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https://www.readbyqxmd.com/read/28535598/antarctic-seals-molecular-biomarkers-as-indicators-for-pollutant-exposure-health-effects-and-diet
#1
K Lehnert, L Weirup, K C Harding, T Härkönen, O Karlsson, J Teilmann
Weddell (Leptonychotes weddellii), Ross (Ommatophoca rossii) and crabeater seals (Lobodon carcinophaga) are phocid seals with a circumpolar distribution around Antarctica. As long-lived and large top predators, they bioaccumulate contaminants and are considered as sentinels of ecosystem health. Antarctic seals are increasingly exposed to climate change, pollution, shipping and fisheries. To reveal and understand possible anthropogenic impacts on their immune and health status, this study investigates sensitive biomarkers of the xenobiotic metabolism and immune system in relation to mercury (Hg) burden...
May 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28535554/anesthetic-considerations-and-perioperative-management-of-spinal-cord-stimulators-literature-review-and-initial-recommendations
#2
Michael E Harned, Brandon Gish, Allison Zuelzer, Jay S Grider
BACKGROUND: Patients with implanted spinal cord stimulators (SCS) present to the anesthesia care team for management at many different points along the care continuum. Currently, the literature is sparse on the perioperative management. What is available is confusing; monopolar electrocautery is contraindicated but often used, full body magnetic resonance imaging (MRI) is safe with particular systems but with other manufactures only head and specific extremities exams are safe. Moreover, there are anesthetizing locations outside of the operating room where implanted SCS can interact with surrounding medical equipment and pose significant risk to patient and device...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535503/determining-an-upper-reference-value-for-the-urinary-fluoride-creatinine-ratio-in-healthy-children-younger-than-7-years
#3
F Vida Zohoori, A Maguire
The urinary fluoride/creatinine ratio (UF/Cr) in a spot urine sample could be a useful systemic F exposure monitoring tool. No reference value for UF/Cr currently exists, therefore this study aimed to establish an upper reference value for a UF/Cr, corresponding to excessive systemic F exposure, i.e., >0.07 mg F/kg body weight (b.w.)/day, in children. Subsidiary aims were to examine the relationship between (i) total daily F intake (TDFI) and 24-h urinary F excretion (DUFE); (ii) DUFE and UF/Cr, and (iii) TDFI and UF/Cr...
May 24, 2017: Caries Research
https://www.readbyqxmd.com/read/28535341/fully-stretchable-optoelectronic-sensors-based-on-colloidal-quantum-dots-for-sensing-photoplethysmographic-signals
#4
Tae-Ho Kim, Chang-Seok Lee, Sangwon Kim, Jaehyun Hur, Sangmin Lee, Keun Wook Shin, Young-Zoon Yoon, Moon Kee Choi, Jiwoong Yang, Dae-Hyeong Kim, Taeghwan Hyeon, Seongjun Park, Sungwoo Hwang
Flexible and stretchable optoelectronic devices can be potentially applied in displays, biosensors, biomedicine, robotics, and energy generation. The use of nanomaterials with superior optical properties such as quantum dots (QDs) is important in the realization of wearable displays and biomedical devices, but specific structural design as well as selection of materials should preferentially accompany this technology to realize stretchable forms of these devices. Here, we report stretchable optoelectronic sensors manufactured using colloidal QDs and integrated with elastomeric substrates, whose optoelectronic properties are stable under various deformations...
May 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28535311/quantification-of-estradiol-uptake-in-zebrafish-embryos-and-larvae
#5
J Paige Souder, Daniel A Gorelick
Zebrafish are a powerful model system to assess the molecular and cellular effects of exposure to toxic chemicals during embryonic development. To study the effects of environmental endocrine disruptors, embryos and larvae are commonly exposed to supraphysiologic concentrations of these compounds in the water, but their bioavailability in zebrafish is largely unknown. One hypothesis is that supraphysiologic concentrations of estrogens in the water are required to achieve physiologic levels in vivo, however this has not been directly tested...
May 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28534900/interplay-between-many-body-effects-and-coulomb-screening-in-the-optical-bandgap-of-atomically-thin-mos2
#6
Youngsin Park, Sang Wook Han, Christopher C S Chan, Benjamin P L Reid, Robert A Taylor, Nammee Kim, Yongcheol Jo, Hyunsik Im, Kwang S Kim
Due to its unique layer-number dependent electronic band structure and strong excitonic features, atomically thin MoS2 is an ideal 2D system where intriguing photoexcited-carrier-induced phenomena can be detected in excitonic luminescence. We perform micro-photoluminescence (PL) measurements and observe that the PL peak redshifts nonlinearly in mono- and bi-layer MoS2 as the excitation power is increased. The excited carrier-induced optical bandgap shrinkage is found to be proportional to n(4/3), where n is the optically-induced free carrier density...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28534861/advising-consumption-of-green-vegetables-beef-and-full-fat-dairy-products-has-no-adverse-effects-on-the-lipid-profiles-in-children
#7
Ellen José van der Gaag, Romy Wieffer, Judith van der Kraats
In children, little is known about lipid profiles and the influence of dietary habits. In the past, we developed a dietary advice for optimizing the immune system, which comprised green vegetables, beef, whole milk, and full-fat butter. However, there are concerns about a possible negative influence of the full-fat dairy products of the diet on the lipid profile. We investigated the effect of the developed dietary advice on the lipid profile and BMI (body mass index)/BMI-z-score of children. In this retrospective cohort study, we included children aged 1-16 years, of whom a lipid profile was determined in the period between June 2011 and November 2013 in our hospital...
May 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28534433/skating-start-propulsion-three-dimensional-kinematic-analysis-of-elite-male-and-female-ice-hockey-players
#8
Jaymee R Shell, Shawn M K Robbins, Philippe C Dixon, Philippe J Renaud, René A Turcotte, Tom Wu, David J Pearsall
The forward skating start is a fundamental skill for male and female ice hockey players. However, performance differences by athlete's sex cannot be fully explained by physiological variables; hence, other factors such as skating technique warrant examination. Therefore, the purpose of this study was to evaluate the body movement kinematics of ice hockey skating starts between elite male and female ice hockey participants. Male (n = 9) and female (n = 10) elite ice hockey players performed five forward skating start accelerations...
May 23, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28534330/-preliminary-results-of-submucosal-tunneling-endoscopic-septum-division-in-the-treatment-of-esophageal-diverticulum
#9
Mingyan Cai, Meidong Xu, Quanlin Li, Weifeng Chen, Yan Zhu, Danfeng Zhang, Liqing Yao, Pinghong Zhou
OBJECTIVE: To evaluate the safety and efficacy of submucosal tunneling endoscopic septum division (STESD) for escophageal diverticulum. METHODS: Clinical data of six consecutive patients with symptomatic esophageal diverticula who received STESD in Endoscopy Center of Zhongshan Hospital, Fudan University from April 2016 to November 2016 were analyzed retrospectively. STESD was performed as following: mucosal entry was made 3 cm from the septum of esophageal diverticulum; submucosal tunnel was created towards the septum; after the satisfactory exposure of the septum, endoscopic division was made down to the bottom of the diverticulum; mucosal closure of the tunnel entry was made...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28534298/formulation-and-in-vitro-characterization-of-bioactive-mesoporous-silica-with-doxorubicin-and-metronidazole-intended-for-bone-treatment-and-regeneration
#10
Katarzyna Czarnobaj, Magdalena Prokopowicz, Wiesław Sawicki
The purpose of this study was to evaluate the surface mineralization activity and in vitro drug behavior potential of two forms of mesoporous silica: powder and granulate. Ordered mesoporous SiO2 powder was synthesized by surfactant-assisted sol-gel process using tetraethoxysilane as a silica precursor and hexadecyltrimethylammonium bromide as the structure-directing agent. The granulate was prepared using silica powder and ethyl cellulose as a binding agent. Metronidazole (MT)-an anti-inflammatory substance and doxorubicin hydrochloride (ChD)-an anti-cancer drug were chosen as drug models for delivery studies...
May 22, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28534168/father-s-obesity-programs-the-adipose-tissue-in-the-offspring-via-the-local-renin-angiotensin-system-and-mapks-pathways-especially-in-adult-male-mice
#11
Fernanda Ornellas, Isabele Bringhenti, Brenda Akemi N F Mattos, Carlos Alberto Mandarim-de-Lacerda, Marcia Barbosa Aguila
PURPOSE: Studies demonstrated the influence of mother's obesity on offspring. However, the father is also related to programming the future generation. The study aimed to evaluate the effects of father's obesity upon white adipose tissue (WAT) remodeling, resulting in activation of signaling pathways and inflammation in male and female offspring. METHODS: Male C57BL/6 mice received control diet (lean father group; 17% energy from lipids) or high-fat diet (obese father group; 49% energy from lipids) for 8 weeks before mating...
May 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28534027/current-concepts-and-unresolved-questions-in-dietary-protein-requirements-and-supplements-in-adults
#12
REVIEW
Stuart M Phillips
Protein needs for otherwise healthy individuals older than 19 years are defined by the recommended dietary allowance (RDA) at 0.80 g protein/kg/day. There is no recommendation in the current RDA for subpopulations of older adults or people in various pathological situations. Despite the lack of a separate recommendation, there exists a growing body of evidence that is strongly suggestive of an increased need and/or benefit for protein in older persons. That is, intakes beyond the RDA are, in older persons, associated with benefits...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28533933/negative-wound-pressure-therapy-is-safe-and-useful-in-pediatric-burn-patients
#13
Yanhan Ren, Philip Chang, Robert L Sheridan
INTRODUCTION: Negative Pressure Wound Therapy (NPWT) has proven to be a powerful tool in facilitating healing of difficult wounds of a variety of etiologies. The pediatric experience with NPWT has been limited due to concerns about vascular compression and pain associated with treatment. METHOD: A retrospective review was performed to evaluate the therapeutic effect of NPWT on children with difficult wounds due to burns or soft-tissue trauma. NPWT was instituted in the operating room under general anesthesia using a commercially available system...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28533902/the-influence-of-in-ovo-injection-with-the-prebiotic-dinovo%C3%A2-on-the-development-of-histomorphological-parameters-of-the-duodenum-body-mass-and-productivity-in-large-scale-poultry-production-conditions
#14
Adrianna Sobolewska, Gabriela Elminowska-Wenda, Joanna Bogucka, Agata Dankowiakowska, Anna Kułakowska, Agata Szczerba, Katarzyna Stadnicka, Michał Szpinda, Marek Bednarczyk
BACKGROUND: Among various feed additives currently used in poultry nutrition, an important role is played by bioactive substances, including prebiotics. The beneficial effect of these bioactive substances on the gastrointestinal tract and immune system give rise to improvements in broiler health and performance nutrition, thus increasing the productivity of these birds. An innovative method for introducing bioactive substances into chickens is the in ovo injection into eggs intended for hatching...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28533782/towards-an-integrative-understanding-of-diet-host-gut-microbiome-interactions
#15
Mark N Read, Andrew J Holmes
Over the last 20 years, a sizeable body of research has linked the microbiome and host diet to a remarkable diversity of diseases. Yet, unifying principles of microbiome assembly or function, at levels required to rationally manipulate a specific individual's microbiome to their benefit, have not emerged. A key driver of both community composition and activity is the host diet, but diet-microbiome interactions cannot be characterized without consideration of host-diet interactions such as appetite and digestion...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28533778/dnase1l3-regulates-inflammasome-dependent-cytokine-secretion
#16
Guilan Shi, Kennady N Abbott, Wenbo Wu, Russell D Salter, Peter A Keyel
Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating apoptotic bodies is not cleared, leading to anti-DNA antibody production. Compared to early anti-DNA and anti-chromatin responses, other autoantibody responses and general immune activation in Dnase1L3(-/-) mice are greatly delayed. We investigated the possibility that immune activation, specifically inflammasome activation, is regulated by Dnase1L3. Here, we report that Dnase1L3 inhibition blocked both NLR family, pyrin domain containing 3 (NLRP3) and NLRC4 inflammasome-mediated release of high-mobility group box 1 protein and IL-1β...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28533757/multiscale-modeling-of-bone-healing-toward-a-systems-biology-approach
#17
REVIEW
Edoardo Borgiani, Georg N Duda, Sara Checa
Bone is a living part of the body that can, in most situations, heal itself after fracture. However, in some situations, healing may fail. Compromised conditions, such as large bone defects, aging, immuno-deficiency, or genetic disorders, might lead to delayed or non-unions. Treatment strategies for those conditions remain a clinical challenge, emphasizing the need to better understand the mechanisms behind endogenous bone regeneration. Bone healing is a complex process that involves the coordination of multiple events at different length and time scales...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28533692/changes-in-muscle-strength-after-diet-induced-weight-reduction-in-adult-men-with-obesity-a-prospective-study
#18
Bokun Kim, Takehiko Tsujimoto, Rina So, Xiaoguang Zhao, Sechang Oh, Kiyoji Tanaka
BACKGROUND AND OBJECTIVE: The benefits of weight reduction for musculoskeletal disorders are well understood. Steep declines in muscle mass following considerable weight reduction can decrease muscle strength and, consequently, physical performance. However, only a limited number of studies have examined the changes in muscle mass and strength in the context of interventional weight reduction programs. Thus, we investigated the influence of muscle mass decrease caused by diet-induced weight reduction on muscle strength in obese men...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28533660/genes-emotions-and-gut-microbiota-the-next-frontier-for-the-gastroenterologist
#19
REVIEW
Arturo Panduro, Ingrid Rivera-Iñiguez, Maricruz Sepulveda-Villegas, Sonia Roman
Most medical specialties including the field of gastroenterology are mainly aimed at treating diseases rather than preventing them. Genomic medicine studies the health/disease process based on the interaction of the human genes with the environment. The gastrointestinal (GI) system is an ideal model to analyze the interaction between our genes, emotions and the gut microbiota. Based on the current knowledge, this mini-review aims to provide an integrated synopsis of this interaction to achieve a better understanding of the GI disorders related to bad eating habits and stress-related disease...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28533402/behavioral-and-neural-correlates-to-multisensory-detection-of-sick-humans
#20
Christina Regenbogen, John Axelsson, Julie Lasselin, Danja K Porada, Tina Sundelin, Moa G Peter, Mats Lekander, Johan N Lundström, Mats J Olsson
Throughout human evolution, infectious diseases have been a primary cause of death. Detection of subtle cues indicating sickness and avoidance of sick conspecifics would therefore be an adaptive way of coping with an environment fraught with pathogens. This study determines how humans perceive and integrate early cues of sickness in conspecifics sampled just hours after the induction of immune system activation, and the underlying neural mechanisms for this detection. In a double-blind placebo-controlled crossover design, the immune system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharide (LPS)]...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
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