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https://www.readbyqxmd.com/read/28449569/baclofen-abuse-due-to-its-hypomanic-effect-in-patients-with-alcohol-dependence-and-comorbid-major-depressive-disorder
#1
Soumitra Ghosh, Dhrubajyoti Bhuyan
Baclofen is a gamma-aminobutyric acid type B receptor agonist used as an anti-craving agent for treatment of alcohol dependence. It has gained popularity in the recent times because it is well tolerated even in patients with hepatic impairments. Herein we are summarizing the latest literature about baclofen induced hypomania and are reporting a case of baclofen abuse because of its mood elevating property in a patient of alcohol dependence with comorbid major depressive disorder. Literature review and case study of a 36-year-old male with alcohol dependence with comorbid major depressive disorder was prescribed with tablet baclofen as an anti-craving agent along with antidepressant medicines...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28421980/guidelines-for-the-recognition-and-management-of-mixed-depression
#2
Stephen M Stahl, Debbi A Morrissette, Gianni Faedda, Maurizio Fava, Joseph F Goldberg, Paul E Keck, Yena Lee, Gin Malhi, Ciro Marangoni, Susan L McElroy, Michael Ostacher, Joshua D Rosenblat, Eva Solé, Trisha Suppes, Minoru Takeshima, Michael E Thase, Eduard Vieta, Allan Young, Mark Zimmerman, Roger S McIntyre
A significant minority of people presenting with a major depressive episode (MDE) experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may have important prognostic and treatment implications, the DSM-5 codified a new nosological entity, the "mixed features specifier," referring to individuals meeting threshold criteria for an MDE and subthreshold symptoms of (hypo)mania or to individuals with syndromal mania and subthreshold depressive symptoms. The mixed features specifier adds to a growing list of monikers that have been put forward to describe phenotypes characterized by the admixture of depressive and hypomanic symptoms (e...
February 28, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28407229/weight-gain-with-add-on-second-generation-antipsychotics-in-bipolar-disorder-a-naturalistic-study
#3
H Najar, E Joas, M Kardell, E Pålsson, M Landén
OBJECTIVE: Our aim was to investigate the prevalence and magnitude of weight gain in-patients with bipolar disorder when treated with a second-generation antipsychotic as an add-on treatment to a mood stabilizer in routine clinical practice. METHODS: Data were derived from the quality register for bipolar disorder in Sweden (BipoläR). Patients with bipolar disorder who started add-on treatment with a SGA (n = 575) were compared at next yearly follow-up with age and sex matched patients who were only treated with a mood stabilizer (n = 566)...
April 13, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28401296/associations-of-specific-psychiatric-disorders-with-isolated-focal-dystonia-and-monogenic-and-idiopathic-parkinson-s-disease
#4
Susanne Steinlechner, Johann Hagenah, Hans-Jürgen Rumpf, Christian Meyer, Ulrich John, Tobias Bäumer, Norbert Brüggemann, Meike Kasten, Alexander Münchau, Christine Klein, Rebekka Lencer
Comorbidity of psychiatric disorders in patients with movement disorders is common. Often, psychiatric symptoms manifest before the onset of the movement disorder, thus not representing a mere reaction to its burden. How the disease mechanisms of psychiatric and movement disorders are related is still poorly understood. The aim of the present study was to compare prevalence rates of specific psychiatric disorders between different movement disorders including isolated focal dystonia (IFD, N = 91), monogenic Parkinson's disease (PD, N = 41), idiopathic PD (N = 45), and a sample from a Northern Germany general population (TACOS Study; N = 4075)...
April 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28390496/kindling-of-life-stress-in-bipolar-disorder-effects-of-early-adversity
#5
Benjamin G Shapero, Rachel B Weiss, Taylor A Burke, Elaine M Boland, Lyn Y Abramson, Lauren B Alloy
Most theoretical frameworks regarding the role of life stress in bipolar disorders (BD) do not incorporate the possibility of a changing relationship between psychosocial context and episode initiation across the course of the disorder. The kindling hypothesis theorizes that over the longitudinal course of recurrent affective disorders, the relationship between major life stressors and episode initiation declines (Post, 1992). The present study aimed to test an extension of the kindling hypothesis in BD by examining the effect of early life adversity on the relationship between proximal life events and prospectively assessed mood episodes...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28390495/aggression-protects-against-the-onset-of-major-depressive-episodes-in-individuals-with-bipolar-spectrum-disorder
#6
Tommy H Ng, Rachel D Freed, Madison K Titone, Jonathan P Stange, Rachel B Weiss, Lyn Y Abramson, Lauren B Alloy
A growing body of research suggests that bipolar spectrum disorders (BSDs) are associated with high aggression. However, little research has prospectively examined how aggression may affect time to onset of hypomanic/manic versus major depressive episodes. In a longitudinal study, we tested the hypothesis that aggression would prospectively predict a shorter time to the onset of hypomanic/manic episodes and a longer time to the onset of major depressive episodes, based on the behavioral approach system theory of BSDs...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28368159/personality-disorder-symptom-severity-predicts-onset-of-mood-episodes-and-conversion-to-bipolar-i-disorder-in-individuals-with-bipolar-spectrum-disorder
#7
Tommy H Ng, Taylor A Burke, Jonathan P Stange, Patricia D Walshaw, Rachel B Weiss, Snezana Urosevic, Lyn Y Abramson, Lauren B Alloy
Although personality disorders (PDs) are highly comorbid with bipolar spectrum disorders (BSDs), little longitudinal research has been conducted to examine the prospective impact of PD symptoms on the course of BSDs. The aim of this study is to examine whether PD symptom severity predicts shorter time to onset of bipolar mood episodes and conversion to bipolar I disorder over time among individuals with less severe BSDs. Participants (n = 166) with bipolar II disorder, cyclothymia, or bipolar disorder not otherwise specified completed diagnostic interview assessments of PD symptoms and self-report measures of mood symptoms at baseline...
April 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28365865/socio-demographic-and-clinical-characterization-of-patients-with-bipolar-disorder-i-vs-ii-a-nationwide-italian-study
#8
A Carlo Altamura, Massimiliano Buoli, Bruno Cesana, Bernardo Dell'Osso, Gianluigi Tacchini, Umberto Albert, Andrea Fagiolini, Andrea de Bartolomeis, Giuseppe Maina, Emilio Sacchetti
Bipolar disorders (BDs) are prevalent, comorbid and disabling conditions, associated with the highest suicide risk among psychiatric illnesses. In the last few years, new efforts to better characterize the socio-demographic and clinical profiles of BD type I vs II have been documented by several reports, with novel and insightful findings in the field. The present multicenter study aimed to provide a comprehensive and reliable representation of the Italian reality, through the analysis of the largest national sample of bipolar patients collected so far...
April 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28364588/a-latent-profile-analysis-of-schizotypal-dimensions-associations-with-psychopathology-and-personality
#9
Eduardo Fonseca-Pedrero, Javier Ortuño-Sierra, Alicia Pérez de Álbeniz, José Muñiz, Alex S Cohen
The main goal of the present study was to explore the latent structure of schizotypal traits in non-clinical young adults, and compare the latent profiles in clinical and personality characteristics: mental distress, psychosis-proneness, hypomanic experiences, and anticipatory and consummatory pleasure. A large sample of college students (N =1002; mean age =21.11 years; SD =3.92) were administered the Schizotypal Personality Questionnaire-Brief Revised, the Mood Disorder Questionnaire, the short version of the Oxford-Liverpool Inventory of Feelings and Experiences, the General Health Questionnaire-12, and the Temporal Experience of Pleasure Scale...
February 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28357133/the-association-between-self-reported-and-clinically-determined-hypomanic-symptoms-and-the-onset-of-major-mood-disorders
#10
Sarah Margaret Goodday, Martin Preisig, Mehdi Gholamrezaee, Paul Grof, Jules Angst, Anne Duffy
BACKGROUND: Hypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder. AIMS: To determine whether hypomanic symptoms differentiate offspring of parents with bipolar disorder (high risk) and offspring of well parents (control) and predict the development of mood episodes. METHOD: High-risk and control offspring were prospectively assessed using semi-structured clinical interviews annually and completed the Hypomania Checklist-32 Revised (HCL-32)...
March 2017: BJPsych Open
https://www.readbyqxmd.com/read/28300934/an-evolutionary-approach-to-mania-studying-sardinian-immigrants-to-argentina
#11
Mauro G Carta, Alessandra Perra, Michela Atzeni, Silvia D'Oca, Maria F Moro, Peter K Kurotschka, Daniela Moro, Federica Sancassiani, Luigi Minerba, Maria V Brasesco, Gustavo Mausel, Antonio E Nardi, Leonardo Tondo
Objective: To ascertain lifetime prevalence of positivity to a screening questionnaire for bipolar disorders (BD) in Sardinian immigrants to Argentina and residents of Sardinia and assess whether such positivity affects quality of life (QoL) in either group. Our hypothesis is that screen positivity for BD may be more frequent in immigrants. Methods: Observational study. Subjects were randomly selected from the membership lists of associations of Sardinian immigrants in Argentina...
March 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28291043/repetitive-transcranial-magnetic-stimulation-and-treatment-emergent-mania-and-hypomania-a-review-of-the-literature
#12
Fady Rachid
BACKGROUND: This review focuses on treatment-emergent mania/hypomania (TEM) associated with repetitive transcranial magnetic stimulation (rTMS). METHODS: English-language studies involving possible rTMS-induced mania/hypomania published between 1966 and 2015 were retrieved through a Medline search using the search terms mania, hypomania, mixed affective state, treatment-emergent, repetitive transcranial magnetic stimulation, and rTMS. Fifteen case series and controlled studies describing TEM associated with rTMS treatment have been published involving 24 individuals, most of whom were diagnosed with either bipolar I or II disorder or major depressive disorder...
March 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28288308/the-link-between-hypomania-risk-and-creativity-the-role-of-heightened-behavioral-activation-system-bas-sensitivity
#13
Bin-Na Kim, Seok-Man Kwon
BACKGROUND: The relationship between bipolar disorder (BD) and creativity is well-known; however, relatively little is known about its potential mechanism. We investigated whether heightened behavioral activation system (BAS) sensitivity may mediate such relationship. METHODS: Korean young adults (N=543) completed self-report questionnaires that included the Hypomanic Personality Scale (HPS), the Behavioral Activation System(BAS) Scale, the Everyday Creativity Scale (ECS), the Positive Affect and Negative Affect Schedule (PANAS), and the Altman Self-Rating Mania Scale (ASRM)...
March 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28264739/remission-and-recovery-associated-with-lurasidone-in-the-treatment-of-major-depressive-disorder-with-subthreshold-hypomanic-symptoms-mixed-features-post-hoc-analysis-of-a-randomized-placebo-controlled-study-with-longer-term-extension
#14
Joseph F Goldberg, Daisy Ng-Mak, Cynthia Siu, Chien-Chia Chuang, Krithika Rajagopalan, Antony Loebel
OBJECTIVE: This post-hoc analysis assessed rates of symptomatic and functional remission, as well as recovery (combination of symptomatic and functional remission), in patients treated with lurasidone for major depressive disorder (MDD) associated with subthreshold hypomanic symptoms (mixed features). METHOD: Patients with MDD plus two or three manic symptoms (defined as per the DSM-5 mixed-features specifier) were randomly assigned to flexible-dose lurasidone 20-60 mg/day (n=109) or placebo (n=100) for 6 weeks, followed by a 3-month open-label, flexible-dose extension study for U...
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28249202/what-can-daily-life-assessment-tell-us-about-the-bipolar-spectrum
#15
Sarah H Sperry, Thomas R Kwapil
Evidence suggests that bipolar psychopathology is better characterized as a spectrum than by categorical diagnoses. The examination of symptoms and impairment associated with bipolar spectrum psychopathology is important and can be enhanced by methods that examine affect, thoughts, and behavior in daily life. The present study extended findings that provide validation of a continuum of bipolar psychopathology in daily life. Young adults (n=294) completed the Hypomanic Personality Scale (HPS) and experience sampling using smartphones...
February 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28241886/comparison-of-associated-features-and-drug-treatment-between-co-occurring-unipolar-and-bipolar-disorders-in-depressed-eating-disorder-patients
#16
Mei-Chih Meg Tseng, Chin-Hao Chang, Shih-Cheng Liao, Hsi-Chung Chen
BACKGROUND: To examine the differences of associated characteristics and prescription drug use between co-occurring unipolar and bipolar disorders in patients with eating disorders (EDs). METHODS: Patients with EDs and major depressive episode (MDE) were recruited from psychiatric outpatient clinics. They were interviewed and completed self-administered measures assessing eating and general psychopathology. The prescribed drugs at the index outpatient visit were recorded...
February 27, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28211548/the-33-item-hypomania-checklist-hcl-33-a-study-of-the-consistency-between-self-and-external-assessments-in-polish-bipolar-patients
#17
Dorota Łojko, Dominika Dudek, Jules Angst, Marcin Siwek, Michał Michalak, Janusz Rybakowski
OBJECTIVES: The Hypomania Checklist (HCL) has become an important tool for the assessment of hypomanic symptoms in patients with mood disorders and in the general population. The HCL-33 scale, containing 33 symptom items, is a new instrument which, in addition to the self-administered questionnaire, has a version for external rating. The aim of this study is to evaluate the consistency between the self - and external assessments using the HCL-33 in Polish patients with bipolar disorder...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28188565/poor-quality-of-life-and-functioning-in-bipolar-disorder
#18
Louisa G Sylvia, Rebecca E Montana, Thilo Deckersbach, Michael E Thase, Maurcio Tohen, Noreen Reilly-Harrington, Melvin G McInnis, James H Kocsis, Charles Bowden, Joseph Calabrese, Keming Gao, Terence Ketter, Richard C Shelton, Susan L McElroy, Edward S Friedman, Dustin J Rabideau, Andrew A Nierenberg
BACKGROUND: This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder. METHODS: Adult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28184334/mixed-states-in-bipolar-disorder-etiology-pathogenesis-and-treatment
#19
REVIEW
Ather Muneer
Many bipolar disorder patients exhibit mixed affective states, which portend a generally more severe illness course and treatment resistance. In the previous renditions of Diagnostic and Statistical Manual mixed states were narrowly defined in the context of bipolar I disorder, but with the advent of DSM-5 the term "mixed episode" was dropped and replaced by "mixed features" specifier which could be broadly applied to manic, hypomanic and depressive episodes in both the bipolar spectrum and major depressive disorders...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28160351/comparison-of-treatment-outcome-using-two-definitions-of-rapid-cycling-in-subjects-with-bipolar-ii-disorder
#20
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Robert J DeRubeis
OBJECTIVES: We examined differences in treatment outcome between Diagnostic and Statistical Manual Fourth Edition (DSM-IV)-defined rapid cycling and average lifetime-defined rapid cycling in subjects with bipolar II disorder. We hypothesized that, compared with the DSM-IV definition, the average lifetime definition of rapid cycling may better identify subjects with a history of more mood lability and a greater likelihood of hypomanic symptom induction during long-term treatment. METHODS: Subjects ≥18 years old with a bipolar II major depressive episode (n=129) were categorized into DSM-IV- and average lifetime-defined rapid cycling and prospectively treated with either venlafaxine or lithium monotherapy for 12 weeks...
February 2017: Bipolar Disorders
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