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https://www.readbyqxmd.com/read/27910087/menstrual-migraine-and-treatment-options-review
#1
REVIEW
Kasra Maasumi, Stewart J Tepper, Jennifer S Kriegler
OBJECTIVE: A review of treatment options for menstrual migraine. BACKGROUND: Migraine affects ∼30 million people in the US. A subset of female migraineurs have migraines that are mainly associated with menstruation. Menstrual migraine (MM) is divided into pure MM and menstrually related migraine. Pure MM attacks occur only with menstruation and have a prevalence of 1%. Menstrually related migraine has a prevalence of 6-7%, and occurs both during menstruation as well as during the rest of the cycle...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27909097/induction-of-migraine-like-photophobic-behavior-in-mice-by-both-peripheral-and-central-cgrp-mechanisms
#2
Bianca N Mason, Eric A Kaiser, Adisa Kuburas, Maria-Cristina M Loomis, John A Latham, Leon F Garcia-Martinez, Andrew F Russo
: The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine. While migraine can be treated using CGRP antagonists that act peripherally, the relevant sites of CGRP action remain unknown. To address the role of CGRP both within and outside the central nervous system, we used CGRP-induced light aversive behavior in mice as a measure of migraine-associated photophobia. Peripheral (intraperitoneal, IP) injection of CGRP resulted in light aversive behavior in wild-type CD1 mice similar to aversion previously seen following central (intracerebroventricular, ICV) injection...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27904122/triptan-induced-reversible-cerebral-vasoconstriction-syndrome-two-case-reports-with-a-literature-review
#3
Yuji Kato, Takeshi Hayashi, Satoko Mizuno, Yohsuke Horiuchi, Masayuki Ohira, Norio Tanahashi, Masaki Takao
We encountered two patients with sumatriptan-induced reversible cerebral vasoconstriction syndrome (RCVS). The present patients were taking sumatriptan for the first time because they had been tentatively diagnosed with a migraine. On reviewing the literature, we found nine other cases of triptan-induced RCVS, predominantly among women aged 30 to 40 years. RCVS has been precipitated by triptan at the first ever use, after daily use, and even with long-term use at a normal dose. Patients with acute onset of severe headache should be thoroughly evaluated, and triptan should be administered appropriately...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27899434/development-of-cgrp-dependent-pain-and-headache-related-behaviours-in-a-rat-model-of-concussion-implications-for-mechanisms-of-post-traumatic-headache
#4
Dara Bree, Dan Levy
BACKGROUND AND OBJECTIVE: Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies...
November 29, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27866934/pharmacodynamic-action-and-mechanism-of-du-liang-soft-capsule-a-traditional-chinese-medicine-capsule-on-treating-nitroglycerin-induced-migraine
#5
Min Hou, Qing Tang, Qiang Xue, Xiaona Zhang, Yang Liu, Sheng Yang, Liechun Chen, Xiaoyu Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Du Liang soft capsule (DL) is a traditional Chinese medicine for treating migraines; it is made from two Chinese herbs, including Ligusticum striatum DC., root; Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., root. AIM OF THE STUDY: In the present study, we aimed to elucidate the pharmacodynamic action of DL and its mechanism in an animal model of migraines induced by glyceryl trinitrate (GTN). MATERIALS AND METHODS: Sixty rats were randomly divided into six groups, including a normal control group, model control group, positive group (Sumatriptan 0...
November 17, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27858938/triptans-and-third-nerve-paresis-a-case-series-of-three-patients
#6
E S Novitskaya, C A Cates, O M Bowes, A J Vivian
PurposeThe aim of this report is to increase awareness of a possible association between cranial nerve paresis and the use of sumatriptan in migraine sufferers, particularly in patients who have additional vascular risk factors.Patients and methodsWe describe a series of three cases where third nerve paresis developed in patients who were treated with the oral form of sumatriptan. All of the patients had a clear history of repetitive migraine headache and none of them had previous third nerve paresis.ConclusionAmong a variety of medications for the treatment of migraine, there are some drugs with vasoconstrictive effects, particularly triptans...
November 18, 2016: Eye
https://www.readbyqxmd.com/read/27807736/-analgesic-drugs-during-pregnancy
#7
S Hultzsch, C Schaefer
Some important limitations must be taken into consideration for analgesic therapy during pregnancy. Paracetamol is the agent of choice for mild to moderate pain in any stage of pregnancy. Ibuprofen is the non-steroidal anti-inflammatory drug (NSAID) of choice; however, these substances are contraindicated after 28 weeks of gestation due to the increasing risk of premature closure of the ductus arteriosus and impairment of fetal kidney function. Even opioids can be used for severe pain but peripartum administration can lead to neonatal respiratory depression and adaptation disorders and long-term therapy up to the end of pregnancy can lead to neonatal withdrawal symptoms...
November 2, 2016: Der Schmerz
https://www.readbyqxmd.com/read/27770405/pharmacology-of-reflex-blinks-in-the-rat-a-novel-model-for-headache-research
#8
M G Jones, A P Andreou, S B McMahon, D Spanswick
BACKGROUND: Migraineurs are highly sensitive to the nitric oxide donor glyceryl trinitrate which triggers attacks in many sufferers. In animal studies, glyceryl trinitrate increases neuronal activity in the trigeminovascular pathway and elevates neurotransmitter levels in the brainstem. Many migraineurs also display alterations in blink reflexes, known to involve brainstem circuits. We investigated the effect of GTN on evoked blinks in the anaesthetised rat to determine whether such reflexes may prove useful as the basis for a novel animal model to evaluate potential anti-migraine therapeutic agents...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27698153/long-term-use-of-daily-sumatriptan-injections-in-severe-drug-resistant-chronic-cluster-headache
#9
Werner R Verslegers, Massimo Leone, Alberto Proietti Cecchini
No abstract text is available yet for this article.
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27681528/sumatriptan-nasal-powder-a-review-in-acute-treatment-of-migraine
#10
Zaina T Al-Salama, Lesley J Scott
Sumatriptan nasal powder delivered by a breath powered delivery device (ONZETRA(®) Xsail(®)) is indicated for the acute treatment of migraine with or without aura in adults. This narrative review discusses the clinical use of sumatriptan nasal powder in this population and summarizes its pharmacological properties. In migraineurs, sumatriptan nasal powder treatment was associated with significantly greater rates of pain relief than placebo from 0.5-2 h postdose after a single treatment in the phase 3 TARGET trial, with these benefits sustained at 24 and 48 h postdose...
October 2016: Drugs
https://www.readbyqxmd.com/read/27680211/critical-neural-targets-for-the-level-of-human-consciousness-arousal-arrest-and-unconsciousness-after-sumatriptan-administration
#11
Jaakko W Långsjö, Kai Lehtimäki, Jyrki Ruohonen, Anne Sajanti, Satu Sandell, Hannu T Heikkilä, Antti Brander, Kari Saarinen, Lauri Herrala
BACKGROUND: Insufficient understanding of the mechanisms of consciousness can make unconsciousness a diagnostic challenge, directly effecting the treatment and the outcome of the patient. Consciousness is a product of brainstem arousal (wakefulness, the level of consciousness) and cortical information integration (awareness, the contents of consciousness). The thalamus serves as a critical hub in the arousal pathway. The nuclei within the internal medullary lamina, together with the associated thalamocortical connections, have been implicated as being especially important for human consciousness...
September 28, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27664332/nasal-drug-absorption-from-powder-formulations-the-effect-of-three-types-of-hydroxypropyl-cellulose-hpc
#12
Akiko Tanaka, Tomoyuki Furubayashi, Manami Tomisaki, Mayuko Kawakami, Shunsuke Kimura, Daisuke Inoue, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Despite the numerous advantages of powder formulations, few studies have described their nasal drug absorption. The first aim of this study was to compare the drug absorption from powder formulation with that from a liquid formulation in rats. Since pharmaceutical excipients are usually added to most powder formulations, the second aim of the study was to investigate the effect of hydroxypropyl cellulose (HPC) on nasal drug absorption from the powder. Three types of HPC with different polymerization degrees were used: HPC(SL), HPC(M), and HPC(H)...
September 21, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27624669/non-ablative-fractional-laser-to-facilitate-transdermal-delivery
#13
Sindhu S Ganti, Ajay K Banga
The advances in laser technology have led to its rapidly expanding applications in dermatology. This study aims at the novel use of a non-ablative fractional laser to enhance transdermal permeation of diclofenac sodium and sumatriptan succinate. The effects of the laser on skin were characterized visually with dye binding, scanning electron microscopy, pore permeability index, and histology. In vitro transdermal permeation of drugs through laser treated and untreated human dermatomed skin was analyzed over 24 h and quantified by HPLC...
November 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27621672/the-effect-of-weight-body-mass-index-age-sex-and-race-on-plasma-concentrations-of-subcutaneous-sumatriptan-a-pooled-analysis
#14
Sagar Munjal, Anirudh Gautam, Alan M Rapoport, Dennis M Fisher
OBJECTIVE/BACKGROUND: Factors such as body size (weight and body mass index [BMI]), age, sex, and race might influence the clinical response to sumatriptan. We evaluated the impact of these covariates on the plasma concentration (Cp) profile of sumatriptan administered subcutaneously. METHODS: We conducted three pharmacokinetic studies of subcutaneous sumatriptan in 98 healthy adults. Sumatriptan was administered subcutaneously (236 administrations) as either DFN-11 3 mg, a novel 0...
2016: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/27613076/a-randomized-trial-comparing-the-pharmacokinetics-safety-and-tolerability-of-dfn-02-an-intranasal-sumatriptan-spray-containing-a-permeation-enhancer-with-intranasal-and-subcutaneous-sumatriptan-in-healthy-adults
#15
Sagar Munjal, Anirudh Gautam, Elliot Offman, Elimor Brand-Schieber, Kent Allenby, Dennis M Fisher
OBJECTIVE/BACKGROUND: Intranasal sumatriptan (Imitrex(®) ) may be an alternative for patients who refuse injections and cannot tolerate oral agents, but due to low bioavailability and slow absorption, the clinical utility of the currently marketed formulation is limited, highlighting an unmet need for an effective non-oral migraine medication with a rapid onset of action. To overcome the slow absorption profile associated with intranasal administration, we evaluated the impact of 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM, Intravail A-3™), a permeation enhancer, on sumatriptan's pharmacokinetic profile by comparing the pharmacokinetic characteristics of two commercial sumatriptan products, 4 mg subcutaneous and 6 mg subcutaneous in healthy adults, with DFN-02 - a novel intranasal agent comprised of sumatriptan 10 mg plus 0...
October 2016: Headache
https://www.readbyqxmd.com/read/27612914/migraine-in-children-a-review
#16
S Ahmed, S Tabassum, S M Rahman, S Akhter, M M Rahman, F Bayes, S Roy
Recurrent headache is common in children. Among them migraine is the most common disabling cause of primary headache. It causes serious disability in child's life and family. It causes negative impact on their quality of life. Clinical characteristic of migraine in children differ from adult. It may be shorter in duration and bifrontal or bitemporal in location in contrast to adult which is longer in duration and usually unilateral. It is less common before 3 years of age. Males are more affected before puberty...
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27582896/eletriptan-in-the-management-of-acute-migraine-an-update-on-the-evidence-for-efficacy-safety-and-consistent-response
#17
REVIEW
Matilde Capi, Martina Curto, Luana Lionetto, Fernando de Andrés, Giovanna Gentile, Andrea Negro, Paolo Martelletti
Migraine is a multifactorial, neurological and disabling disorder, also characterized by several autonomic symptoms. Triptans, selective serotonin 5-HT1B/1D agonists, are the first-line treatment option for moderate-to-severe headache attacks. In this paper, we review the recent data on eletriptan clinical efficacy, safety, and tolerability, and potential clinically relevant interactions with other drugs. Among triptans, eletriptan shows a consistent and significant clinical efficacy and a good tolerability profile in the treatment of migraine, especially for patients with cardiovascular risk factors without coronary artery disease...
September 2016: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/27560333/sumatriptan-patch-is-temporarily-suspended
#18
Diane S Aschenbrenner
No abstract text is available yet for this article.
September 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27558798/naratriptan-aggregation-in-lipid-bilayers-perspectives-from-molecular-dynamics-simulations
#19
Irene Wood, Mónica Pickholz
In order to understand the interaction between naratriptan and a fully hydrated bilayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidyl-choline (POPC), we carried out molecular dynamics simulations. The simulations were performed considering neutral and protonated ionization states, starting from different initial conditions. At physiological pH, the protonated state of naratriptan is predominant. It is expected that neutral compounds could have larger membrane partition than charged compounds. However, for the specific case of triptans, it is difficult to study neutral species in membranes experimentally, making computer simulations an interesting tool...
September 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27535977/l-arginine-l-glutamate-enhances-gastric-motor-function-in-rats-and-dogs-and-improves-delayed-gastric-emptying-in-dogs
#20
Ikumi Ishibashi-Shiraishi, Seiji Shiraishi, Shinichi Fujita, Saori Ogawa, Masahiko Kaneko, Manabu Suzuki, Tatsuro Tanaka
Amino acids are not only constituents of proteins, but also have multiple physiologic functions. Recent findings have revealed that ingested amino acids either activate luminal receptors or are metabolized, causing physiologic reactions in the gastrointestinal (GI) tract. We examined the effect of oral L-arginine L-glutamate (ArgGlu), a pharmaceutical amino acid salt used i.v. for the treatment of hyperammonemia, on gastric motor function in rats and dogs. Gastric emptying was determined using phenol red and (13)C-breath test methods, whereas gastric relaxation was determined using the barostat method...
November 2016: Journal of Pharmacology and Experimental Therapeutics
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