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https://www.readbyqxmd.com/read/28742771/perioperative-amino-acid-infusion-for-preventing-hypothermia-and-improving-clinical-outcomes-during-surgery-under-general-anesthesia-a-systematic-review-and-meta-analysis
#1
Yoshitaka Aoki, Yukie Aoshima, Kazuyuki Atsumi, Ryo Kaminaka, Rintaro Nakau, Kyoko Yanagita, Makiko Kora, Shunsuke Fujii, Junichiro Yokoyama
Amino acid (AA) infusion is sometimes selected to avoid hypothermia during general anesthesia. However, the widespread clinical use of AA infusion therapy has not been established. This study aimed to clarify the evidence that AA infusion can increase patient body temperature and improve clinical outcomes using the Grading of Recommendations Assessment, Development, and Evaluation system. We searched MEDLINE (PubMed), Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (Japana Centra Revuo Medicina) in November 2015...
July 24, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28742756/cost-effectiveness-of-mindfulness-based-stress-reduction-vs-cognitive-behavioral-therapy-or-usual-care-among-adults-with-chronic-low-back-pain
#2
Patricia M Herman, Melissa L Anderson, Karen J Sherman, Benjamin H Balderson, Judith A Turner, Daniel C Cherkin
STUDY DESIGN: Economic evaluation alongside a randomized trial of cognitive-behavioral therapy (CBT) and mindfulness-based stress reduction (MBSR) versus usual care alone (UC) for chronic low-back pain (CLBP). OBJECTIVE: Determine the one-year cost-effectiveness of CBT and MBSR compared to UC. SUMMARY OF BACKGROUND DATA: CLBP is expensive in terms of healthcare costs and lost productivity. Mind-body interventions have been found effective for back pain, but their cost-effectiveness is unexplored...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742334/health-effects-of-dietary-oxidized-tyrosine-and-dityrosine-administration-in-mice-with-nutrimetabolomic-strategies
#3
Yuhui Yang, Hui Zhang, Biao Yan, Tianyu Zhang, Ying Gao, Yonghui Shi, Guowei Le
This study aims to investigate the health effects of long-term dietary oxidized tyrosine (O-Tyr) and its main product (dityrosine) administration on mice metabolism. Mice received daily intragastric administration of either O-Tyr (320 μg/kg body weight), dityrosine (Dityr, 320 μg/kg body weight) or saline for consecutive six weeks. Urine and plasma samples were analyzed by NMR-based metabolomics strategies. Body weight, clinical chemistry, oxidative damage indexes and histopathological data were obtained as complementary information...
July 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28742161/abundance-and-co-occurrence-of-extracellular-capsules-increases-environmental-breadth-implications-for-the-emergence-of-pathogens
#4
Olaya Rendueles, Marc Garcia-Garcerà, Bertrand Néron, Marie Touchon, Eduardo P C Rocha
Extracellular capsules constitute the outermost layer of many bacteria, are major virulence factors, and affect antimicrobial therapies. They have been used as epidemiological markers and recently became vaccination targets. Despite the efforts to biochemically serotype capsules in a few model pathogens, little is known of their taxonomic and environmental distribution. We developed, validated, and made available a computational tool, CapsuleFinder, to identify capsules in genomes. The analysis of over 2500 prokaryotic genomes, accessible in a database, revealed that ca...
July 24, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28742060/suppressed-kondo-effect-and-kosterlitz-thouless-type-phase-transition-induced-by-level-difference-in-a-triple-dot-device
#5
Yong-Chen Xiong, Hai-Ming Huang, Wen-Lei Zhao, Amel Laref
Quantum dot system provides an ideal platform for quantum information processing, within which to demonstrate the quantum states is one of the most important issue for quantum simulation and quantum computation. In this paper, we report a peculiar electron state in a parallel triple dot device where the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction is invalid when the level differences of the dots sweep into appropriate regime. This extraordinary tendency then results in an antiferromagnetic spin coupling between two of the dots and may lead to zero or full conductance, relying deeply on the relation of the two level spacings...
July 25, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28742041/admm-%C3%A2-projective-dynamics-fast-simulation-of-hyperelastic-models-with-dynamic-constraints
#6
Matthew Overby, George E Brown, Jie Li, Rahul Narain
We apply the alternating direction method of multipliers (ADMM) optimization algorithm to implicit time integration of elastic bodies, and show that the resulting method closely relates to the recently proposed projective dynamics algorithm. However, as ADMM is a general purpose optimization algorithm applicable to a broad range of objective functions, it permits the use of nonlinear constitutive models and hard constraints while retaining the speed, parallelizability, and robustness of projective dynamics...
July 24, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28741491/watson-for-genomics-moving-personalized-medicine-forward
#7
Kahn Rhrissorrakrai, Takahiko Koyama, Laxmi Parida
The confluence of genomic technologies and cognitive computing has brought us to the doorstep of widespread usage of personalized medicine. Cognitive systems, such as Watson for Genomics (WG), integrate massive amounts of new omic data with the current body of knowledge to assist physicians in analyzing and acting on patient's genomic profiles.
August 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28741464/expression-of-mastoparan-b-a-venom-peptide-via-escherichia-coli-c43-de3-coupled-with-an-artificial-oil-body-cyanogen-bromide-technology-platform
#8
Tzyy-Rong Jinn, Sheng-Kuo Hsieh, Yu-Jen Yu, Nou-Ying Tang, Jhao-Ren Lin
Here, we successfully use the oleosin-based fusion expression strategy coupled with the artificial oil body (AOB)-cyanogen bromide (CNBr) platform to produce bioactive MPB peptide which, in a manner identical to that of its native counterpart. In this study, the MPB peptide was interlinked with recombinant oleosin (rOle(127M→L)) by a methionine residue, a CNBr cleavage site. The recombinant rOle(127M→L)-MPB fusion gene was cloned into the pET30a(+) vector and was expressed in E. coli (DE3) after IPTG induction under optimized conditions...
July 24, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28741230/new-therapeutic-strategies-for-lewy-body-dementias
#9
REVIEW
Latha Velayudhan, Dominic Ffytche, Clive Ballard, Dag Aarsland
This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available symptom treatment strategies are based on monoaminergic, cholinergic and glutaminergic neurotransmitter systems. Relatively robust evidence exists for cholinesterase inhibitors for cognitive impairment in LBD and in Parkinson's disease for antidepressants, clozapine and recently pimavanserin for psychosis. interpidine (RVT 101) and nelotanserin are currently under investigation. Non-pharmacological interventions, such as cognitive stimulation, physical exercises and neuromodulation strategies, may be useful in Parkinson's disease but have not yet been tested in dementias...
September 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28741222/network-of-anatomical-texts-nanatex-an-open-source-project-for-visualizing-the-interaction-between-anatomical-terms
#10
Ryusuke Momota, Aiji Ohtsuka
Anatomy is the science and art of understanding the structure of the body and its components in relation to the functions of the whole-body system. Medicine is based on a deep understanding of anatomy, but quite a few introductory-level learners are overwhelmed by the sheer amount of anatomical terminology that must be understood, so they regard anatomy as a dull and dense subject. To help them learn anatomical terms in a more contextual way, we started a new open-source project, the Network of Anatomical Texts (NAnaTex), which visualizes relationships of body components by integrating text-based anatomical information using Cytoscape, a network visualization software platform...
July 24, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28741141/detonation-nanodiamonds-are-promising-nontoxic-delivery-system-for-urothelial-cells
#11
Daša Zupančič, Mateja Erdani Kreft, Maja Grdadolnik, Dimitar Mitev, Aleš Iglič, Peter Veranič
Detonation nanodiamonds (DNDs) are carbon-based nanomaterials that are among the most promising nanoparticles available for biomedical applications so far. This is due to their biocompatibility, which could be contributed to their inert core and conformable surface nature. However, DNDs cytotoxicity for urothelial cells and the routes of their internalization remains an open question in the aspect of nanodiamond surface. We therefore analyzed four types of DNDs for cytotoxicity and internalization with normal urothelial cells and two types of cancer urothelial cell lines in vitro...
July 24, 2017: Protoplasma
https://www.readbyqxmd.com/read/28741118/strategies-to-decrease-injection-site-pain-in-botulinum-toxin-therapy
#12
Lejla Paracka, Katja Kollewe, Florian Wegner, Dirk Dressler
Botulinum toxin is now used for numerous indications including dystonias, spasticity, cerebral palsy, hyperhidrosis, cosmetics and chronic migraine. It has to be injected into its target tissues thus causing injection site pain. We wanted to compare the efficacy of various analgesic interventions suggested for reduction of injection site pain. In 13 healthy controls, pain thresholds in the fingertips II and III bilaterally were determined by the Mechanical Pain Threshold Test and the Repetitive Pain Stimulation Test at baseline and under nitrous oxide/oxygen, ice spray, local anaesthetic cream and forearm ischaemia...
July 24, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28740961/isolated-thyroid-metastasis-from-renal-cell-carcinoma
#13
Ali Solmaz, Ali Muhammedoğlu, Serdar Altınay, Candaş Erçetin, Erkan Yavuz, Osman Bilgin Gülçiçek, Şenay Yalçın, Yeşim Erbil
Metastatic neoplasms of the thyroid are uncommon when compared to primary tumors of the gland. Renal cell carcinoma (RCC) is a highly aggressive tumor of the urinary system. It can spread all over the body. Isolated solitary metastases of RCC to the thyroid are very rarely observed. A 64-year-old woman with a history of left radical nephrectomy for RCC, was referred to our clinic with palpable thyroid nodule. Ultrasound confirmed the nodule on the left lobe. Histopathological examination of the thyroidectomy specimen revealed that there were two solitary metastasis of RCC...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740938/whole-body-vibration-exercise-is-well-tolerated-in-patients-with-duchenne-muscular-dystrophy-a-systematic-review
#14
Eloá Moreira-Marconi, Danubia C Sá-Caputo, Carla F Dionello, Eliane O Guedes-Aguiar, Cintia R Sousa-Gonçalves, Danielle S Morel, Laisa L Paineiras-Domingos, Patricia L Souza, Cristiane R Kütter, Rebeca G Costa-Cavalcanti, Glenda Costa, Patricia C Paiva, Claudia Figueiredo, Samuel Brandão-Sobrinho-Neto, Christina Stark, Marianne Unger, Mario Bernardo-Filho
BACKGROUND: Duchenne muscular dystrophy (DMD) is caused by a defective gene located on the X-chromosome, responsible for the production of the dystrophin protein. Complications in the musculoskeletal system have been previously described in DMD patients. Whole body vibration exercise (WBVE) is a treatment that improves musculoskeletal function in movement disorders. The aim of this study was to review the effects of WBVE on functional mobility, bone and muscle in DMD patients. MATERIALS AND METHODS: Four databases were searched...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28740928/magnetic-resonance-imaging-guided-reirradiation-of-recurrent-and-second-primary-head-and-neck-cancer
#15
Allen M Chen, Minsong Cao, Sophia Hsu, James Lamb, Argin Mikaeilian, Yingli Yang, Nzhde Agazaryan, Daniel A Low, Michael L Steinberg
PURPOSE: To report a single-institutional experience using magnetic resonance imaging (MRI) guided radiation therapy for the reirradiation of recurrent and second cancers of the head and neck. METHODS AND MATERIALS: Between October 2014 and August 2016, 13 consecutive patients with recurrent or new primary cancers of the head and neck that occurred in a previously irradiated field were prospectively enrolled in an institutional registry trial to investigate the feasibility and efficacy of MRI guided radiation therapy using a 0...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740862/giant-convecting-mud-balls-of-the-early-solar-system
#16
Philip A Bland, Bryan J Travis
Carbonaceous asteroids may have been the precursors to the terrestrial planets, yet despite their importance, numerous attempts to model their early solar system geological history have not converged on a solution. The assumption has been that hydrothermal alteration was occurring in rocky asteroids with material properties similar to meteorites. However, these bodies would have accreted as a high-porosity aggregate of igneous clasts (chondrules) and fine-grained primordial dust, with ice filling much of the pore space...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28740852/body-posture-postural-stability-and-metabolic-age-in-patients-with-parkinson-s-disease
#17
Jacek Wilczyński, Agnieszka Pedrycz, Dariusz Mucha, Tadeusz Ambroży, Dawid Mucha
BACKGROUND: The study aims to analyze the relationship between body posture and composition, as well as postural stability in Parkinson's disease patients. MATERIAL AND METHODS: 32 people were evaluated. The study was conducted in the Laboratory of Posturology at Jan Kochanowski University in Kielce (Poland). Body posture was examined using the optoelectronic body posture Formetric Diers Method III 4D. Postural stability was evaluated using the Biodex Balance System platform...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28740605/synthesis-of-a-fluorescently-labeled-68-ga-dota-toc-analog-for-somatostatin-receptor-targeting
#18
Sukhen C Ghosh, Servando Hernandez Vargas, Melissa Rodriguez, Susanne Kossatz, Julie Voss, Kendra S Carmon, Thomas Reiner, Agnes Schonbrunn, Ali Azhdarinia
Fluorescently labeled imaging agents can identify surgical margins in real-time to help achieve complete resections and minimize the likelihood of local recurrence. However, photon attenuation limits fluorescence-based imaging to superficial lesions or lesions that are a few millimeters beneath the tissue surface. Contrast agents that are dual-labeled with a radionuclide and fluorescent dye can overcome this limitation and combine quantitative, whole-body nuclear imaging with intraoperative fluorescence imaging...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28740572/effect-of-whole-body-cryotherapy-on-antioxidant-systems-in-experimental-rat-model
#19
Bronisława Skrzep-Poloczek, Ewa Romuk, Bernadeta Wiśnowiska, Aleksander J Owczarek, Piotr Choręza, Aleksander Sieroń, Ewa Birkner, Dominika Stygar
BACKGROUND: The purpose of this study was to verify the effect of whole-body cryotherapy (WBC) in rats on their antioxidant systems, lipid peroxidation products, and their total oxidative status at different exposure times and temperatures. METHODS: Antioxidants in serum, plasma, liver, and erythrocytes were evaluated in two study groups following 1 min of exposure to -60°C and -90°C, for 5 and 10 consecutive days. RESULTS: WBC increased the activity of superoxide dismutase, catalase in the group subjected to 5 and 10 days exposure, -60°C...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28740466/a-tyrosine-hydroxylase-characterization-of-dopaminergic-neurons-in-the-honey-bee-brain
#20
Stevanus R Tedjakumala, Jacques Rouquette, Marie-Laure Boizeau, Karen A Mesce, Lucie Hotier, Isabelle Massou, Martin Giurfa
Dopamine (DA) plays a fundamental role in insect behavior as it acts both as a general modulator of behavior and as a value system in associative learning where it mediates the reinforcing properties of unconditioned stimuli (US). Here we aimed at characterizing the dopaminergic neurons in the central nervous system of the honey bee, an insect that serves as an established model for the study of learning and memory. We used tyrosine hydroxylase (TH) immunoreactivity (ir) to ensure that the neurons detected synthesize DA endogenously...
2017: Frontiers in Systems Neuroscience
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