Hao-Xiang Yuan, Ya-Ting Chen, Yu-Quan Li, Yan-Sheng Wang, Zhi-Jun Ou, Yan Li, Jian-Jun Gao, Meng-Jie Deng, Yuan-Kai Song, Li Fu, Hong-Bo Ci, Feng-Jun Chang, Yang Cao, Yu-Peng Jian, Bi-Ang Kang, Zhi-Wei Mo, Da-Sheng Ning, Yue-Ming Peng, Ze-Long Liu, Xiao-Jun Liu, Ying-Qi Xu, Jun Xu, Jing-Song Ou
Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), in patients after cardiac surgery. We previously found that post-operative patients showed an increase in endothelial cell-derived extracellular vesicles (eEVs) with components of coagulation and acute inflammatory responses. However, the mechanism underlying the onset of ALI owing to the release of eEVs after cardiopulmonary bypass, remains unclear...
May 17, 2023: Science China. Life Sciences