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https://www.readbyqxmd.com/read/28636139/review-of-hplc-and-lc-ms-ms-assays-for-the-determination-of-various-non-steroidal-anti-androgens-nsaa-used-in-the-treatment-of-prostate-cancer
#1
REVIEW
P S Suresh, Nuggehally R Srinivas, Ramesh Mullangi
Prostate cancer is the most common cancer and one of the leading causes for cancer deaths in men. One of the commonly used approaches to treat metastatic prostate cancer was via first generation non-steroidal anti-androgens (NSAA) namely flutamide, nilutamide, bicalutamide and topilutamide. Most of the prostate cancer patients who are initially responsive develop a most aggressive form of disease called castration-resistant prostate cancer (CRPC). Second generation NSAA receptor antagonists (enzalutamide, apalutamide and darolutamide) are emerging as additional new options to treat CRPC...
June 21, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28635868/-the-modern-possibilities-for-the-application-of-photogrammetry-in-forensic-medical-traumatology
#2
V A Fetisov, I Yu Makarov, A A Gusarov, A S Lorents, S A Smirenin, V B Stragis
The authors discuss the modern possibilities and prospects for the application of photogrammetry (FM) in forensic medical traumatology based on the results of the analysis of the many-year experience reported in the foreign periodicals with special reference to road traffic injuries, gunshot wounds, and animals' bites. The examples of objective difficulties and promising prospects for the further application of the FM techniques in the practical work of forensic medical experts and medical criminalists are considered with reference to the use of various FM-based methods and equipment including 3D laser scanners, chambers, stereoscopic mounting attachments, etc...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28634081/quantitative-proteomic-reveals-the-dynamic-of-protein-profile-during-zebrafish-final-oocyte-maturation
#3
Chunmei Ge, Weiqun Lu, Aqin Chen
The molecular mechanisms underlying final oocyte maturation zebrafish (Danio rerio) remain poorly understood. The present study aimed to employ iTRAQ approach for a comprehensive characterization of during zebrafish oocyte maturation proteome and for comparison between fully-grow immature and mature oocytes prior to ovulation. A total of 1568 proteins were identified, which was representing the largest zebrafish isolated oocytes proteome dataset to date. Differential expression analysis revealed 190 proteins significantly changes between immature and mature oocytes, which 136 proteins were up-regulated and 54 proteins were down-regulated in mature oocytes comparison with immature oocytes...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28633862/ultrasound-assisted-methods-for-enhanced-extraction-of-phycobiliproteins-from-marine-macro-algae-gelidium-pusillum-rhodophyta
#4
Rochak Mittal, Hrishikesh A Tavanandi, Vaibhav A Mantri, K S M S Raghavarao
Extraction of phycobiliproteins (R-phycoerythrin, R-PE and R-phycocyanin, R-PC) from macro-algae is difficult due to the presence of large polysaccharides (agar, cellulose etc.) present in the cell wall which offer major hindrance for cell disruption. The present study is aimed at developing most suitable methodology for the primary extraction of R-PE and R-PC from marine macro-algae, Gelidium pusillum(Stackhouse) Le Jolis. Such extraction of phycobiliproteins by using ultrasonication and other conventional methods such as maceration, maceration in presence of liquid nitrogen, homogenization, and freezing and thawing (alone and in combinations) is reported for the first time...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633116/spatial-and-temporal-variation-in-autochthonous-and-allochthonous-contributors-to-increased-organic-carbon-and-nitrogen-burial-in-a-plateau-lake
#5
Changchun Huang, Ling Yao, Yunlin Zhang, Tao Huang, Mingli Zhang, A-Xing Zhu, Hao Yang
Increased organic carbon and nitrogen accumulation rates (OCAR and ONAR) in lake sediment significantly regulate the global carbon cycle. However, the reasons for and contributors to the increased OCAR and ONAR are unclear. Seven sediment cores, collected in July 2014 from Dianchi Lake, China, were used to evaluate the effects of autochthonous and allochthonous sources on OCAR and ONAR. The results indicate that OCAR and ONAR increased by factors of 4.33 and 7.34 over the past hundred years (1900-2000), particularly after algal blooms began to occur frequently (beginning in the 1980s)...
June 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28632385/fatigue-resistant-bioinspired-composite-from-synergistic-two-dimensional-nanocomponents
#6
Sijie Wan, Qi Zhang, Xiaohang Zhou, Dechang Li, Baohua Ji, Lei Jiang, Qunfeng Cheng
Portable and wearable electronics require much more flexible graphene-based electrode with high fatigue life, which could repeatedly bend, fold, or stretch without sacrificing its mechanical properties and electrical conductivity. Herein, a kind of ultrahigh fatigue resistant graphene-based nanocomposite via tungsten disulfide (WS2) nanosheets is synthesized by introducing a synergistic effect with covalently cross-linking inspired by the orderly layered structure and abundant interfacial interactions of nacre...
June 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28632338/difluoromethylation-reactions-of-organic-compounds
#7
Damian E Yerien, Sebastian Barata-Vallejo, Al Postigo
The relevance of the -CF2H moiety has attracted considerable attention from organic synthetic and medicinal chemistry communities, because this group can act as a more lipophilic isostere of the carbinol, thiol, hydroxamic acid or amide groups. Being weakly acidic, the CF2H moiety can establish hydrogen bonding interactions to improve the binding selectivity of biologically active compounds. Therefore, the hydroxyl, amino, and thio substituents of lead structures are routinely replaced by a CF2H motif in drug discovery, with great benefits in the pharmacological activity of drugs and drug candidates and agrochemicals...
June 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28632275/architectures-of-soft-robotic-locomotion-enabled-by-simple-mechanical-principles
#8
Liangliang Zhu, Yunteng Cao, Yilun Liu, Zhe Yang, Xi Chen
In nature, a variety of limbless locomotion patterns flourish, from the small or basic life forms (Escherichia coli, amoebae, etc.) to the large or intelligent creatures (e.g., slugs, starfishes, earthworms, octopuses, jellyfishes, and snakes). Many bioinspired soft robots based on locomotion have been developed in the past few decades. In this work, based on the kinematics and dynamics of two representative locomotion modes (i.e., worm-like crawling and snake-like slithering), we propose a broad set of innovative designs for soft mobile robots through simple mechanical principles...
June 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28632266/proteomic-analysis-reveals-xuesaitong-injection-attenuates-myocardial-ischemia-reperfusion-injury-by-elevating-pyruvate-dehydrogenase-mediated-aerobic-metabolism
#9
Xiaoping Zhao, Feng Zhang, Yi Wang
Xuesaitong injection (XST), which mainly consists of Panax notoginseng saponins, has been widely used for treating cardio-cerebral vascular diseases. However, the underlying mechanisms of XST associated with its cardioprotective effects are still unclear. To identify the potential target proteins of XST, two-dimensional gel electrophoresis (2-DE)-based proteomics was utilized to analyze the protein profile of myocardium in rats with myocardial ischemia/reperfusion (I/R) injury. The differentially expressed proteins were identified by matrix assisted laser desorption/ionization time-of-flight mass spectrometry...
June 20, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28632200/the-beginning-and-development-of-the-theranostic-approach-in-nuclear-medicine-as-exemplified-by-the-radionuclide-pair-86-y-and-90-y
#10
Frank Rösch, Hans Herzog, Syed M Qaim
In the context of radiopharmacy and molecular imaging, the concept of theranostics entails a therapy-accompanying diagnosis with the aim of a patient-specific treatment. Using the adequate diagnostic radiopharmaceutical, the disease and the state of the disease are verified for an individual patient. The other way around, it verifies that the radiopharmaceutical in hand represents a target-specific and selective molecule: the "best one" for that individual patient. Transforming diagnostic imaging into quantitative dosimetric information, the optimum radioactivity (expressed in maximum radiation dose to the target tissue and tolerable dose to healthy organs) of the adequate radiotherapeutical is applied to that individual patient...
June 20, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28632170/current-research-in-lidar-technology-used-for-the-remote-sensing-of-atmospheric-aerosols
#11
REVIEW
Adolfo Comerón, Constantino Muñoz-Porcar, Francesc Rocadenbosch, Alejandro Rodríguez-Gómez, Michaël Sicard
Lidars are active optical remote sensing instruments with unique capabilities for atmospheric sounding. A manifold of atmospheric variables can be profiled using different types of lidar: concentration of species, wind speed, temperature, etc. Among them, measurement of the properties of aerosol particles, whose influence in many atmospheric processes is important but is still poorly stated, stands as one of the main fields of application of current lidar systems. This paper presents a review on fundamentals, technology, methodologies and state-of-the art of the lidar systems used to obtain aerosol information...
June 20, 2017: Sensors
https://www.readbyqxmd.com/read/28631716/-anogenital-mammary-like-glands-and-related-diseases-part-2-malignant-tumors-of-the-anogenital-glands
#12
A M Konstantinova, I E Belousova, D Kacerovska, M Michal, K V Shelekhova, D V Kazakov
Mammary-like glands are a normal anatomical component of the anogenital region and can give rise to many benign and malignant tumors that morphologically mimic the similar diseases of the breast. The literature review is complemented by a description of 199 cases of malignant tumors of mammary-like glands. The paper presents the clinical and morphological characteristics of various malignant tumors of mammary-like glands, including extramammary Paget's disease, ductal, tubulolobular, adenoid cystic adenocarcinoma, low-grade phyllodes tumor, etc...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28631673/-the-problems-associated-with-the-treatment-of-stenosing-laryngotracheitis-in-the-children-the-results-of-the-35-year-long-experience
#13
L A Safronenko, A P Davydova, V V Karpov, M G Lukashevich, V A Novikov
Stenosing laryngotracheitis (SLT) affecting the children is considered to be an emergency pediatric condition associated with ENT pathology. Its treatment presents a serious challenge for otolaryngologists, pediatricians, specialists in communicable diseases, allergologists, etc. We have undertaken a retrospective analysis of the available data with a view to summarizing the tendencies in the evolution of SLT morbidity. The results of the 35 year-long experience with the use of the currently available therapeutic strategies for the treatment of the children suffering from stenosing laryngotracheitis are presented...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28630489/host-guest-assembly-for-highly-sensitive-probing-of-a-chiral-mono-alcohol-with-a-zinc-trisporphyrinate
#14
Cong-Cong Zhuo, Li Li, Chuan-Jiang Hu, Jian-Ping Lang
A zinc trisporphyrinate has been developed as a chirality sensor for chiral mono-alcohols. In its structure, there are two "spaces" surrounded by three porphyrin moieties, which allow guests to fill in. It has shown extremely high CD sensitivity for a chiral mono-alcohol with a naphthyl substituent, 1-(1-naphthyl)ethanol, at μM level, which is at least three orders of magnitude lower concentration than previous reports. A crystallographic study of the host-guest complex reveals the binding of 1-(1-naphthyl)ethanol to the zinc trisporphyrinate is greatly enhanced by multipoint interactions, such as coordination interactions, hydrogen bonding, π-π and CH···π interactions etc...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630483/comprehensive-analysis-of-passive-generation-of-parabolic-similaritons-in-tapered-hydrogenated-amorphous-silicon-photonic-wires
#15
Chao Mei, Feng Li, Jinhui Yuan, Zhe Kang, Xianting Zhang, Binbin Yan, Xinzhu Sang, Qiang Wu, Xian Zhou, Kangping Zhong, Liang Wang, Kuiru Wang, Chongxiu Yu, P K A Wai
Parabolic pulses have important applications in both basic and applied sciences, such as high power optical amplification, optical communications, all-optical signal processing, etc. The generation of parabolic similaritons in tapered hydrogenated amorphous silicon photonic wires at telecom (λ ~ 1550 nm) and mid-IR (λ ≥ 2100 nm) wavelengths is demonstrated and analyzed. The self-similar theory of parabolic pulse generation in passive waveguides with increasing nonlinearity is presented. A generalized nonlinear Schrödinger equation is used to describe the coupled dynamics of optical field in the tapered hydrogenated amorphous silicon photonic wires with either decreasing dispersion or increasing nonlinearity...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629940/highly-informative-multiclass-profiling-of-lipids-by-ultra-high-performance-liquid-chromatography-low-resolution-quadrupole-mass-spectrometry-by-using-electrospray-ionization-and-atmospheric-pressure-chemical-ionization-interfaces
#16
Marco Beccaria, Veronica Inferrera, Francesca Rigano, Krzysztof Gorynski, Giorgia Purcaro, Janusz Pawliszyn, Paola Dugo, Luigi Mondello
A simple, fast, and versatile method, using an ultra-high performance liquid chromatography system coupled with a low resolution (single quadrupole) mass spectrometer was optimized to perform multiclass lipid profiling of human plasma. Particular attention was made to develop a method suitable for both electrospray ionization and atmospheric pressure chemical ionization interfaces (sequentially in positive- and negative-ion mode), without any modification of the chromatographic conditions (mobile phase, flow-rate, gradient, etc...
June 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28629694/interleukin-6-participation-in-pathology-of-ocular-diseases
#17
REVIEW
Forouhe Zahir-Jouzdani, Fatemeh Atyabi, Nazanin Mojtabavi
Interleukin-6 (IL-6) is a multifunctional cytokine that affects a variety of cells in the body such as osteoclasts, hepatocytes, endothelial cells, epithelial cells, white and red blood cells and etc. Elevated levels of IL-6 have been detected in many ocular diseases. Studies show that IL-6 has a major role in the pathology of glaucoma, CRVO, macular edema, ocular neovascularization, posterior capsule opacity formation, keratitis, dry eye disease, allergic eye disease, ocular autoimmune disease, corneal chemical burn, ocular inflammation and so on...
June 10, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28629615/a-simple-method-to-compare-firing-pin-marks-using-stereomicroscope-and-microsoft-office-windows-8-tools
#18
R Suresh
Pertinent marks of fired cartridge cases such as firing pin, breech face, extractor, ejector, etc. are used for firearm identification. A non-standard semiautomatic pistol and four .22rim fire cartridges (head stamp KF) is used for known source comparison study. Two test fired cartridge cases are examined under stereomicroscope. The characteristic marks are captured by digital camera and comparative analysis of striation marks is done by using different tools available in the Microsoft word (Windows 8) of a computer system...
June 7, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28629105/indispensable-role-of-biochar-inherent-mineral-constituents-in-its-environmental-applications-a-review
#19
Xiaoyun Xu, Yinghao Zhao, Jingke Sima, Ling Zhao, Ondřej Mašek, Xinde Cao
Biochar typically consists of both carbon and mineral fractions, and the carbon fraction has been generally considered to determine its properties and applications. Recently, an increasing body of research has demonstrated that mineral components inherent in biochar, such as alkali or alkaline earth metals in the form of carbonates, phosphates, or oxides, could also influence the properties and thus the applications. The review articles published thus far have mainly focused on multiple environmental and agronomic applications of biochar, including carbon sequestration, soil improvement, environmental remediation, etc...
June 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28628861/enhancement-in-recovery-of-drugs-with-high-protein-binding-efficiency-from-human-plasma-using-magnetic-nanoparticles
#20
Aniruddha Bhati, Rucha P Desai, C N Ramchand
In this paper, we propose an alternate method for bioanalytical extraction of drugs from human plasma samples using bare magnetic nanoparticles. The magnetic nanoparticles (MNPs) were used for deproteination of biological samples that further assist in extraction of plasma bound drugs for bioanalytical studies. The method uses basic solvents (ethanol, methanol, etc.) rather than the expensive and toxic solvents. The MNPs provide several advantages like avoiding the use of centrifuge machine, and making extraction time effective...
June 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
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