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Zhichao Yang, Xueyu Xu, Lingxia Sun, Xue Zhao, Hao Wang, John Paul Fawcett, Yan Yang, Jingkai Gu
A rapid and sensitive assay based on supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS) has been developed and validated for the determination of oxcarbazepine (OXC) and its chiral metabolite licarbazine (Lic) in beagle dog plasma using carbamazepine as internal standard. Chiral analysis in a run time of only 3 min was performed on an ACQUITY UPC(2) ™ Trefoil™ CEL2 column (3.0 × 150 mm, 2.5 μm) at 50 °C by isocratic elution with a mobile phase of supercritical carbon dioxide (purity ≥ 99...
May 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Russell J Lewis, Mike K Angier, Robert D Johnson
During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. A case recently received by CAMI screened positive for the anticonvulsant medication carbamazepine (CBZ; Tegretol(®)) by gas chromatography-mass spectrometry (GC-MS). The CBZ found during this routine screening procedure was subsequently confirmed using a CBZ-specific GC-MS procedure. It was later discovered that the accident victim had been prescribed oxcarbazepine (OXCBZ; Trileptal(®))...
October 2014: Journal of Analytical Toxicology
V I Guzeva, V V Guzeva
Objective. To investigate the effect of modern antiepileptic drugs on the hormonal profile of girls with epilepsy. Materials and methods. Levels of thyroid-stimulating hormone (TSH), thyrogiobulin antibodies (a/b TG), triiodothyronine (T3), thyroxine (T4), parathyroid hormone (P) and cortisol (C) were determined in the blood of 50 girls with epilepsy, aged from 8 to 17 years. In 19 girls, repeated measures of TSH, a/b TG, T3, T4 and C were taken 2-12 months after the first study. Valproate, carbamazepine, and topamax were used for treatment...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
P K Jensen
The anti-epileptic activity of oxcarbazepine (OXC) was compared with that of carbamazepine (CBZ) and the primary active metabolite of OXC, a monohydroxy derivative (MHD). Altogether 255 patients receiving either OXC or MHD (192 and 63 patients respectively) were included in the analysis of efficacy. Out of these 255 patients a total of 40 were children. The duration of treatment varied between 8 and 24weeks. The daily dose of OXC or MHD varied between 600 and 5400 mg (in children 600-2400 mg). Out of five studies two were double-blind controlled studies (including a total of 105 patients) whereas the remaining three were open studies...
1990: Behavioural Neurology
J W Faigle, G P Menge
Hepatic oxygenases of the cytochrome P-450 family play a major role in the clearance of various anti-epileptic drugs. These enzymes are susceptible both to induction and to inhibition. Phenytoin, carbamazepine (CBZ), primidone, and phenobarbitone, for instance, are potent enzyme inducers. Other drugs, such as chloramphenicol, propoxyphene, verapamil, and viloxazine, inhibit cytochrome P-450. Pharmacokinetic behaviour is thus often altered, especially in combined medication, so that the dosage has to be re-adjusted if an optimum therapeutic outcome is to be ensured...
1990: Behavioural Neurology
Bernhard J Steinhoff
Oxcarbazepine (OXC) is a 10-keto-analogue of carbamazepine, which was developed and labeled as a follow-up antiepileptic drug, that was intended to overcome some of the pharmacological drawbacks of carbamazepine with similar efficacy. The main advantage is the nonoxidative metabolic pathway that allows a lower enzyme-induction profile and fewer drug interactions. OXC is rapidly and extensively reduced by cytosolic hepatic enzymes to its monohydroxylated derivative (MHD), thus OXC may be regarded as a prodrug with MHD representing the active antiepileptic agent...
March 2009: Expert Review of Clinical Pharmacology
Herng-Sheng Lee, Shih-Yu Wang, Donald M Salter, Chih-Chien Wang, Shyi-Jou Chen, Hueng-Chuen Fan
BACKGROUND: This study investigated whether long-term treatment with antiepileptic drugs (AEDs) had negative effects on statural growth and serum calcium levels in children with epilepsy in Taiwan. METHODS: Children with epilepsy treated with one prescription of AEDs (monotherapy) for at least 1 year were selected. The AEDs included valproic acid (VPA; Deparkin) in 27 children (11 boys and 16 girls) aged 4-18 years, oxcarbazepine (Trileptal) in 30 children (15 boys and 15 girls) aged 5-18 years, topiramate (Topamax) in 19 children (10 boys and 9 girls) aged 6-18 years, and lamotrigine (Lamicta) in eight children (5 boys and 3 girls) aged 5-13 years...
2013: BMC Pediatrics
Luca Vaghi, Emanuela Calcio Gaudino, Giancarlo Cravotto, Giovanni Palmisano, Andrea Penoni
A library of new heterocyclic systems was synthesized starting from oxcarbazepine (OXC, Trileptal, 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide). The key for these transformations is the α-enolizable ketone present on the [d]-side of our starting material OXC, thus, an in depth investigation of the literature to find heteroannulation reactions for substrates carrying an α-enolizable ketone gave us a boost to discover an excellent derivatization strategy and [3+2], [4+2] and [4+1] approaches were successfully developed...
2013: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shu-Hao Wei, Cheng-Chao Liu, Pi-Chuan Fan
BACKGROUND: Few clinical studies have assessed the efficacy and safety of oxcarbazepine (OXC) oral suspension in Asian pediatric patients and particularly in infants. The aim of this study was to investigate and compare the efficacy, tolerability, and side effects of OXC oral suspension in Taiwanese infants and children with various types of epilepsy. METHODS: A retrospective review of the efficacy, tolerability, and side effects of OXC oral suspension in a tertiary medical center in Taiwan was conducted and included children (1-9 years old) and infants (<1 year old) diagnosed with epilepsy, which was classified into idiopathic partial, symptomatic partial, or multifocal subtypes...
February 2014: Paediatric Drugs
Achille Edem Tchalla, Benoit Marin, Claude Mignard, Devender Bhalla, Emmanuel Tabailloux, Didier Mignard, Pierre Jallon, Pier-Marie Preux
PURPOSE: To describe seizure types and risk factors among elderly people with newly diagnosed epileptic seizures living on La Réunion, a French Island in the Southern Indian Ocean. METHODS: We describe an elderly population with newly diagnosed epileptic seizures using data from the EPIREUN study conducted between July 1, 2004 and June 30, 2005. The methodology is described in detail in the EPIREUN study report (Mignard et al., 2009). KEY FINDINGS: There were 153 single unprovoked seizures (84...
December 2011: Epilepsia
E D Belousova, K Iu Mukhin, N A Ermolenko, V I Guzeva, M D Tysiachina, M B Mironov, A S Petrukhin
A prospective non-randomized non-controlled multicenter trial has been conducted. The trial included 254 children, aged from 11 months to 18 years (mean age 9.3 +/- 4.5 years), with predominantly focal forms of epilepsy treated with trileptal (oxcarbazepine). The observation period was 31 weeks. Efficacy and safety of therapy was assessed in 3 visits: screening and assignment to therapy (visit 1), the end of titration and achievement of maintenance dose (visit 2), assessment of maintenance therapy (visit 3)...
2010: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
J Gros-Otero, M Gorroño-Echebarría, J Benítez-Herreros
CLINICAL CASE: A case is presented of a patient who developed skin lesions on the legs and a bilateral anterior uveitis after taking Oxcarbazepine (Trileptal). DISCUSSION: The presence of uveitis in the context of an allergic reaction to an anticonvulsant is a very uncommon and can affect the internal organs. For this reason, it should be taken into account when carrying out a full assessment of a patient with a possible hypersensitivity reaction to a particular drug...
November 2010: Archivos de la Sociedad Española de Oftalmología
Tapani Keränen, Annamari Sorri, Eeva Moilanen, Pauli Ylitalo
OBJECTIVE: The effects of single and repeated doses of oral activated charcoal (OAC) on the absorption and elimination of the antiepileptic drugs, lamotrigine (CAS 84057-84-1, LTG, Lamictal) and oxcarbazepine (CAS 28721-07-5, OXC, Trileptal) were studied in healthy volunteers to assess the therapeutic potential of OAC in the treatment of LTG and OXC overdose. METHODS: In three open, randomized, cross-over sessions with > or = 14 days washout, LTG 100 mg and OXC 600 mg were given orally, each to 6 subjects...
2010: Arzneimittel-Forschung
S G Burd, L Iu Glukhova, O L Badalian
The trial included 302 patients with focal and generalized forms of epilepsy, aged from 18 to 73 years (mean age 33.23+/-12.73 years). Oxcarbazepine (trileptal) was prescribed in accordance to recommendations and titration schemes (continuous and single-stage) conventional in Russia. Trileptal was prescribed as the start antiepileptic therapy to 46.1% of patients. In other patients, antiepileptic drugs used previously were withdrawn mainly to their low clinical efficacy and poor tolerability. The duration of the study was 12 weeks...
2010: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
(no author information available yet)
A prospective non-randomized non-controlled multicenter trial has been conducted. The trial included 254 children, aged from 11 months to 18 years (mean age 9.3 +/- 4.5 years), with predominantly focal forms of epilepsy treated with trileptal (oxcarbazepine). The observation period was 31 weeks. Efficacy and safety of therapy was assessed in 3 visits: screening and assignment to therapy (visit 1), the end of titration and achievement of maintenance dose (visit 2), assessment of maintenance therapy (visit 3)...
2010: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
P N Vlasov, V V Molochkova
No abstract text is available yet for this article.
2009: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
V I Guzeva, V V Guzeva, O V Guzeva
Thirty-nine boys with epilepsy, aged 8-17 years, and 61 sex- and age-matched controls have been examined. Changes of blood hormone levels were found in patients received carbamazepines, valproates, polytherapy as well as in non-treated patients. The increase of levels of progesterone, testosterone, FSH and LH, decrease of prolactin and estradiol levels and influence on thyroid gland hormones, as reflected by increasing of T4 and decreasing of T3 compared to carbamazepines, were found during the treatment with trileptal in the older group...
2008: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
L V Sokolova, V V Kalinin, E V Zheleznova, A A Zemlianaia, D A Polianskiĭ, A V Basamygin
An aim of the study was to compare the spectrum of effects of oxcarbazepine and carbamazepine in patients with partial temporal epilepsy. Seventy-two patients (24 men and 48 women) diagnosed with cryptogenic partial epilepsy have been examined. Fifty-one patients received carbamazepine as a monotherapy in dosage 300-1200 mg/day, 21 patients were treated with oxcarbazepine in dosage 600-1500 mg daily. The results revealed the similar effects of two drugs. However some differences were also found: the effect of oxcarbazepine on complex partial seizures was more pronounced comparing to carbamazepine...
2008: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Ignacio Valencia, Agustín Legido
In this paper we review the current information regarding the use of new antiepileptic drugs (AEDs) used as monotherapy in children. We specifically include the following AEDs: lamotrigine (Lamictal), topiramate (Topamax), zonisamide (Zonegran), levetiracetam (Keppra), and oxcarbazepine (Trileptal). All of these AEDs have a broad spectrum of action in the treatment of partial and generalized seizures, except Oxcarbazepine, which is effective only in partial seizures. It is unclear whether or not monotherapy with the new AEDs offers higher efficacy and/or lower side effects compared to classic AEDs (phenobarbital, phenytoin, carbamazepine, or valproate) thereby significantly improving the quality of life in children with epilepsy...
2009: Medicina
C Souppart, Q Yin, M Merz, P Hu, J Jiang, S Appel-Dingemanse
OBJECTIVE: Oxcarbazepine (Trileptal) is an antiepileptic drug used as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and children. The primary objective of this study was to assess the bioequivalence of Trileptal oral suspension formulation vs. the film-coated tablet after single and multiple twice-daily administrations in fasted, healthy Chinese male subjects. METHODS: This was an open-label, randomized, two-period crossover study in 19 healthy Chinese male subjects...
October 2008: International Journal of Clinical Pharmacology and Therapeutics
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