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Arterial Disease

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https://www.readbyqxmd.com/read/28239641/macrovascular-and-microvascular-cerebral-blood-flow-in-adults-at-risk-for-alzheimer-s-disease
#1
Lindsay R Clark, Sara E Berman, Leonardo A Rivera-Rivera, Siobhan M Hoscheidt, Burcu F Darst, Corinne D Engelman, Howard A Rowley, Cynthia M Carlsson, Sanjay Asthana, Patrick Turski, Oliver Wieben, Sterling C Johnson
INTRODUCTION: Capillary hypoperfusion is reported in asymptomatic adults at-risk for Alzheimer's disease (AD), but the extent that can be explained by reduced flow in intracranial arteries is unknown. METHODS: One hundred fifty-five asymptomatic adults enriched for AD risk (mean age 61 years) completed arterial spin labeling (pcASL) and 4D-flow MRI sequences. Voxel-wise regression models investigated the relationship between mean flow in bilateral cerebral arteries and capillary perfusion, and tested potential moderators of this relationship...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28238922/impact-of-implantation-defects-on-intermediate-outcome-of-supera-stent-for-popliteal-artery-stenosis
#2
Enrique M San Norberto, Ruth Fuente, Cintia M Flota, James H Taylor, Carlos Vaquero
BACKGROUND: Reports our experience during the first 50 cases of use of Supera stent for popliteal atherosclerotic lesions treatment. METHODS: This prospective single-arm trial enrolled the first 50 limbs (46 patients) treated in our center with a Supera stent for symptomatic atherosclerotic disease of the popliteal artery and a follow-up longer than 12 months. RESULTS: Tissue loss (43.5%) was the most common primary indication for intervention, followed by claudication (37...
February 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28238920/pancreaticoduodenal-and-gastroduodenal-artery-aneurysms-associated-with-celiac-artery-occlusive-disease
#3
Frank C Vandy, Kristen A Sell, Jonathan L Eliason, Dawn M Coleman, John E Rectenwald, James C Stanley
OBJECTIVE: The purpose of this study was to better define the clinical relevance of aneurysms affecting collateral vessels in patients with celiac artery (CA) occlusive disease. METHODS: True pancreaticoduodenal artery (PDA) and gastroduodenal artery (GDA) aneurysms associated with celiac artery (CA) stenoses or occlusions reported from 1970 to 2010 in the English literature and similar cases treated at the University of Michigan were reviewed. Clinical presentations and differing treatment modalities were documented and analyzed...
February 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28238588/rest-stress-limb-perfusion-imaging-in-humans-with-contrast-ultrasound-using-intermediate-power-imaging-and-microbubbles-resistant-to-inertial-cavitation
#4
Brian P Davidson, James Hodovan, J Todd Belcik, Federico Moccetti, Aris Xie, Azzdine Y Ammi, Jonathan R Lindner
BACKGROUND: Contrast-enhanced ultrasound (CEU) limb perfusion imaging is a promising approach for evaluating peripheral artery disease (PAD). However, low signal enhancement in skeletal muscle has necessitated high-power intermittent imaging algorithms, which are not clinically feasible. We hypothesized that CEU using a combination of intermediate power and a contrast agent resistant to inertial cavitation would allow real-time limb stress perfusion imaging. METHODS: In normal volunteers, CEU of the calf skeletal muscle was performed on separate days with Sonazoid, Optison, or Definity...
February 23, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28238413/genetic-variation-within-the-y-chromosome-is-not-associated-with-histological-characteristics-of-the-atherosclerotic-carotid-artery-or-aneurysmal-wall
#5
Saskia Haitjema, Jessica van Setten, James Eales, Sander W van der Laan, Ilaria Gandin, Jean-Paul P M de Vries, Gert J de Borst, Gerard Pasterkamp, Folkert W Asselbergs, Fadi J Charchar, James F Wilson, Saskia C A de Jager, Maciej Tomaszewski, Hester M den Ruijter
BACKGROUND AND AIMS: Haplogroup I, a common European paternal lineage of the Y chromosome, is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroup on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance. METHODS: We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n = 1217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n = 393)...
February 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28238270/effects-of-trimetazidine-on-interleukin-2-and-interleukin-8-concentrations-in-patients-with-coronary-artery-disease
#6
Aleksander Danikiewicz, Janusz Szkodziński, Bartosz Hudzik, Ilona Korzonek-Szlacheta, Mariusz Gasior, Barbara Zubelewicz-Szkodzińska
Trimetazidine (TMZ) exhibits metabolic and cardioprotective effects. The aim of this study was to access the effects of TMZ on IL-2 and IL-8 serum concentrations in 156 patients with stable coronary artery disease. They underwent treadmill exercise test (TET) before and after 3-month TMZ treatment. IL-2 and IL-8 concentrations were determined before and after each TET. Before treatment, TET didn't influence IL-2 concentrations, whereas IL-8 concentrations increased. TMZ treatment led to a decrease in IL-2 concentrations before TET, as well as it made the observed difference in IL-8 concentrations become statistically insignificant following the second TET...
February 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28238244/nt-probnp-as-a-potential-marker-of-left-atrial-dysfunction-in-rheumatic-mitral-stenosis-correlation-with-left-atrial-function-after-pbmv
#7
Rashi Khare, Sudhanshu Dwivedi
BACKGROUND: Rheumatic heart disease is a common reason for cardiovascular morbidity and mortality. Plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are known to rise in patients with MS, but the role of this compound as a non-invasive marker of left atrial (LA) dysfunction is yet to be established. The study aim was to correlate levels of NT-proBNP in patients with rheumatic mitral stenosis (MS), with echocardiographic parameters of LA function including tissue Doppler-derived strain/strain rate (S/Sr) indices, hemodynamic parameters of LA function, before and after percutaneous balloon mitral valvotomy (PBMV) for a follow up of one year...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28238236/the-impact-of-gender-on-outcomes-following-transcatheter-aortic-valve-implantation-true-effect-or-bias
#8
Vasileios F Panoulas, Neil Ruparelia, Russel Franks, Sayan Sen, Ben Ariff, Nilesh Sutaria, Angela Frame, Petros Nihoyannopoulos, Iqbal S Malik, Ghada W Mikhail
Transcatheter aortic valve implantation (TAVI) is currently the treatment of choice for patients with severe aortic stenosis (AS) who are unsuitable for surgical aortic valve replacement (SAVR), and is an acceptable alternative for those at high and intermediate surgical risk. In published TAVI registries and meta-analyses, whilst women are significantly older they present with fewer comorbidities compared to men (including coronary artery disease, peripheral vascular disease, diabetes and chronic obstructive pulmonary disease)...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28238235/prevalence-and-impact-of-prosthesis-patient-mismatch-following-surgical-aortic-valve-replacement-for-pure-aortic-regurgitation
#9
Vincent Auffret, Pierre Voisine, Alexandre Cinq-Mars, Éric Charbonneau, Florent Le Ven, Sacha-Michelle Dubois-Sénéchal, Eduardo Brenna, François Dagenais, Michelle Dubois, Carine Ridard, Mario Sénéchal
BACKGROUND: Prosthesis-patient mismatch (PPM) is highly prevalent among patients undergoing aortic valve replacement (AVR) to treat aortic stenosis. Data regarding the prevalence and impact of PPM on left ventricular remodeling and outcomes in patients who have undergone surgical AVR to treat pure severe aortic regurgitation (AR) are, however, scarce. METHODS: A retrospective analysis was conducted of clinical and echocardiographic data acquired from 50 consecutive patients with pure severe AR, without evidence of significant coronary artery disease, who underwent AVR between 2004 and 2010 at the authors' institution...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28238233/cardiac-fibrosis-in-aortic-stenosis-and-hypertensive-heart-disease-assessed-by-magnetic-resonance-t1-mapping
#10
Florian von Knobelsdorff-Brenkenhoff, Anna-Katharina Mueller, Marcel Prothmann, Pierre Hennig, Matthias A Dieringer, Luisa Schmacht, Andreas Greiser, Jeanette Schulz-Menger
BACKGROUND: Continuous pressure overload may lead to subclinical myocardial tissue changes in patients with hypertensive heart disease (HHD) and aortic stenosis (AS). The study aim was to detect interstitial fibrosis using quantitative cardiovascular magnetic resonance. METHODS: Fifteen patients with HHD (arterial hypertension + septal wall thickness ≥13 mm), 33 with AS (eight mild, 15 moderate, 10 severe), and 60 healthy controls were enrolled. Native T1 maps (modified Look-Locker inversion recovery) were obtained in a basal, mid-ventricular, and apical shortaxis slice of the left ventricle to assess cardiac fibrosis...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28238152/myocardial-infarction-in-neonates-a-review-of-an-entity-with-significant-morbidity-and-mortality
#11
REVIEW
Koyelle Papneja, Anthony K Chan, Tapas K Mondal, Bosco Paes
Coronary artery disease is a global problem with high mortality rates and significant residual sequelae that affect long-term quality of life. Myocardial infarction (MI) in neonates is a recognized, uncommon entity, but the incidence and broad spectrum of the disease is unknown and likely underestimated due to limited reporting which in the majority is confined to acute ischemic events. The challenges involve clinical diagnosis which masquerades in the early phase as non-specific symptoms and signs that are commonly found in a host of neonatal disorders...
February 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28237973/modulatory-effects-of-melatonin-and-vitamin%C3%A2-%C3%A2-c-on-oxidative-stress-mediated-haemolytic-anaemia-and-associated-cardiovascular-dysfunctions-in-rats
#12
Temitayo Olabisi Ajibade, Ademola Adetokunbo Oyagbemi, Ladoke A Durotoye, Temidayo Olutayo Omóbòwálé, Ebunoluwa Racheal Asenuga, Funsho Olakitike Olayemi
Background Phenylhydrazine (PHE) in experimental animal models has been widely reported to cause haemolytic anaemia, via the induction of oxidative stress and thus causing deleterious cardiovascular complications. Hence, this study was designed to evaluate the possible modulatory role of melatonin (MLT) or vitamin C when co-administered with PHE. Methods Anaemia was established with PHE administration. MLT or vitamin C was co-administered with PHE. Haematological parameters, markers of oxidative stress, enzymic and non-enzymic antioxidants, blood pressure and electrocardiograms were assessed...
February 25, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#13
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28237648/risk-factors-for-abdominal-aortic-aneurysm-in-the-korean-population
#14
Sang-Ah Han, Jin Hyun Joh, Ho-Chul Park
BACKGROUND: Ultrasound screening shows a clinical benefit in reducing abdominal aortic aneurysm (AAA)-related mortality. However, its cost-effectiveness remains unclear. Understanding the relationship between risk factors and AAA is important to maximize the benefit of AAA screening. However, risk factors for AAA have not been reported in Korea. The purpose of this study was to determine the prevalence of and risk factors for AAA among the Korean population. METHODS: The study population consisted of patients >50 years of age who consented for AAA screening...
February 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28237549/il-37-increased-in-patients-with-acute-coronary-syndrome-and-associated-with-a-worse-clinical-outcome-after-st-segment-elevation-acute-myocardial-infarction
#15
Kun Liu, Qiang Tang, Xinyuan Zhu, Xinchun Yang
BACKGROUND: IL-37 emerges as a natural suppressor of inflammatory responses. The potential role of IL-37 in the pathology of atherosclerosis is unclear. The purpose of this study was to assess IL-37 profile in acute coronary syndrome (ACS) and the prognostic role of this cytokine in patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). METHODS: In a case-control study, we prospectively enrolled 216 patients undergoing the first coronary angiography, which consisted of 5 groups: normal (n=57), stable angina (SAP, n=36), unstable angina (UAP, n=42), non-STEMI (n=36), STEMI (n=45)...
February 22, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28237540/heritability-of-the-femoral-intima-media-thickness
#16
Bence Fejer, Adam D Tarnoki, David L Tarnoki, Pierleone Lucatelli, Levente Littvay, Pal Maurovich-Horvat, Adam L Jermendy, Attila Kovacs, Erika Godor, Corrado Fagnani, Maria A Stazi, Andrea A Molnar, Fabrizio Fanelli, Carlo Cirelli, Filippo Farina, Claudio Baracchini, Giorgio Meneghetti, Giacomo Pucci, Gyorgy Jermendy, Bela Merkely, Giuseppe Schillaci, Emanuela Medda
BACKGROUND: The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. MATERIALS AND METHODS: 388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers. RESULTS: Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter...
February 22, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28237536/early-experience-of-macitentan-for-pulmonary-arterial-hypertension-in-adult-congenital-heart-disease
#17
S Herbert, W Gin-Sing, L Howard, R M R Tulloh
BACKGROUND: Endothelin receptor antagonists (ERA) have been recognised as effective therapy for pulmonary arterial hypertension in congenital heart disease (CHD-PH), and Eisenmenger syndrome (ES) since the Breathe 5 study. A new dual receptor antagonist - Macitentan - is currently undergoing trials to determine its efficacy in simple ES. To date there is little information on this therapy in CHD and we report our first experience, some with more complex diseases. METHODS: Data was collected prospectively from September 2014...
February 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28237515/adiporon-an-adiponectin-receptor-agonist-attenuates-pdgf-induced-vsmc-proliferation-through-inhibition-of-mtor-signaling-independent-of-ampk-implications-toward-suppression-of-neointimal-hyperplasia
#18
Arwa Fairaq, Noha M Shawky, Islam Osman, Prahalathan Pichavaram, Lakshman Segar
Hypoadiponectinemia is associated with an increased risk of coronary artery disease. Although adiponectin replenishment mitigates neointimal hyperplasia and atherosclerosis in mouse models, adiponectin therapy has been hampered in a clinical setting due its large molecular size. Recent studies demonstrate that AdipoRon (a small-molecule adiponectin receptor agonist) improves glycemic control in type 2 diabetic mice and attenuates postischemic cardiac injury in adiponectin-deficient mice, in part, through activation of AMP-activated protein kinase (AMPK)...
February 22, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28237302/yiqifumai-powder-injection-attenuates-coronary-artery-ligation-induced-myocardial-remodeling-and-heart-failure-through-modulating-mapks-signaling-pathway
#19
Li-Zhi Pang, Ai-Chun Ju, Xian-Jie Zheng, Fang Li, Yun-Fei Song, Yan Zhao, Yuan-Feng Gu, Fei-Leng Chen, Chun-Hua Liu, Jin Qi, Zhen Gao, Jun-Ping Kou, Bo-Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: YiQiFuMai Powder Injection (YQFM), a traditional Chinese medicine prescription re-developed based on Sheng-Mai-San, is a classical and traditional therapeutic for clinical heart failure (HF) and angina. However, its potential mechanism against HF remains unclear. AIM OF THE STUDY: The present study observes the therapeutic role of YQFM and mechanisms underlying its effects on coronary artery ligation (CAL)-induced myocardial remodeling (MR) and HF...
February 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28237083/association-of-the-fads-gene-cluster-with-coronary-artery-disease-and-plasma-lipid-concentrations-in-the-northern-chinese-han-population
#20
Yixia Wu, Lixin Zeng, Xueyan Chen, Yang Xu, Lin Ye, Ling Qin, Liping Chen, Lin Xie
We investigated the association of single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster with coronary artery disease (CAD) in a case-control study and evaluated the possible influence of genetic variation on total cholesterol (TC) and triglyceride concentrations in the controls. In total, 497 CAD patients and 495 unrelated controls were genotyped for eight SNPs in the FADS gene cluster, and the blood lipid levels of subjects were measured. Three genetic models, including codominant, dominant and recessive, were used to analyze the genotypic relationship with CAD and plasma lipid levels...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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