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https://www.readbyqxmd.com/read/28103252/comparative-and-evolutionary-analysis-of-grass-pollen-allergens-using-brachypodium-distachyon-as-a-model-system
#1
Akanksha Sharma, Niharika Sharma, Prem Bhalla, Mohan Singh
Comparative genomics have facilitated the mining of biological information from a genome sequence, through the detection of similarities and differences with genomes of closely or more distantly related species. By using such comparative approaches, knowledge can be transferred from the model to non-model organisms and insights can be gained in the structural and evolutionary patterns of specific genes. In the absence of sequenced genomes for allergenic grasses, this study was aimed at understanding the structure, organisation and expression profiles of grass pollen allergens using the genomic data from Brachypodium distachyon as it is phylogenetically related to the allergenic grasses...
2017: PloS One
https://www.readbyqxmd.com/read/28103188/numerical-inversion-of-srnf-maps-for-elastic-shape-analysis-of-genus-zero-surfaces
#2
Hamid Laga, Qian Xie, Ian H Jermyn, Anuj Srivastava
Recent developments in elastic shape analysis (ESA) are motivated by the fact that it provides a comprehensive framework for simultaneous registration, deformation, and comparison of shapes. These methods achieve computational efficiency using certain square-root representations that transform invariant elastic metrics into Euclidean metrics, allowing for the application of standard algorithms and statistical tools. For analyzing shapes of embeddings of S2 in R3, Jermyn et al. [1] introduced square-root normal fields (SRNFs), which transform an elastic metric, with desirable invariant properties, into the L2 metric...
January 5, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28101866/titin-and-nebulin-in-thick-and-thin-filament-length-regulation
#3
Larissa Tskhovrebova, John Trinick
In this review we discuss the history and the current state of ideas related to the mechanism of size regulation of the thick (myosin) and thin (actin) filaments in vertebrate striated muscles. Various hypotheses have been considered during of more than half century of research, recently mostly involving titin and nebulin acting as templates or 'molecular rulers', terminating exact assembly. These two giant, single-polypeptide, filamentous proteins are bound in situ along the thick and thin filaments, respectively, with an almost perfect match in the respective lengths and structural periodicities...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28101649/molecular-mechanism-of-sarcopenia-and-cachexia-recent-research-advances
#4
REVIEW
Kunihiro Sakuma, Wataru Aoi, Akihiko Yamaguchi
Skeletal muscle provides a fundamental basis for human function, enabling locomotion and respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) and normal aging (sarcopenia). Although many negative regulators (atrogin-1, muscle ring finger-1, nuclear factor-kappaB (NF-κB), myostatin, etc.) have been proposed to enhance protein degradation during both sarcopenia and cachexia, the adaptation of these mediators markedly differs within both conditions. Sarcopenia and cachectic muscles have been demonstrated to be abundant in myostatin-linked molecules...
January 19, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28101456/overview-of-albumin-and-its-purification-methods
#5
REVIEW
Ramin Raoufinia, Ali Mota, Neda Keyhanvar, Fatemeh Safari, Sara Shamekhi, Jalal Abdolalizadeh
As the most frequent plasma protein, albumin constitutes more than 50% of the serum proteins in healthy individuals. It has a key role in oncotic pressure maintenance and it is known as a versatile protein carrier for transportation of various endogenous and exogenous ligands. Reduced amounts of albumin in the body will lead to different kinds of diseases such as hypovolemia and hypoproteinemia. It also has various indications in shocks, burns, cardiopulmonary bypass, acute liver failure and etc. Further applications in research consist of cell culture supplement, drug delivery carrier and protein/drug stabilizer...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100951/an-unusual-cause-of-duodenal-obstruction-persimmon-phytobezoar
#6
Shengxian Fan, Jing Wang, Yousheng Li
Duodenal phytobezoar, an unusual cause of acute duodenal obstruction, is rarely seen. The most common cause of this type of bezoar is persimmon. It frequently arises from underlying gastrointestinal tract pathologies (gastric surgery, etc.). Here, we report the case of a 66-year-old man who had undergone distal gastrectomy with Billroth I reconstruction for gastric cancer and experienced severe epigastric discomfort, abdominal pain, and vomiting for a few days. The abdominal computed tomography scan showed a large-sized mass in the horizontal portion of the duodenum...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28100943/comparison-of-the-clinical-outcome-and-complications-in-laparoscopic-hernia-repair-of-inguinal-hernia-with-mesh-fixation-using-fibrin-glue-vs-tacker
#7
Prasant Chandra, Deepak Phalgune, Shashank Shah
Although laparoscopic repair offers a quick and less morbid way of treating hernias, complications like hematoma, seroma, neuralgia, recurrence, mesh infection, hydrocele, etc. are known. The present study was undertaken to compare various clinical outcomes between mesh fixation using fibrin glue and mesh fixation with tacker in a 3-months follow-up. One hundred patients aged 18 to 60 years having inguinal hernia admitted in Poona Hospital and Research Centre, Pune, between October 2012 and November 2014 for laparoscopic hernia surgery and ready to participate in this study were included...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28100199/antioxidant-and-hepatoprotective-potential-of-lawsonia-inermis-l-leaves-against-2-acetylaminofluorene-induced-hepatic-damage-in-male-wistar-rats
#8
Manish Kumar, Paramjeet Kaur, Madhu Chandel, Amrit Pal Singh, Arpana Jain, Satwinderjeet Kaur
BACKGROUND: Lawsonia inermis (Lythraceae) is an ethnomedicinal plant, traditionally known for curing several ailments such as skin diseases, bacterial infections, jaundice, renal lithiases and inflammation etc. The present work deals with assessment of in vitro antioxidant and in vivo hepatoprotective potential of butanolic fraction (But-LI) of Lawsonia inermis L. leaves. METHODS: Antioxidant activity was evaluated using deoxyribose degradation, lipid peroxidation inhibition and ferric reducing antioxidant power (FRAP) assay...
January 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28100105/inventing-a-co-axial-atomic-resolution-patch-clamp-to-study-a-single-resonating-protein-complex-and-ultra-low-power-communication-deep-inside-a-living-neuron-cell
#9
Subrata Ghosh, Satyajit Sahu, Lokesh Agrawal, Takashi Shiga, Anirban Bandyopadhyay
To read the signals of single molecules in vitro on a surface, or inside a living cell or organ, we introduce a coaxial atom tip (coat) and a coaxial atomic patch clamp (COAPAP). The metal-insulator-metal cavity of these probes extends to the atomic scale (0.1[Formula: see text]nm), it eliminates the cellular or environmental noise with a S/N ratio 10(5). Five ac signals are simultaneously applied during a measurement by COAT and COAPAP to shield a true signal under environmental noise in five unique ways. The electromagnetic drive in the triaxial atomic tips is specifically designed to sense anharmonic vibrational and transmission signals for any systems between 0...
January 18, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28099529/a-possible-role-of-the-full-length-nascent-protein-in-post-translational-ribosome-recycling
#10
Debasis Das, Dibyendu Samanta, Arpita Bhattacharya, Arunima Basu, Anindita Das, Jaydip Ghosh, Abhijit Chakrabarti, Chanchal Das Gupta
Each cycle of translation initiation in bacterial cell requires free 50S and 30S ribosomal subunits originating from the post-translational dissociation of 70S ribosome from the previous cycle. Literature shows stable dissociation of 70S from model post-termination complexes by the concerted action of Ribosome Recycling Factor (RRF) and Elongation Factor G (EF-G) that interact with the rRNA bridge B2a/B2b joining 50S to 30S. In such experimental models, the role of full-length nascent protein was never considered seriously...
2017: PloS One
https://www.readbyqxmd.com/read/28099126/aminoguanidine-pretreatment-prevents-methotrexate-induced-small-intestinal-injury-in-the-rat-by-attenuating-nitrosative-stress-and-restoring-the-activities-of-vital-mitochondrial-enzymes
#11
Kasthuri Natarajan, Premila Abraham, Rekha Kota, Dhayakani Selvakumar
BACKGROUND: One of the major toxic side effects of methotrexate (MTX) is enterocolitis, for which there is no efficient standard treatment. Nitric oxide overproduction has been reported to play an important role in MTX-induced mucositis. This study was designed to investigate whether pretreatment with aminoguanidine (AG) - a selective iNOS inhibitor - prevents MTX-induced mucositis in rats. MATERIALS AND METHODS: Rats were pretreated with AG (30 and 50 mg/kg body weight) i...
January 18, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28098967/synthesis-of-fluorinated-graphene-coal-layered-double-hydroxide-composites-as-electrode-materials-for-supercapacitors
#12
Weijun Peng, Hongqiang Li, Shaoxian Song
CoAl-layered double hydroxide/fluorinated graphene (CoAl-LDH/FGN) composites were fabricated via a two-step hydrothermal method. The synthesized CoAl-LDH/FGN composites have been characterised by Powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Transmission electron microscopy (TEM), Field-emission scanning electron microscopy (FESEM) and Energy dispersive X-ray spectroscopy (EDS), and Electrochemical measurements. The results indicated that the fluorinated carbon with various configuration forms were grafted onto the framework of graphene, and the C-F bond configuration and fluorine content could be tuned by the fluorination time...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28098818/a-study-on-coexistence-capability-evaluations-of-the-enhanced-channel-hopping-mechanism-in-wbans
#13
Zhongcheng Wei, Yongmei Sun, Yuefeng Ji
As an important coexistence technology, channel hopping can reduce the interference among Wireless Body Area Networks (WBANs). However, it simultaneously brings some issues, such as energy waste, long latency and communication interruptions, etc. In this paper, we propose an enhanced channel hopping mechanism that allows multiple WBANs coexisted in the same channel. In order to evaluate the coexistence performance, some critical metrics are designed to reflect the possibility of channel conflict. Furthermore, by taking the queuing and non-queuing behaviors into consideration, we present a set of analysis approaches to evaluate the coexistence capability...
January 14, 2017: Sensors
https://www.readbyqxmd.com/read/28098748/propagation-modeling-and-defending-of-a-mobile-sensor-worm-in-wireless-sensor-and-actuator-networks
#14
Tian Wang, Qun Wu, Sheng Wen, Yiqiao Cai, Hui Tian, Yonghong Chen, Baowei Wang
WSANs (Wireless Sensor and Actuator Networks) are derived from traditional wireless sensor networks by introducing mobile actuator elements. Previous studies indicated that mobile actuators can improve network performance in terms of data collection, energy supplementation, etc. However, according to our experimental simulations, the actuator's mobility also causes the sensor worm to spread faster if an attacker launches worm attacks on an actuator and compromises it successfully. Traditional worm propagation models and defense strategies did not consider the diffusion with a mobile worm carrier...
January 13, 2017: Sensors
https://www.readbyqxmd.com/read/28098299/vacancies-in-functional-materials-for-clean-energy-storage-and-harvesting-the-perfect-imperfection
#15
Guowei Li, Graeme R Blake, Thomas T M Palstra
Vacancies exist throughout nature and determine the physical properties of materials. By manipulating the density and distribution of vacancies, it is possible to influence their physical properties such as band-gap, conductivity, magnetism, etc. This can generate exciting applications in the fields of water treatment, energy storage, and physical devices such as resistance-change memories. In this review, we focus on recent progress in vacancy engineering for the design of materials for energy harvesting applications...
January 18, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28098082/occupational-health-profile-of-workers-employed-in-the-manufacturing-sector-of-india
#16
REVIEW
Shivali Suri, Ranjan Das
BACKGROUND: The occupational health scenario of workers engaged in the manufacturing sector in India deserves attention for their safety and increasing productivity. We reviewed the status of the manufacturing sector, identified hazards faced by workers, and assessed the existing legislations and healthcare delivery mechanisms. METHODS: From October 2014 to March 2015, we did a literature review by manual search of pre-identified journals, general electronic search, electronic search of dedicated websites/databases and personal communication with experts of occupational health...
September 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28097527/breast-cancer-screening-and-social-media-a-content-analysis-of-evidence-use-and-guideline-opinions-on-twitter
#17
Anthony Nastasi, Tyler Bryant, Joseph K Canner, Mark Dredze, Melissa S Camp, Neeraja Nagarajan
There is ongoing debate regarding the best mammography screening practices. Twitter has become a powerful tool for disseminating medical news and fostering healthcare conversations; however, little work has been done examining these conversations in the context of how users are sharing evidence and discussing current guidelines for breast cancer screening. To characterize the Twitter conversation on mammography and assess the quality of evidence used as well as opinions regarding current screening guidelines, individual tweets using mammography-related hashtags were prospectively pulled from Twitter from 5 November 2015 to 11 December 2015...
January 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28097306/universal-trichloroacetic-acid-peel-technique-for-light-and-dark-skin
#18
Nabil Fanous, Shadi Zari
Importance: Despite their great potential, medium and deep trichloroacetic acid peels are underused in light-skinned patients and are rarely used in darker-skinned patients because of the widespread fear of pigmentary complications and scarring. This concern has led many physicians to opt for the use of lighter types of peels (glycolic acid peel, Jessner peel, etc) and different lasers and intense light technologies. Trichloroacetic acid peels have been described in numerous publications...
January 12, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28096066/-happiness-inventors-informing-positive-computing-technologies-through-participatory-design-with-children
#19
Svetlana Yarosh, Stephen Matthew Schueller
BACKGROUND: Positive psychological interventions for children have typically focused on direct adaptations of interventions developed for adults. As the community moves toward designing positive computing technologies to support child well-being, it is important to use a more participatory process that directly engages children's voices. OBJECTIVE: Our objectives were, through a participatory design study, to understand children's interpretations of positive psychology concepts, as well as their perspectives on technologies that are best suited to enhance their engagement with practice of well-being skills...
January 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28095781/link-prediction-in-drug-target-interactions-network-using-similarity-indices
#20
Yiding Lu, Yufan Guo, Anna Korhonen
BACKGROUND: In silico drug-target interaction (DTI) prediction plays an integral role in drug repositioning: the discovery of new uses for existing drugs. One popular method of drug repositioning is network-based DTI prediction, which uses complex network theory to predict DTIs from a drug-target network. Currently, most network-based DTI prediction is based on machine learning - methods such as Restricted Boltzmann Machines (RBM) or Support Vector Machines (SVM). These methods require additional information about the characteristics of drugs, targets and DTIs, such as chemical structure, genome sequence, binding types, causes of interactions, etc...
January 17, 2017: BMC Bioinformatics
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