, Syuji Koyama, Yoshitaka Kise, Akifumi Togari, Shigemi Gotoh, Eiichiro Ariji
OBJECTIVES: An animal experiment clarified that insertion of an orthodontic apparatus activated the trigeminal neurons of the medulla oblongata. Orthodontic tooth movement is known to be associated with the sympathetic nervous system and controlled by the nucleus of the hypothalamus. However, the transmission of both has not been demonstrated in humans. The purpose of this study were to examine the activated cerebral areas using brain functional magnetic resonance imaging (MRI), when orthodontic tooth separators were inserted, and to confirm the possibility of the transmission route from the medulla oblongata to the hypothalamus...
March 15, 2018: International Journal of Oral Science
Chad A Glenn, Cordell M Baker, Andrew K Conner, Josh D Burks, Phillip A Bonney, Robert G Briggs, Adam D Smitherman, James D Battiste, Michael E Sughrue
BACKGROUND: Resection of the T1 contrast-enhancing portion of glioblastoma has been shown to increase patient survival though it is not well-known if GBM resection beyond these boundaries has an additional survival benefit. OBJECTIVE: In this study, we examined the effect of resecting the enhancement and a margin of brain tissue surrounding the enhancement in patients with glioblastoma of the temporal lobe. METHODS: We identified 32 consecutive patients with temporal lobe glioblastoma who underwent initial resection between 2012 and 2015...
March 16, 2018: World Neurosurgery
Conor Owens-Walton, David Jakabek, Xiaozhen Li, Fiona A Wilkes, Mark Walterfang, Dennis Velakoulis, Danielle van Westen, Jeffrey C L Looi, Oskar Hansson
We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls...
March 7, 2018: Psychiatry Research
Giovanni Cirillo, Vincenzo Todisco, Gioacchino Tedeschi
OBJECTIVE: To assess the long-term effects of subcutaneous immunoglobulin (SCIg) on neurophysiological and clinical parameters in patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). METHODS: 16 drug-naïve CIDP patients, fulfilling the clinical and neurophysiological criteria for typical CIDP, were treated with one cycle of intravenous immunoglobulin (IVIg) (0.4 g/kg/day for 5 consecutive days) and then shifted to the subcutaneous treatment (SCIg) (0...
February 19, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Louis Ross, Ahsan M Naduvil, Juan C Bulacio, Imad M Najm, Jorge A Gonzalez-Martinez
BACKGROUND: Laser ablation surgery has had encouraging results in the treatment of multiple intracranial diseases including primary and metastatic brain tumors, radiation necrosis, and epilepsy. The use of the stereoelectroencephalography (SEEG) method in combination with laser thermocoagulation therapy with the goal of modulating epileptic networks in patients with neocortical nonlesional phamacoresistant epilepsy has not been previously described. OBJECTIVE: To describe the novel methodological and conceptual aspects related to SEEG-guided laser ablations in patients with magnetic resonance imaging (MRI)-negative pharmacoresistant neocortical focal epilepsy...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
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