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Mingjun Bi, Qin Li, Dadong Guo, Xiaoyu Ding, Weikang Bi, Yueheng Zhang, Yong Zou
Carbon monoxide (CO) poisoning is one of the leading causes of toxicity-related mortality and morbidity worldwide, primarily manifested by acute and delayed central nervous system (CNS) injuries and other organ damages. However, its definite pathogenesis is poorly understood. The aim of this study was to explore the pathogenesis of the ultrastructural and functional impairment of mitochondria and the protection of sulphoraphane (SFP) at different dosages on hippocampus neurons in rats after exposure to CO. We found that CO poisoning could induce advanced cognitive dysfunction, while the mitochondrial ultrastructure of neurons in rats of the CO poisoning group was seriously damaged and mitochondrial membrane potential (ΔΨm) was accordingly reduced by transmission electron microscopy (TEM) and JC-1 fluorescent probe assay...
June 2017: Basic & Clinical Pharmacology & Toxicology
Sebnem Izmir Guner, Mustafa Teoman Yanmaz, Ahmet Selvi, Cigdem Usul
Although the deterioration in pulmonary functions is a well-known important problem due to the treatment of the Hodgkin's lymphoma patients, the immediate and long term effects of the therapy and its distinctive components were not shown clearly yet. We planned to investigate effects of multiple agent chemotherapy and/or radiotherapy to pulmonary functions immediately and thereafter and the possible effects of the managing this situation. 34 patients were included the study. The patients were evaluated for peak expiratory flow (PEF), forced expiratory volume in 1 s (FEV1), forced expiratory vital capacity (FVC), mean total lung capacity (TLC) values, FEV1/FVC ratio, diffusing capacity for carbonmonoxide (DLco), diffusing capacity for carbonmonoxide corrected for hemoglobin concentration (DLCO) before and at 1, 6 and 12 months after the initiation of the treatment...
December 2016: Indian Journal of Hematology & Blood Transfusion
Raya Brandenburg, Sylvia Brinkman, Nicolette F de Keizer, Jozef Kesecioglu, Jan Meulenbelt, Dylan W de Lange
CONTEXT: Intoxicated patients are frequently admitted from the emergency room to the ICU for observational reasons. The question is whether these admissions are indeed necessary. OBJECTIVE: The aim of this study was to develop a model that predicts the need of ICU treatment (receiving mechanical ventilation and/or vasopressors <24 h of the ICU admission and/or in-hospital mortality). MATERIALS AND METHODS: We performed a retrospective cohort study from a national ICU-registry, including 86 Dutch ICUs...
January 2017: Clinical Toxicology
Vildan Güngörer, Nurdan Kökten Yisldırım
AIM: The study aimed to retrospectively examine the demographic and etiological characteristics, prognosis and length of stay in intensive care unit of intoxicated patients hospitalized in Level two Pediatric Intensive Care Unit in Maternity and Child Health Hospital of Samsun. MATERIAL AND METHODS: The study retrospectively examined the records of patients hospitalized between 14(th) March 2014 and 14(th) March 2015 in Level two Pediatric Intensive Care Unit in Maternity and Child Health Hospital of Samsun with respect to age, gender, cause of poisoning, time of emergency department admission, length of hospitalization and prognosis...
March 2016: Türk Pediatri Arşivi
Hatice Boztepe, Zahide Yalaki, Yıldız Dallar Bilge
AIM: The aim of our study was to investigate the relation of blood carboxyhemoglobin level with presentation finding and clinical properties and to demonstrate neurological and cardiological findings which are indicators of tissue hypoxia in patients followed up because of carbonmonoxide (CO) poisoning. MATERIAL AND METHODS: Three hundred and twenty-five patients who were followed up because of carbonmonoxide poisoning between 2011 and 2013 in our pediatric emergency department were evaluated prospectively...
December 2014: Türk Pediatri Arşivi
U Mahammad Yasin, Pulikallu Sashi, Abani K Bhuyan
Similarities in global properties of homopolymers and unfolded proteins provide approaches to mechanistic description of protein folding. Here, hydrodynamic properties and relaxation rates of the unfolded state of carbonmonoxide-liganded cytochrome c (cyt-CO) have been measured using nuclear magnetic resonance and laser photolysis methods. Hydrodynamic radius of the unfolded chain gradually increases as the solvent turns increasingly better, consistent with theory. Curiously, however, the rate of intrachain contact formation also increases with an increasing denaturant concentration, which, by Szabo, Schulten, and Schulten theory for the rate of intramolecular contact formation in a Gaussian polymer, indicates growing intramolecular diffusion...
October 10, 2013: Journal of Physical Chemistry. B
Syed Ghulam Musharraf, Madiha Goher, Amjad Hussain, M Iqbal Choudhary
UNLABELLED: HASH(0x39785a0) BACKGROUND: Electrospray tandem mass spectrometry approach is widely used for the rapid characterization of natural products. This paper describes the gas-phased ESI-MS/MS fragmentation of abietane-type diterpenoids and their novel dimeric conjugate, salvialeriafone (1) using both positive and negative ion electrospray ionization quadropole time-of-flight mass spectrometry (ESI-QqTOF-MS/MS) hybrid instrument. Diterpenoids are widely distributed throughout the plant kingdom and posses interesting biological activities...
2012: Chemistry Central Journal
Hidehiro Iida, Ulla Ruotsalainen, Maija Mäki, Merja Haaparnata, Jörgen Bergman, Liisa-Maria Voipio-Pulkki, Pirjo Nuutila, Kazuhiro Koshino, Juhani Knuuti
OBJECTIVES: (15)O-water-perfusable tissue fraction (PTF) has been shown to be a potential index for assessing myocardial viability in PET, an alternative to (18)F-fluorodeoxyglucose (FDG). This study aimed to directly compare these two independent methods in assessing myocardial viability in patients with abnormal wall motion. METHODS: PET study was performed on 16 patients with previous myocardial infarction, before coronary artery bypass graft operation (CABG)...
October 2012: Annals of Nuclear Medicine
Mordechai R Kramer, Yael Refaely, Nimrod Maimon, Dror Rosengarten, Oren Fruchter
BACKGROUND: A clinical study was performed to assess the safety and efficacy of bilateral AeriSeal Emphysematous Lung Sealant System (ELS) treatment in patients with advanced emphysema out to 1 year. METHODS: Twenty patients received treatment at four subsegments, two in each upper lobe. Tenhad upper lobe disease, and 10 had homogeneous disease. Treatments were administered under moderate sedation. Efficacy was assessed at 3, 6, and 12 months. RESULTS: Procedure times were short (15...
November 2012: Chest
R Bhatia, F Chacko, V Lal, B R Mittal
A 40-year-old male presented with acutely oncoming neuropsychiatric symptoms in the form of extrapyramidal disturbances, personality change, behavior changes and urinary incontinence. One month prior to this symptomatology, he had been found unconscious in his closed room where a coal fire was burning overnight. He recovered completely in two days with supportive therapy. Magnetic resonance imaging during this presentation showed bilateral white matter changes suggestive of demyelination. Tc99m-ECD SPECT study revealed hypoperfusion in bilateral frontal region...
May 2007: Indian Journal of Occupational and Environmental Medicine
Jiaoyan Huang, Hyun-Deok Choi, Philip K Hopke, Thomas M Holsen
Continuous atmospheric measurements of speciated mercury (Hg) (elemental mercury (Hg⁰), reactive gaseous mercury (RGM), and particulate mercury (Hgp)) were made in Rochester, NY from Dec 2007 to May 2009. Continuous measurements of ozone (O₃), sulfur dioxide (SO₂), carbonmonoxide (CO), particulate matter (PM₂.₅), and meteorological data were also available. A principle components analysis (PCA) of 3886 observations of 13 variables for the period identified six major factors. Melting snow was observed to be a source of Hg⁰in winters...
November 15, 2010: Environmental Science & Technology
Zeynep Kekec, Gulsah Seydaoglul, Hasan Sever, Figen Ozturk
We aimed to determine the effect NAC (N-acetylcysteine) and melatonin on the histopathological and biochemical paramethers in the rats poisoned with CO (Carbon monoxide) experimentally. Winster albino female rats were placed in a plexiglass chamber and they were poisoned with CO. After the poisoning, rats were randomly divided into 3 groups. The group given only normal saline, was used as a control group (n = 9). The second group was given 30 mg/kg intraperitonally NAC (n = 10). And the third group was treated with 10 mg/kg of melatonin intramuscularly (n = 9)...
2010: Bratislavské Lekárske Listy
A K Boor
1. Photomicrographs of crystals of pure carbonmonoxide hemoglobin of the following species are presented; ox, sheep, hog, dog, turkey, rat, horse, chicken and guinea pig. Photomicrographs of the oxyhemoglobin crystals of the following species are also shown: ox, sheep, hog, dog, rat, horse and guinea pig. The crystals were formed from the pure protein by adding a suitable amount of ethyl alcohol and maintaining a temperature of 0 degrees C., or lower. 2. In some species a sufficient difference is shown between the carbonmonoxide hemoglobin and oxyhemoglobin crystals to distinguish these compounds, but the photographs of crystals of carbonmonoxide hemoglobin and oxyhemoglobin of some species, such as guinea pig, show no appreciable difference...
January 20, 1930: Journal of General Physiology
Nuria Plattner, Markus Meuwly
The influence of electrostatic multipole moments up to hexadecapole on the dynamics of photodissociated carbon monoxide (CO) in myoglobin is investigated. The CO electrostatic potential is expressed as an expansion into atomic multipole moments of increasing order up to octopole which are obtained from a distributed multipole analysis. Three models with increasingly accurate molecular multipoles (accurate quadrupole, octopole, and hexadecapole moments, respectively) are developed and used in molecular dynamics simulations...
April 1, 2008: Biophysical Journal
P Muralidhar Reddy, Kanne Shanker, Rondla Rohini, M Sarangapani, Vadde Ravinder
Some new organometallics of ruthenium(II) of the type [RuCl2(COD)(CO)L] (1a-f) and [RuCl2(COD)L2] (2a-f) (where L is substituted tertiary phosphines), have been synthesized by using precursors [RuCl2(COD)(CO)(CH3CN)] (1) and [RuCl2(COD)(CH3CN)2] (2) with the substituted tertiary phosphine ligands in 1:1 and 1:2 molar ratio. The organometallics (2a-f) have been further reacted with carbonmonoxide to produce compounds of the type [RuCl2(CO)L2] (3a-f). These compounds were characterized by elemental analysis, IR, NMR (1H, 13C and 31P), mass and electronic spectral data...
October 2008: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Alessandra Bonamore, Andrea Attili, Fabio Arenghi, Bruno Catacchio, Emilia Chiancone, Veronica Morea, Alberto Boffi
Novel chimeric proteins made of a globin domain fused with a "cofactor free" monooxygenase domain have been identified within the Streptomyces avermitilis and Frankia sp. genomes by means of bioinformatics methods. Structure based sequence alignments show that the globin domains of both proteins can be unambiguously assigned to the truncated hemoglobin family, in view of the striking similarity to the truncated hemoglobins from Mycobacterium tuberculosis, Thermobifida fusca and Bacillus subtilis. In turn, the non-heme domains belong to a family of small (about 100 aminoacids) homodimeric proteins annotated as antibiotic biosynthesis monooxygenases, despite the lack of a cofactor (e...
August 15, 2007: Gene
Bengu Cobanoglu, Ibrahim H Ozercan, M Resat Ozercan, Orhan Yalcin
Although the effects of cigarette smoking and/or thinner inhalation on various organs have been investigated, there isn't enough study available in literature about their effects on kidneys. Therefore, in this study we investigated the effect of smoking and/or inhalation on the rat kidney. In this study, stand-alone inhalation of thinner and cigarette smoke and their application together were used to determine histopathologic changes, primarily the influences on rat kidneys. The study included 60 Wistar Albino species male rats...
March 2007: Inhalation Toxicology
D Krishna Rao, Rajesh Kumar, M Yadaiah, Abani K Bhuyan
This paper describes the structural and dynamic properties of a hitherto uncovered alkali molten globule (MG) state of horse "ferrocytochrome c" (ferrocyt c). Several experimental difficulties mainly because of heme autoxidation and extraordinary stability of ferrocyt c have been overcome by working with the carbonmonoxide-bound molecule under extremely basic condition (pH 13) in a strictly anaerobic atmosphere. Structural and molecular properties extracted from basic spectroscopic experiments suggest that cations drive the base-denatured CO-liganded protein to the MG state...
March 14, 2006: Biochemistry
Giorgio Schirò, Marco Cammarata, Matteo Levantino, Antonio Cupane
In this work, we use a sol-gel protocol to trap and compare the R and T quaternary states of both the deoxygenated (deoxyHb) and carbonmonoxide (HbCO) derivatives of human hemoglobin. The near infrared optical absorption band III and the infrared CO stretching band are used to detect the effect of quaternary structure on the spectral properties of deoxyHb and HbCO; comparison with myoglobin allows for an assessment of tertiary and quaternary contributions to the measured band shifts. The R<-->T transition is shown to cause a blue shift of the band III by approximately 35 cm(-1) for deoxyHb and a red shift of the CO stretching band by only approximately 0...
April 1, 2005: Biophysical Chemistry
Oznur Akkoca, Banu Eriş Gülbay, Akin Kaya, Cansel Atinkaya, Hakan Kutlay, Gülseren Karabiyikoğlu, Hadi Akay
UNLABELLED: Although there are a lot of physiologic tests to evaluate the preoperative cardio-pulmonary reserve in the patients who candidate lung resection, there is no a single gold standard test to suggest the postoperative pulmonary complications. In this study, we researched the importance of the exercise testing in the evaluation preoperative cardio-pulmonary reserve. We analyzed a series of 26 consecutive patients with a resectable lung disease [26 male patients, mean age 51.5 +/- 15...
2004: Tüberküloz Ve Toraks
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