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https://www.readbyqxmd.com/read/27867936/effects-of-lithium-monotherapy-for-bipolar-disorder-on-gene-expression-in-peripheral-lymphocytes
#1
Amit Anand, Jeanette N McClintick, Jill Murrell, Harish Karne, John I Nurnberger, Howard J Edenberg
BACKGROUND: This study investigated the effect of lithium monotherapy on peripheral lymphocyte gene expression in bipolar disorder (BD). METHOD: Twenty-two medication-free bipolar subjects (11 hypomanic, 11 depressed) were started on lithium monotherapy. Closely matched healthy subjects (n = 15) were included as controls but did not receive treatment. Blood RNA samples were collected at baseline and after 2 and 8 weeks of treatment. RNA expression was measured using the Affymetrix GeneChip® Human Gene 1...
October 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27862615/the-reciprocal-relationship-between-bipolar-disorder-and-social-interaction-a-qualitative-investigation
#2
Rebecca Owen, Patricia Gooding, Robert Dempsey, Steven Jones
BACKGROUND: Evidence suggests that social support can influence relapse rates, functioning and various clinical outcomes in people with bipolar disorder. Yet 'social support' is a poorly defined construct, and the mechanisms by which it affects illness course in bipolar disorder remain largely unknown. Key aims of this study were to ascertain which facets of social interaction affect mood management in bipolar disorder, and how symptoms of bipolar disorder can influence the level of support received...
November 13, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27831463/what-is-the-role-of-conventional-antidepressants-in-the-treatment-of-major-depressive-episodes-with-mixed-features-specifier
#3
Gianni L Faedda, Ciro Marangoni
The newly introduced Mixed Features Specifier of Major Depressive Episode and Disorder (MDE/MDD) is especially challenging in terms of pharmacological management. Prior to the publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the symptoms of the mixed features specifier were intradepressive hypomanic symptoms, always and only associated with bipolar disorder (BD). Intradepressive hypomanic symptoms, mostly referred to as depressive mixed states (DMX), have been poorly characterized, and their treatment offers significant challenges...
November 10, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27813593/case-report-case-study-of-a-patient-presenting-both-type-ii-bipolar-affective-disorder-and-klinefelter-syndrome
#4
H Delavenne, J M Khoury, F Thibaut, F D Garcia
Klinefelter syndrome (KS) is the most common sex chromosomal disorder with an estimated prevalence of 1 in 500-1000. Increased incidences of anxiety, depression, substance abuse, psychotic and behavioral disorders, and sexual disorders have been reported in patients with KS. The aim of this case study was to report a case of a man with untreated KS who was also diagnosed with type II bipolar disorder. This case report raises awareness regarding psychiatric diagnoses that may be associated with such a highly prevalent condition...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27810714/symptom-quality-versus-quantity-in-judging-prognosis-using-nesarc-predictive-validators-to-locate-uncomplicated-major-depression-on-the-number-of-symptoms-severity-continuum
#5
Jerome C Wakefield, Mark F Schmitz
BACKGROUND: Uncomplicated major depressive disorder (UMDD) is defined as MDD that does not include any of six pathosuggestive features: more than six months duration, marked functional impairment, sense of worthlessness, suicidal ideation, psychotic ideation, and psychomotor retardation. Complicated MDD (CMDD) includes all episodes containing one or more of these features. UMDD has been shown to be lower than CMDD and indistinguishable from no-MDD-history on predictive pathology validators...
October 14, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27769005/a-genome-wide-association-study-suggests-the-association-of-muskelin-with-early-onset-bipolar-disorder-implications-for-a-gabaergic-epileptogenic-neurogenesis-model
#6
Malik Nassan, Qingqin Li, Paul E Croarkin, Wenan Chen, Colin L Colby, Marin Veldic, Susan L McElroy, Gregory D Jenkins, Euijung Ryu, Julie M Cunningham, Marion Leboyer, Mark A Frye, Joanna M Biernacka
BACKGROUND: Although multiple genes have been implicated in bipolar disorder (BD), they explain only a small proportion of its heritability. Identifying additional BD risk variants may be impaired by phenotypic heterogeneity, which is usually not taken into account in genome-wide association studies (GWAS). BD with early age at onset is a more homogeneous familial form of the disorder associated with greater symptom severity. METHODS: We conducted a GWAS of early-onset BD (onset of mania/hypomania ≤19 years old) in a discovery sample of 419 cases and 1034 controls and a replication sample of 181 cases and 777 controls...
September 30, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27766498/mood-spectrum-comorbidity-in-patients-with-anorexia-and-bulimia-nervosa
#7
Mario Miniati, Antonella Benvenuti, Elena Bologna, Alessandra Maglio, Biagio Cotugno, Gabriele Massimetti, Simona Calugi, Mauro Mauri, Liliana Dell'Osso
PURPOSE: To investigate the presence of mood spectrum signs and symptoms in patients with anorexia nervosa, restricting subtype (AN-R) or bulimia nervosa (BN). METHOD: 55 consecutive female patients meeting DSM-IV criteria for eating disorders (EDs) not satisfying DSM-IV criteria for Axis I mood disorders were evaluated with the Lifetime Mood Spectrum Self-Report (MOODS-SR) and the Mini-International Neuropsychiatric Interview (MINI). The MOODS-SR explored the subthreshold comorbidity for mood spectrum symptoms in patients not reaching the threshold for a mood disorder Axis I diagnosis...
October 20, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/27759213/early-report-on-brain-arousal-regulation-in-manic-vs-depressive-episodes-in-bipolar-disorder
#8
Dirk Alexander Wittekind, Janek Spada, Alexander Gross, Tilman Hensch, Philippe Jawinski, Christine Ulke, Christian Sander, Ulrich Hegerl
OBJECTIVES: The arousal regulation model of affective disorders attributes an important role in the pathophysiology of affective disorders to dysregulation of brain arousal regulation. According to this model, sensation avoidance and withdrawal in depression and sensation seeking and hyperactivity in mania can be explained as auto-regulatory attempts to counteract a tonically high (depression) or unstable (mania) arousal. The aim of this study was to compare brain arousal regulation between manic and depressive bipolar patients and healthy controls...
September 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27728870/characterization-and-structure-of-hypomania-in-a-british-nonclinical-adolescent-sample
#9
Georgina M Hosang, Alastair G Cardno, Daniel Freeman, Angelica Ronald
BACKGROUND: This study aimed to test the validity of using the Hypomania Checklist-16 [HCL-16] to measure hypomania in a British adolescent community sample. Limited research is available concerning the characterization of hypomania among community adolescent samples, particularly in the UK, despite its potential importance for early intervention policy development. METHOD: To explore the structure and characterization of hypomania in a British adolescent nonclinical cohort, over 1400 17 year olds (Mean=17...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27663811/are-ssris-responsible-for-precipitating-suicidal-ideation-in-teenagers-with-subsyndromal-bipolar-affective-disorder-who-have-been-misdiagnosed-with-unipolar-depression
#10
Stephen Hogg, Sereena Ansari, Qasim Masood, Mark Agius, Zoltan Rihmer
Concerns have recently been raised about a possible link between suicidal ideation and the use of SSRIs in teenagers diagnosed with unipolar depression, such that the USA FDA and UK CSM have issued warnings regarding the use of SSRIs in adolescents with depression. We investigated this phenomenon first by recognizing that the initial presentation of unipolar and bipolar depression may only differ in subtle ways and with the result being that a significant number of patients are misdiagnosed at the expense of patient outcomes...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27642544/daily-actigraphy-profiles-distinguish-depressive-and-interepisode-states-in-bipolar-disorder
#11
Anda Gershon, Nilam Ram, Sheri L Johnson, Allison G Harvey, Jamie M Zeitzer
Disruptions in activity are core features of mood states in bipolar disorder (BD). This study sought to identify activity patterns that discriminate between mood states in BD. Locomotor activity was collected using actigraphy for six weeks in participants with inter-episode BD type I (n=37) or participants with no lifetime mood disorders (n=39). The 24-hour activity pattern of each participant-day was characterized and within-person differences in activity patterns were examined across mood states. Results show that among participants with BD, depressive days are distinguished from other mood states by an overall lower activity level, and a pattern of later activity onset, a midday elevation of activity, and low evening activity...
July 2016: Clinical Psychological Science
https://www.readbyqxmd.com/read/27624435/child-behavior-checklist-profiles-in-adolescents-with-bipolar-and-depressive-disorders
#12
Kukju Kweon, Hyun-Jeong Lee, Kee Jeong Park, Yeonho Joo, Hyo-Won Kim
OBJECTIVE: We aimed to evaluate the Child Behavior Checklist (CBCL) profiles in youths with bipolar and depressive disorders. METHODS: Seventy-four subjects with a mean age of 14.9±1.6years (36 boys) with mood disorders and their parents were recruited from September 2011 to June 2013 in the Department of Psychiatry, Asan Medical Center, Seoul, Korea. Diagnosis of mood disorder and comorbid psychiatric disorder was confirmed by child psychiatrists using the Schedule for Affective Disorders and Schizophrenia for School Age Children - Present and Lifetime version (K-SADS-PL)...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27623122/-interest-of-scopolamine-as-a-treatment-of-major-depressive-disorder
#13
A Rigal, S Mouchabac, C S Peretti
INTRODUCTION: The number of patients with depression in the world is 350 millions according to estimates. The search for new treatments, particularly in forms of resistant depression, is necessary given the growing number of patients experiencing treatment failure and resistance. Scopolamine, an anticholinergic antimuscarinic molecule, is one of the treatments under evaluation. It falls within the assumptions of cholinergic disruption of the pathophysiology of depression, at different levels (genetic, receptorial [muscarinic and glutamate receptors], hormonal, synaptic…)...
September 9, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27618746/treatment-of-mixed-features-in-bipolar-disorder
#14
Joshua D Rosenblat, Roger S McIntyre
Mood episodes with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)-defined mixed features are highly prevalent in bipolar disorder (BD), affecting ~40% of patients during the course of illness. Mixed states are associated with poorer clinical outcomes, greater treatment resistance, higher rates of comorbidity, more frequent mood episodes, and increased rates of suicide. The objectives of the current review are to identify, summarize, and synthesize studies assessing the efficacy of treatments specifically for BD I and II mood episodes (ie, including manic, hypomanic, and major depressive episodes) with DSM-5-defined mixed features...
September 13, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27570960/-post-traumatic-stress-disorder-among-incomers-in-remire-montjoly-prison-french-guiana
#15
Romain Arnal, Gülen Ayhan, Éric Pinganaud, Célia Basurko, Louis Jehel
Despite the recent interest in psychiatric illness in prison, the psychopathology of the Remire-Montjoly prison population remains largely unknown. Subject to significant population movements, French Guiana and its prison houses a very mixed population in which recent history has left a strong mark (earthquake in Haïti, civil war in Suriname, violence related to gold mining population and drug trafficking). These negative life events appear as potential vectors of psychological trauma. Additionally, strong links have been established in the literature between post-traumatic stress disorder (PTSD) and many other psychiatric disorders, including suicidal behavior and addictions...
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27523498/increased-activity-or-energy-as-a-primary-criterion-for-the-diagnosis-of-bipolar-mania-in-dsm-5-findings-from-the-step-bd-study
#16
Rodrigo Machado-Vieira, David A Luckenbaugh, Elizabeth D Ballard, Ioline D Henter, Mauricio Tohen, Trisha Suppes, Carlos A Zarate
OBJECTIVE: DSM-5 describes "a distinct period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increased activity or energy" as a primary criterion for mania. Thus, increased energy or activity is now considered a core symptom of manic and hypomanic episodes. Using data from the Systematic Treatment Enhancement Program for Bipolar Disorder study, the authors analyzed point prevalence data obtained at the initial visit to assess the diagnostic validity of this new DSM-5 criterion...
August 13, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27505230/increased-dna-and-rna-damage-by-oxidation-in-patients-with-bipolar-i-disorder
#17
A S Jacoby, M Vinberg, H E Poulsen, L V Kessing, K Munkholm
The mechanisms underlying bipolar disorder (BD) and the associated medical burden are unclear. Damage generated by oxidation of nucleosides may be implicated in BD pathophysiology; however, evidence from in vivo studies is limited and the extent of state-related alterations is unclear. This prospective study investigated for we believe the first time the damage generated by oxidation of DNA and RNA strictly in patients with type I BD in a manic or mixed state and subsequent episodes and remission compared with healthy control subjects...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27476619/childhood-interleukin-6-c-reactive-protein-and-atopic-disorders-as-risk-factors-for-hypomanic-symptoms-in-young-adulthood-a-longitudinal-birth-cohort-study
#18
J F Hayes, G M Khandaker, J Anderson, D Mackay, S Zammit, G Lewis, D J Smith, D P J Osborn
BACKGROUND: There are no existing longitudinal studies of inflammatory markers and atopic disorders in childhood and risk of hypomanic symptoms in adulthood. This study examined if childhood: (1) serum interleukin-6 (IL-6) and C-reactive protein (CRP); and (2) asthma and/or eczema are associated with features of hypomania in young adulthood. METHOD: Participants in the Avon Longitudinal Study of Parents and Children, a prospective general population UK birth cohort, had non-fasting blood samples for IL-6 and CRP measurement at the age of 9 years (n = 4645), and parents answered a question about doctor-diagnosed atopic illness before the age of 10 years (n = 7809)...
August 1, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27423353/a-discussion-of-various-aspects-of-panic-disorder-depending-on-presence-or-absence-of-agoraphobia
#19
Ken Inoue, Hisanobu Kaiya, Naomi Hara, Yuji Okazaki
OBJECTIVE: The quality of life of individuals with panic disorder and agoraphobia can be improved by the alleviation of agoraphobia. In other words, examining panic disorder in terms of whether agoraphobia is present is crucial. The current study examined panic disorder from this perspective. METHODS: Subjects were 253 patients who met the diagnostic criteria for panic disorder (lifetime) according to the Mini International Neuropsychiatric Interview (MINI). Of those patients, 179 had agoraphobia and 74 did not...
August 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27412387/brain-networks-modulated-by-subthalamic-nucleus-deep-brain-stimulation
#20
Ettore A Accolla, Maria Herrojo Ruiz, Andreas Horn, Gerd-Helge Schneider, Tanja Schmitz-Hübsch, Bogdan Draganski, Andrea A Kühn
Deep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson's disease. Given the frequent occurrence of stimulation-induced affective and cognitive adverse effects, a better understanding about the role of the subthalamic nucleus in non-motor functions is needed. The main goal of this study is to characterize anatomical circuits modulated by subthalamic deep brain stimulation, and infer about the inner organization of the nucleus in terms of motor and non-motor areas...
September 2016: Brain: a Journal of Neurology
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