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Xue Lian Li, Na Xie, Song Wang Wang, Qian Hong Wu, Yan Ma, Wei Shu, Hong Mei Chen, Li Qun Zhang, Xiao Guang Wu, Li Ping Ma, Nan Ying Che, Meng Qiu Gao
The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT...
September 2017: Biomedical and Environmental Sciences: BES
Saif Khan, Pallavi Somvanshi, Tulika Bhardwaj, Raju K Mandal, Sajad A Dar, Mohd Wahid, Arshad Jawed, Mohtashim Lohani, Mahvish Khan, Mohammed Y Areeshi, Shafiul Haque
The emergence of multi-drug resistant strains and co-occurrence of tuberculosis with HIV creates a major burden to the human health globally. Failure of primary antibacterial therapy necessitates the identification of new mycobacterial drugs. In this study, a comprehensive analysis involving bottom-up systems biology approach was applied wherein we have identified potential therapeutic targets of Mycobacterium tuberculosis infections. Our study prioritized M. tuberculosis therapeutic targets (aspartate-β-semialdeyhde dehydrogenase [ASD], dihydrodipicolinate reductase and diaminopimelate decarboxylase) based on flux and elementary mode analysis using direct mathematical modeling of the relevant metabolic pathways...
March 2018: Journal of Cellular Biochemistry
Chandrakant Patil, Rashmi Kharat Patil, Prasad Deshmukh, Jyotirmoy Biswas, Bassin John
Tuberculosis has global presence and no part of human body is immune to it, most frequent site beings lungs. Nasopharyngeal tuberculosis is a rare type of extrapulmonary tuberculosis comprising only less than 1% of tuberculosis found in the upper respiratory tract. The authors are presenting here a case of primary tuberculousis affecting the nasopharynx (adenoids) which is one of the rare differential diagnosis of nasopharyngeal mass. Isolated nasopharyngeal tuberculosis is a rare condition even in the endemic areas...
March 2013: Asian Pacific Journal of Tropical Medicine
O Bravo Domínguez, M Vela Colina, E Amilibia Cabeza, R D Ramírez Ruiz, A Ros Vergara, D Dinarés Jaumeandreu, L Encina Ruiz, G Arias Cuchi, E Cánovas Robles
Case report of a secretory otitia of sluggish unfolding that put forward serious diagnostic difficulties resulting, at last, to be an otic tuberculousis. Review and discussion on bibliography on otic tuberculousis, its presentation forms, diagnosis difficulties, complications and management.
2002: Anales Otorrinolaringológicos Ibero-americanos
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