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https://www.readbyqxmd.com/read/28723642/suppression-of-microrna-384-enhances-autophagy-of-airway-smooth-muscle-cells-in-asthmatic-mouse
#1
Zhe Cheng, Xi Wang, Lingling Dai, Liuqun Jia, Xiaogang Jing, Ying Liu, Huan Wang, Pengfei Li, Lin An, Meng Liu
Injury to airway smooth muscle (ASM) cells hallmarks the pathological progression of asthma, a chronic inflammatory airway disease. MicroRNAs (miRNAs) play essential roles in the development of asthma as well as airway remodeling. Here we studied the involvement of miRNAs in the regulation of autophagic survival of ASM cells and airway disorder. We analyzed autophagy-associated factors LC3 and Beclin-1 by RT-qPCR and protein blotting in purified airway smooth muscle cells from ovalbumin (OVA)-induced asthmatic mice...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723225/preferential-generation-of-15-hete-pe-induced-by-il-13-regulates-goblet-cell-differentiation-in-human-airway-epithelial-cells
#2
Jinming Zhao, Yoshinori Minami, Emily Etling, John M Coleman, Sarah N Lauder, Victoria Tyrrell, Maceler Aldrovandi, Valerie O'Donnell, Hans-Erik Claesson, Valerian Kagan, Sally Wenzel
RATIONALE: Type-2-associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase (15LO1) is induced by the Type-2 cytokines/IL-13 in human airway epithelial cells (HAEC) in vitro and is increased in fresh asthmatic HAECs ex vivo. 15LO1 generates a variety of products, including 15-hydroxyeicosatetraenoic acid (15-HETE), 15-HETE-phosphatidyethanoloamine (PE) (15-HETE-PE) and 13-hydroxyoctadecadienoic acid (13-HODE). The current study investigated the 15LO1 metabolite profile at baseline and after IL-13 treatment, and the influence on goblet cell differentiation in HAECs...
July 19, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28714611/mapping-targetable-inflammation-and-outcomes-with-cystic-fibrosis-biomarkers
#3
Olivia Giddings, Charles R Esther
Cystic fibrosis is characterized by an overly exuberant neutrophilic inflammatory response to pathogens and other stimuli that starts very early in disease. The overwhelming nature of this response is a primary cause of remodeling and destruction of the airways, suggesting that anti-inflammatory therapies could be beneficial in CF. However, finding therapies that can effectively reduce the inflammatory response without compromising host defenses remains elusive. New approaches towards mapping inflammatory targets promise to aid in developing novel therapeutic strategies and improve outcomes in individuals with CF...
July 17, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28713812/the-biology-of-eosinophils-and-their-role-in-asthma
#4
REVIEW
Claire N McBrien, Andrew Menzies-Gow
This review will describe the structure and function of the eosinophil. The roles of several relevant cell surface molecules and receptors will be discussed. We will also explore the systemic and local processes triggering eosinophil differentiation, maturation, and migration to the lungs in asthma, as well as the cytokine-mediated pathways that result in eosinophil activation and degranulation, i.e., the release of multiple pro-inflammatory substances from eosinophil-specific granules, including cationic proteins, cytokines, chemokines growth factors, and enzymes...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28713373/15-deoxy-delta-12-14-prostaglandin-j2-inhibits-lung-inflammation-and-remodeling-in-distinct-murine-models-of-asthma
#5
Diego S Coutinho, Edna A Anjos-Valotta, Caio V M F do Nascimento, Ana Lucia A Pires, Marcelo H Napimoga, Vinícius F Carvalho, Rafael C Torres, Patrícia M R E Silva, Marco A Martins
15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ2 based on distinct murine models of allergic asthma triggered by either ovalbumin (OVA) or house dust mite extract (HDM). Characteristics of lung inflammation, airway hyper-reactivity (AHR), mucus exacerbation, and lung remodeling in sensitized A/J mice treated or not with 15d-PGJ2 were assessed...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28711603/mir-139-5p-inhibits-proliferation-and-promoted-apoptosis-of-human-airway-smooth-muscle-cells-by-downregulating-the-brg1-gene
#6
Huanying Zhang, Zhongmei Sun, Lianfeng Yu, Jie Sun
MicroRNAs have emerged as critical regulators in the pathogenesis of asthma. However, the role of microRNAs in asthma needs to be further elucidated. In this study, we found that miR-139-5p was greatly decreased in airway smooth muscle (ASM) cells from asthmatic humans as well as ASM cells stimulated with cytokines. Overexpression of miR-139-5p markedly suppressed ASM cell proliferation and promoted cell apoptosis, whereas knockdown of miR-139-5p had the opposite effect. Further study verified that Brg1, a chromatin remodeling factor, was upregulated in ASM cells treated with cytokines and acted as a direct target of miR-139-5p...
July 12, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28709839/fungal-immunomodulatory-protein-fve-could-modulate-airway-remodel-through-by-affect-il17-cytokine
#7
Yu-Tzu Lee, Chia-Ta Wu, Hai-Lun Sun, Jiunn-Liang Ko, Ko-Haung Lue
BACKGROUND: Asthma is one of the most common allergic diseases. Our previous studies have reported that FIP-fve in acute allergic mouse model can reduce inflammation, improve the balance of the Th1/Th2 system. However, the effects of reducing airway remodeling on FIP-fve is still unknown. OBJECTIVE: We hypothesized that orally administrated FIP-fve should be able to reduce airway remodeling in chronic allergic models. METHODS: The chronic asthma animal model was established with 6-8 weeks female Balb/c mice...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28704475/protective-effect-of-galectin-9-in-murine-model-of-lung-emphysema-involvement-of-neutrophil-migration-and-mmp-9-production
#8
Yuko Horio, Hidenori Ichiyasu, Keisuke Kojima, Naoki Saita, Yohei Migiyama, Toyohisa Iriki, Kazuhiko Fujii, Toshiro Niki, Mitsuomi Hirashima, Hirotsugu Kohrogi
PURPOSE: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and pulmonary emphysema. Persistent inflammation and remodeling of the lungs and airways result in reduced lung function and a lower quality of life. Galectin (Gal)-9 plays a crucial role as an immune modulator in various diseases. However, its role in the pathogenesis of pulmonary emphysema is unknown. This study investigates whether Gal-9 is involved in pulmonary inflammation and changes in emphysema in a porcine pancreatic elastase (PPE)-induced emphysema model...
2017: PloS One
https://www.readbyqxmd.com/read/28697969/childhood-severe-asthma-new-insights-on-remodelling-and-biomarkers
#9
REVIEW
Sejal Saglani
Severe asthma in children is characterised by severe and multiple aeroallergen sensitisation, food allergy, eosinophilic airway inflammation and airway remodelling. However, it is a heterogeneous disease with considerable variability in the manifestation of each of these characteristics between patients. Recent data from mechanistic studies that have used translational approaches including neonatal mouse models and airway bronchoscopic samples, have shown specific molecular mediators that drive remodelling and steroid resistance in paediatric severe asthma will be discussed...
June 12, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28696800/effect-of-nintedanib-on-airway-inflammation-and-remodeling-in-a-murine-chronic-asthma-model
#10
Hwa Young Lee, Jung Hur, In Kyoung Kim, Ji Young Kang, Hyoung Kyu Yoon, Sook Young Lee, Soon Suk Kwon, Young Kyoon Kim, Chin Kook Rhee
INTRODUCTION: Nintedanib is a multi-tyrosine kinase receptor inhibitor recently approved for treatment of idiopathic pulmonary fibrosis. Although angiogenesis is a key process involved in airway structural changes in patients with bronchial asthma, the effect of nintedanib targeting the angiokinase pathway on airway inflammation and remodeling has not been evaluated. METHODS: We used a 3-month ovalbumin (OVA) challenge mouse model of airway remodeling. Nintedanib was orally administrated during the challenge period, and the effects were examined based on the percentage of airway inflammatory cells, airway hyper-reactivity (AHR), peribronchial goblet cell hyperplasia, total lung collagen and smooth muscle area...
July 11, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28696794/the-effects-of-asthma-medications-on-reactive-oxygen-species-production-in-human-monocytes
#11
Ming-Kai Tsai, Yi-Ching Lin, Ming-Yii Huang, Min-Sheng Lee, Chang-Hung Kuo, Po-Lin Kuo, Ching-Hsiung Lin, Chih-Hsing Hung
OBJECTIVE: Asthma is a chronic inflammatory airway disease induced by many environmental factors. The inhalation of allergens and pollutants promote the reactive oxygen species (ROS) production leading to airway inflammation, hyper-responsiveness and remodeling in allergic asthma. The effects of asthma medications on ROS production are unclear. The present study investigated the anti-ROS effects of current asthma medications including inhaled corticosteroid (ICS; budesonide and fluticasone), leukotriene receptor antagonist (LTRA; montelukast), long acting β2 agonists (LABAs; salmeterol and formoterol) and a new extra-LABA (indacaterol)...
July 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28695816/research-advances-in-the-role-of-bromodomain-containing-protein-4-in-epithelial-mesenchymal-transition-in-asthma
#12
Yan Zheng, Jun Wang, Qiugen Li
Asthma is a chronic airway disease characterized by airway inflammation and airway remodeling. Chronic airway inflammation can be involved in airway remodeling in asthmatic patients by incuding epithelial-mesenchymal transition (EMT).Bromodomain-containing protein 4 (BRD4) is a key transcriptional regulator in mammals,and many evidences have shown that BRD4 plays a pivotal role in airway remodeling via nuclear factor-κB/RelA signaling pathway. This review summarizes the recent advances in the role of BRD4 in regulating EMT,with an attempt to elucidate the molecular mechanisms of asthma and inform the prevention and control of asthma...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28692348/the-g-allele-of-mmp12-82-a%C3%A2-%C3%A2-g-promoter-polymorphism-as-a-protective-factor-for-copd-in-bulgarian-population
#13
Tanya Tacheva, Dimo Dimov, Elina Aleksandrova, Monika Bialecka, Maya Gulubova, Tatyana Vlaykova
Chronic inflammation and remodelling of the small airways are features related to chronic obstructive pulmonary disease (COPD). In the current study, we aimed to explore the possible role of MMP12 -82 A > G (rs2276109) promoter polymorphism in the development of COPD in a population from Bulgaria (167 patients with COPD and 119 control individuals). The genotype and allele distributions differed significantly between COPD patients and controls (p = .010 and p = .043, respectively, χ(2) test)...
July 10, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28689843/nonpharmacologic-therapy-for-severe-persistent-asthma
#14
Chase Hall, Linda Nici, Shweta Sood, Richard ZuWallack, Mario Castro
The treatment of asthma largely depends on guideline-based pharmacologic therapies. However, nonpharmacologic therapies for asthma such as pulmonary rehabilitation, focused breathing techniques, and bronchial thermoplasty have an important, yet underappreciated, role. Structured pulmonary rehabilitation programs can reduce dyspnea and increase cardiopulmonary fitness. The educational component of these programs can ensure that therapies are being used appropriately, increase compliance, and decrease health care utilization...
July 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28689020/ferulic-acid-supresses-th2-immune-response-and-prevents-remodeling-in-ovalbumin-induced-pulmonary-allergy-associated-with-inhibition-of-epithelial-derived-cytokines
#15
Alessa Sin Singer Brugiolo, Ana Cláudia Carvalho Gouveia, Caio César de Souza Alves, Flávia Márcia de Castro E Silva, Érick Esteves de Oliveira, Ana Paula Ferreira
Asthma is characterized by intermittent airway obstruction and chronic inflammation, orchestrated primarily by Th2 cytokines. There is a strong rationale for developing new asthma therapies, since current treatment protocols present side effects and may not be effective in cases of difficult-to-control asthma. The purpose of this study was to evaluate the effect of ferulic acid, a phenolic acid commonly present in plants, in the ovalbumin-induced pulmonary allergy murine model. METHODS: BALB/c mice were sensitized and challenged with ovalbumin, and treatments were provided by gavage...
July 5, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28687463/non-asthmatic-eosinophilic-bronchitis-and-its-relationship-with-asthma
#16
REVIEW
Kefang Lai, Ruchong Chen, Wen Peng, Wenzhi Zhan
Non-asthmatic eosinophilic bronchitis (NAEB) is an important cause of chronic cough. The patients with NAEB present irritable cough as a sole or major symptom. They share similar features with asthmatic patients: sputum eosinophilia and responds well to glucocorticosteroids. However, compared with asthma, NAEB subjects have a normal spirometry and absence of airway hyperresponsiveness. The inflammatory cells and airway remodeling might result in the difference of mechanism between NAEB and asthma. On the prognosis of NAEB, only a few studies have been conducted in the last two decades...
July 4, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28686347/epo-modified-mscs-can-inhibit-asthmatic-airway-remodeling-in-an-animal-model
#17
Xin-Peng Han, Fang-Qi Zhang, Xiang-Shu Tan, Liang Liu, Wen-Xian Ma, Hai-Feng Ou-Yang, Chang-Gui Wu
OBJECTIVE: There was no effective measures can be obtained at present to reverse or prevent airway remodeling. We investigated the therapeutic effect of Erythropoietin (EPO) gene modified mesenchymal stem cells (MSCs) on asthmatic airway remodeling and the possible underlied molecular mechanisms. METHODS: EPO gene was transfected into MSCs via lentivirus vector. The transfected cells (EPO-MSCs) were identi?ed by ?ow cytometry and the EPO secreting function was detected by PCR and western blot...
July 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28683207/loss-of-vascular-cd34-results-in-increased-sensitivity-to-lung-injury
#18
Bernard C Lo, Matthew J Gold, Sebastian Scheer, Michael R Hughes, Jessica Cait, Erin Debruin, Fanny S F Chu, David C Walker, Hesham Soliman, Fabio M Rossi, Marie-Renée Blanchet, Georgia Perona-Wright, Colby Zaph, Kelly M McNagny
Survival during lung injury requires a coordinated program of damage limitation and rapid repair. CD34 is a cell surface sialomucin expressed by epithelial, vascular and stromal cells that promotes cell adhesion, coordinates inflammatory cell recruitment, and drives angiogenesis. To test whether CD34 also orchestrates pulmonary damage and repair, we induced acute lung injury in wild type (WT) and Cd34-/- mice by bleomycin (BLM) administration. We found that Cd34-/- mice displayed severe weight loss and early mortality compared to WT controls...
July 6, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28679203/activation-of-human-peripheral-blood-eosinophils-by-cytokines-in-a-comparative-time-course-proteomic-phosphoproteomic-study
#19
Kizhake V Soman, Susan J Stafford, Konrad Pazdrak, Zheng Wu, Xuemei Luo, Wendy I White, John E Wiktorowicz, William J Calhoun, Alexander Kurosky
Activated eosinophils contribute to airway dysfunction and tissue remodeling in asthma and thus are considered an important factor in asthma pathology. We report here comparative proteomic and phosphoproteomic changes upon activation of eosinophils using eight cytokines individually and in selected cytokine combinations in time-course reactions. Differential protein and phosphoprotein expressions were determined by mass spectrometry after 2-dimensional gel electrophoresis (2DGE) and by LC-MS/MS. We found that each cytokine-stimulation produced significantly different changes in the eosinophil proteome and phosphoproteome, with phosphoproteomic changes being more pronounced and having an earlier onset...
July 5, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28677664/allergenic-proteases-cleave-the-chemokine-cx3cl1-directly-from-the-surface-of-airway-epithelium-and-augment-the-effect-of-rhinovirus
#20
M Loxham, D E Smart, N J Bedke, N P Smithers, I Filippi, C Blume, E J Swindle, K Tariq, P H Howarth, S T Holgate, D E Davies
CX3CL1 has been implicated in allergen-induced airway CD4(+) T-lymphocyte recruitment in asthma. As epidemiological evidence supports a viral infection-allergen synergy in asthma exacerbations, we postulated that rhinovirus (RV) infection in the presence of allergen augments epithelial CX3CL1 release. Fully differentiated primary bronchial epithelial cultures were pretreated apically with house dust mite (HDM) extract and infected with rhinovirus-16 (RV16). CX3CL1 was measured by enzyme-linked immunosorbent assay and western blotting, and shedding mechanisms assessed using inhibitors, protease-activated receptor-2 (PAR-2) agonist, and recombinant CX3CL1-expressing HEK293T cells...
July 5, 2017: Mucosal Immunology
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