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Alpha-lipoic-acid

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https://www.readbyqxmd.com/read/28900454/the-effect-of-alpha-lipoic-acid-supplementation-on-anthropometric-indices-and-food-intake-in-patients-who-experienced-stroke-a-randomized-double-blind-placebo-controlled-clinical-trial
#1
Vida Mohammadi, Fariborz Khorvash, Awat Feizi, Gholamreza Askari
BACKGROUND: Stroke as a devastating condition is a major cause of death worldwide. It is accountable for long-term disability with high personal and social cost in adults. Alpha-lipoic acid (ALA) is an eight-carbon, sulfur-containing compound with antioxidant properties which reduces body weight, changes other anthropometric indices, and regulates food intake by suppressing appetite and increasing metabolism This study was designed to evaluate the possible effects of ALA supplementation on anthropometric indices and dietary intake in patients with stroke...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28894553/effect-of-alpha-lipoic-acid-on-asymmetric-dimethylarginine-and-disability-in-multiple-sclerosis-patients-a-randomized-clinical-trial
#2
Mohammad Khalili, Madjid Soltani, Shirin Amiri Moghadam, Parvin Dehghan, Amirreza Azimi, Omid Abbaszadeh
BACKGROUND: Multiple Sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system. Oxidative stress plays a major role in the onset and progression of MS. Asymmetric dimethylarginine (ADMA) formation is dependent on oxidative stress status. OBJECTIVE: We examined whether alpha-lipoic acid (ALA) as a potent antioxidant could improve the Expanded Disability Status Scale (EDSS) and decrease plasma level of ADMA in multiple sclerosis patients...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28880400/effects-of-ivermectin-and-its-combination-with-alpha-lipoic-acid-on-expression-of-igfbp-3-and-hspa1-genes-and-male-rat-fertility
#3
Z K El-Maddawy, W S H Abd El Naby
This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin-like growth factor binding protein-3 (IGFBP-3) and heat-shock protein A1 (HSPA1)) genes in the testes, as well as on male rat fertility parameters. Results revealed that expression levels of IGFBP-3 and HSPA1 were significantly increased in testis of the IVM-treated group relative to the control group...
September 7, 2017: Andrologia
https://www.readbyqxmd.com/read/28872362/ferulic-acid-but-not-alpha-lipoic-acid-effectively-protects-thp-1-derived-macrophages-from-oxidant-and-pro-inflammatory-response-to-lps
#4
Izabela Szulc-Kielbik, Michal Kielbik, Magdalena Klink
OBJECTIVE: The diet supplementation with antioxidants-rich products is a way to protect people from free radical-induced diseases. In this study, we compare the anti-inflammatory/antioxidant activity of two compounds available as supplements: alpha lipoic acid (ALA) and ferulic acid (FA). MATERIALS AND METHODS: The free radical scavenging capacity of ALA and FA in the cell free system was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Anti-inflammatory activity of both compounds was determined, in vitro, on THP-1 derived macrophages model, both resting (not stimulated) and inflammatory (lipopolysaccharide- or tumor-necrosis factor α-stimulated)...
September 5, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28845931/-adjuvant-antioxidant-therapy-in-varicocele-infertility
#5
S I Gamidov, R I Ovchinnikov, A Yu Popova, A Yu Avakyan, G T Sukhikh
INTRODUCTION: Infertility affects an estimated 15% of couples globally. Male factor infertility accounts for about a half of infertility cases. About 40% of infertile men have varicocele. The aim of this study was to investigate the efficacy and safety of a complex of acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (SpermActin-forte) (SA) for adjuvant antioxidant therapy after microsurgical varicocelectomy (MVE) in men with varicocele and assess its impact on the level of DNA fragmentation in sperm cells...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28834388/dry-eye-disease-and-oxidative-stress
#6
REVIEW
Sophia Seen, Louis Tong
Dry eye, an age-related condition, is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability. Environmental factors are also often implicated in dry eye including exposure to pollutants, ultraviolet (UV) radiation and ozone as well as the chronic use of preserved eyedrops such as in the treatment of glaucoma. These factors increase oxidative stress and ocular surface inflammation. Here, we reviewed the cellular, animal and clinical studies that point to the role of oxidative stress in dry eye disease...
August 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28830289/in-vitro-evaluation-of-%C3%AE-lipoic-acid-loaded-lipid-nanocapsules-for-topical-delivery
#7
Nan Xia, Tian Liu, Qiang Wang, Qiang Xia, Xiaoli Bian
This study aimed at in vitro evaluation of α-lipoic acid-loaded lipid nanocapsules for topical delivery, which was prepared by hot high-pressure homogenisation. Stable particles could be formed and particle size was 148.54 ± 2.31 nm with polydispersity index below 0.15. Encapsulation efficiency and drug loading of α-lipoic acid were 95.23 ± 0.45% and 2.81 ± 0.37%. Antioxidant study showed α-lipoic acid could be protected by lipid nanocapsules without loss of antioxidant activity. Sustained release of α-lipoic acid from lipid nanocapsules was obtained and cumulative release was 62...
September 3, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28826695/natural-health-products-and-diabetes-a-practical-review
#8
REVIEW
Candace Necyk, Leyanna Zubach-Cassano
The prevalence of natural health product (NHP) use in Canada is extensive. Patients with chronic diseases, including diabetes, use NHPs at a higher rate than the general population. Many NHPs exert hypoglycemic effects, among other effects relevant to diabetes management. To provide a practical, clinical review of NHPs with such effects targeted to pharmacists, a literature search was performed to collect data on the efficacy and safety profiles of 10 commonly used NHPs that exert antidiabetic properties. The following NHPs are included in this clinical review: alpha-lipoic acid, chromium, magnesium, bitter melon, cinnamon, fenugreek, gymnema, milk thistle, Reishi mushroom and white mulberry...
August 18, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28814089/antioxidant-therapy-impresses-in-oxidative-stress-induced-kidney-cells
#9
M Alpay, G Kismali, O Meral, T Sel, R Ozmerdivenli, O Pasin
INTRODUCTION:   Renal cell cancer (RCC) is not a single entity, but consists of different types of tumors derived from various parts of the nephron (epithelium or renal tubules). It is known that cancer initiation and progression is related to the balance between oxidants and antioxidants directly. Interestingly, advanced stages of cancer such as metastasis, angiogenesis are associated with cell oxidative capacity. Familiar antioxidative substances such as carotenes and vitamin C inhibit oxidation of other molecules during carcinogenesis...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28772267/alpha-lipoic-acid-alleviates-high-glucose-suppressed-osteogenic-differentiation-of-mc3t3-e1-cells-via-antioxidant-effect-and-pi3k-akt-signaling-pathway
#10
Kai Dong, Pengjie Hao, Sheng Xu, Shutai Liu, Wenjuan Zhou, Xilong Yue, Xiaohui Rausch-Fan, Zhonghao Liu
BACKGROUND/AIMS: Patients with diabetes mellitus have a higher risk of dental implant failure. One major cause is high-glucose induced oxidative stress. Alpha-lipoic acid (ALA), a naturally occurring compound and dietary supplement, has been established as a potent antioxidant that is a strong scavenger of free radicals. However, few studies have yet investigated the effect of ALA on osteogenic differentiation of osteoblasts cultured with high glucose medium. The aim of this study is to investigate the effects of ALA on the osteoblastic differentiation in MC3T3-E1 cells under high glucose condition...
August 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28722258/in-vitro-evaluation-of-chitosan-coated-liposome-containing-both-coenzyme-q10-and-alpha-lipoic-acid-cytotoxicity-antioxidant-activity-and-antimicrobial-activity
#11
Guodong Zhao, Caibiao Hu, Ying Xue
BACKGROUND: Chitosan-coated liposome containing both coenzyme Q10 and alpha-lipoic acid (CCAL) was a novel multifunctional nano delivery system exhibited long-term stability at room temperature and high encapsulation efficiency. Which containing two kinds of antioxidants (coenzyme Q10 and alpha-lipoic acid) and two antibacterial agents (chitosan and alpha-lipoic acid). However, the further biocompatibility, such as cytotoxicity and antioxidant activity, and antimicrobial activity of CCAL, has not been systematically evaluated...
July 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28677037/suppression-of-a-cancer-stem-like-phenotype-mediated-by-alpha-lipoic-acid-in-human-lung-cancer-cells-through-down-regulation-of-%C3%AE-catenin-and-oct-4
#12
Preeyaporn Plaimee Phiboonchaiyanan, Pithi Chanvorachote
PURPOSE: Cancer stem cells (CSCs) that possess the ability of self-renewal and multi-potency have been shown to drive tumor progression and metastasis. The majority of recent studies has focused on potential molecules targeting CSCs so as to develop novel strategies for efficient cancer treatment or protection. Here, we show how alpha-lipoic acid (LA), an endogenous mitochondrial anti-oxidant, affects the CSC-like phenotypes of human non-small cell lung cancer-derived H23, H292 and H460 cells...
July 4, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28676917/biochemical-and-clinical-relevance-of-alpha-lipoic-acid-antioxidant-and-anti-inflammatory-activity-molecular-pathways-and-therapeutic-potential
#13
REVIEW
Daniele Tibullo, Giovanni Li Volti, Cesarina Giallongo, Sonia Grasso, Daniele Tomassoni, Carmelina Daniela Anfuso, Gabriella Lupo, Francesco Amenta, Roberto Avola, Vincenzo Bramanti
BACKGROUND: The molecular nature of lipoic acid (LA) clarifies its capability of taking part to a variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is the antioxidant activity due to its ability to scavenge and inactivate free radicals. Furthermore, LA has been shown to chelate toxic metals both directly and indirectly by its capability to enhance intracellular glutathione (GSH) levels. This last property is due to its ability to interact with GSH and recycle endogenous GSH...
July 4, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28660607/the-effects-of-alpha-lipoic-acid-on-diabetic-myopathy
#14
D Jurisic-Erzen, G Starcevic-Klasan, D Ivanac, S Peharec, D Girotto, R Jerkovic
PURPOSE: Increased oxidative stress and impaired antioxidant defense are important mechanisms in the pathogenesis of diabetic myopathy. Since diabetes mellitus type 1 decreases muscle regeneration capacity the present study was designed to determine the influence of alpha-lipoic acid (ALA), a potent biological antioxidant, on the process of regeneration of diabetic rat skeletal muscles. METHODS: 40 Wistar rats were divided into three groups: control (n = 8), untreated diabetic group (n = 16) and ALA treated diabetic group (n = 16)...
June 28, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28659591/alpha-lipoic-acid-suppresses-p2x-receptor-activities-and-visceral-hypersensitivity-to-colorectal-distention-in-diabetic-rats
#15
Ji Hu, Xin Qin, Zhen-Yuan Song, Pan-Pan Yang, Yu Feng, Qian Sun, Guang-Yin Xu, Hong-Hong Zhang
The present study was designed to investigate the roles of P2X3 receptors in dorsal root ganglion (DRG) neurons in colonic hypersensitivity and the effects of alpha-lipoic acid (ALA) on P2X3 receptor activity and colonic hypersensitivity of diabetic rats. Streptozotocin (STZ) was used to induce diabetic model. Abdominal withdrawal reflex (AWR) responding to colorectal distention (CRD) was recorded as colonic sensitivity. ATP-induced current density of colon-specific DRG (T13-L2 DRGs) neurons was measured with whole-cell patch clamp...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629898/alpha-lipoic-acid-supplement-in-obesity-treatment-a-systematic-review-and-meta-analysis-of-clinical-trials
#16
REVIEW
Nazli Namazi, Bagher Larijani, Leila Azadbakht
BACKGROUND & AIMS: Previous studies have supported positive roles of antioxidant supplements on weight-loss. One antioxidant supplement is Alpha-lipoic acid. However, recommending ALA as an anti-obesity supplement remains controversial. Accordingly, the purpose of the present study was to perform a meta-analysis on the effects of ALA supplement on anthropometric indices among adult subjects. METHODS: We searched five electronic databases till September 2016. Placebo-controlled clinical trials were included...
June 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28611356/the-osteogenesis-promoting-effects-of-alpha-lipoic-acid-against-glucocorticoid-induced-osteoporosis-through-the-nox4-nf-kappab-jnk-and-pi3k-akt-pathways
#17
Shi-Yu Lu, Chang-Yuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhi-Hao Liu, Ke-Xin Liu, Hui-Jun Sun, Mo-Zhen Liu
Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally endogenous anti-oxidant, possesses anti-oxidative and anti-apoptosis activities, implicating LA as a therapeutic agent for the treatment of GIOP. In this study, the osteogenesis-promoting effects of LA against GIOP were investigated and the mechanisms were further probed. Here, the results showed that LA inhibited oxidative stress, suppressed apoptosis and improved osteopenia by promoting the expression of osteogenesis markers, including ALP, COL-I, OCN, BMP-2, RUNX2 and OSX...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606823/alpha-lipoic-acid-attenuates-acute-neuroinflammation-and-long-term-cognitive-impairment-after-polymicrobial-sepsis
#18
Amanda Della Giustina, Mariana Pereira Goldim, Lucinéia Gainski Danielski, Drielly Florentino, Khiany Mathias, Leandro Garbossa, Aloir Neri Oliveira Junior, Maria Eduarda Fileti, Graciela Freitas Zarbato, Naiana da Rosa, Ana Olívia Martins Laurentino, Jucélia Jeremias Fortunato, Francielle Mina, Tatiani Bellettini-Santos, Josiane Budni, Tatiana Barichello, Felipe Dal-Pizzol, Fabricia Petronilho
Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS). Evidence points towards inflammation and oxidative stress as major steps associated with brain dysfunction in sepsis. Thus, we investigated the α-lipoic acid (ALA) effect as an important antioxidant compound on brain dysfunction in rats. Wistar rats were subjected to sepsis by cecal ligation and perforation (CLP) or sham (control) and treated orally with ALA (200 mg/kg after CLP) or vehicle...
September 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28602729/alpha-lipoic-acid-impairs-body-weight-gain-of-young-broiler-chicks-via-modulating-peripheral-ampk
#19
Yufeng Wang, Nadia Everaert, Zhigang Song, Eddy Decuypere, Daniel Vermeulen, Johan Buyse
In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was aimed to explore the potential role of hepatic AMPK in the energy homeostasis of broiler chickens. Diets with 0, 0.05% or 0.1% alpha-lipoic acid (α-LA), a known AMPK inhibitor were provided to broiler chicks for 7days. As a result, α-LA supplementation decreased the relative growth rate of broiler chicks. Hepatic AMPKα2 mRNA levels were significantly upregulated by dietary α-LA, in concert with the increased phosphorylated AMPKα protein levels...
September 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28598563/alpha-lipoic-acid-prevents-doxorubicin-induced-nephrotoxicity-by-mitigation-of-oxidative-stress-inflammation-and-apoptosis-in-rats
#20
El-Sayed M El-Sayed, Ahmed M Mansour, Waleed S El-Sawy
This study aimed to evaluate the protective effects of alpha lipoic acid (ALA) against doxorubicin (DOX)-induced nephrotoxicity in rats. A single dose of DOX (7.5 mg/kg i.v.) induced nephrotoxicity evidenced by significant elevations in kidney weight, kidney/body weight ratio, serum urea, creatinine, tumor necrosis factor alpha, and renal contents of malondialdehyde, nitric oxide, cyclooxygenase-2, and caspase-3. Also, it causes significant reduction in final body weight, serum albumin, renal contents of reduced glutathione and superoxide dismutase activity...
June 9, 2017: Journal of Biochemical and Molecular Toxicology
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