keyword
MENU ▼
Read by QxMD icon Read
search

etc

keyword
https://www.readbyqxmd.com/read/29351463/intermediary-metabolism-and-fatty-acid-oxidation-novel-targets-of-electron-transport-chain-driven-injury-during-ischemia-and-reperfusion
#1
Qun Chen, Masood S Younus, Jeremy Thompson, Ying Hu, John M Hollander, Edward J Lesnefsky
BACKGROUND: Cardiac ischemia-reperfusion (IR) damages the electron transport chain (ETC) causing mitochondrial and cardiomyocyte injury. Reversible blockade of the ETC at complex I during ischemia protects the ETC and decreases cardiac injury. In the present study, we used an unbiased proteomic approach to analyze the extent of ETC-driven mitochondrial injury during IR. METHODS: Isolated-perfused mouse (C57BL/6) hearts underwent 25 min global ischemia (37{degree sign}C) and 30 min reperfusion...
December 29, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351261/three-dimensional-terahertz-coded-aperture-imaging-based-on-single-input-multiple-output-technology
#2
Shuo Chen, Chenggao Luo, Bin Deng, Hongqiang Wang, Yongqiang Cheng, Zhaowen Zhuang
As a promising radar imaging technique, terahertz coded-aperture imaging (TCAI) can achieve high-resolution, forward-looking, and staring imaging by producing spatiotemporal independent signals with coded apertures. In this paper, we propose a three-dimensional (3D) TCAI architecture based on single input multiple output (SIMO) technology, which can reduce the coding and sampling times sharply. The coded aperture applied in the proposed TCAI architecture loads either purposive or random phase modulation factor...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29351223/a-novel-walking-detection-and-step-counting-algorithm-using-unconstrained-smartphones
#3
Xiaomin Kang, Baoqi Huang, Guodong Qi
Recently, with the development of artificial intelligence technologies and the popularity of mobile devices, walking detection and step counting have gained much attention since they play an important role in the fields of equipment positioning, saving energy, behavior recognition, etc. In this paper, a novel algorithm is proposed to simultaneously detect walking motion and count steps through unconstrained smartphones in the sense that the smartphone placement is not only arbitrary but also alterable. On account of the periodicity of the walking motion and sensitivity of gyroscopes, the proposed algorithm extracts the frequency domain features from three-dimensional (3D) angular velocities of a smartphone through FFT (fast Fourier transform) and identifies whether its holder is walking or not irrespective of its placement...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29351081/characterization-of-phosphate-transporter-s-and-understanding-their-role-in-leishmania-donovani-parasite
#4
K J Sindhu, Amit Kumar Kureel, Sheetal Saini, Smita Kumari, Pankaj Verma, Ambak Kumar Rai
Inorganic phosphate (Pi) is shown to be involved in excretion of methylglyoxal (MG) in the promastigote form of Leishmania donovani parasite. Absence of Pi leads to its accumulation inside the parasite. Accumulation of MG is toxic to the parasite and utilizes glyoxylase as well as excretory pathways for its detoxification. In addition, Pi is also reported to regulate activities of ectoenzymes and energy metabolism (glucose to pyruvate) etc. Thus, it is known to cumulatively affect the growth of Leishmania parasite...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29351064/molecular-target-analysis-of-stearoyl-coa-desaturase-genes-of-protozoan-parasites
#5
He Lu, Xin Qin, Jing Zhang, Shuang Zhang, Yu Zhu, Wei Hua Wu
Protozoan parasites can synthesize polyunsaturated fatty acids. They possess stearoyl-CoA desaturase to convert stearate into oleate and linoleate. Stearoyl-CoA desaturase are the key enzymes required for the synthesis of unsaturated fatty acids. It seems attractive to evaluate the possibility of using unsaturated fatty acid biosynthesis pathways as drug targets. In this study, the authors investigate codon usage bias, base composition variations and protein sequence in ten available complete stearoyl-CoA desaturase gene sequences from Toxoplasma gondii, Neospora caninum etc...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29350904/nanoplatform-assembled-from-a-cd44-targeted-prodrug-and-smart-liposomes-for-dual-targeting-of-tumor-microenvironment-and-cancer-cells
#6
Yaqi Lv, Chaoran Xu, Xiangmei Zhao, Chenshi Lin, Xin Yang, Xiaofei Xin, Li Zhang, Chao Qin, Xiaopeng Han, Lei Yang, Wei He, Lifang Yin
The tumor microenvironment (TME) plays a critical role in tumor initiation, progression, invasion and metastasis. Therefore, a therapy that combines chemotherapeutic drugs with a TME modulator could be a promising route for cancer treatment. This paper reports a nanoplatform self-assembled from a hyaluronic acid (HA)-paclitaxel (PTX) (HA-PTX) prodrug and marimastat (MATT)-loaded thermosensitive liposomes (LTSLs) (MATT-LTSLs) for the dual targeting of the TME and cancer cells. Interestingly, the prodrug HA-PTX can self-assemble on both positively and negatively charged liposomes, forming hybrid nanoparticles (HNPs, 100 nm)...
January 19, 2018: ACS Nano
https://www.readbyqxmd.com/read/29350645/developments-in-the-management-of-bone-metastases-with-interventional-radiology
#7
Francesco Arrigoni, Federico Bruno, Luigi Zugaro, Raffaele Natella, Salvatore Cappabianca, Umberto Russo, Vito Roberto Papapietro, Alessandra Splendiani, Ernesto Di Cesare, Carlo Masciocchi, Antonio Barile
Interventional radiology has known an exponential growth in the last years. Technological advances of the last decades, have made it possible to use new treatments on a larger scale, with safe and effective results. They could be considered as palliative treatments for painful lesions but also curative procedures, as single treatment or specially in combination with other techniques (surgery, radiation and oncology therapies, etc.).The main diffuse techniques are those of thermal ablation that destroy the target lesion through the heat; however there are also endovascular therapies that destroy the target tissue thanks to devascularization...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350112/a-comparison-of-hiv-risk-behaviors-between-young-black-cisgender-men-who-have-sex-with-men-and-young-black-transgender-women-who-have-sex-with-men
#8
Richard A Crosby, Laura F Salazar, Brandon Hill, Leandro Mena
This study compared sexually transmitted infection (STI)-associated risks between young Black cisgender men who have sex with men (YBMSM) and young Black transwomen who have sex with men (YBTWSM). Comparisons pertained to: (1) prevalence of infections; (2) sexual risk; (3) partner-related risks; and (4) socioeconomic marginalization. YBMSM (n = 577) and YBTWSM (n = 32) were recruited from an STI clinic in the USA. Volunteers completed a computer-assisted self-interview and medical records were abstracted for STI/HIV information...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29350055/therapeutic-strategies-and-nano-drug-delivery-applications-in-management-of-ageing-alzheimer-s-disease
#9
Govindarajan Karthivashan, Palanivel Ganesan, Shin-Young Park, Joon-Soo Kim, Dong-Kug Choi
In recent years, the incidental rate of neurodegenerative disorders has increased proportionately with the aging population. Alzheimer's disease (AD) is one of the most commonly reported neurodegenerative disorders, and it is estimated to increase by roughly 30% among the aged population. In spite of screening numerous drug candidates against various molecular targets of AD, only a few candidates - such as acetylcholinesterase inhibitors are currently utilized as an effective clinical therapy. However, targeted drug delivery of these drugs to the central nervous system (CNS) exhibits several limitations including meager solubility, low bioavailability, and reduced efficiency due to the impediments of the blood-brain barrier (BBB)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29350035/selective-proton-deuteron-transport-through-nafion-graphene-nafion-sandwich-structures-at-very-high-current-density
#10
Saheed Bukola, Ying Liang, Carol Korzeniewski, Joel Harris, Stephen Creager
Ion current densities near 1 A cm-2 at modest bias voltages (< 200 mV) are reported for proton and deuteron transmission across single-layer graphene in polyelectrolyte-membrane (PEM)-style hydrogen pump cells. The graphene is sandwiched between two Nafion membranes and covers the entire area between two platinum-carbon electrodes, such that proton transfer is forced to occur through the graphene layer. Raman spectroscopy confirms that buried graphene layers are single-layer and relatively free of defects following the hot-press procedure used to make the sandwich structures...
January 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29349972/-current-therapy-progress-on-the-recurrent-patellar-dislocation
#11
REVIEW
Wan-Quan Cao, Zi-Quan Yang, Gang Wang, Ya-Xun Men, Xiang-Yun Cheng
Patients who suffer from the recurrent patellar dislocation mainly show the recurrent dislocation of patellar, giving way, most patients have the history of trauma or dysplasia of keen joint. Traditional therapies of recurrent patellar dislocation include medical retinaculum placation, lateral retinaculum release, tibial tubercle osteotomy, femoral trochleoplasty etc. In recent years, with the development of anatomical and biomechanical researches on medial patellofemoral ligament(MPFL), more and more experts focus on the role of MPFL played in preventing the patellar dislocation...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349542/laparoscopic-pancreaticoduodenectomy-with-reconstruction-of-the-mesentericoportal-vein-with-the-parietal-peritoneum-and-the-falciform-ligament
#12
Safi Dokmak, Béatrice Aussilhou, Mélanie Calmels, Houcine Maghrebi, Fadhel Samir Ftériche, Olivier Soubrane, Alain Sauvanet
BACKGROUND: With the improvement of the surgical technique of Laparoscopic pancreaticoduodenectomy (LPD), indications will be extended to patients with vascular invasion. With LPD, vascular grafts for reconstruction are more frequently needed because adequate mobilization is not always done and vascular grafts can safely facilitate reconstruction. We describe our experience of reconstruction with the falciform ligament. METHODS: Venous reconstruction is performed after removal of the specimen...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29348687/far-field-superfocusing-along-with-enhanced-near-field-emission-from-hybrid-spiral-plasmonic-lens-inscribed-with-nano-corrals-slit-diffractor
#13
Priyanshu Jain, Tanmoy Maiti
Here, we have numerically calculated electric field intensity and phase of the emission from various hybrid spiral plasmonic lenses (HSPL) in near field as well as in far-field. We have proposed a novel HSPL inscribed with nano corrals slit (NCS) and compared its focusing ability with other HSPLs inscribed with circular slit and circular grating. With the use of nano corrals slit, we have been able to improve light intensity in the far-field without compromising near-field intensity. Our NCS-HSPL outperforms other HSPLs and standalone SPL in near-field as well as far-field...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348043/superhydrophobic-coatings-with-high-repellency-to-daily-consumed-liquid-foods-based-on-food-grade-waxes
#14
Xia Zhao, Tao Hu, Junping Zhang
The applications of superhydrophobic coatings in daily life are receiving increasing attention. Here, we report a general approach for preparing superhydrophobic coatings with high repellency to daily consumed liquid foods based on food grade waxes. The coatings are prepared by spray-coating the homogeneous wax suspensions in ethanol followed by annealing at 40 °C. The wax suspensions are formed by the heating dissolution-cooling precipitation-ultrasonication process thanks to the unique solubility of the waxes in ethanol...
January 10, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29347997/openbiodiv-o-ontology-of-the-openbiodiv-knowledge-management-system
#15
Viktor Senderov, Kiril Simov, Nico Franz, Pavel Stoev, Terry Catapano, Donat Agosti, Guido Sautter, Robert A Morris, Lyubomir Penev
BACKGROUND: The biodiversity domain, and in particular biological taxonomy, is moving in the direction of semantization of its research outputs. The present work introduces OpenBiodiv-O, the ontology that serves as the basis of the OpenBiodiv Knowledge Management System. Our intent is to provide an ontology that fills the gaps between ontologies for biodiversity resources, such as DarwinCore-based ontologies, and semantic publishing ontologies, such as the SPAR Ontologies. We bridge this gap by providing an ontology focusing on biological taxonomy...
January 18, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29347751/surface-deformation-during-an-action-potential-in-pearled-cells
#16
Matan Mussel, Christian Fillafer, Gal Ben-Porath, Matthias F Schneider
Electric pulses in biological cells (action potentials) have been reported to be accompanied by a propagating cell-surface deformation with a nanoscale amplitude. Typically, this cell surface is covered by external layers of polymer material (extracellular matrix, cell wall material, etc.). It was recently demonstrated in excitable plant cells (Chara braunii) that the rigid external layer (cell wall) hinders the underlying deformation. When the cell membrane was separated from the cell wall by osmosis, a mechanical deformation, in the micrometer range, was observed upon excitation of the cell...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347748/asymmetric-couplings-enhance-the-transition-from-chimera-state-to-synchronization
#17
Changhai Tian, Hongjie Bi, Xiyun Zhang, Shuguang Guan, Zonghua Liu
Chimera state has been well studied recently, but little attention has been paid to its transition to synchronization. We study this topic here by considering two groups of adaptively coupled Kuramoto oscillators. By searching the final states of different initial conditions, we find that the system can easily show a chimera state with robustness to initial conditions, in contrast to the sensitive dependence of chimera state on initial conditions in previous studies. Further, we show that, in the case of symmetric couplings, the behaviors of the two groups are always complementary to each other, i...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347696/stochastic-dynamics-of-genetic-broadcasting-networks
#18
Davit A Potoyan, Peter G Wolynes
The complex genetic programs of eukaryotic cells are often regulated by key transcription factors occupying or clearing out of a large number of genomic locations. Orchestrating the residence times of these factors is therefore important for the well organized functioning of a large network. The classic models of genetic switches sidestep this timing issue by assuming the binding of transcription factors to be governed entirely by thermodynamic protein-DNA affinities. Here we show that relying on passive thermodynamics and random release times can lead to a "time-scale crisis" for master genes that broadcast their signals to a large number of binding sites...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346428/revisiting-facial-resemblance-in-couples
#19
Yetta Kwailing Wong, Wing Wah Wong, Kelvin F H Lui, Alan C-N Wong
It is widely believed that couples look alike. Consistently, previous research reported higher facial similarity for couples than non-couples, and that facial similarity predicts marital satisfaction. However, it is unclear if facial similarity in couples shown in previous studies was solely driven by extrinsic features like hairstyle, glasses, etc. Also unclear is what attributes are perceived as similar from the faces of a couple. In three experiments, we showed that faces were considered more similar in couples than non-couples even without extrinsic features...
2018: PloS One
https://www.readbyqxmd.com/read/29346330/formulation-of-poloxamers-for-drug-delivery
#20
REVIEW
Andrew M Bodratti, Paschalis Alexandridis
Poloxamers, also known as Pluronics®, are block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which have an amphiphilic character and useful association and adsorption properties emanating from this. Poloxamers find use in many applications that require solubilization or stabilization of compounds and also have notable physiological properties, including low toxicity. Accordingly, poloxamers serve well as excipients for pharmaceuticals. Current challenges facing nanomedicine revolve around the transport of typically water-insoluble drugs throughout the body, followed by targeted delivery...
January 18, 2018: Journal of Functional Biomaterials
keyword
keyword
82448
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"