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https://www.readbyqxmd.com/read/29783661/analysis-of-short-term-smoking-effects-in-pbmc-of-healthy-subjects-preliminary-study
#1
Joanna Wieczfinska, Tomasz Kowalczyk, Przemyslaw Sitarek, Ewa Skała, Rafal Pawliczak
Early structural changes exist in the small airways before the establishment of Chronic Obstructive Pulmonary Disease (COPD). These changes are believed to be induced by oxidation. The aim of this study was to analyze the influence of short-term smoking on the expression of the genes contributing to airway remodeling and their relationship with the oxidative status of human blood cells. Blood mononuclear cells were isolated from 16 healthy volunteers and treated with cigarette smoke ingredients (CSI): nicotine, 1-Nitrosodimethylamine, N-Nitrosopyrrolidyne, vinyl chloride, acetone, and acrolein...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29775222/abca1-inhibits-pdgf-induced-proliferation-and-migration-of-rat-airway-smooth-muscle-cell-through-blocking-tlr2-nf-%C3%AE%C2%BAb-nfatc1-signaling
#2
Wei Cheng, Kun Yan, Yanni Chen, Wen Zhang, Zongzheng Ji, Chengxue Dang
Airway remodeling is a key feature of asthma, characterized by abnormal proliferation and migration of airway smooth muscle cells (ASMCs). ABCA1, a member of the ATP-binding cassette family of active transporters, plays an essential role in the progression of lung diseases. However, the contributions of ABCA1 in ASMCs remain to be explored. The purpose of the present study was to investigate the functional role and potential molecular mechanism of ABCA1 in platelet derived growth factor (PDGF)-induced primary rat ASMC proliferation and migration...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29766674/assessment-of-airway-inflammation-and-remodeling-in-children-with-severe-asthma-the-next-challenge
#3
EDITORIAL
Guillaume Lezmi, Jacques de Blic
No abstract text is available yet for this article.
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29765214/tiotropium-inhibits-methacholine-induced-extracellular-matrix-production-via-%C3%AE-catenin-signaling-in-human-airway-smooth-muscle-cells
#4
Yating Huo, Lili Guan, Jiawen Xu, Luqian Zhou, Rongchang Chen
Background: Airway remodeling is an important feature of chronic obstructive pulmonary disease (COPD) that is associated with disease severity and irreversible airflow limitation. An extensive alteration of the extracellular matrix (ECM) surrounding the airway smooth muscle (ASM) bundle is one of the pathological manifestations of airway remodeling, which contributes to the decline in lung function. Tiotropium, a long-acting inhaled muscarinic receptor antagonist, has been confirmed to play a role in preventing airway remodeling including ECM deposition beyond bronchodilation in vivo, but the relationship between ASM cell (ASMC) relaxation and ECM production remains unclear...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29758289/exposure-to-a-combination-of-formaldehyde-and-dinp-aggravated-asthma-like-pathology-through-oxidative-stress-and-nf-%C3%AE%C2%BAb-activation
#5
Jun Kang, Jiufei Duan, Jing Song, Chen Luo, Hong Liu, Baizhan Li, Xu Yang, Wei Yu, Mingqing Chen
Several epidemiological and experimental studies indicate a positive association between exposure to formaldehyde or phthalates and allergic asthma. However, nothing is yet known about the effects of exposure to formaldehyde and phthalates together, nor the role of each on allergic asthma. Here, we investigated the effects of a combined exposure to formaldehyde and diisononyl phthalate (DINP) on asthma-like pathology in mice, and determined the underlying mechanisms implicated in NF-κB and ROS. Mice were exposed to formaldehyde and/or DINP and sensitization with OVA...
May 11, 2018: Toxicology
https://www.readbyqxmd.com/read/29745796/mechanical-properties-of-the-airway-tree-heterogeneous-and-anisotropic-pseudoelastic-and-viscoelastic-tissue-responses
#6
Mona Eskandari, Alberto Leyva Arvayo, Marc Elliot Levenston
Airway obstruction and pulmonary mechanics remain understudied despite lung disease being the third cause of death in the United States. Lack of relevant data has lead computational pulmonary models to infer mechanical properties from available material data for the trachea. Additionally, the time-dependent, viscoelastic behaviors of airways have been largely overlooked, despite the potential physiologic relevance and utility as metrics of tissue remodeling and disease progression. Here we address the clear need for airway-specific material characterization to inform biophysical studies of the bronchial tree...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29743070/the-anti-proliferative-and-anti-inflammatory-response-of-copd-airway-smooth-muscle-cells-to-hydrogen-sulfide
#7
Mark M Perry, Bernadett Tildy, Alberto Papi, Paolo Casolari, Gaetano Caramori, Karen Limbert Rempel, Andrew J Halayko, Ian Adcock, Kian Fan Chung
BACKBROUND: COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway smooth muscle (ASM). We have previously demonstrated that hydrogen sulfide (H2 S) can inhibit ASM cell proliferation and CXCL8 release, from cells isolated from non-smokers. METHODS: We examined the effect of H2 S upon ASM cells from COPD patients...
May 9, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29729549/targeting-arginase-and-nitric-oxide-metabolism-in-chronic-airway-diseases-and-their-co-morbidities
#8
REVIEW
Mariska Pm van den Berg, Herman Meurs, Reinoud Gosens
In the airways, arginase and NOS compete for the common substrate l-arginine. In chronic airway diseases, such as asthma and COPD, elevated arginase expression contributes to airway contractility, hyperresponsiveness, inflammation and remodeling. The disrupted l-arginine homeostasis, through changes in arginase and NOS expression and activity, does not only play a central role in the development of various airways diseases such as asthma or COPD. It possibly also affects l-arginine homeostasis throughout the body contributing to the emergence of co-morbidities...
May 2, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29729496/progressive-increase-in-allergen-concentration-abrogates-immune-tolerance-in-ovalbumin-induced-murine-model-of-chronic-asthma
#9
Gurupreet S Sethi, Amarjit S Naura
Persistent inflammation and remodeling of airways are the major hallmarks of asthma. Though airway inflammation diminishes in ovalbumin (OVA)-based mouse model of chronic asthma owing to immune-tolerance linked with repeated allergen exposure, which limits the application of the disease model. Accordingly, the present study was designed to develop a murine model of chronic asthma which presents persistent airway inflammation coupled with remodeling traits. Herein, OVA-sensitized BALB/c mice were challenged with increasing (modified protocol) or constant concentration (conventional protocol) of the allergen for 6 weeks; 3 times/week...
May 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29729200/reduction-in-polyamine-catabolism-leads-to-spermine-mediated-airway-epithelial-injury-and-induces-asthma-features
#10
Vaibhav Jain, Shikha Raina, Atish Prabhakar Gheware, Rita Singh, Rakhshinda Rehman, Vinny Negi, Tracy Murray Stewart, Ulaganathan Mabalirajan, Adarsh Kumar Mishra, Robert A Casero, Anurag Agrawal, Balaram Ghosh
BACKGROUND: Airway epithelial injury is a crucial component of acute and severe asthma pathogenesis and a promising target for treatment of refractory asthma. However, the underlying mechanism of epithelial injury remains poorly explored. Though high levels of polyamines, mainly spermine, have been found in asthma and co-morbidity, their role in airway epithelial injury and the cause of their altered levels in asthma has not been explored. METHODS: We measured key polyamine metabolic enzymes in lung samples from normal and asthmatic subjects and in mice with OVA-induced allergic airway inflammation (AAI)...
May 5, 2018: Allergy
https://www.readbyqxmd.com/read/29728628/chronic-features-of-allergic-asthma-are-enhanced-in-the-absence-of-resistin-like-molecule-beta
#11
Kim S LeMessurier, Maneesha Palipane, Meenakshi Tiwary, Brian Gavin, Amali E Samarasinghe
Asthma is characterized by inflammation and architectural changes in the lungs. A number of immune cells and mediators are recognized as initiators of asthma, although therapeutics based on these are not always effective. The multifaceted nature of this syndrome necessitate continued exploration of immunomodulators that may play a role in pathogenesis. We investigated the role of resistin-like molecule-beta (RELM-β), a gut antibacterial, in the development and pathogenesis of Aspergillus-induced allergic airways disease...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29722559/mir-142-3p-is-associated-with-aberrant-wingless-integrase-i-wnt-signaling-during-airway-remodeling-in-asthma
#12
Sabine Bartel, Gianni Carraro, Francesca Alessandrini, Susanne Krauss-Etschmann, Fabio L M Ricciardolo, Saverio Bellusci
BACKGROUND: Asthma is characterized by a chronic inflammation and remodeling of the airways. While inflammation can be controlled, therapeutic options to revert remodeling do not exist. Thus, there is a large and unmet need to understand the underlying molecular mechanisms in order to develop novel therapies. OBJECTIVE: we previously identified a pivotal role for miR-142-3p in regulating airway smooth muscle precursor (ASM) cell proliferation during lung development by fine-tuning the Wingless/Integrase I (WNT) signaling...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29720689/a-4-week-model-of-house-dust-mite-hdm-induced-allergic-airways-inflammation-with-airway-remodeling
#13
L N Woo, W Y Guo, X Wang, A Young, S Salehi, A Hin, Y Zhang, J A Scott, C W Chow
Animal models of allergic airways inflammation are useful tools in studying the pathogenesis of asthma and potential therapeutic interventions. The different allergic airways inflammation models available to date employ varying doses, frequency, duration and types of allergen, which lead to the development of different features of asthma; showing varying degrees of airways inflammation and hyper-responsiveness (AHR) and airways remodeling. Models that also exhibit airway remodeling, a key feature of asthma, in addition to AHR and airway inflammation typically require 5-12 weeks to develop...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29715518/methacholine-induces-extracellular-matrix-production-by-human-airway-smooth-muscle-cells-through-%C3%AE-catenin-signaling
#14
Yating Huo, Jiawen Xu, Lili Guan, Weiliang Wu, Bingpeng Guo, Yuqiong Yang, Lin Lin, Yonger Ou, Fangfang Jiang, Luqian Zhou, Rongchang Chen
Altered extracellular matrix (ECM) production by airway smooth muscle cells (ASMCs) is an important feature of airway remodeling. Muscarinic receptor agonists contribute to ECM production in vivo, but the mechanisms involved remain unclear. This study attempted to investigate the role of methacholine in promoting ECM production by human ASMCs (HASMCs) and the underlying mechanism. We found that methacholine induced the expression of collagen I protein and multiple ECM genes. β-catenin signaling was activated in this process upon GSK3β phosphorylation, leading to upregulation of total and active β-catenin...
April 28, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29707330/aberrant-epithelial-remodeling-with-impairment-of-cilia-architecture-in-non-cystic-fibrosis-bronchiectasis
#15
Zhuang-Gui Chen, Ying-Ying Li, Zhao-Ni Wang, Ming Li, Hui-Fang Lim, Yu-Qi Zhou, Liang-Ming Cai, Ya-Ting Li, Li-Fen Yang, Tian-Tuo Zhang, De-Yun Wang
Background: Aberrant epithelial remodeling and/or abnormalities in mucociliary apparatus in airway epithelium contribute to infection and inflammation. It is uncertain if these changes occur in both large and small airways in non-cystic fibrosis bronchiectasis (non-CF bronchiectasis). In this study, we aim to investigate the histopathology and inflammatory profile in the epithelium of bronchi and bronchioles in bronchiectasis. Methods: Excised lung tissue sections from 52 patients with non-CF bronchiectasis were stained with specific cellular markers and analyzed by immunohistochemistry and immunofluorescence to assess the epithelial structures, including ciliated cells and goblet cells morphology...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29697285/grading-severity-of-productive-cough-based-on-symptoms-and-airflow-obstruction
#16
Rodrigo Vazquez Guillamet, Hans Petersen, Paula Meek, Akshay Sood, Yohannes Tesfaigzi
The binary approach to the diagnosis of Chronic Bronchitis (CB) is a major barrier to the study of the disease. We investigated whether severity of productive cough can be graded using symptoms and presence of fixed airflow obstruction (FAO), and whether the severity correlates with health status, exposures injurious to the lung, biomarkers of inflammation, and measures of airway wall thickening. Findings from a cross-sectional sample of 1,422 participants from the Lovelace Smokers Cohort (LSC) were validated in 4,488 participants from the COPDGene cohort (COPDGene)...
April 26, 2018: COPD
https://www.readbyqxmd.com/read/29692536/performance-of-quantitative-ct-parameters-in-assessment-of-disease-severity-in-copd-a-prospective-study
#17
Ishan Kumar, Ashish Verma, Avinash Jain, S K Agarwal
Background: Both emphysematous destruction of lung parenchyma and airway remodeling is thought to contribute to airflow limitation in cases of chronic obstructive pulmonary disease (COPD). Objective: To evaluate the value of quantitative computed tomography (QCT) parameters of emphysema and airway disease with disease severity in patients with COPD. Materials and Methods: We prospectively studied 50 patients with COPD, which included nonsmokers and patients with different degrees of cumulative smoking exposure...
January 2018: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29686745/low-level-laser-therapy-reduces-lung-inflammation-in-an-experimental-model-of-chronic-obstructive-pulmonary-disease-involving-p2x7-receptor
#18
Gabriel da Cunha Moraes, Luana Beatriz Vitoretti, Auriléia Aparecida de Brito, Cintia Estefano Alves, Nicole Cristine Rigonato de Oliveira, Alana Dos Santos Dias, Yves Silva Teles Matos, Manoel Carneiro Oliveira-Junior, Luis Vicente Franco Oliveira, Renata Kelly da Palma, Larissa Carbonera Candeo, Adriana Lino-Dos-Santos-Franco, Anna Carolina Ratto Tempestine Horliana, João Antonio Gimenes Júnior, Flavio Aimbire, Rodolfo Paula Vieira, Ana Paula Ligeiro-de-Oliveira
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29680290/estrogen-receptor-beta-signaling-inhibits-pdgf-induced-human-airway-smooth-muscle-proliferation
#19
Nilesh Sudhakar Ambhore, Rathnavali Katragadda, Rama Satyanarayana Raju Kalidhindi, Michael A Thompson, Christina M Pabelick, Y S Prakash, Sathish Venkatachalem
Airway smooth muscle (ASM) cell hyperplasia driven by persistent inflammation is a hallmark feature of remodeling in asthma. Sex steroid signaling in the lungs is of considerable interest, given epidemiological data showing more asthma in pre-menopausal women and aging men. Our previous studies demonstrated that estrogen receptor (ER) expression increases in asthmatic human ASM; however, very limited data are available regarding differential roles of ERα vs. ERβ isoforms in human ASM cell proliferation. In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved...
April 19, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29678746/thirdhand-smoke-component-can-exacerbate-a-mouse-asthma-model-via-mast-cells
#20
Mang Yu, Kaori Mukai, Mindy Tsai, Stephen J Galli
BACKGROUND: Thirdhand smoke (THS) represents the accumulation of secondhand smoke on indoor surfaces and in dust, which, over time, can become more toxic than secondhand smoke. Although it is well known that children of smokers are at increased risk for developing asthma and for exacerbation of that disease if they already have it, how exposure to THS may influence the development or exacerbation of asthma remains unknown. OBJECTIVE: We investigated whether epicutaneous exposure to an important component of THS, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), can influence asthma pathology in a model elicited in mice by repeated intranasal challenge with cockroach antigen (CRA)...
April 17, 2018: Journal of Allergy and Clinical Immunology
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