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Alpha-lipoic-acid

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https://www.readbyqxmd.com/read/29760339/the-potential-antifibrotic-impact-of-apocynin-and-alpha-lipoic-acid-in-concanavalin-a-induced-liver-fibrosis-in-rats-role-of-nadph-oxidases-1-and-4
#1
Mostafa R Fayed, Reem N El-Naga, El-Sayed Akool, Ebtehal El-Demerdash
Liver fibrosis results from chronic inflammation that precipitates excessive accumulation of extracellular matrix. Oxidative stress is involved in its pathogenesis. This study aimed to elucidate the potential antifibrotic effect of the NADPH oxidase (NOX) inhibitor, apocynin against concanavalin A (ConA)-induced immunological model of liver fibrosis, and to investigate the ability of the antioxidant, alpha-lipoic acid (α-LA) to potentiate this effect. Rats were treated with apocynin and/or α-LA for six weeks...
2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29753588/effects-of-alpha-lipoic-acid-supplementation-on-c-reactive-protein-level-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#2
S Saboori, E Falahi, E Eslampour, M Zeinali Khosroshahi, E Yousefi Rad
BACKGROUND AND AIM: The aim of this meta-analysis was to assess effects of alpha-lipoic acid supplementation on C-reactive protein (CRP) levels in clinical trial studies. METHODS AND RESULTS: A systematic search was carried out on clinical trial studies published in PubMed, ISI Web of Science, Cochrane Library and Scopus databases completed by manual search on reference list of eligible studies accomplished by November 4, 2017. Of a total number of 508 studies found in the first step of literature search, only 11 were included with 264 participants in supplementation groups and 287 in control groups...
April 17, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29737931/rux-largely-restores-lungs-in-iraq-pm-exposed-mice-up-regulating-regulatory-t-cells-tregs
#3
David Lin, Jonathan Li, Rabail Razi, Niha Qamar, Laurie Levine, Thomas Zimmerman, Sayyed A Hamidi, Millicent Schmidt, Marc G Golightly, Todd Rueb, Andrea Harrington, Merrill Garnett, Frank Antonawich, Steven McClain, Courtney Cox, Po Hsuan Huang, Anthony M Szema
Background Military personnel post-deployment to Iraq and Afghanistan have noted new-onset respiratory illness. This study's primary objective was to further develop an animal model of Iraq Afghanistan War Lung Injury (IAW-LI) and to test a novel class of anti-injury drug called RuX. Methods Particulate Matter (PM) samples were obtained in Iraq then characterized by spectromicroscopy. C57BL/6 mice underwent orotracheal instillation with PM, followed by drinkable treatment with RuX. Lung histology, inspiratory capacity (FlexiVent), thymic/splenic regulatory T cell (Treg) number, and whole-lung genomics were analyzed...
May 8, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29736880/comparison-of-peripheral-nerve-protection-between-insulin-based-glucose-control-and-alpha-lipoic-acid-ala-in-the-streptozotocin-stz-induced-diabetic-rat
#4
Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comparison to that of glucose control is unclear. In this study, we compared the neuroprotective potential of glucose control and ALA. Animals were divided into 6 groups based on the intervention used, as follows: normal, diabetes (DM), DM+racemic form of ALA, DM+R form of ALA, DM+once daily insulin glargine, and DM+once daily insulin glargine with twice daily insulin glulisine...
May 7, 2018: Endocrine
https://www.readbyqxmd.com/read/29736639/chronic-co-exposure-to-chlorpyrifos-and-deltamethrin-pesticides-induces-alterations-in-serum-lipids-and-oxidative-stress-in-wistar-rats-mitigating-role-of-alpha-lipoic-acid
#5
Chidiebere Uchendu, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, King Akpofure Nelson Esievo
The study evaluated the effect of combination of chlorpyrifos (CPF) and deltamethrin (DLT) on serum lipid profiles and oxidative stress in rats, and the mitigating role of alpha-lipoic acid (ALA). Thirty male rats were used for the 120-day study. Serum samples obtained at termination were evaluated for the levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), malondialdehyde (MDA), and the activities of antioxidant enzymes. The levels of low-density lipoprotein-cholesterol (LDL), very low-density lipoprotein-cholesterol (VLDL), and atherogenic index (AI) were calculated...
May 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29732526/neuroprotective-evidence-of-alpha-lipoic-acid-and-desvenlafaxine-on-memory-deficit-in-a-neuroendocrine-model-of-depression
#6
Caren Nádia Soares de Sousa, Lucas Nascimento Meneses, Germana Silva Vasconcelos, Ingridy da Silva Medeiros, Márcia Calheiros Chaves Silva, Fayçal Mouaffak, Oussama Kebir, Cláudio Manuel Gonçalves da Silva Leite, Manoel Cláudio Azevedo Patrocinio, Danielle Macedo, Silvânia Maria Mendes Vasconcelos
Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when combined to antidepressants. Female mice received vehicle or corticosterone (CORT) 20 mg/kg, s.c. for 14 days. From the 15th to 21st day, the animals were divided in groups: vehicle, CORT, CORT+desvenlafaxine (DVS) 10 or 20 mg/kg, ALA 100 or 200 mg/kg, DVS10+ALA100, DVS20+ALA100, DVS10+ALA200, or DVS20+ALA200. Tail suspension (TST), social interaction (SIT), novel object recognition (NOR), and Y-maze tests were conducted...
May 7, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29727539/-efficacy-of-alpha-lipoic-acid-combined-with-tamoxifen-citrate-in-the-treatment-of-oligoasthenospermia
#7
Hang Zhang, Ya-Xuan Wang, Jing-Dong Li, Xue-Liang Chang, Zhi-Hai Teng, Yan-Ping Zhang, Shu-Wen Yang, Wei Li
Objective: To investigate the effect of alpha-lipoic acid (α-LA) combined with tamoxifen citrate (TC) in the treatment of oligoasthenospermia. METHODS: From June to November 2016, we treated 60 patients with oligoasthenospermia in our Department of Andrology, 30 (the trial group) with oral α-LA (0.6 g, qd) + TC (20 mg, qd) and the other 30 (the control group) with oral L-carnitine (1g, bid) + TC (20 mg, qd). Before and after 3 months of medication, we examined the semen parameters of the patients and the levels of their seminal oxidative stress biomarkers, including methylenedioxyamphetamine (MDA) and total antioxidant capacity (TAC) in the seminal plasma...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726290/alpha-lipoic-acid-in-obstetrics-and-gynecology
#8
Chiara Di Tucci, Mara Di Feliciantonio, Flaminia Vena, Carmela Capone, Michele Carlo Schiavi, Daniela Pietrangeli, Ludovico Muzii, Pierluigi Benedetti Panici
Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate. In this review, we analyzed the action of ALA in gynecology and obstetrics focusing in particular on neuropathic pain and antioxidant and anti-inflammatory action. A comprehensive literature search was performed in PubMed and Cochrane Library for retrieving articles in English language on the antioxidant and anti-inflammatory effects of ALA in gynecological and obstetrical conditions...
May 4, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29721235/does-alpha-lipoic-acid-supplementation-modulate-cardiovascular-risk-factors-in-patients-with-stroke-a-randomized-double-blind-clinical-trial
#9
Vida Mohammadi, Fariborz Khorvash, Awat Feizi, Gholamreza Askari
Background: Stroke as a devastating condition is one of the major causes of death worldwide. It is accountable for long time disability with high personal and social cost in adults. There are several risk factors for stroke such as diabetes and hypertension. Alpha-lipoic acid (ALA) as an antioxidant can be a risk modifier in these patients. We designed this trial to scrutinize the possible effects of ALA consumption on some cardiovascular risk factors in patients experienced stroke. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 67 patients experienced stroke were randomly allocated into two groups (taking a 600 mg ALA supplement or placebo daily for 12 weeks)...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29696608/regulation-of-aging-and-oxidative-stress-pathways-in-aged-pancreatic-islets-using-alpha-lipoic-acid
#10
Navid Nobakht-Haghighi, Mahban Rahimifard, Maryam Baeeri, Mohammad Amin Rezvanfar, Shermineh Moini Nodeh, Hamed Haghi-Aminjan, Emre Hamurtekin, Mohammad Abdollahi
Oxidative stress has been involved in the aging process and the pathogenesis of type-2 diabetes, which is a serious health problem worldwide. This study investigates the anti-aging, anti-apoptotic, and antioxidant properties of alpha-lipoic acid (ALA), aiming to improve aged rat pancreatic cells. In this regard, half maximal effective concentration (EC50 ) of ALA based on the survival of aged pancreatic islet cells was determined as 100 µM. Following this, p38 and p53 genes expression as key factors in aging, oxidative stress biomarkers, insulin secretion, and Pdx1 protein expression were evaluated using real-time PCR, ELISA reader, and fluorescence microscope...
April 25, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29696421/treatment-modalities-for-burning-mouth-syndrome-a-systematic-review
#11
REVIEW
Isadora Follak de Souza, Belkiss Câmara Mármora, Pantelis Varvaki Rados, Fernanda Visioli
OBJECTIVES: In the burning mouth syndrome (BMS), patients experience a burning sensation in the oral cavity with no associated injury or clinical manifestation. The etiology of this condition is still poorly understood, and therefore, treatment is challenging. The aim of this study is to perform a systematic review of treatment possibilities described in the literature for BMS. MATERIALS AND METHODS: PubMed, Embase, and SciELO databases were searched for randomized clinical trials published between 1996 and 2016...
April 25, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29663489/high-glucose-induced-excessive-reactive-oxygen-species-promote-apoptosis-through-mitochondrial-damage-in-rat-cartilage-endplate-cells
#12
Zengxin Jiang, Wei Lu, Qingmin Zeng, Defang Li, Lei Ding, Jingping Wu
PURPOSE: Diabetes mellitus (DM) is an important factor in intervertebral disc degeneration (IDD). Apoptosis of cartilage endplate (CEP) cells is one of the initiators of IDD. However, the effects of high glucose on CEP cells are still unknown. Therefore, we conducted the present study to evaluate the effects of high glucose on CEP cells and to identify the mechanisms of those effects. METHODS: Rat CEP cells were isolated and cultured in 10% foetal bovine serum (FBS, normal control) or high-glucose medium (10% FBS + 0...
April 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29653414/new-insights-on-the-modulatory-roles-of-metformin-or-alpha-lipoic-acid-versus-their-combination-in-dextran-sulfate-sodium-induced-chronic-colitis-in-rats
#13
Fatma S Samman, Samah M Elaidy, Soha S Essawy, Mohammad S Hassan
BACKGROUND: Dextran sulfate sodium (DSS)-induced colitis is the most widely used model that resembles ulcerative colitis (UC) in human with challenging chronic mechanistic oxidative stress-inflammatory/immunological cascades. In models of acute colitis, reduction of oxidative stress and inflammatory burdens beside manipulation of many transcriptional factors were achieved by metformin or alpha-lipoic acid (α-LA). Currently, in vivo DSS-induced chronic colitis was conducted and the possible therapeutic roles of metformin and/or α-LA were explored...
November 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29627873/disease-modifying-treatment-in-progressive-multiple-sclerosis
#14
REVIEW
John Robert Ciotti, Anne Haney Cross
PURPOSE OF REVIEW: Multiple sclerosis (MS) is an immune-mediated disorder that affects the central nervous system (CNS), often first affecting people in early adulthood. Although most MS patients have a relapsing-remitting course (RRMS) at disease onset, a substantial proportion later develop chronic progression, termed secondary progressive MS (SPMS). Approximately 10% of MS patients experience chronic progression from disease onset, termed primary progressive multiple sclerosis (PPMS)...
April 7, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29597044/ex-vivo-absorption-study-of-lysine-r-lipoate-salt-a-new-pharmaceutical-form-of-r-ala
#15
Francesco Amenta, Michela Buccioni, Diego Dal Ben, Catia Lambertucci, Aleix Martí Navia, Michael A Ngouadjeu Ngnintedem, Massimo Ricciutelli, Andrea Spinaci, Rosaria Volpini, Gabriella Marucci
Alpha-lipoic acid (ALA) oral supplements were used in many pathologies associated with increased oxidative stress. Although only R-ALA is considered the biologically active form, R,S-ALA is used in therapeutic applications even showing poor water solubility. The aim of this work was to study the absorption and transport mechanism across the intestinal barrier of new R-ALA stable and water soluble form, consisting in the lysine R-ALA salt, in presence and absence of specific inhibitors of Na+ /multivitamin (SMVT) and monocarboxylic acids (MCT)...
March 26, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29591887/pathological-effects-of-cigarettes-on-the-reproductive-system-and-the-protective-effects-of-alpha-lipoic-acid-in-female-rats
#16
Halil Asci, Onur Erol, Hamit Yasar Ellidag, Esra Nur Tola, Mehtap Savran, Ozlem Ozmen
Cigarette smoking (CS) has some detrimental effects that occur via oxidative stress (OS). The aim of this work was to demonstrate the pathological and immunohistochemical effects of CS and the protective effects of a strong antioxidant alpha lipoic acid (ALA) on CS-induced genital system changes in a rat model. Twenty-eight female rats were randomly allocated to three groups as control, CS-exposed, and CS-exposed and ALA-treated. Reproductive tract organs were collected for biochemical and pathological examinations...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29576255/first-description-of-the-alpha-lipoic-acid-intoxication-in-an-adult-patient-worldwide-following-oral-administration
#17
Muge Gulen, Yeliz Simsek, Emre Oner, Salim Satar
No abstract text is available yet for this article.
March 14, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29575431/integrated-transcriptomic-and-proteomic-analyses-reveal-%C3%A9-lipoic-acid-regulated-cell-proliferation-via-grb2-mediated-signalling-in-hepatic-cancer-cells
#18
Lan Yang, Xiliang Wang, Juan Xu, Ya Wen, Manqiao Zhang, Jingxiao Lu, Rongfu Wang, Xiaojuan Sun
Hepatocellular carcinoma is the most frequent primary liver cancer worldwide. The use of antioxidants as cancer prevention and treatment agents has become a focus of research in recent years due to their limited adverse effects. Alpha lipoic acid (ɑ-LA) is synthesized in the liver and is considered a naturally occurring antioxidant. In this study, a total of 4446 differentially expressed genes (2097 down-regulated and 2349 up-regulated) were identified via RNA-Seq in HepG2 cells after exposure to α-LA for 24 hrs...
March 25, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29571016/the-role-of-nutrients-in-the-pathogenesis-and-treatment-of-migraine-headaches-review
#19
REVIEW
Elyas Nattagh-Eshtivani, Mahmood Alizadeh Sani, Monireh Dahri, Faezeh Ghalichi, Abed Ghavami, Pishva Arjang, Ali Tarighat-Esfanjani
OBJECTIVE: Migraine as a disabling neurovascular disease affects 6% of men and 18% of women worldwide. The deficiency of many nutrients including magnesium, niacin, riboflavin, cobalamin, coenzymes Q10, carnitine, α-lipoic acid and vitamin D is associated with migraine. Some researchers postulate that mitochondrial dysfunction and impaired antioxidant status can cause migraine. Also increase in homocysteine level can lead to migraine attacks; therefore, some Nutraceuticals play a vital role in migraine prevention...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568025/are-pharmacological-treatments-for-oro-facial-pain-effective
#20
Debra Fischoff, Silvia Spivakovsky
Data sourcesElectronic searches of PubMed, the Cochrane Library, Embase, the National Health Service Economic Evaluation Database and HTA until March 2017. Also handsearched referenced in the original articles. Grey literature was not included.Study selectionRandomised controlled trials with more than ten participants with oro-facial pain duration of more than three months were sub grouped into: TMD-muscle pain (TMD-m), TMD-joint pain (TMD-j), burning mouth syndrome (BMS) and other oro-facial pain. Studies include any pharmacological treatment against another pharmacological, non-pharmacological treatment, placebo or no treatment...
March 23, 2018: Evidence-based Dentistry
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