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https://www.readbyqxmd.com/read/29351335/the-effects-of-an-acute-exercise-bout-on-gh-and-igf-1-in-prediabetic-and-healthy-african-americans-a-pilot-study-investigating-gene-expression
#1
Nathaniel T Berry, Monica Hubal, Laurie Wideman
The incidence of pre-diabetes (PD) and Type-2 Diabetes Mellitus (T2D) is a worldwide epidemic. African American (AA) individuals are disproportionately more likely to become diabetic than other ethnic groups. Over the long-term, metabolic complications related to diabetes result in significant alterations in growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Considering the limited exercise-related studies in the area of gene expression changes with disease progression, the objective of this study was to examine differences in exercise-induced gene expression related to the GH and IGF-1 pathways in peripheral blood mononuclear cells (PBMCs) of healthy (CON) and PD AA individuals...
2018: PloS One
https://www.readbyqxmd.com/read/29348496/natriuretic-peptides-promote-glucose-uptake-in-a-cgmp-dependent-manner-in-human-adipocytes
#2
Marine Coué, Valentin Barquissau, Pauline Morigny, Katie Louche, Corinne Lefort, Aline Mairal, Christian Carpéné, Nathalie Viguerie, Peter Arner, Dominique Langin, Mikael Rydén, Cedric Moro
Robust associations between low plasma level of natriuretic peptides (NP) and increased risk of type 2 diabetes (T2D) have been recently reported in humans. Adipose tissue (AT) is a known target of NP. However it is unknown whether NP signalling in human AT relates to insulin sensitivity and modulates glucose metabolism. We here show in two European cohorts that the NP receptor guanylyl cyclase-A (GC-A) expression in subcutaneous AT was down-regulated as a function of obesity grade while adipose NP clearance receptor (NPRC) was up-regulated...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29346340/disparities-in-preconception-health-indicators-%C3%A2-behavioral-risk-factor-surveillance-system-2013-2015-and-pregnancy-risk-assessment-monitoring-system-2013-2014
#3
Cheryl Robbins, Sheree L Boulet, Isabel Morgan, Denise V D'Angelo, Lauren B Zapata, Brian Morrow, Andrea Sharma, Charlan D Kroelinger
PROBLEM/CONDITION: Preconception health is a broad term that encompasses the overall health of nonpregnant women during their reproductive years (defined here as aged 18-44 years). Improvement of both birth outcomes and the woman's health occurs when preconception health is optimized. Improving preconception health before and between pregnancies is critical for reducing maternal and infant mortality and pregnancy-related complications. The National Preconception Health and Health Care Initiative's Surveillance and Research work group suggests ten prioritized indicators that states can use to monitor programs or activities for improving the preconception health status of women of reproductive age...
January 19, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29339109/bitter-gourd-reduces-elevated-fasting-plasma-glucose-levels-in-an-intervention-study-among-prediabetics-in-tanzania
#4
Michael B Krawinkel, Christine Ludwig, Mark E Swai, Ray-Yu Yang, Kwok Pan Chun, Sandra D Habicht
ETHNOPHARMACOLOGICAL RELEVANCE: Impaired glucose tolerance and diabetes mellitus have become major health issues even in non-industrialized countries. As access to clinical management is often poor, dietary interventions and alternative medicines are required. For bitter gourd, Momordica charantia L., antidiabetic properties have been claimed. AIM OF THE STUDY: The main objective of the intervention study was to assess antidiabetic effects of daily bitter gourd consumption of 2...
January 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29337019/prediabetes-is-associated-with-microalbuminuria-reduced-kidney-function-and-chronic-kidney-disease-in-the-general-population-the-kora-cooperative-health-research-in-the-augsburg-region-f4-study
#5
M R P Markus, T Ittermann, S E Baumeister, C Huth, B Thorand, C Herder, M Roden, U Siewert-Markus, W Rathmann, W Koenig, M Dörr, H Völzke, S Schipf, C Meisinger
BACKGROUND AND AIMS: We investigated the associations of serum fasting (FG) and 2-h postload (2HG) glucose from an oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), fasting insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) with urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). METHODS AND RESULTS: We performed cross-sectional analyses of 2713 subjects (1429 women; 52.7%) without known type 2 diabetes, aged 31-82 years, from the KORA (Cooperative Health Research in the Augsburg Region) F4-Study...
December 22, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29335249/hypertension-and-diabetes-mellitus-coprediction-and-time-trajectories
#6
Vasilis Tsimihodimos, Clicerio Gonzalez-Villalpando, James B Meigs, Ele Ferrannini
Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects, development of diabetes mellitus is characterized by a relatively rapid increase in plasma glucose values. Whether a similar phenomenon occurs during the development of hypertension is not known. We analyzed the pattern of blood pressure (BP) changes during the development of hypertension in patients with or without diabetes mellitus using data from the MCDS (Mexico City Diabetes Study; a population-based study of diabetes mellitus in Hispanic whites) and in the FOS (Framingham Offspring Study, a community-based study in non-Hispanic whites) during a 7-year follow-up...
January 15, 2018: Hypertension
https://www.readbyqxmd.com/read/29335039/replacing-carbohydrate-during-a-glucose-challenge-with-the-egg-white-portion-or-whole-eggs-protects-against-postprandial-impairments-in-vascular-endothelial-function-in-prediabetic-men-by-limiting-increases-in-glycaemia-and-lipid-peroxidation
#7
Joshua D McDonald, Chureeporn Chitchumroonchokchai, Jinhui Li, Eunice Mah, Allison N Labyk, Elizabeth J Reverri, Kevin D Ballard, Jeff S Volek, Richard S Bruno
Eggs attenuate postprandial hyperglycaemia (PPH), which transiently impairs vascular endothelial function (VEF). We hypothesised that co-ingestion of a glucose challenge with egg-based meals would protect against glucose-induced impairments in VEF by attenuating PPH and oxidative stress. A randomised, cross-over study was conducted in prediabetic men (n 20) who ingested isoenegertic meals (1674 kJ (400 kcal)) containing 100 g glucose (GLU), or 75 g glucose with 1·5 whole eggs (EGG), seven egg whites (WHITE) or two egg yolks (YOLK)...
January 16, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29332012/classical-adiponectin-leptin-resistin-and-new-chemerin-vaspin-omentin-adipocytokines-in-patients-with-prediabetes
#8
Antoaneta Gateva, Yavor Assyov, Adelina Tsakova, Zdravko Kamenov
Background In the last decade, there has been an increased interest toward fat tissue as an endocrine organ that secretes many cytokines and bioactive mediators that play a role in insulin sensitivity, inflammation, coagulation and the pathogenesis of atherosclerosis. The aim of this study was to investigate classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokine levels in subjects with prediabetes [impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)] and obese subjects with normoglycemia...
January 15, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29329778/high-intensity-interval-training-versus-continuous-training-on-physiological-and-metabolic-variables-in-prediabetes-and-type-2-diabetes-a-meta-analysis
#9
REVIEW
Angélica Trevisan De Nardi, Tainara Tolves, Thatiane Larissa Lenzi, Luis Ulisses Signori, Antônio Marcos Vargas da Silva
AIMS: To compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on functional capacity and cardiometabolic markers in individuals prediabetes and type 2 diabetes (T2D). METHODS: The search was performed in PubMed (MEDLINE), EMBASE, PEDro, CENTRAL, Scopus, LILACS database, and Clinical Trials from the inception to July 2017, included randomized clinical trials that compared the use of HIIT and MICT in prediabetes and T2D adults...
January 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29329117/ce-original-research-physical-activity-among-chinese-american-immigrants-with-prediabetes-or-type-2-diabetes
#10
Sophia H Hu, Mei R Fu, Shan Liu, Yen-Kuang Lin, Wen-Yin Chang
Findings from this mixed-methods study reveal deficits and suggest areas for change. ABSTRACT: Background: Although the benefits of aerobic exercise and strength training for patients with type 2 diabetes have been studied extensively, research on physical activity among Chinese American immigrants diagnosed with prediabetes or type 2 diabetes has been limited. PURPOSE: We sought to learn more about this population's knowledge of physical activity, the types and intensity levels performed, and the barriers to such activity...
January 11, 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29325776/prevalence-of-prediabetes-and-diabetes-mellitus-among-adults-residing-in-cameroon-a-systematic-review-and-meta-analysis
#11
REVIEW
Jean Joel Bigna, Jobert Richie Nansseu, Jean-Claude Katte, Jean Jacques Noubiap
AIMS: To summarize current data on the prevalence of prediabetes and diabetes mellitus in Cameroon. METHODS: Population-based cross-sectional studies published between January 1, 2000 and April 30, 2017 including apparently healthy adults residing in Cameroon were searched in PubMed, EMBASE, African Journals Online, and African Index Medicus. We used a random-effects model to pool data. RESULTS: All included studies had a low risk of bias...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325562/increased-epicardial-adipose-tissue-thickness-is-a-predictor-of-new-onset-diabetes-mellitus-in-patients-with-coronary-artery-disease-treated-with-high-intensity-statins
#12
Jeehoon Kang, Young-Chan Kim, Jin Joo Park, Sehun Kim, Si-Hyuck Kang, Young Jin Cho, Yeonyee E Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi
BACKGROUND: Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicardial adipose tissue (EAT) refers to the visceral fat surrounding the heart, which is associated with metabolic diseases. We sought to determine the association between EAT thickness and NODM in CAD patients treated with high-intensity statins. METHODS: We conducted a retrospective medical record review of CAD patients treated with high-intensity statins for at least 6 months after percutaneous coronary intervention performed between January 2009 and June 2013 at Seoul National University Bundang Hospital...
January 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29323186/combination-of-high-fat-high-fructose-diet-and-low-dose-streptozotocin-to-model-long-term-type-2-diabetes-complications
#13
David André Barrière, Christophe Noll, Geneviève Roussy, Farah Lizotte, Anissa Kessai, Karyn Kirby, Karine Belleville, Nicolas Beaudet, Jean-Michel Longpré, André C Carpentier, Pedro Geraldes, Philippe Sarret
The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption. Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of streptozotocin (HF/HF/Stz) to emulate the long-term complications of T2DM. HF/HF/Stz rats, monitored over 56 weeks, exhibited metabolic dysfunctions associated with the different stages of the T2DM disease progression in humans: an early prediabetic phase characterized by an hyperinsulinemic period with modest dysglycemia, followed by a late stage of T2DM with frank hyperglycemia, normalization of insulinemia, marked dyslipidemia, hepatic fibrosis and pancreatic β-cell failure...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319746/obesity-physical-activity-and-prediabetes-in-adult-children-of-people-with-diabetes
#14
Lidia G Compeán-Ortiz, Laura Elena Trujillo-Olivera, Ana María Valles-Medina, Eunice Reséndiz-González, Beatriz García-Solano, Beatriz Del Angel Pérez
OBJECTIVES: Determine prevalence of obesity / overweight, physical activity (PA) and prediabetes in adult children of parents with type 2 diabetes; identify differences according to sociodemographic variables, and describe the relationship of obesity/overweight with fasting glucose (FG) and glycosylated hemoglobin (A1C). METHODS: Cross-sectional study in 30 Mexican families with 53 participating adult children. Obesity / overweight was determined with Body Mass Index (BMI), Waist Circumference (WC) and body fat percentage (BFP); PA with the short International Physical Activity Questionnaire (IPAQ), and prediabetes with FG...
January 8, 2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29317841/obesity-in-mexico-prevalence-comorbidities-associations-with-patient-outcomes-and-treatment-experiences
#15
Marco D DiBonaventura, Henrik Meincke, Agathe Le Lay, Janine Fournier, Erik Bakker, Allison Ehrenreich
Objective: The goal of this study is to investigate obesity and its concomitant effects including the prevalence of comorbidities, its association with patient-reported outcomes and costs, and weight loss strategies in a sample of Mexican adults. Methods: Mexican adults (N=2,511) were recruited from a combination of Internet panels and street intercepts using a random-stratified sampling framework, with strata defined by age and sex, so that they represent the population...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29317451/duration-of-diabetes-and-prediabetes-during-adulthood-and-subclinical-atherosclerosis-and-cardiac-dysfunction-in-middle-age-the-cardia-study
#16
Jared P Reis, Norrina B Allen, Michael P Bancks, J Jeffrey Carr, Cora E Lewis, Joao A Lima, Jamal S Rana, Samuel S Gidding, Pamela J Schreiner
OBJECTIVE: To determine whether the duration of diabetes and duration of prediabetes estimated during a 25-year period in early adulthood are each independently associated with coronary artery calcified plaque (CAC) and abnormalities in left ventricular structure and function later in life. RESEARCH DESIGN AND METHODS: Participants were 3,628 white and black adults aged 18-30 years without diabetes or prediabetes at baseline (1985-1986) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study...
January 9, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29313817/prediabetes-and-its-impact-on-clinical-outcome-after-coronary-intervention-in-a-broad-patient-population
#17
Marlies M Kok, Clemens von Birgelen, Naveed Sattar, Paolo Zocca, Marije M Löwik, Peter W Danse, Carl E Schotborgh, Martijn Scholte, Marc Hartmann, Gert D Kant, Cees Doelman, Melvyn Tjon Joe Gin, Martin G Stoel, Gert van Houwelingen, Gerard C M Linssen, Maarten J IJzerman, Carine J M Doggen, Liefke C van der Heijden
AIMS: It is unclear whether detection of prediabetes(Pre-DM) by routine assessment of glycated haemoglobin A1c(HbA1c) and fasting plasma glucose(FPG) among patients undergoing percutaneous coronary intervention(PCI) with contemporary drug-eluting stents(DES) may help identify subjects with increased event risk. We assessed the relation between glycaemia status and 1-year outcome after PCI. METHODS AND RESULTS: Glycaemia status was determined in 2,362 non-diabetic BIO-RESORT participants, treated at all four study sites, to identify Pre-DM (HbA1c 42-47mmol/mol; FPG 6...
January 9, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29311441/yellow-tongue-coating-is-associated-with-diabetes-mellitus-among-japanese-non-smoking-men-and-women-the-toon-health-study
#18
Kiyohide Tomooka, Isao Saito, Shinya Furukawa, Koutatsu Maruyama, Eri Eguchi, Hiroyasu Iso, Takeshi Tanigawa
BACKGROUND: Yellow tongue coating is one of the clinical signs for diabetes mellitus according to traditional East Asian medicine. Few reports have been available on the association between yellow tongue coating and the prevalence of type 2 diabetes in the general population. We examined that association among population samples of non-smoking men and women. METHODS: The study subjects were Japanese non-smoking men (n = 315) and women (n = 654) aged 30-79 years who resided in Toon city and participated in the Toon Health Study from July 2011 through November 2014...
December 28, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29305401/changes-in-gut-microbiota-related-metabolites-and-long-term-successful-weight-loss-in-response-to-weight-loss-diets-the-pounds-lost-trial
#19
Yoriko Heianza, Dianjianyi Sun, Steven R Smith, George A Bray, Frank M Sacks, Lu Qi
OBJECTIVE: Adiposity and the gut microbiota are both related to the risk of type 2 diabetes. We aimed to comprehensively examine how changes induced by a weight-loss diet intervention in gut microbiota-related metabolites, such as trimethylamine N-oxide (TMAO) and its precursors (choline and l-carnitine), were associated with improvements in adiposity and regional fat deposition. RESEARCH DESIGN AND METHODS: This study included 510 overweight and obese individuals who were randomly assigned one of four diets varying in macronutrient intake...
January 5, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29302549/validity-of-indian-diabetes-risk-score-and-its-association-with-body-mass-index-and-glycosylated-hemoglobin-for-screening-of-diabetes-in-and-around-areas-of-lucknow
#20
Mohammad Mustufa Khan, Gyanendra Kumar Sonkar, Roshan Alam, Sudhir Mehrotra, M Salman Khan, Ajay Kumar, Satyendra Kumar Sonkar
Objectives: The present study aimed to assess the validity of Indian Diabetes Risk Score (IDRS) and its association with body mass index (BMI) and glycosylated hemoglobin (HbA1c) for screening of diabetes and obesity. Methodology: A cross-sectional study was designed, and samples were randomly enrolled from Lucknow and its adjoining areas. Totally, 405 subjects were included in the study. We used diabetes risk factors (age, waist circumference, physical activity, and family history of diabetes) for screening of diabetes and abdominal obesity (AO) and BMI for screening of general obesity...
April 2017: Journal of Family Medicine and Primary Care
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