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Ang1-7

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https://www.readbyqxmd.com/read/28531801/ace-2-ang1-7-mas-cascade-mediates-ace-inhibitor-captopril-protective-effects-in-estrogen-deficient-osteoporotic-rats
#1
Hatem M Abuohashish, Mohammed M Ahmed, Dina Sabry, Mahmoud M Khattab, Salim S Al-Rejaie
The local role of the renin angiotensin system (RAS) was documented recently beside its conventional systemic functions. Studies showed that the effector angiotensin II (AngII) alters bone health, while inhibition of the angiotensin converting enzyme (ACE-1) preserved these effects. The newly identified Ang1-7 exerts numerous beneficial effects opposing the AngII. Thus, the current study examines the role of Ang1-7 in mediating the osteo-preservative effects of ACEI (captopril) through the G-protein coupled Mas receptor using an ovariectomized (OVX) rat model of osteoporosis...
May 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28463644/reduced-sympathetic-stimulus-and-angiotensin-1-7-are-related-to-diastolic-dysfunction-in-spinal-cord-injured-subjects
#2
Roberto Schreiber, Layde R Paim, Guilherme de Rossi, José R Matos-Souza, Anselmo Costa E Silva, Cláudio D Nogueira, Eliza R Azevedo, Karina C Alonso, Zaira Palomino, Andrei C Sposito, Dulce E Casarini, José I Gorla, Alberto Cliquet, Wilson Nadruz
Chronic spinal cord injury (SCI) is often associated with reductions in left ventricular (LV) diastolic function. Impairments in sympathetic activity and activation of the renin-angiotensin system are reported in SCI individuals and may hypothetically be implicated in this association. Hence, the present study verified the relationship between these two neuro-hormonal and cardiac functional and structural characteristics in SCI individuals. Twenty-two men with SCI (injury level above T6 and no voluntary motion below the injury) and 11 able-bodied men were evaluated by clinical, hemodynamic, laboratory and echocardiographic analysis, and had plasmatic renin, angiotensin I (ANGI), angiotensin II (ANGII), angiotensin 1-7 (ANG1-7) and noradrenaline levels measured...
May 2, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28442323/the-ace-2-ang1-7-mas-cascade-enhances-bone-structure-and-metabolism-following-angiotensin-ii-type-1-receptor-blockade
#3
Hatem M Abuohashish, Mohammed M Ahmed, Dina Sabry, Mahmoud M Khattab, Salim S Al-Rejaie
The renin angiotensin system (RAS) regulates numerous systemic functions and is expressed locally in skeletal tissues. Angiotensin1-7 (Ang1-7) is a beneficial member of the RAS, and the therapeutic effects of a large number of angiotensin receptors blockers (ARBs) are mediated by an Ang1-7-dependent cascade. This study examines whether the reported osteo-preservative effects of losartan are mediated through the angiotensin converting enzyme2 (ACE-2)/Ang1-7/Mas pathway in ovariectomized (OVX) rats. Sham and OVX animals received losartan (10mg/kg/d p...
April 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28413960/circulating-ace2-in-cardiovascular-and-kidney-diseases
#4
Lidia Anguiano, Marta Riera, Julio Pascual, María José Soler
Angiotensin converting enzyme(ACE) 2 is a homologue of ACE that catalyzes the conversion of Angiotensin(Ang) II into Ang1-7, which induces vasodilation, anti-fibrotic, anti-proliferative and anti-inflammatory effects. Given that ACE2 counterbalances the effects of Ang II, it has been proposed as a biomarker in kidney disease patients. Circulating ACE2 has been studied in human and experimental studies under physiological and pathological conditions and different techniques have been assessed to determine its enzymatic activity...
April 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28389995/cardiovascular-effect-of-inflammation-and-nonsteroidal-anti-inflammatory-drugs-on-renin-angiotensin-system-in-experimental-arthritis
#5
Waheed Asghar, Ali Aghazadeh-Habashi, Fakhreddin Jamali
A co-morbidity of inflammatory conditions is increased cardio-renal risks. Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) which are used to treat pain and inflammation are also associated with increase in such risks. We hypothesized that inflammation and NSAIDs impose the cardio-renal risk through the activation of the renin-angiotensin-system (RAS), a regulating pathway of the renal and cardiovascular homeostasis. We investigated the effect of adjuvant arthritis and NSAIDs on the RAS. Western blotting and ELISA were used to measure the RAS components...
April 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28249221/the-correlation-between-inflammatory-injury-induced-by-lps-and-ras-in-eph4-ev-cells
#6
Kun Wang, Xiaoqian Liu, Hang Xiao, Huanhuan Wang, Yuanshu Zhang
Renin-angiotensin system (RAS) plays an important role of regulating inflammatory injury. However, it is not clear about the correlation between renin-angiotensin system (RAS) and inflammation induced by LPS in mammary gland cells. So immunofluorescence was performed to verify the ACE2 expression in mammary gland cells. MTT assay was performed to detect cell viability. ELISA was performed to detect cytokines in cell supernatant. Western Blot was performed to analyze RAS levels and ACE2 level change was observed by immunofluorescence...
February 26, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27638906/the-unfolded-protein-response-controls-er-stress-induced-apoptosis-of-lung-epithelial-cells-through-angiotensin-generation
#7
Hang Nguyen, Bruce D Uhal
Recent work from this laboratory showed that endoplasmic reticulum (ER) stress-induced apoptosis of alveolar epithelial cells (AECs) is regulated by the autocrine angiotensin (ANG)II/ANG1-7 system. The proteasome inhibitor MG132 or surfactant protein C (SP-C) BRICHOS domain mutation G100S induced apoptosis in human AECs by activating the proapoptotic cathepsin D and reducing antiapoptotic angiotensin converting enzyme-2 (ACE-2). This study tested the hypothesis that ER stress-induced apoptosis of human AECs might be mediated by influence of the unfolded protein response (UPR) on the autocrine ANGII/ANG1-7 system...
November 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27508792/-op-6d-03-mode-of-action-of-rb150-an-aminopeptidase-a-inhibitor-prodrug-as-a-centrally-acting-antihypertensive-agent-in-doca-salt-hypertensive-rats
#8
R Hmazzou, A Flahault, Y Marc, C Llorens-Cortes
OBJECTIVE: In the brain, angiotensin III (AngIII) generated from angiotensin II (AngII) by aminopeptidase A (APA) exerts a tonic stimulatory action on the control of blood pressure (BP) in hypertensive rats. Inhibition of brain APA by RB150 (also known as QGC001), an orally active prodrug of the specific and selective APA inhibitor EC33, blocks brain AngIII formation and normalizes BP in hypertensive rats. Thus, RB150 has emerged as the prototype of a new class of centrally-acting antihypertensive agents and is currently evaluated in a phase II clinical trial in hypertensive patients...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27073699/renal-blood-flow-response-to-angiotensin-1-7-versus-hypertonic-sodium-chloride-7-5-administration-after-acute-hemorrhagic-shock-in-rats
#9
Maryam Maleki, Mehdi Nematbakhsh
Background. Angiotensin 1-7 (Ang1-7) plays an important role in renal circulation. Hemorrhagic shock (HS) may cause kidney circulation disturbance, and this study was designed to investigate the renal blood flow (RBF) response to Ang1-7 after HS. Methods. 27 male Wistar rats were subjected to blood withdrawal to reduce mean arterial pressure (MAP) to 45 mmHg for 45 min. The animals were treated with saline (group 1), Ang1-7 (300 ng·kg(-1) min(-1)), Ang1-7 in hypertonic sodium chloride 7.5% (group 3), and hypertonic solution alone (group 4)...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/26963721/anti-inflammatory-action-of-angiotensin-1-7-in-experimental-colitis
#10
Maitham A Khajah, Maryam M Fateel, Kethireddy V Ananthalakshmi, Yunus A Luqmani
BACKGROUND: There is evidence to support a role for angiotensin (Ang) 1-7 in reducing the activity of inflammatory signaling molecules such as MAPK, PKC and SRC. Enhanced angiotensin converting enzyme 2 (ACE2) expression has been observed in patients with inflammatory bowel disease (IBD) suggesting a role in its pathogenesis, prompting this study. METHODS: The colonic expression/activity profile of ACE2, Ang 1-7, MAS1-receptor (MAS1-R), MAPK family and Akt were determined by western blot and immunofluorescence...
2016: PloS One
https://www.readbyqxmd.com/read/26637635/angiotensin-1-7-mas-inhibits-apoptosis-in-alveolar-epithelial-cells-through-upregulation-of-map-kinase-phosphatase-2
#11
Indiwari Gopallawa, Bruce D Uhal
Earlier work from this laboratory showed that autocrine generation of angiotensin II and c-Jun-NH2-terminal kinase phosphorylation (p-JNK) are both required events in alveolar epithelial cell (AEC) apoptosis. Although earlier data showed that angiotensin-(1-7) [ANG-(1-7)] protects against AEC apoptosis, the pathways by which ANG-(1-7)/mas activation prevent JNK phosphorylation and apoptosis are poorly understood. Therefore, in the current study, it was theorized that ANG-(1-7) activates a mitogen-activated protein kinase phosphatase (MKP) and thereby reduces JNK phosphorylation to inhibit apoptosis and promote cell survival...
February 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/26630181/angiotensin-1-7-significantly-reduces-diabetes-induced-leukocyte-recruitment-both-in-vivo-and-in-vitro
#12
Fleur Bossi, Stella Bernardi, Daniele De Nardo, Alessandra Bramante, Riccardo Candido, Renzo Carretta, Fabio Fischetti, Bruno Fabris
OBJECTIVE: Recent studies have demonstrated that Ang1-7 has anti-inflammatory effects. Since the formation of Ang1-7 is significantly altered in the setting of diabetes, here we aimed to evaluate whether Ang1-7 infusion could ameliorate diabetes-induced leukocyte recruitment. METHODS: Wild-type male Wistar rats were randomly allocated to the following groups: control + saline, control + Ang1-7, diabetes + saline, diabetes + Ang1-7. Diabetes was induced by streptozotocin...
January 2016: Atherosclerosis
https://www.readbyqxmd.com/read/26421009/role-of-mas-receptor-antagonist-a799-in-renal-blood-flow-response-to-ang-1-7-after-bradykinin-administration-in-ovariectomized-estradiol-treated-rats
#13
Aghdas Dehghani, Shadan Saberi, Mehdi Nematbakhsh
Background. The accompanied role of Mas receptor (MasR), bradykinin (BK), and female sex hormone on renal blood flow (RBF) response to angiotensin 1-7 is not well defined. We investigated the role of MasR antagonist (A779) and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats. Methods. Ovariectomized Wistar rats received estradiol (OVE) or vehicle (OV) for two weeks. Catheterized animals were subjected to BK and A799 infusion and mean arterial pressure (MAP), RBF, and renal vascular resistance (RVR) responses to Ang 1-7 (0, 100, and 300 ng kg(-1) min(-1)) were determined...
2015: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/26271886/differential-regulation-of-angiotensin-converting-enzyme-2-and-nuclear-factor-%C3%AE%C2%BAb-by-angiotensin-ii-receptor-subtypes-in-type-2-diabetic-kidney
#14
Anuradha Pandey, Santosh Kumar Goru, Almesh Kadakol, Vajir Malek, Anil Bhanudas Gaikwad
Angiotensin II (Ang II) acts through Angiotensin Converting Enzyme (ACE)/Ang II type 1 receptor (AT1R) axis to promote renal failure whereas the Ang II type 2 receptor (AT2R)/Angiotensin Converting Enzyme 2 (ACE2)/Ang1-7/Mas axis constitutes the protective arm of Renin Angiotensin System (RAS). Though Ang II has been known to activate the Nuclear Factor-κB (NF-κB) signalling pathway through different receptor subtype(s) in different tissues under various diseases, the subtype orchestrating this stimulation in type 2 diabetic kidney remains elusive...
November 2015: Biochimie
https://www.readbyqxmd.com/read/26251197/angiotensin1-7-protects-cardiomyocytes-from-hypoxia-reoxygenation-induced-oxidative-stress-by-preventing-ros-associated-mitochondrial-dysfunction-and-activating-the-akt-signaling-pathway
#15
Pengjun Zhao, Fen Li, Wei Gao, Jing Wang, Lijun Fu, Yiwei Chen, Meirong Huang
Angiotensin1-7 (Ang1-7) is a biologically active member of the renin-angiotensin system, which has been reported to exhibit protective effect in myocardial ischemia reperfusion-induced injury. However, the molecular basis of this effect is not well understood. It has been proposed that oxidative stress-induced cardiomyocyte apoptosis is a major consequence of hypoxia/reoxygenation (H/R) injury. This study investigates the protective effect of Ang1-7 against H/R-induced oxidative stress in rat H9C2 cells. Our results showed that Ang1-7 (80nM) treatment significantly protected cells from H/R-induced oxidative injury via improving cell viability and reducing cell apoptosis...
October 2015: Acta Histochemica
https://www.readbyqxmd.com/read/26205288/mechanisms-of-improvement-of-left-ventricular-function-by-intracoronary-human-umbilical-cord-derived-mesenchymal-stem-cell-infusion-in-very-old-patients-with-coronary-chronic-total-occlusion
#16
Xia Li, You-dong Hu, Ying Chen, Hua-lan Zhou, Feng-lin Zhang, Dian-xuan Guo, Qing-na Zhao
We have evaluated the safety and efficacy of intracoronary human umbilical cord-derived mesenchymal stem cell (hUCMSC) treatment for very old patients with coronary chronic total occlusion. hUCMSCs could improve in the degree of ischemic myocardium, decrease in the infarct size and rise in left ventricular ejection fraction, but the involved mechanisms remain to be fully identified. We analyzed levels of circulating leukocytes, highsensitivity C-reactive protein (hs-CRP), interleukins (ILs), tumor necrosis factor-a (TNF-a), soluble tumor necrosis factor receptor-1 (sTNFR-1), soluble tumor necrosis factor receptor-2 (sTNFR-2), NT-proBNP, BNP, angiotensin 1-7 (Ang1-7), angiotensin II (Ang II) and aldosterone (Ald) in patients with hUCMSC therapy at baseline, 12, and 24 months...
2015: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26146467/molecular-and-cellular-mechanisms-of-the-inhibitory-effects-of-ace-2-ang1-7-mas-axis-on-lung-injury
#17
Indiwari Gopallawa, Bruce D Uhal
An established body of recent literature has demonstrated potent inhibitory effects of the angiotensin converting enzyme-2 (ACE-2)/ANG1-7/ Mas axis on acute lung injury and lung fibrogenesis. One of the mechanisms of this inhibition is the enzymatic action of ACE-2 to degrade its main substrate angiotensin (ANG) II, thereby reducing the injurious and profibrotic activities of this octapeptide. Another, potentially more important mechanism is the production by ACE-2 of the heptapeptide ANG1-7, which inhibits the actions of ANGII through its own receptor Mas, the product of the oncogene of the same name...
January 1, 2014: Current Topics in Pharmacology
https://www.readbyqxmd.com/read/25741281/g-protein-coupled-receptors-of-the-renin-angiotensin-system-new-targets-against-breast-cancer
#18
REVIEW
Sylvie Rodrigues-Ferreira, Clara Nahmias
G-protein coupled receptors (GPCRs) constitute the largest family of membrane receptors, with high potential for drug discovery. These receptors can be activated by a panel of different ligands including ions, hormones, small molecules, and vasoactive peptides. Among those, angiotensins [angiotensin II (AngII) and angiotensin 1-7] are the major biologically active products of the classical and alternative renin-angiotensin system (RAS). These peptides bind and activate three different subtypes of GPCRs, namely AT1, AT2, and Mas receptors, to regulate cardiovascular functions...
2015: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/25688208/structural-determinants-for-binding-to-angiotensin-converting-enzyme-2-ace2-and-angiotensin-receptors-1-and-2
#19
Daniel Clayton, Iresha Hanchapola, Walter G Thomas, Robert E Widdop, Alexander I Smith, Patrick Perlmutter, Marie-Isabel Aguilar
Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin-angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7. This conversion inactivates the vasoconstrictive action of Ang II and yields a peptide that acts as a vasodilatory molecule at the Mas receptor and potentially other receptors. Given the growing complexity of RAS and level of cross-talk between ligands and their corresponding enzymes and receptors, the design of molecules with selectivity for the major RAS binding partners to control cardiovascular tone is an on-going challenge...
2015: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/25371522/role-of-mas-receptor-antagonist-a779-on-pressure-diuresis-and-natriuresis-and-renal-blood-flow-in-the-absence-of-angiotensin-ii-receptors-type-1-and-2-in-female-and-male-rats
#20
A Mansoori, S Oryan, M Nematbakhsh
Sexual differences in blood pressure are associated with angiotensin 1-7 (Ang1-7) and its receptor and enzyme function targeting. Blockade of angiotensin II (AngII) receptors type 1 and 2 (AT1R and AT2R) inhibits some actions of Ang1-7. We described the role of Ang1-7 receptor (MasR) antagonist (A779) on kidney hemodynamics when AT1R and AT2R are blocked with losartan and PD123319. In anaesthetized male and female rats after blockade of both AT1R and AT2R, the renal perfusion pressure (RPP) was controlled in two levels of 80 and 100 mmHg via an adjustable clamp placed around the aorta above the level of the renal arteries...
October 2014: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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