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https://www.readbyqxmd.com/read/29771142/the-development-of-a-mouse-model-of-mtbi-induced-post-traumatic-migraine-and-identification-of-the-delta-opioid-receptor-as-a-novel-therapeutic-target
#1
Laura S Moye, Madeline L Novack, Alycia F Tipton, Harish Krishnan, Subhash C Pandey, Amynah Aa Pradhan
Background Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this study was to develop a mouse model of post-traumatic headache and identify mechanisms and novel targets associated with this disorder. Methods We combined the closed head weight-drop method and the nitroglycerin chronic migraine model...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29760572/breath-powered-sumatriptan-dry-nasal-powder-an-intranasal-medication-delivery-system-for-acute-treatment-of-migraine
#2
REVIEW
Stewart J Tepper, Merrilee R Johnstone
There is a need for fast-acting, non-oral medication options for migraine because some attacks develop rapidly and some are accompanied by nausea, vomiting, and gastroparesis, which can hinder oral medication uptake and absorption. The most commonly prescribed migraine medications are oral triptans, with sumatriptan as the most common. However, oral triptans are associated with adverse events (AEs) of atypical sensations that may be problematic for patients. Subcutaneous (SC) injectable sumatriptan and conventional liquid triptan nasal spray formulations are also available, but the frequency of atypical sensations is the highest with SC sumatriptan, and the intense bitter taste of conventional liquid triptan nasal spray discourages use...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29556858/cyclic-vomiting-syndrome-in-children
#3
REVIEW
Anne Donnet, Sylvain Redon
PURPOSE OF REVIEW: Cyclic vomiting syndrome (CVS) is a misrecognized and probably underdiagnosed episodic syndrome associated with migraine, occurring preferentially in childhood. Attacks are stereotyped for each individual, with predictable periodicity. This review summarizes recent clinical and paraclinical observations in this syndrome, and current approaches in explorations and therapeutics. RECENT FINDINGS: Clinical phenotype during prodromal, vomiting, and recovery phases contains visceral and neuropsychological symptoms, but also cranial and systemic symptoms...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29555828/activation-of-5-ht1a-receptors-in-the-hypothalamic-paraventricular-nuclei-pvn-negatively-regulates-cytochrome-p450-expression-and-activity-in-rat-liver
#4
Ewa Bromek, Marta Rysz, Anna Haduch, Jacek Wojcikowski, Władysława Anna Daniel
Our recent work suggested a negative effect for the serotonergic innervation of the paraventricular nuclei (PVN) of the hypothalamus on growth hormone secretion and growth hormone-dependent expression of cytochrome P450 2C11 (CYP2C11). The aim of our present research was to determine the effect of the activation of the 5-HT1 or 5-HT2 receptors in the PVN on the expression and activity of cytochrome P450 in male rat liver. The serotonergic agonists 5-CT (5-carboxyamidotryptamine, a 5-HT1 receptor-type agonist), 8-OH-DPAT (8-hydroxy-2-(di-n-propyloamino)-tetralin, a 5-HT1A receptor agonist), sumatriptan (a 5-HT1B/D receptor agonist) and DOI (2,5-dimethoxy-4-iodoamphetamine, a 5-HT2A/C receptor agonist) were individually injected into the PVN...
March 19, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29536529/cluster-headache-clinical-phenotypes-tobacco-nonexposed-never-smoker-and-no-parental-secondary-smoke-exposure-as-a-child-versus-tobacco-exposed-results-from-the-united-states-cluster-headache-survey
#5
Todd D Rozen
OBJECTIVE: To present results from the United States Cluster Headache Survey comparing the clinical presentation of tobacco nonexposed and tobacco-exposed cluster headache patients. BACKGROUND: Cluster headache is uniquely tied to a personal history of tobacco usage/cigarette smoking and, if the individual cluster headache sufferer did not smoke, it has been shown that their parent(s) typically did and that individual had significant secondary smoke exposure as a child...
March 14, 2018: Headache
https://www.readbyqxmd.com/read/29529715/interventions-for-preventing-high-altitude-illness-part-2-less-commonly-used-drugs
#6
REVIEW
Alejandro Gonzalez Garay, Daniel Molano Franco, Víctor H Nieto Estrada, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of mainly cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (˜ 8200 feet). Acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude ascent. In this second review, in a series of three about preventive strategies for HAI, we assessed the effectiveness of five of the less commonly used classes of pharmacological interventions...
March 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29501863/the-in-vitro-pharmacology-and-non-clinical-cardiovascular-safety-studies-of-a-novel-5-ht-4-receptor-agonist-dsp-6952
#7
Tadashi Tsubouchi, Takeshi Kunimatsu, Shinji Tsujimoto, Akihiko Kiyoshi, Yasunori Katsura, Seiko Oku, Kazuhiro Chihara, Yukiko Mine, Toru Yamada, Isao Shimizu, Kiyoko Bando
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine4 (5-HT4 ) receptor agonists. DSP-6952 had a strong affinity of Ki = 51.9 nM for 5-HT4(b) receptor, and produced contraction in the isolated guinea pig colon with EC50 of 271.6 nM and low intrinsic activity of 57%, similar to tegaserod and mosapride. In the development of the 5-HT4 receptor agonists, cardiovascular risk was deliberately evaluated, because some related prokinetics were reported to cause with cardiovascular adverse events, such as ventricular arrhythmias or ischemia...
May 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29497328/managing-cluster-headache-with-sphenopalatine-ganglion-stimulation-a-review
#8
REVIEW
Denys Fontaine, Serena Santucci, Michel Lanteri-Minet
Cluster headache (CH) is a primary headache and considered as one of the worst pains known to man. The sphenopalatine ganglion (SPG) plays a pivotal role in cranial autonomic symptoms associated with pain. Lesioning procedures involving the SPG and experimental acute SPG stimulation have shown some degree of efficacy with regard to CH. A neuromodulation device, chronically implanted in the pterygopalatine fossa, has been specifically designed for acute on-demand SPG stimulation. In a pilot placebo-controlled study in 28 patients suffering from refractory chronic CH, alleviation of pain was achieved in 67...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29495103/effects-of-sumatriptan-nasal-spray-imigran-on-human-nasal-mucosa
#9
L-H Cheng, P-C Wu, Y-Y Lin, Y-H Chu, H-W Wang
OBJECTIVES: Sumatriptan (Imigran) is a potent and highly selective 5-HT1 receptor agonist often used in treating acute migraine. Intranasal sumatriptan is well absorbed and is generally effective in relieving headache. However, the effects of Imigran on human nasal mucosa have rarely been well explored, to verify the effect of Imigran, which act on human nasal mucosa directly in vitro. DESIGN AND PARTICIPANTS: We examined the effectiveness of Imigran on human nasal mucosa by testing: (i) effect on human nasal mucosa resting tension; (ii) effect on contraction caused by 10-6  mol/L methoxamine as a sympathetic mimetic; and (iii) effect of the drugs on electrically induced on human nasal mucosa contractions...
March 1, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29491331/-a-case-of-short-lasting-unilateral-neuralgiform-headache-with-conjunctival-injection-and-tearing-triggered-by-mumps-meningitis-in-a-patient-with-recurrent-primary-stabbing-headache
#10
Yuki Unai, Kenta Sato
A 32-year-old man with a 16-year history of recurrent primary stabbing headache was admitted to our hospital, owing to mumps meningitis. On day 2 of admission, he began experiencing episodes of unbearable intermittent stabbing pain, each lasting few seconds, with conjunctival injection and tearing, on the temporal side of the left orbit. We suspected trigeminal autonomic cephalgias, and administered non-steroidal anti-inflammatory drugs (NSAIDs), oxygen, and sumatriptan; however, the pain episodes persisted...
March 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29410249/biphasic-effect-of-sumatriptan-on-ptz-induced-seizures-in-mice-modulation-by-5-ht1b-d-receptors-and-nos-no-pathway
#11
Maziar Gooshe, Keyvan Ghasemi, Mohammad Mojtaba Rohani, Abbas Tafakhori, Shayan Amiri, Vajiheh Aghamollaii, Mona Ahmadi, Ahmad Reza Dehpour
Sumatriptan has been among the top choices in the management of migraine headaches. The association between migraine and epilepsy highlights the possible effect of sumatriptan on seizures. In this regard, we investigated sumatriptan effects on PTZ-induced seizures thresholds and delineated the modulatory role of 5-HT1B/D receptors and NOS/NO pathway. Our data revealed the anti-convulsant effects of lower doses of sumatriptan, and pro-convulsant effects of higher doses of sumatriptan. GR 127935, a selective 5-HT1B/D antagonist, could abolish the sumatriptan anti-convulsant effects, but it was ineffective against the sumatriptan pro-convulsant effects...
April 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29396788/cilostazol-induced-migraine-does-not-respond-to-sumatriptan-in-a-double-blind-trial
#12
Katrine Falkenberg, Bára Óladóttir Á Dunga, Song Guo, Messoud Ashina, Jes Olesen
BACKGROUND: Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine patients and therefore is valid for testing of future anti-migraine medications has never been investigated. METHODS: In a cross-over study, 30 patients received cilostazol (200 mg p.o.) on two separate days each day followed by oral self-administered placebo or sumatriptan 50 mg...
February 2, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29382888/a-unique-inbred-rat-strain-with-sustained-cephalic-hypersensitivity-as-a-model-of-chronic-migraine-like-pain
#13
Gordon Munro, Steffen Petersen, Inger Jansen-Olesen, Jes Olesen
Animal models of migraine-like pain enabling ongoing study of behaviour typically involve the systemic administration of chemical vasodilators or dural administration of inflammatory algogens. However, neither method mediates prolonged effects on behavior indicative of enduring pathophysiological changes occurring within dural or trigeminal pain circuits. We generated successive generations of a unique inbred rat strain, spontaneous trigeminal allodynia (STA) rats, previously reported to exhibit an episodic migraine-like behavioural phenotype...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29376196/a-sumatriptan-coarse-grained-model-to-explore-different-environments-interplay-with-experimental-techniques
#14
Irene Wood, Juan M R Albano, Pedro L O Filho, Veronica Muniz Couto, Marcelo A de Farias, Rodrigo V Portugal, Eneida de Paula, Cristiano L P Oliveira, Monica Pickholz
In this work, we developed a coarse-grained model of sumatriptan suitable for extensive molecular dynamics simulations. First, we confirmed the interfacial distribution of this drug in bilayers through cryogenic transmission electron microscopy and small-angle X-ray scattering techniques, as was predicted by our previous atomistic simulations. Based on these simulations, we developed a coarse-grained model for sumatriptan able to reproduce its overall molecular behavior, captured by atomistic simulations and experiments...
January 29, 2018: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29371973/17-%C3%AE-estradiol-induces-spreading-depression-and-pain-behavior-in-alert-female-rats
#15
Alexander J Sandweiss, Karissa E Cottier, Mary I McIntosh, Gregory Dussor, Thomas P Davis, Todd W Vanderah, Tally M Largent-Milnes
Aims: Test the putative contribution of 17-β-estradiol in the development of spreading depression (SD) events and head pain in awake, non-restrained rats. Main Methods: Female, Sprague-Dawley rats were intact or underwent ovariectomy followed one week later by surgery to place electrodes onto the dura to detect epidural electroencephalographic activity (dEEG). dEEG activity was recorded two days later for 12 hours after systemic administration of 17-β-estradiol (180 μg/kg, i...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29352328/attenuation-of-serotonin-induced-itch-by-sumatriptan-possible-involvement-of-endogenous-opioids
#16
Nazgol-Sadat Haddadi, Arash Foroutan, Saeed Shakiba, Khashayar Afshari, Sattar Ostadhadi, Maryam Daneshpazhooh, Ahmad-Reza Dehpour
Serotonin (5-hydroxytryptamine or 5-HT) is a neurotransmitter in itch and impaired serotonin signaling has been linked to a variety of itch conditions. Intradermal injection of 5-HT induces scratching behavior in mice through stimulation of 5-HT receptors. Previous studies have demonstrated that selective 5-HT1B/1D receptors agonists, including sumatriptan, inhibits neurotransmission. We have also reported that sumatriptan suppresses chloroquine-induced itch. Therefore, we investigated if sumatriptan has inhibitory effects on serotonin-induced itch in mice...
March 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29350125/current-management-migraine-headache
#17
Stephen D Silberstein
Migraine varies in its frequency, severity, and impact; treatment should consider these variations and the patient's needs and goals. Migraine pharmacologic treatment may be acute (abortive) or preventive (prophylactic), and patients often require both. New medication devices are available or in development, including an intracutaneous, microneedle system of zolmitriptan and sumatriptan, and breath-powered powder sumatriptan intranasal treatment. Lasmiditan, a 5-HT1F receptor agonist, is in development for acute treatment, as are small molecule calcitonin gene-related peptide (CGRP) receptor antagonists (Gepants) for acute and preventive treatment...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29297654/review-of-non-invasive-vagus-nerve-stimulation-gammacore-efficacy-safety-potential-impact-on-comorbidities-and-economic-burden-for-episodic-and-chronic-cluster-headache
#18
Mkaya Mwamburi, Eric J Liebler, Andrew T Tenaglia
The FDA has cleared gammaCore (non-invasive vagus nerve stimulator [nVNS]) for the treatment of episodic cluster headache (eCH). With the exception of subcutaneous sumatriptan, all other treatments are used off label and have many limitations. The FDA approval process for devices differs from that of drugs. We performed a review of the literature to evaluate new evidence on various aspects of gammaCore treatment and impact. The ACute Treatment of Cluster Headache Studies (ACT1 and ACT2), both double-blind sham-controlled randomized trials, did not meet the primary endpoints of the trials but each demonstrated significant superiority of gammaCore among patients with eCH...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29290056/presynaptic-serotonin-5-ht-1b-d-receptor-mediated-inhibition-of-glycinergic-transmission-to-the-frog-spinal-motoneurons
#19
N I Kalinina, Aleksey V Zaitsev, N P Vesselkin
Endogenous monoamine 5-hydroxytryptamine (5-HT, serotonin) is a phylogenetically ancient neurotransmitter present in vertebrates. The functions of 5-HT in central nervous system are intensively studied; however, the presynaptic effects of 5-HT in frog spinal motoneurons are practically unexplored. We have previously shown that 5-HT decreases the frequency of glycinergic miniature inhibitory postsynaptic potentials (mIPSPs), but does not affect the frequency of GABAergic mIPSPs and increases the frequency of glutamatergic postsynaptic potentials...
March 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29275494/differences-in-pediatric-headache-prescription-patterns-by-diagnosis
#20
Jonathan Rabner, Allison Ludwick, Alyssa LeBel
BACKGROUND: Few studies have reported prescription patterns for headache medication. OBJECTIVE: The aim was to present the rates of specific medication prescribed to pediatric patients diagnosed with migraine, tension-type headache (TTH), and new daily persistent headache (NDPH), as well as differences in those prescription patterns by diagnosis, age, and gender. PATIENTS AND METHODS: A query using the i2b2 platform yielded 14,591 patients [migraine 10,547 (72...
December 23, 2017: Paediatric Drugs
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