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https://www.readbyqxmd.com/read/29357946/follistatin-like-protein-1-plays-a-tumor-suppressor-role-in-clear-cell-renal-cell-carcinoma
#1
Yan Liu, Xiaojie Tan, Wenbin Liu, Xi Chen, Xiaomei Hou, Dan Shen, Yibo Ding, Jianhua Yin, Ling Wang, Hongwei Zhang, Yongwei Yu, Jianguo Hou, Timothy C Thompson, Guangwen Cao
BACKGROUND: We previously showed that the expression of follistatin-like protein 1 (FSTL1) was significantly down-regulated in metastatic clear-cell renal cell carcinoma (ccRCC). In this study, we aimed to characterize the role of FSTL1 in the development of ccRCC. METHODS: The effects of FSTL1 on cell activity and cell cycle were investigated in ccRCC cell lines with altered FSTL1 expression. Gene expression microarray assays were performed to identify the major signaling pathways affected by FSTL1 knockdown...
January 22, 2018: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29317401/acute-and-chronic-increases-of-circulating-fstl1-normalize-energy-substrate-metabolism-in-pacing-induced-heart-failure
#2
Mitsuru Seki, Jeffery C Powers, Sonomi Maruyama, Maria A Zuriaga, Chia-Ling Wu, Clara Kurishima, Lydia Kim, Jesse Johnson, Anthony Poidomani, Tao Wang, Eric Muñoz, Sudarsan Rajan, Joon Y Park, Kenneth Walsh, Fabio A Recchia
BACKGROUND: FSTL1 (follistatin-like protein 1) is an emerging cardiokine/myokine that is upregulated in heart failure (HF) and is found to be cardioprotective in animal models of cardiac injury. We tested the hypothesis that circulating FSTL1 can affect cardiac function and metabolism under baseline physiological conditions and in HF. METHODS AND RESULTS: FSTL1 was acutely (10 minutes) or chronically (2 weeks) infused to attain clinically relevant blood levels in conscious dogs with cardiac tachypacing-induced HF...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29212066/fstl1-promotes-glioma-growth-through-the-bmp4-smad1-5-8-signaling-pathway
#3
Xin Jin, Er Nie, Xu Zhou, Ailiang Zeng, Tianfu Yu, Tongle Zhi, Kuan Jiang, Yingyi Wang, Junxia Zhang, Yongping You
BACKGROUND: Gliomas result in the highest morbidity and mortality rates of intracranial primary central nervous system tumors because of their aggressive growth characteristics and high postoperative recurrence. They are characterized by genetic instability, intratumoral histopathological variability and unpredictable clinical behavior in patients. Proliferation is a key aspect of the clinical progression of malignant gliomas, complicating complete surgical resection and enabling tumor regrowth and further proliferation of the surviving tumor cells...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29135371/follistatin-like-protein-1-upregulates-dendritic-cell-based-immunity-in-patients-with-nasopharyngeal-carcinoma
#4
Hong Wang, Shiping Huang, Senyong Wu, Shaolin Yin, Anzhou Tang, Wensheng Wen
Follistatin-like protein-1 (FSTL1) is an inflammatory factor that can induce an inflammatory response and is expressed in cancers. However, little is known about its content and function in nasopharyngeal carcinoma (NPC). Interleukin (IL)-12 and IL-4 are primarily secreted by dendritic cells (DCs) and activated T lymphocytes, respectively; these factors can induce Th cell differentiation and cytotoxic lymphocyte production, both of which facilitate tumors through the STAT4 and STAT6 pathways, respectively. In this study, the relationship between FSTL1 and both IL-12 and IL-4 as well as the functional mechanism of these cytokines was explored...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29126163/identification-of-novel-cancer-biomarkers-of-prognostic-value-using-specific-gene-regulatory-networks-grn-a-novel-role-of-rad51ap1-for-ovarian-and-lung-cancers
#5
Dimple Chudasama, Valeria Bo, Marcia Hall, Vladimir Anikin, Jeyarooban Jeyaneethi, Jane Gregory, George Pados, Allan Tucker, Amanda Harvey, Ryan Pink, Emmanouil Karteris
To date, microarray analyses have led to the discovery of numerous individual "molecular signatures" associated with specific cancers. However, there are serious limitations for the adoption of these multi-gene signatures in the clinical environment for diagnostic or prognostic testing as studies with more power need to be carried out. This may involve larger richer cohorts and more advanced analyses.In this study, we conduct analyses -based on GRN- to reveal distinct and common biomarkers across cancer types...
November 8, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29115636/fstl1-suppresses-tumor-cell-proliferation-invasion-and-survival-in-non-small-cell-lung-cancer
#6
Xiaolei Ni, Xiaoming Cao, Yongquan Wu, Jian Wu
Follistatin like-1 (FSTL1) is a secreted glycoprotein involved in a series of physiological and pathological processes. However, its contribution to the development of cancer, especially the pathogenesis of NSCLC, remains to be elucidated. We explored the expression, function, and molecular mechanism of FSTL1 in NSCLC. In this study, we detected the expression of FSTL1 in a panel of NSCLC cell lines and lung normal epithelial cell line by qRT-PCR and western blot analysis and found that FSTL1 was downregulated in NSCLC cells compared with normal control...
October 31, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048681/effects-of-fstl1-on-cell-proliferation-in-breast-cancer-cell-line-mda%C3%A2-mb%C3%A2-231-and-its-brain-metastatic-variant-mda%C3%A2-mb%C3%A2-231%C3%A2-br
#7
Jiaqiang An, Lulu Wang, Yuanli Zhao, Qiang Hao, Ying Zhang, Jingyi Zhang, Chun Yang, Li Liu, Wenjuan Wang, Dongliang Fang, Tao Lu, Yan Gao
In the past decades, altered Follistatin‑like 1 (FSTL1) expression has been documented in a variety of cancers, while its functional roles are poorly understood. Particularly in breast cancer, the expression of FSTL1 and its signaling pathway remain to be determined. In the present study, an elevated FSTL1 expression and a supressed cell proliferation were detected in a specific brain metastatic cell line MDA‑MB‑231‑BR (231‑BR), compared with its parental cell line MDA‑MB‑231. However, this protein was hardly detected in the other three breast cancer cell lines...
September 26, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28901425/knockdown-of-fstl1-attenuates-hepatic-stellate-cell-activation-through-the-tgf%C3%A2-%C3%AE-1-smad3-signaling-pathway
#8
Hongye Shang, Xiangjin Liu, Hui Guo
Follistatin‑like 1 (Fstl1) is a secreted glycoprotein that belongs to the follistatin and SPARC (secreted protein, acidic and rich in cysteine) families and was identified to serve a critical role in lung fibrosis. However, the role of Fstl1 in liver fibrosis remains undefined. Therefore, the aim of the present study was to investigate the role of Fstl1 in liver fibrosis. The results indicated that Fstl1 was highly expressed in human hepatic fibrosis tissues and activated hepatic stellate cells (HSCs). Furthermore, knockdown of Fstl1effectively suppressed HSC proliferation and the protein expression levels of α‑SMA and collagen I in transforming growth factor (TGF)‑β1‑treated HSCs...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28883005/fstl1-promotes-metastasis-and-chemoresistance-in-esophageal-squamous-cell-carcinoma-through-nf%C3%AE%C2%BAb-bmp-signaling-cross-talk
#9
Marco Chi-Chung Lau, Kai Yu Ng, Tin Lok Wong, Man Tong, Terence K Lee, Xiao-Yan Ming, Simon Law, Nikki P Lee, Annie L Cheung, Yan-Ru Qin, Kwok Wah Chan, Wen Ning, Xin-Yuan Guan, Stephanie Ma
Esophageal squamous cell carcinoma (ESCC) has a generally poor prognosis, and molecular markers to improve early detection and predict outcomes are greatly needed. Here, we report that the BMP-binding follistatin-like protein FSTL1 is overexpressed in ESCCs, where it correlates with poor overall survival. Genetic amplification of FSTL1 or chromosome 3q, where it is located, occurred frequently in ESCC, where FSTL1 copy number correlated positively with higher FSTL1 protein expression. Elevating FSTL1 levels by various means was sufficient to drive ESCC cell proliferation, clonogenicity, migration, invasion, self-renewal, and cisplatin resistance in vitro and tumorigenicity and distant metastasis in vivo Conversely, FSTL1 attenuation by shRNA or neutralizing antibody elicited the opposite effects in ESCC cells...
September 7, 2017: Cancer Research
https://www.readbyqxmd.com/read/28857515/effects-of-fstl1-on-the-proliferation-and-motility-of-breast-cancer-cells-and-vascular-endothelial-cells
#10
Yang Yang, Tianhao Mu, Te Li, Songbo Xie, Jun Zhou, Min Liu, Dengwen Li
BACKGROUND: Treatments that prevent the motility of breast cancer cells and inhibit formation of new capillary vessels are urgently needed. FSTL1 is a secreted protein that has been implicated in maintaining the normal physiological function of the cardiovascular system, in addition to a variety of other biological functions. We investigated the role of FSTL1 in the proliferation and migration of breast cancer and vascular endothelial cells. METHODS: Human umbilical vein endothelial cells and human breast cancer BT-549 cells were used to test the effects of FSTL1 and the N-terminal domain of FSTL1...
November 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28852127/bbs4-regulates-the-expression-and-secretion-of-fstl1-a-protein-that-participates-in-ciliogenesis-and-the-differentiation-of-3t3-l1
#11
Victoria Prieto-Echagüe, Sukanya Lodh, Laura Colman, Natalia Bobba, Leonardo Santos, Nicholas Katsanis, Carlos Escande, Norann A Zaghloul, Jose L Badano
Bardet-Biedl syndrome is a model ciliopathy. Although the characterization of BBS proteins has evidenced their involvement in cilia, extraciliary functions for some of these proteins are also being recognized. Importantly, understanding both cilia and cilia-independent functions of the BBS proteins is key to fully dissect the cellular basis of the syndrome. Here we characterize a functional interaction between BBS4 and the secreted protein FSTL1, a protein linked to adipogenesis and inflammation among other functions...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852126/decrease-of-fstl1-bmp4-smad-signaling-predicts-poor-prognosis-in-lung-adenocarcinoma-but-not-in-squamous-cell-carcinoma
#12
Jean Chiou, Chia-Yi Su, Yi-Hua Jan, Chih-Jen Yang, Ming-Shyan Huang, Yung-Luen Yu, Michael Hsiao
Follistatin-related protein 1 (FSTL1) plays a critical role in lung development through regulating BMP4-p-Smad1/5/8-Smad4 pathway. Regarding that many developmental pathways in embryogenesis are dysregulated in cancer, we aim to unravel the role of FSTL1-BMP4-Smad pathway in lung cancer. Our results showed low FSTL1 immunoexpression was significantly correlated with poor prognosis while patients with low BMP4 or low Smad4 immunoexpression showed a trend toward poor prognosis. When stratified by different histological types, low FSTL1, BMP4, and Smad4 expression retained their trends in predicting poor prognosis in lung adenocarcinoma (LUAD) but not in lung squamous cell carcinoma (SCC)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845090/the-correlation-between-fstl1-expression-and-airway-remodeling-in-asthmatics
#13
Yahui Liu, Tian Liu, Jinxiang Wu, Tao Li, Xingai Jiao, Haiqing Zhang, Jiping Zhao, Junfei Wang, Lin Liu, Liuzhao Cao, Shuo Li, Jiawei Xu, Jianfeng Xu, Xiaohui Ma, Lei Yang, Liang Dong
BACKGROUND: Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES: To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. METHODS: We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28827448/egf-hijacks-mir-198-fstl1-wound-healing-switch-and-steers-a-two-pronged-pathway-toward-metastasis
#14
Gopinath M Sundaram, Hisyam M Ismail, Mohsin Bashir, Manish Muhuri, Candida Vaz, Srikanth Nama, Ghim Siong Ow, Ivshina Anna Vladimirovna, Rajkumar Ramalingam, Brian Burke, Vivek Tanavde, Vladimir Kuznetsov, E Birgitte Lane, Prabha Sampath
Epithelial carcinomas are well known to activate a prolonged wound-healing program that promotes malignant transformation. Wound closure requires the activation of keratinocyte migration via a dual-state molecular switch. This switch involves production of either the anti-migratory microRNA miR-198 or the pro-migratory follistatin-like 1 (FSTL1) protein from a single transcript; miR-198 expression in healthy skin is down-regulated in favor of FSTL1 upon wounding, which enhances keratinocyte migration and promotes re-epithelialization...
October 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28826313/effect-of-omega-3-polyunsaturated-fatty-acids-supplementation-on-body-composition-and-circulating-levels-of-follistatin-like-1-in-males-with-coronary-artery-disease-a-randomized-double-blind-clinical-trial
#15
Shirin Jafari Salim, Shahab Alizadeh, Mahmoud Djalali, Ebrahim Nematipour, Mohammad Hassan Javanbakht
Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45-65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blind, placebo-controlled trial study...
November 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28765894/follistatin-like-protein-1-increases-transepithelial-resistance-in-kidney-epithelial-cells-through-akt-signaling
#16
Fei Chen, Qiang Hu, Huihui Huang, Binbin Chen, Yin Xia, Wenjing Liu
Tight junctions are intercellular junctional structures that control paracellular permeability across epithelial cell sheets, and serve as a barrier to the intramembranic diffusion of components between apical and basolateral cell membrane domains. Follistatin‑like protein 1 (FSTL1) has been reported to promote cellular metabolism and survival. FSTL1 has been revealed to be highly expressed in adult kidney tissues, and high FSTL1 levels have been reported in mouse and human serum samples; however, the roles of FSTL1 in the regulation of kidney function remain to be elucidated...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28705792/deletion-of-fstl1-follistatin-like-1-from-the-endocardial-endothelial-lineage-causes-mitral-valve-disease
#17
Stuti Prakash, Luis J J Borreguero, Marc Sylva, Lorena Flores Ruiz, Fereshte Rezai, Quinn D Gunst, José-Luis de la Pompa, Jan M Ruijter, Maurice J B van den Hoff
OBJECTIVE: Fstl1 (Follistatin-like 1) is a secreted protein that is expressed in the atrioventricular valves throughout embryonic development, postnatal maturation, and adulthood. In this study, we investigated the loss of Fstl1 in the endocardium/endothelium and their derived cells. APPROACH AND RESULTS: We conditionally ablated Fstl1 from the endocardial lineage using a transgenic Tie2-Cre mouse model. These mice showed a sustained Bmp and Tgfβ signaling after birth...
September 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28680581/endothelial-follistatin-like-1-regulates-the-postnatal-development-of-the-pulmonary-vasculature-by-modulating-bmp-smad-signaling
#18
Navessa P Tania, Harm Maarsingh, I Sophie T Bos, Andrea Mattiotti, Stuti Prakash, Wim Timens, Quinn D Gunst, Luis J Jimenez-Borreguero, Martina Schmidt, Maurice J B van den Hoff, Reinoud Gosens
Bone morphogenetic protein (BMP) signaling regulates vascular smooth muscle maturation, endothelial cell proliferation, and tube formation. The endogenous BMP antagonist Follistatin-like 1 (Fstl1) is highly expressed in pulmonary vascular endothelium of the developing mouse lung, suggesting a role in pulmonary vascular formation and vascular homeostasis. The aim of this study was to investigate the role of Fstl1 in the pulmonary vascular endothelium. To this aim, Fstl1 was conditionally deleted from endothelial and endothelial-derived cells using Tie2-cre driven Fstl1-KO mice (Fstl1-eKO mice)...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28655132/fstl1-contributes-to-tumor-progression-via-attenuating-apoptosis-in-a-akt-gsk-3%C3%AE-dependent-manner-in-hepatocellular-carcinoma
#19
Wei Yang, Yaqi Wu, Cong Wang, Zhikui Liu, Meng Xu, Xin Zheng
BACKGROUND: Several investigations have demonstrated that follistatin-like 1 (FSTL1) is implicated in the initiation and progression of diverse cancers. It remains unclear whether FSTL1 acted as a cancer-promoting gene through its overexpression in HCC. PATIENTS AND METHODS: We detected FSTL1 protein expression in 210 consecutive HCC cases curatively resected in our hospital between 2004 and 2007. The correlation between FSTL1 expression in HCC tissues and post-surgical prognosis of HCCs was analyzed...
July 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28624955/presynaptic-inhibition-of-nociceptive-neurotransmission-by-somatosensory-neuron-secreted-suppressors
#20
REVIEW
Kaicheng Li, Bing Cai, Changlin Li, Xu Zhang
Noxious stimuli cause pain by activating cutaneous nociceptors. The Aδ- and C-fibers of dorsal root ganglion (DRG) neurons convey the nociceptive signals to the laminae I-II of spinal cord. In the dorsal horn of spinal cord, the excitatory afferent synaptic transmission is regulated by the inhibitory neurotransmitter γ-aminobutyric acid and modulators such as opioid peptides released from the spinal interneurons, and by serotonin, norepinepherine and dopamine from the descending inhibitory system. In contrast to the accumulated evidence for these central inhibitors and their neural circuits in the dorsal spinal cord, the knowledge about the endogenous suppressive mechanisms in nociceptive DRG neurons remains very limited...
June 15, 2017: Science China. Life Sciences
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