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Alpha-lipoic-acid

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https://www.readbyqxmd.com/read/28296595/time-course-effect-of-r-alpha-lipoic-acid-on-cellular-metabolomics-in-cultured-hepatoma-cells
#1
Naoko Ikuta, Keita Chikamoto, Yuya Asano, Yoshiaki Yasui, Haruka Yokokawa, Keiji Terao, Gerald Rimbach, Seiichi Matsugo
Alpha-lipoic acid (LA) is a powerful antioxidant. LA has two enantiomers, R(+)-LA (R-LA) and S(-)-LA (S-LA). Of these, R-LA is naturally occurring and an essential cofactor in energy metabolism. R-LA treatment has been reported to affect glucose metabolism in rat hepatoma cells. This study analyzed the time course of metabolite levels in LA-treated cultured H4IIEC3 rat hepatoma cells, including a specific evaluation of the effect of R-LA and the enantioselectivity of LA. Principal component analysis showed that this experiment was well designed to observe enantioselectivity...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28295905/alpha-lipoic-acid-ala-as-a-supplementation-for-weight-loss-results-from-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
S Kucukgoncu, E Zhou, K B Lucas, C Tek
OBJECTIVES: Obesity is associated with significant morbidity and mortality rates. Even modest weight loss may be associated with health benefits. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant. Studies have suggested anti-obesity properties of ALA; however, results are inconsistent. The purpose of this study is to conduct a meta-analysis of the effect of ALA on weight and body mass index (BMI). METHODS: A comprehensive, systematic literature search identified 10 articles on randomized, double-blind, placebo-controlled studies involving ALA...
March 13, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28272982/role-of-alpha-lipoic-acid-in-ameliorating-cyclosporine-a-induced-pancreatic-injury-in-albino-rats-a-structural-ultrastructural-and-morphometric-study
#3
Hala F Abd-Ellah, Nadia R A Abou-Zeid
The aim of this study was to investigate the effectiveness of alpha-lipoic acid (α-LA) against cyclosporine A (CsA)-induced pancreatic toxicity in rats. Thirty-two male albino rats were divided into four equal groups. Group I treated orally (per os, p.o.) with vehicles and served as control; Group II received α-LA (100 mg/kg b.w. /day, p.o.) for 21 days; Group III received CsA (25 mg/kg b.w./day, p.o.) for 21 days; and Group IV received α-LA 1 hr before oral treatment by CsA for 21 days. Histological examination of the pancreas of CsA-treated rats showed marked changes represented by wide interlobular septae that contained congested blood vessels, cytoplasmic vacuolation of some acinar cells, and distortion of the other cells...
March 8, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28262510/regeneration-of-glutathione-by-%C3%AE-lipoic-acid-via-nrf2-are-signaling-pathway-alleviates-cadmium-induced-hepg2-cell-toxicity
#4
Jiayu Zhang, Xue Zhou, Wenbo Wu, Jiachun Wang, Hong Xie, Zhigang Wu
Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis...
February 27, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28258730/effects-of-alpha-lipoic-acid-on-multiple-cytokines-and-biomarkers-and-recurrence-of-atrial-fibrillation-within-1-year-of-catheter-ablation
#5
Celestino Sardu, Gaetano Santulli, Matteo Santamaria, Michelangela Barbieri, Cosimo Sacra, Pasquale Paolisso, Fabio D'Amico, Nicola Testa, Igor Caporaso, Giuseppe Paolisso, Raffaele Marfella, Maria Rosaria Rizzo
Catheter ablation (CA) is a procedure commonly used to restore sinus rhythm in patients with atrial fibrillation (AF). However, AF recurrence after CA remains a relevant clinical issue. We tested the effects of an oral antioxidant treatment (alpha lipoic acid [ALA]) on AF recurrence post-CA. Patients with paroxysmal AF have been enrolled in a randomized, prospective, double-blind, controlled placebo trial. After CA, patients have been randomly assigned to receive ALA oral supplementation (ALA group) or placebo (control group) and evaluated at baseline and after a 12-month follow-up: 73 patients completed the 12-month follow-up (ALA: 33 and control: 40)...
February 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28249792/alpha-lipoic-acid-after-median-nerve-decompression-at-the-carpal-tunnel-a%C3%A2-randomized-controlled-trial
#6
Filippo Boriani, Donatella Granchi, Giulia Roatti, Luciano Merlini, Tania Sabattini, Nicola Baldini
PURPOSE: The postoperative course of median nerve decompression in carpal tunnel syndrome may be associated with complications. The aim of this study was to explore the possible effects of alpha-lipoic acid (ALA) in the postoperative period after surgical decompression of the median nerve at the wrist. METHODS: We conducted a double-blind prospective, randomized, controlled trial. A total of 64 patients with proven carpal tunnel syndrome were enrolled and randomly assigned into 1 of 2 groups: group A (n = 32) patients had surgical decompression of the median nerve followed by ALA for 40 days, and group P (n = 32) patients had surgical decompression followed by placebo...
February 26, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28247977/burning-mouth-syndrome-a-systematic-review-of-treatments
#7
REVIEW
Yuan F Liu, Yohanan Kim, Timothy Yoo, Peter Han, Jared C Inman
Burning mouth syndrome (BMS) is a chronic oral pain syndrome that primarily affects peri- and postmenopausal women. It is characterized by oral mucosal burning and may be associated with dysgeusia, paresthesia, dysesthesia, and xerostomia. The etiology of the disease process is unknown, but is thought to be neuropathic in origin. The goal of this systematic review was to assess the efficacy of the various treatments for BMS. Literature searches were conducted through PubMed, Web of Science, and Cochrane Library databases, which identified 22 randomized, controlled trials...
March 1, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28239907/effects-of-oral-%C3%AE-lipoic-acid-administration-on-body-weight-in-overweight-or-obese-subjects-a-crossover-randomized-double-blind-placebo-controlled-trial
#8
Nong Li, Weili Yan, Xiaojuan Hu, Yongdi Huang, Fugang Wang, Weiguo Zhang, Qian Wang, Xiaoling Wang, Kehong Sun
OBJECTIVE: Alpha-lipoic acid (ALA) has shown beneficial properties on diabetes and obesity. The aim of this study was to examine the effects of oral ALA on body weight in subjects with overweight or obese. DESIGN: Single-centre, randomized, double-blind, crossover controlled study. PARTICIPANTS: A total of 166 subjects of Chinese Han ethnicity with a BMI ≥25 kg/m(2) were screened and 103 subjects fulfilled the study requirements, in terms of informed consent and participation to the study...
January 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28239826/observational-multicentric-survey-on-carpal-tunnel-syndrome-demographic-and-clinical-data-from-34-italian-centers
#9
R Luchetti, S Tognon, M Cacciavillani, S Ronco, N Buzzelli, G Lanni
OBJECTIVE: To evaluate the current management of carpal tunnel syndrome (CTS) at a national level. PATIENTS AND METHODS: A multicentric observational study was conducted in 34 Italian centers by specialists participating in the Management of Peripheral Neuropathies Study Group on 377 patients (age, mean±SD 56±14.4 years, 73.2% females) with CTS. The characteristics of the disease and its management were recorded at baseline and during a 2-month follow-up using a standardized clinical record and assessed with validated clinical tests...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28177698/influence-of-alpha-lipoic-acid-on-nicotine-induced-lung-and-liver-damage-in-experimental-rats
#10
Hayam Ateyya, Manar A Nader, Ghalia M Attia, Nagla A El-Sherbeeny
Nicotine mediates some of the injurious effects caused by consuming tobacco products. This work aimed at investigating the defensive role of alpha-lipoic acid (ALA) with its known antioxidant and antiinflammatory effect in nicotine-induced lung and liver damage. Rats were arranged into 4 groups: control, nicotine, ALA, and ALA-nicotine groups. Oxidative stress and antioxidant status were determined by assessing thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and glutathione (GSH) levels in lung and liver...
October 12, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28133612/tang-luo-ning-improves-mitochondrial-antioxidase-activity-in-dorsal-root-ganglia-of-diabetic-rats-a-proteomics-study
#11
Taojing Zhang, Yanbin Gao, Yanbin Gong, Hui Zhou, Peifeng Xie, Song Guan, Wenming Yi
Tang-luo-ning (TLN) is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN). In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN. Diabetic rats were established by injection of streptozocin (STZ) and divided into model, alpha lipoic acid (ALA), and TLN groups. Mitochondrial proteins were isolated from dorsal root ganglia and proteomic analysis was used to quantify the differentially expressed proteins...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28132911/effect-of-alpha-lipoic-acid-on-leukotriene-a4-hydrolase
#12
María José Torres, Angélica Fierro, C David Pessoa-Mahana, Javier Romero-Parra, Gonzalo Cabrera, Mario Faúndez
Leukotriene A4 hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A4 to leukotriene B4 and the hydrolysis of the peptide proline-glycine-proline. Imbalances in leukotriene B4 synthesis are related to several pathologic conditions. Currently there are no available drugs capable to modulate the synthesis of leukotriene B4 or to block its receptors. Here we show the inhibitory profile of alpha lipoic acid on the activity of leukotriene A4 Hydrolase...
January 26, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28074465/effects-of-alpha-lipoic-acid-on-ischemia-reperfusion-injury-in-rat-hindlimb-ischemia-model
#13
Arif Aydın, Alpagan Mustafa Yıldırım
BACKGROUND: This study was performed to evaluate the effect of alpha lipoic acid (ALA) on prevention of ischemia-reperfusion (IR) injury in rat hindlimb ischemia model. METHODS: Forty male Sprague Dawley rats weighing between 250 and 300 g were divided into 4 groups of 10 rats. Hindlimb composite island flaps were raised in all rats. Clamps were applied to femoral vessels of all subjects, but immediately released without causing ischemia in Group 1. In Group 2, after 4 hours of ischemia, 24 hours of reperfusion was performed...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28068366/overproduction-of-%C3%AE-lipoic-acid-by-gene-manipulated-escherichia-coli
#14
Yirong Sun, Wenbin Zhang, Jincheng Ma, Hongshen Pang, Haihong Wang
Alpha-lipoic acid (LA) is an important enzyme cofactor widely used by organisms and is also a natural antioxidant for the treatment of pathologies driven by low levels of endogenous antioxidants. In order to establish a safer and more efficient process for LA production, we developed a new biological method for LA synthesis based on the emerging knowledge of lipoic acid biosynthesis. We first cloned the lipD gene, which encodes the lipoyl domain of the E2 subunit of pyruvate dehydrogenase, allowing high levels of LipD production...
2017: PloS One
https://www.readbyqxmd.com/read/28065798/monitoring-treatment-of-acute-kidney-injury-with-damage-biomarkers
#15
T J Pianta, L Succar, T Davidson, N A Buckley, Z H Endre
BACKGROUND: Damage biomarkers may identify mechanisms and sites of acute kidney injury (AKI). However, the utility of novel AKI biomarkers differs by context, and their utility for monitoring treatment of AKI is unknown. We hypothesized that selected AKI biomarkers would facilitate monitoring of mechanism-specific treatment. We examined this using a panel of biomarkers to monitor cisplatin-induced AKI treatment with alpha-lipoic acid (α-LA) that has previously been demonstrated to ameliorate cisplatin induced AKI...
February 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28065420/effectiveness-of-dietary-supplements-in-spinal-cord-injury-subjects
#16
REVIEW
Angela Navarrete-Opazo, Pilar Cuitiño, Inés Salas
BACKGROUND: Individuals with spinal cord injury (SCI) consume more dietary supplements than the general population. However, there is limited information regarding the clinical effectiveness of dietary supplements in SCI population. OBJECTIVE: To systematically review the effectiveness of dietary supplements for the prevention or treatment of health-related conditions associated with SCI. METHODS: Randomized or non-randomized controlled clinical trials were selected, comparing the effect of any dose and form of a dietary supplement (defined by the Dietary Supplement Health and Education Act), with either no treatment, placebo, or other medication...
December 19, 2016: Disability and Health Journal
https://www.readbyqxmd.com/read/28035366/inhibitory-effects-of-alpha-lipoic-acid-on-oxidative-stress-in-the-rostral-ventrolateral-medulla-in-rats-with-salt-induced-hypertension
#17
Yu-Peng Huang, Hong-Yan Jin, Hui-Ping Yu
Oxidative stress in the rostral ventrolateral medulla (RVLM) plays an important role in the pathophysiology of hypertension. Alpha‑lipoic acid (ALA) is widely recognized for its potent superoxide inhibitory properties, and it can safely penetrate deep into the brain. The aim of this study was to explore whether ALA supplementation attenuates hypertensive responses and cardiac hypertrophy by decreasing the NAD(P)H oxidase (NOX)-derived overproduction of reactive oxygen species (ROS) in the mitochondria in the RVLM, and thus attenuating the development of salt‑induced hypertension...
February 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28009525/effects-of-alpha-lipoic-acid-supplementation-on-plasma-adiponectin-levels-and-some-metabolic-risk-factors-in-patients-with-schizophrenia
#18
Bojana Vidović, Srđan Milovanović, Aleksandra Stefanović, Jelena Kotur-Stevuljević, Marija Takić, Jasmina Debeljak-Martačić, Maja Pantović, Brižita Đorđević
Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alpha-lipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27998794/effects-of-troxerutin-on-cognitive-deficits-and-glutamate-cysteine-ligase-subunits-in-the-hippocampus-of-streptozotocin-induced-type-1-diabetes-mellitus-rats
#19
Songyun Zhang, Hongyan Li, Lihui Zhang, Jie Li, Ruiying Wang, Mian Wang
Increasing evidence demonstrates an association between diabetes and hippocampal neuron damage. This study aimed to determine the effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits (GCLM and GCLC) in the hippocampus of streptozotocin-induced type 1 diabetes mellitus (T1DM) rats. At 12 weeks after streptozotocin injection, T1DM rats were randomly divided into 4 groups (n=15 each group) to receive no treatment (T1DM), saline (T1DM+saline), alpha-lipoic acid (T1DM+alpha-lipoic acid), and troxerutin (T1DM+troxerutin), respectively, for 6 weeks...
December 17, 2016: Brain Research
https://www.readbyqxmd.com/read/27951451/electroencephalographic-study-of-chlorpromazine-alone-or-combined-with-alpha-lipoic-acid-in-a-model-of-schizophrenia-induced-by-ketamine-in-rats
#20
Luis Rafael Leite Sampaio, Lucas Teixeira Nunes Borges, Talita Matias Barbosa, Natalia Castelo Branco Matos, Ricardo de Freitas Lima, Mariana Nascimento de Oliveira, Viviane Nóbrega Gularte, Manoel Cláudio Azevedo Patrocínio, Danielle Macêdo, Otoni Cardoso do Vale, Silvânia Maria Mendes de Vasconcelos
Schizophrenia is characterized by behavioral symptoms, brain function impairments and electroencephalographic (EEG) changes. Dysregulation of immune responses and oxidative imbalance underpins this mental disorder. The present study aimed to investigate the effects of the typical antipsychotic chlorpromazine (CP) alone or combined with the natural antioxidant alpha-lipoic acid (ALA) on changes in the hippocampal average spectral power induced by ketamine (KET). Three days after stereotactic implantation of electrodes, male Wistar rats were divided into groups treated for 10 days with saline (control) or KET (10 mg/kg, IP)...
March 2017: Journal of Psychiatric Research
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