keyword
https://read.qxmd.com/read/37652457/management-of-cluster-headache-treatments-and-their-mechanisms
#21
REVIEW
Kuan-Po Peng, Mark J Burish
BACKGROUND: The management of cluster headache is similar to that of other primary headache disorders and can be broadly divided into acute and preventive treatments. Acute treatments for cluster headache are primarily delivered via rapid, non-oral routes (such as inhalation, nasal, or subcutaneous) while preventives include a variety of unrelated treatments such as corticosteroids, verapamil, and galcanezumab. Neuromodulation is becoming an increasingly popular option, both non-invasively such as vagus nerve stimulation when medical treatment is contraindicated or side effects are intolerable, and invasively such as occipital nerve stimulation when medical treatment is ineffective...
August 2023: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/37631332/optimizing-absorption-for-intranasal-delivery-of-drugs-targeting-the-central-nervous-system-using-alkylsaccharide-permeation-enhancers
#22
REVIEW
Stuart Madden, Enrique Carrazana, Adrian L Rabinowicz
Intranasal delivery of drugs offers several potential benefits related to ease of delivery, rapid onset, and patient experience, which may be of particular relevance to patients with central nervous system (CNS) conditions who experience acute events. Intranasal formulations must be adapted to address anatomical and physiological characteristics of the nasal cavity, including restricted dose volume, limited surface area, and barriers to mucosal absorption, in addition to constraints on the absorption window due to mucociliary clearance...
August 10, 2023: Pharmaceutics
https://read.qxmd.com/read/37615206/clinical-characteristics-and-treatment-patterns-of-patients-with-episodic-cluster-headache-results-from-the-united-states-united-kingdom-and-germany
#23
JOURNAL ARTICLE
Sarah Cotton, Jeffrey S Andrews, Russell M Nichols, James Jackson, Antje Tockhorn-Heidenreich, Gary Milligan, James M Martinez
OBJECTIVE: To describe clinical characteristics and regional treatment patterns of episodic cluster headache (CH). METHODS: A point-in-time survey of physicians and their patients with CH was conducted in the United States, United Kingdom and Germany in 2017. RESULTS: Overall, 1012 patients with episodic CH were analyzed. Demographic and clinical findings were generally consistent across regions. Most patients were men (66.6%) and the mean age was 40...
August 24, 2023: Current Medical Research and Opinion
https://read.qxmd.com/read/37557014/rutaecarpine-alleviates-migraine-in-nitroglycerin-induced-mice-by-regulating-pten-pgk1-signaling-pathway-to-activate-nrf2-antioxidant-system
#24
JOURNAL ARTICLE
Min Xu, Zhenhua Shi, Ziyang He, Xiaoyang Ling, Wenhua Wang, Hua Liu, Mingjie Gong
BACKGROUND: Due to its widespread prevalence, migraine is a common neurovascular condition that has a major impact on people's health and quality of life. Rutaecarpine (RUT) is one of the main effective components of Evodia rutaecarpa, which has a wide range of biological activities. However, the exact mechanism by which RUT improves migraine remain unknown. PURPOSE: The purpose of this study was to investigate whether RUT improves migraine by inhibiting oxidative stress via activating the Nrf2 antioxidant system through the PTEN/PGK1 signaling pathway...
August 7, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37524744/multi-omic-analyses-of-triptan-treated-migraine-attacks-gives-insight-into-molecular-mechanisms
#25
JOURNAL ARTICLE
Lisette J A Kogelman, Katrine Falkenberg, Filip Ottosson, Madeleine Ernst, Francesco Russo, Valdemar Stentoft-Hansen, Samuel Demharter, Peer Tfelt-Hansen, Arieh S Cohen, Jes Olesen, Thomas Folkmann Hansen
Migraine is a common, polygenic disorder that is characterized by moderate to severe headache attacks. Migraine attacks are commonly treated with triptans, i.e. serotonin receptor agonists. However, triptans are effective in ~ 60% of the population, and the mechanisms of triptans are debated. Here, we aim to expose the mechanisms of triptan using metabolomics and transcriptomics in spontaneous migraine attacks. We collected temporal multi-omics profiles on 24 migraine patients, using samples collected at a migraine attack, 2 h after treatment with a triptan, when headache-free, and after a cold-pressor test...
July 31, 2023: Scientific Reports
https://read.qxmd.com/read/37515405/european-academy-of-neurology-guidelines-on-the-treatment-of-cluster-headache
#26
REVIEW
Arne May, Stefan Evers, Peter J Goadsby, Massimo Leone, Gian Camillo Manzoni, Julio Pascual, Vanessa Carvalho, Michele Romoli, Katina Aleksovska, Patricia Pozo-Rosich, Rigmor H Jensen
BACKGROUND AND PURPOSE: Cluster headache is a relatively rare, disabling primary headache disorder with a major impact on patients' quality of life. This work presents evidence-based recommendations for the treatment of cluster headache derived from a systematic review of the literature and consensus among a panel of experts. METHODS: The databases PubMed (Medline), Science Citation Index, and Cochrane Library were screened for studies on the efficacy of interventions (last access July 2022)...
October 2023: European Journal of Neurology
https://read.qxmd.com/read/37488233/duality-in-response-of-intracranial-vessels-to-nitroglycerin-revealed-in-rats-by-imaging-photoplethysmography
#27
JOURNAL ARTICLE
Alexey Y Sokolov, Maxim A Volynsky, Anastasiia V Potapenko, Polina M Iurkova, Valeriy V Zaytsev, Ervin Nippolainen, Alexei A Kamshilin
Among numerous approaches to the study of migraine, the nitroglycerin (NTG) model occupies a prominent place, but there is relatively insufficient information about how NTG affects intracranial vessels. In this study we aim to assess the effects of NTG on blood-flow parameters in meningeal vessels measured by imaging photoplethysmography (iPPG) in animal experiments. An amplitude of the pulsatile component (APC) of iPPG waveform was assessed before and within 2.5 h after the NTG administration in saline (n = 13) or sumatriptan (n = 12) pretreatment anesthetized rats in conditions of a closed cranial window...
July 24, 2023: Scientific Reports
https://read.qxmd.com/read/37455509/predicting-sumatriptan-responsiveness-based-on-structural-connectivity-in-patients-newly-diagnosed-with-migraine
#28
JOURNAL ARTICLE
Dong Ah Lee, Hyung Chan Kim, Ho-Joon Lee, Kang Min Park
BACKGROUND AND PURPOSE: We aimed to determine whether structural brain connectivity is significantly associated with the response to sumatriptan in patients with migraine. METHODS: We retrospectively enrolled patients with newly diagnosed migraine who underwent brain diffusion-tensor imaging (DTI) at the time of diagnosis, with regular follow-up for at least 6 months after the initial diagnosis. Patients were classified into good- and poor-responder groups according to their response to sumatriptan...
June 1, 2023: Journal of Clinical Neurology
https://read.qxmd.com/read/37420564/glassy-carbon-electrode-modified-with-cb-tio-2-layer-for-sensitive-determination-of-sumatriptan-by-means-of-voltammetry-and-flow-injection-analysis
#29
JOURNAL ARTICLE
Joanna Smajdor, Beata Paczosa-Bator, Małgorzata Grabarczyk, Robert Piech
Sumatriptan is an organic chemical compound from the tryptamine group. It is used as a medicine for migraine attacks and in the treatment of cluster headaches. In this work, a new voltammetric method is proposed for highly sensitive SUM determination, using glassy carbon electrodes modified with carbon black and titanium dioxide suspension. The novelty of the presented work is the usage of the mixture of carbon black and TiO2 as glassy carbon electrode modifier for the first time for SUM determination. The mentioned sensor was characterized by great repeatability and sensitivity of measurements, which resulted in the obtention of a wide range of linearity and a low detection limit...
June 7, 2023: Sensors
https://read.qxmd.com/read/37417808/pain-management-after-elective-craniotomy-a-systematic-review-with-procedure-specific-postoperative-pain-management-prospect-recommendations
#30
JOURNAL ARTICLE
François P Mestdagh, Patricia M Lavand'homme, Géraldine Pirard, Girish P Joshi, Axel R Sauter, Marc Van de Velde
BACKGROUND: Pain after craniotomy can be intense and its management is often suboptimal. OBJECTIVES: We aimed to evaluate the available literature and develop recommendations for optimal pain management after craniotomy. DESIGN: A systematic review using procedure-specific postoperative pain management (PROSPECT) methodology was undertaken. DATA SOURCES: Randomised controlled trials and systematic reviews published in English from 1 January 2010 to 30 June 2021 assessing pain after craniotomy using analgesic, anaesthetic or surgical interventions were identified from MEDLINE, Embase and Cochrane Databases...
October 1, 2023: European Journal of Anaesthesiology
https://read.qxmd.com/read/37400775/comparative-efficacy-of-different-treatments-for-menstrual-migraine-a-systematic-review-and-network-meta-analysis
#31
REVIEW
Han Zhang, Jian-Zhi Qi, Zhi-Hua Zhang
BACKGROUND: Menstrual migraine is a subtype of migraine disease that is typically more disabling, longer-lasting, and more challenging to treat. The purpose of this network meta-analysis (NMA) is to compare the relative efficacy of treatments for menstrual migraine. METHODS: We systematically searched databases, including PubMed, EMBASE, and Cochrane, and included all eligible randomized controlled trials in the study. We conducted the statistical analysis using Stata version 14...
July 3, 2023: Journal of Headache and Pain
https://read.qxmd.com/read/37390721/rapid-and-naked-eye-colorimetric-detection-of-ultra-trace-sumatriptan-in-drinking-water-saliva-and-human-urine-samples-based-on-the-aggregation-of-gold-nanoparticles
#32
JOURNAL ARTICLE
Shiva Minaee, Mahmoud Reza Sohrabi, Saeid Mortazavinik
In this study, the determination of sumatriptan (SUM) was performed using a simple, rapid, and precise colorimetric method based on the surface plasmon resonance (SPR) feature of gold nanoparticles (AuNPs). By adding SUM, the aggregation was observed in AuNPs with red-to-blue color shifts. The size distribution of NPs was estimated before and after adding SUM via dynamic light scattering (DLS), which was found to be 15.34 and 97.45 nm, respectively. Characterization of AuNPs, SUM, and AuNPs in combination with SUM was investigated using transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR)...
June 17, 2023: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/37377770/activation-of-the-microglial-p2x7r-nlrp3-inflammasome-mediates-central-sensitization-in-a-mouse-model-of-medication-overuse-headache
#33
JOURNAL ARTICLE
Yanyun Wang, Liang Dong, Yun Zhang, Yixin Zhang, Guangcheng Qin, Dunke Zhang, Lixue Chen, Wei He, Jiying Zhou
BACKGROUND: Excessive use of headache treatments often leads to the development, progression and exacerbation of primary headache, which is defined as medication overuse headache (MOH). A significant pathophysiological mechanism of MOH is central sensitization. Recent evidence suggests that central sensitization in chronic headache is a result of inflammatory responses mediated by microglial activation in the trigeminal nucleus caudalis (TNC). However, it is unknown whether microglial activation has an impact on the central sensitization of MOH...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/37291500/the-efficacy-and-safety-of-metoclopramide-in-relieving-acute-migraine-attacks-compared-with-other-anti-migraine-drugs-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#34
JOURNAL ARTICLE
Hanaa Abdelmonem, Hebatallah Mohamed Abdelhay, Gehad Taha Abdelwadoud, Amira Naser Mohammed Alhosini, Ahmed Eissa Ahmed, Samaher Walied Mohamed, Nada Mostafa Al-Dardery, Mohamed Abd-ElGawad, Mohamed Abdelmonem Kamel
BACKGROUND: Many drugs are prescribed in relieving acute migraine attacks, we aim to compare metoclopramide with other antimigraine drugs. METHODS: We searched online databases like PubMed, Cochrane Library, Scopus, and Web of Science till June 2022 for RCTs that compared metoclopramide alone with placebo or active drugs. The main outcomes were the mean change in headache score and complete headache relief. The secondary outcomes were the rescue medications need, side effects, nausea and recurrence rate...
June 8, 2023: BMC Neurology
https://read.qxmd.com/read/37276164/neurogenic-rosacea-treatment-a-literature-review
#35
REVIEW
Mirjana G Ivanic, Aislyn Oulee, Alexandra Norden, Sogol S Javadi, Michael H Gold, Jashin J Wu
Rosacea is a chronic skin disorder involving central facial erythema secondary to vascular instability and cutaneous inflammation. Rosacea is divided into different subtypes based on the morphology of the rash — erythematotelangiectatic, papulopustular, phymatous, and ocular rosacea. A less-known subtype called neurogenic rosacea has been proposed to categorize patients suffering from rosacea with erythematous flushing and burning sensation that is refractory to traditional treatment. There is minimal data on this subgroup of rosacea patients and its potential treatment options...
June 1, 2023: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/37266988/comparison-table-triptans
#36
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 12, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/37266987/drugs-for-migraine
#37
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 12, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/37255866/use-of-factorial-design-in-formulation-and-evaluation-of-intrarectal-in-situ-gel-of-sumatriptan
#38
JOURNAL ARTICLE
Hanan J Kassab, Hussein K Alkufi, Lina S Hussein
The study's goal was to create an in situ intrarectal mucoadhesive gel of sumatriptan (SMT) combining mucoadhesive polymer (xyloglucan) and thermosensitive polymers (poloxamer 407 and poloxamer 188) to prolong rectal residence time for treatment of migraines. Nine SMT mucoadhesive rectal in situ gel (RIG) formulas were created by mixing poloxamer 407 (18%, 19%, or 20%) with poloxamer 188 (5%), a mucoadhesive polymer at various doses (0.1, 0.2, and 0.3) as well as SMT (25 mg/ml). The prepared suppositories underwent for mucoadhesive force, gelation temperature, and gelation time...
2023: Journal of Advanced Pharmaceutical Technology & Research
https://read.qxmd.com/read/37248787/gastroprotective-effect-of-sumatriptan-against-indomethacin-stress-and-ethanol-induced-gastric-damage-in-male-rats-possible-modulatory-role-of-5-hydroxytryptamine-1b-1d-receptors-and-pro-inflammatory-cytokines
#39
JOURNAL ARTICLE
Aysa Ostovaneh, Faezeh Eslami, Nastaran Rahimi, Pegah Dejban, Hamed Shafaroodi, Ata Abbasi, Shirin Shahsavarhaghighi, Ahmad Reza Dehpour
The current study was aimed to investigate the beneficial effect of sumatriptan, a 5-Hydroxytryptamine 1B/1D (5HT 1B/1D) receptor agonist, on the gastric ulcer in rats via stimulating 5HT1B/1D receptors and suppressing pro-inflammatory cytokines. Rats were allocated into three models of gastric ulcer: indomethacin (30 mg/kg, PO), water immersion restraint stress (WRS), and ethanol (5 ml/kg PO). Animals were administered sumatriptan (0.01, 0.1, 0.3, and 1 mg/kg, i.p) 30 minutes before gastric ulcer induction...
May 30, 2023: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/37209053/the-efficacy-of-different-triptans-for-the-treatment-of-acute-headache-in-pediatric-migraine-a-systematic-review
#40
JOURNAL ARTICLE
Roshan Chanchlani, Amit Agrawal, Dalwinder Janjua, Shaik Nida Hafsa
BACKGROUND: Serotonin receptors 5-HT1B and 5-HT1D in the cerebral arteries are activated by the 5-hydroxytryptophan agonists (triptans) to relieve the discomfort associated with migraines. Even though triptans are often used to treat acute migraines, there is some debate over their effectiveness. OBJECTIVES: Our systematic review aimed to evaluate the effectiveness of triptans acute treatment of migraine in young individuals. METHODS: Utilizing the databases of Google Scholar, Cochrane Library, and PubMed, a literature search was conducted, and all papers published till July 2022 were included...
May 19, 2023: Indian Pediatrics
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