Nisha I Parikh, Folagbayi Arowolo, Matthew S Durstenfeld, Gregory Nah, Joyce Njoroge, Eric Vittinghoff, Carlin S Long, Peter Ganz, David Pearce, Priscilla Hsue, Alan H S Wu, Negin Hajizadeh, Kathleen D Liu, Kara L Lynch
Context: SARS-CoV-2 infects cells via the angiotensin converting enzyme 2 (ACE2) receptor, whose downstream effects "counterbalance" the classical renin angiotensin aldosterone system (RAAS). Objective: We aimed to determine to what extent circulating RAAS biomarker levels differ in persons with and without COVID-19 throughout the disease course. Methods: We measured classical (renin, aldosterone, aldosterone/renin ratio [ARR], Ang2, ACE activity) and nonclassical (ACE2, Ang1,7) RAAS biomarkers in hospitalized COVID-19 patients vs SARS-CoV-2 negative controls...
October 26, 2022: Journal of the Endocrine Society