keyword
https://read.qxmd.com/read/37862212/the-mir-9-5p-cxcl11-pathway-is-a-key-target-of-hydrogen-sulfide-mediated-inhibition-of-neuroinflammation-in-hypoxic-ischemic-brain-injury
#21
JOURNAL ARTICLE
Yijing Zhao, Tong Li, Zige Jiang, Chengcheng Gai, Shuwen Yu, Danqing Xin, Tingting Li, Dexiang Liu, Zhen Wang
We previously showed that hydrogen sulfide (H2 S) has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice. However, the precise mechanism underlying the role of H2 S in this situation remains unclear. In this study, we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine, a H2 S precursor, attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionine β synthase (a major H2 S synthetase in the brain) in the prefrontal cortex...
May 2024: Neural Regeneration Research
https://read.qxmd.com/read/37832398/cancer-associated-fibroblasts-impair-the-cytotoxic-function-of-nk-cells-in-gastric-cancer-by-inducing-ferroptosis-via-iron-regulation
#22
JOURNAL ARTICLE
Lizhong Yao, Junyi Hou, Xiongyan Wu, Yifan Lu, Zhijian Jin, Zhenjia Yu, Beiqin Yu, Jianfang Li, Zhongyin Yang, Chen Li, Min Yan, Zhenggang Zhu, Bingya Liu, Chao Yan, Liping Su
As the predominant immunosuppressive component within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) inhibit Natural Killer cell (NK cell) activity to promote tumor progression and immune escape; however, the mechanisms of cross-talk between CAFs and NK cells in gastric cancer (GC) remain poorly understood. In this study, we demonstrate that NK cell levels are inversely correlated with CAFs abundance in human GC. CAFs impair the anti-tumor capacity of NK cells by inducing ferroptosis, a cell death process characterized by the accumulation of iron-dependent lipid peroxides...
October 6, 2023: Redox Biology
https://read.qxmd.com/read/37770480/metabolic-crosstalk-between-skeletal-muscle-cells-and-liver-through-irf4-fstl1-in-nonalcoholic-steatohepatitis
#23
JOURNAL ARTICLE
Shanshan Guo, Yonghao Feng, Xiaopeng Zhu, Xinyi Zhang, Hui Wang, Ruwen Wang, Qiongyue Zhang, Yiming Li, Yan Ren, Xin Gao, Hua Bian, Tiemin Liu, Huanqing Gao, Xingxing Kong
Inter-organ crosstalk has gained increasing attention in recent times; however, the underlying mechanisms remain unclear. In this study, we elucidate an endocrine pathway that is regulated by skeletal muscle interferon regulatory factor (IRF) 4, which manipulates liver pathology. Skeletal muscle specific IRF4 knockout (F4MKO) mice exhibited ameliorated hepatic steatosis, inflammation, and fibrosis, without changes in body weight, when put on a nonalcoholic steatohepatitis (NASH) diet. Proteomics analysis results suggested that follistatin-like protein 1 (FSTL1) may constitute a link between muscles and the liver...
September 28, 2023: Nature Communications
https://read.qxmd.com/read/37759715/pro-inflammatory-biomarkers-combined-with-body-composition-display-a-strong-association-with-knee-osteoarthritis-in-a-community-based-study
#24
JOURNAL ARTICLE
Nader Tarabeih, Alexander Kalinkovich, Adel Shalata, Orabi Higla, Gregory Livshits
Knee osteoarthritis (KOA) is one of the most common progressive, age-dependent chronic degenerative joint diseases. KOA often develops as a result of a gradual articular cartilage loss caused by its wear and tear. Numerous studies suggest that the degradation of the knee joint involves inflammatory components. This process is also associated with body composition, particularly being overweight and muscle mass loss. The present study aimed to search for novel circulating KOA inflammatory biomarkers, taking into account body composition characteristics...
August 28, 2023: Biomolecules
https://read.qxmd.com/read/37694287/skeletal-muscle-derived-fstl1-starting-up-angiogenesis-by-regulating-endothelial-junction-via-activating-src-pathway-can-be-upregulated-by-hydrogen-sulfide
#25
JOURNAL ARTICLE
Meng-Yao Li, Ru-Pan Gao, Qi Zhu, Ying Chen, Bei-Bei Tao, Yi-Chun Zhu
Hydrogen sulfide (H2 S) promotes microangiogenesis and revascularization after ischemia. Neovascularization starts with the destruction of intercellular junctions and is accompanied by various endothelial cell angiogenic behaviors. Follistatin-like 1 (FSTL1) is a cardiovascular-protective myokine that works against ischemic injury. The present study examined whether FSTL1 was involved in H2 S-induced angiogenesis and explored the underlying molecular mechanism. We observed that H2 S accelerated blood perfusion after ischemia in the mouse hindlimb ischemia model...
September 11, 2023: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/37676577/binge-drinking-leads-to-an-oxidative-and-metabolic-imbalance-in-skeletal-muscle-during-adolescence-in-rats-endocrine-repercussion
#26
JOURNAL ARTICLE
Inés Romero-Herrera, Fátima Nogales, Javier Diaz-Castro, Jorge Moreno-Fernandez, María Del Carmen Gallego-Lopez, Julio J Ochoa, Olimpia Carreras, María Luisa Ojeda
Binge drinking (BD) is an especially pro-oxidant model of alcohol consumption, mainly used by adolescents. It has recently been related to the hepatic IR-process. Skeletal muscle is known to be involved in insulin action and modulation through myokine secretion. However, there is no information on muscle metabolism and myokine secretion after BD exposure in adolescents. Two experimental groups of adolescent rats have been used: control and BD-exposed one. Oxidative balance, energy status and lipid, and protein metabolism have been analyzed in muscle, together with myokine serum levels (IL-6, myostatin, LIF, IL-5, fractalkine, FGF21, irisin, BDNF, FSTL1, apelin, FABP3, osteocrin, osteonectin (SPARC), and oncostatin)...
September 7, 2023: Journal of Physiology and Biochemistry
https://read.qxmd.com/read/37666127/gonadal-transcriptome-analysis-of-paradise-fish-macropodus-opercularis-to-reveal-sex-related-genes
#27
JOURNAL ARTICLE
Fan Liu, Xueling Zhang, Xiaokai Wei, Yu Li, Wei Liu, Guochen Gan, Lingling Xiao, Xinyue Wang, Hui Luo
Macropodus opercularis is an ornamental fish species endemic to China, with obvious sexual dimorphism in phenotype. To obtain the gene expression profile of the gonads of M. opercularis and explore its sex-related genes, six cDNA libraries were constructed from the sexually mature M. opercularis, and RNA-seq analysis was performed. The sequenced clean data were assembled by de novo splicing to generate 171,415 unigenes, and differentially expressed genes (DEGs) screening revealed that there were 41,638 DEGs in the gonads of M...
August 18, 2023: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://read.qxmd.com/read/37655275/h3k27-acetylation-induced-fstl1-upregulation-by-p300-runx1-co-activation-exacerbated-autophagy-mediated-neuronal-damage-and-nf-%C3%AE%C2%BAb-stimulated-inflammation-in-alzheimer-s-disease
#28
JOURNAL ARTICLE
Dongmei Dai, Junzheng Xie, Yun Zheng, Fangbin Chen, Bin Zhao, Li Miao
Follistatin-like protein 1 (FSTL1) has been demonstrated to participate in the pathogenesis of several neurological diseases. The current study informed the role of H3K27 acetylation-induced FSTL1 upregulation in Alzheimer's disease (AD). Our investigation discovered the upregulated FSTL1 expression and enhanced autophagy activity in AD. FSTL1 knockdown successfully attenuated the injuries of Aβ1-42 -challenged SH-SY5Y cells through the inhibition of autophagy activity. Besides, FSTL1 deficiency suppresses the inflammatory response and NF-κB signaling in AD...
October 2023: Cytotechnology
https://read.qxmd.com/read/37584664/mir-125a-3p-regulates-the-expression-of-fstl1-a-pro-inflammatory-factor-during-adipogenic-differentiation-and-inhibits-adipogenesis-in-mice
#29
JOURNAL ARTICLE
Haifeng Liu, Jie Wen, Xue Tian, Tong Li, Ju Zhao, Jingjing Cheng, Lishi Huang, Ye Zhao, Quanquan Cao, Jun Jiang
Adipogenesis is tightly regulated by various factors, including genes and microRNAs. Excessive fat deposition is the key feature of obesity, which is a low-grade chronic inflammatory disease. Follistatin-like 1 (FSTL1) has been reported to be an important mediator involved in various inflammatory diseases. However, the underlying mechanism of FSTL1 in preadipocyte differentiation and inflammatory response is still unclear. The current study was designed to explore the biological function and potential mechanism of FSTL1 in mouse subcutaneous preadipocyte differentiation...
September 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/37503083/cell-networks-in-the-mouse-liver-during-partial-hepatectomy
#30
Bin Li, Daniel Rodrigo-Torres, Carl Pelz, Brendan Innes, Pamela Canaday, Sunghee Chai, Peter Zandstra, Gary D Bader, Markus Grompe
UNLABELLED: In solid tissues homeostasis and regeneration after injury involve a complex interplay between many different cell types. The mammalian liver harbors numerous epithelial and non-epithelial cells and little is known about the global signaling networks that govern their interactions. To better understand the hepatic cell network, we isolated and purified 10 different cell populations from normal and regenerative mouse livers. Their transcriptomes were analyzed by bulk RNA-seq and a computational platform was used to analyze the cell-cell and ligand-receptor interactions among the 10 populations...
July 18, 2023: bioRxiv
https://read.qxmd.com/read/37440271/cardiac-rgs7-and-rgs11-drive-tgf%C3%AE-1-dependent-liver-damage-following-chemotherapy-exposure
#31
JOURNAL ARTICLE
Kiran Das, Madhuri Basak, Tarun Mahata, Sayan Biswas, Sukhes Mukherjee, Pranesh Kumar, Mahammed Moniruzzaman, Adele Stewart, Biswanath Maity
Off target damage to vital organ systems is an unfortunate side effect of cancer chemotherapy and remains a major limitation to the use of these essential drugs in the clinic. Despite decades of research, the mechanisms conferring susceptibility to chemotherapy driven cardiotoxicity and hepatotoxicity remain unclear. In the livers of patients with a history of chemotherapy, we observed a twofold increase in expression of G protein regulator RGS7 and a corresponding decrease in fellow R7 family member RGS11...
August 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/37411041/transcriptomic-and-proteomic-changes-driving-pulmonary-fibrosis-resolution-in-young-and-old-mice
#32
JOURNAL ARTICLE
Jelena Weckerle, Christoph H Mayr, Katrin Fundel-Clemens, Bärbel Lämmle, Lukasz Boryn, Matthew J Thomas, Tom Bretschneider, Andreas H Luippold, Heinrich J Huber, Coralie Viollet, Wolfgang Rist, Daniel Veyel, Fidel Ramirez, Stephan Klee, Marc Kästle
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of aging. Old mice incomplete, yet only delayed lung function recovery 8 weeks after Bleomycin instillation. This shift in structural and functional repair in old Bleomycin-treated mice was reflected in a temporal shift in gene and protein expression...
July 6, 2023: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/37406975/single-cell-transcriptome-analysis-reveals-cellular-heterogeneity-and-highlights-fstl1-regulated-alveolar-myofibroblasts-in-mouse-lung-at-birth
#33
JOURNAL ARTICLE
Si Zhang, Xiuxue Mo, Yueyue Jin, Zhuan Niu, Maolin Yao, Yue Zhang, Lian Li, Gang Hu, Wen Ning
The matricellular protein, follistatin-like 1 (FSTL1), regulates lung development and saccular formation. Here, we employed single-cell RNA sequencing (scRNA-seq) to construct a transcriptomic atlas of 22,774 individual cells from wild-type (WT) and Fstl1-/- lung (E18.5) samples and identified 27 cell subtypes. We observed abnormal population sizes and gene expression profiles in diverse cell subtypes in Fstl1-/- lung samples. We identified Pdgfra and Tgfbi as genetic markers specifically expressed in postnatal myofibroblasts (MyoFBs)...
July 3, 2023: Genomics
https://read.qxmd.com/read/37369969/fstl1-promotes-alveolar-epithelial-cell-aging-and-worsens-pulmonary-fibrosis-by-affecting-senp1-mediated-desumoylation
#34
JOURNAL ARTICLE
Wei Sun, Xiaoyu Yang, Lijuan Chen, Lu Guo, Hui Huang, Xiaoshu Liu, Yang Yang, Zuojun Xu
Alveolar epithelial cell (AEC) senescence-induced changes of lung mesenchymal cells are key to starting the progress of pulmonary fibrosis. Follistatin-like 1 (FSTL1) plays a central regulatory role in the complex process of senescence and pulmonary fibrosis by enhancing transforming growth factor-β1 (TGF-β1) signal pathway activity. Activation of Smad4 and Ras relies on SUMO-specific peptidase 1 (SENP1)-mediated deSUMOylation during TGF-β signaling pathway activation. We hypothesized that SENP1-mediated deSUMOylation may be a potential therapeutic target by modulating FSTL1-regulated cellular senescence in pulmonary fibrosis...
June 27, 2023: Cell Biology International
https://read.qxmd.com/read/37339276/higher-baseline-serum-myokine-of-fstl1-may-serve-as-a-potential-predictive-biomarker-for-successful-brace-treatment-in-girls-with-adolescent-idiopathic-scoliosis
#35
JOURNAL ARTICLE
Zhenhua Feng, Zhichong Wu, Yanyu Ma, Quanchi Chen, Zhen Liu, Yong Qiu, Zezhang Zhu
STUDY DESIGN: A retrospective case-control study. OBJECTIVE: This study aimed to investigate whether myokine, which is related to exercise and muscle mass, could serve as a biomarker for predicting bracing outcomes. SUMMARY OF BACKGROUND DATA: Several risk factors have been documented to be associated with bracing failure in patients with Adolescent Idiopathic Scoliosis (AIS). However, serum biomarkers have not been extensively explored. METHODS: Skeletally immature females with AIS, without previous histories of bracing or surgery, were included...
June 20, 2023: Spine
https://read.qxmd.com/read/37301628/alaska-backcountry-expeditionary-hunting-promotes-sustained-muscle-protein-synthesis
#36
JOURNAL ARTICLE
Robert H Coker, Brent C Ruby, Melynda S Coker, Larry Bartlett, Brandon Kowalski, Anna V Goropashnaya, Terry Bateman, Mahalakshmi Shankaran, Marc Hellerstein, William J Evans
INTRODUCTION: We have previously described negative energy balance (ie, -9.7±3.4 MJ/d) and weight loss (Δ-1.5 ± 0.7 kg) influenced by high levels of energy expenditure (ie, 17.4±2.6 MJ/d) during remote expeditionary hunting in Alaska. Despite negative energy balance, participants retained skeletal muscle. The purpose of this pilot study was to measure skeletal muscle protein synthesis and examine molecular markers of skeletal muscle protein metabolism under similar conditions of physical and nutrient stress...
June 8, 2023: Wilderness & Environmental Medicine
https://read.qxmd.com/read/37282819/from-phenomenon-to-essence-a-newly-involved-lncrna-kcnq1ot1-protective-mechanism-of-bone-marrow-mesenchymal-stromal-cells-in-liver-cirrhosis
#37
JOURNAL ARTICLE
Hanjing Zhangdi, Yanan Jiang, Yang Gao, Shuang Li, Ruiling Xu, Jing Shao, Jingyang Liu, Ying Hu, Xu Zhang, Xiaoyu Zhang, Lei Zhao, Jihan Qi, Xinyu Geng, Shizhu Jin
Bone marrow mesenchymal stromal cells (BMSCs) have a protective effect against liver cirrhosis. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of liver cirrhosis. Therefore, it is aimed to clarify the lncRNA Kcnq1ot1 involved protective mechanism of BMSCs in liver cirrhosis. This study found that BMSCs treatment attenuates CCl4 -induced liver cirrhosis in mice. Additionally, the expression of lncRNA Kcnq1ot1 is upregulated in human and mouse liver cirrhosis tissues, in addition to TGF-β1-treated LX2 cells and JS1 cells...
June 6, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37238210/fstl1-suppresses-triple-negative-breast-cancer-lung-metastasis-by-inhibiting-m2-like-tumor-associated-macrophage-recruitment-toward-the-lungs
#38
JOURNAL ARTICLE
Ying Yang, Tao Lu, Xiaowei Jia, Yan Gao
Immune cell infiltration into the tumor microenvironment is associated with cancer prognosis. Tumor-associated macrophages play essential roles in tumor initiation, progression, and metastasis. Follistatin-like protein 1 (FSTL1), a widely expressed glycoprotein in human and mouse tissues, is a tumor suppressor in various cancers and a regulator of macrophage polarization. However, the mechanism by which FSTL1 affects crosstalk between breast cancer cells and macrophages remains unclear. By analyzing public data, we found that FSTL1 expression was significantly low in breast cancer tissues compared to normal breast tissues, and high expression of FSTL1 in patients indicated prolonged survival...
May 12, 2023: Diagnostics
https://read.qxmd.com/read/37219765/endothelial-extracellular-vesicles-induce-acute-lung-injury-via-follistatin-like-protein-1
#39
JOURNAL ARTICLE
Hao-Xiang Yuan, Ya-Ting Chen, Yu-Quan Li, Yan-Sheng Wang, Zhi-Jun Ou, Yan Li, Jian-Jun Gao, Meng-Jie Deng, Yuan-Kai Song, Li Fu, Hong-Bo Ci, Feng-Jun Chang, Yang Cao, Yu-Peng Jian, Bi-Ang Kang, Zhi-Wei Mo, Da-Sheng Ning, Yue-Ming Peng, Ze-Long Liu, Xiao-Jun Liu, Ying-Qi Xu, Jun Xu, Jing-Song Ou
Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), in patients after cardiac surgery. We previously found that post-operative patients showed an increase in endothelial cell-derived extracellular vesicles (eEVs) with components of coagulation and acute inflammatory responses. However, the mechanism underlying the onset of ALI owing to the release of eEVs after cardiopulmonary bypass, remains unclear...
May 17, 2023: Science China. Life Sciences
https://read.qxmd.com/read/37138144/lncrna-hcg18-promotes-inflammation-and-apoptosis-in-intervertebral-disc-degeneration-via-the-mir-495-3p-fstl1-axis
#40
JOURNAL ARTICLE
Yi Luo, Youzhi He, Yongfu Wang, Yuxia Xu, Li Yang
Intervertebral disc degeneration (IDD) causes pain in the back and neck. This study investigated the role of long non-coding RNA HLA complex group 18 (HCG18) in a cell model of IDD. An IDD model was established by stimulating nucleus pulposus (NP) cells with interleukin (IL)-1β. MTT assay was performed to evaluate NP cell viability. The apoptosis was detected by flow cytometry. The expressions of HCG18, microRNA (miR)-495-3p, and follistatin-like protein-1 (FSTL1) were measured by RT-qPCR. The interactions of miR-495-3p with HCG18 and FSTL1 were analyzed by luciferase reporter assay...
May 3, 2023: Molecular and Cellular Biochemistry
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