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juliana hidalgo

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https://www.readbyqxmd.com/read/27521332/multiparameter-analysis-of-off-target-effects-of-dasatinib-on-bone-homeostasis-in-patients-with-newly-diagnosed-chronic-myelogenous-leukemia
#1
Daniela Hoehn, Jorge E Cortes, L Jeffrey Medeiros, Elias J Jabbour, Juliana E Hidalgo, Rashmi Kanagal-Shamanna, Carlos E Bueso-Ramos
BACKGROUND: We assessed patients with chronic myelogenous leukemia (CML) for serum calcium (Ca), phosphate (PO4), bone alkaline phosphatase, N-telopeptide (NTx), osteoprotegerin (OPG) levels, and trabecular bone area (TBA) in bone marrow (BM) specimens before and after treatment with dasatinib. We identified a significant increase in percentage of TBA in postdasatinib BM (P = .022). This suggests that dasatinib therapy can increase TBA without significant changes in bone and mineral metabolism...
August 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27496109/donor-derived-t-cell-large-granular-lymphocytic-leukemia-in-a-patient-with-peripheral-t-cell-lymphoma
#2
Juliana E Hidalgo Lopez, Mariko Yabe, Adrian A Carballo-Zarate, Sa A Wang, Jeffrey L Jorgensen, Sairah Ahmed, John Lee, Shaoying Li, Ellen Schlette, Timothy McDonnell, Roberto N Miranda, L Jeffrey Medeiros, Carlos E Bueso-Ramos, C Cameron Yin
T-cell large granular lymphocytic (T-LGL) leukemia after hematopoietic stem cell transplantation (SCT) is rare and its natural history and clinical outcome have not been well described. We report the clinical, morphologic, immunophenotypic, and molecular features of a case of donor-derived T-LGL leukemia in a 16-year-old man who received allogeneic SCT for peripheral T-cell lymphoma not otherwise specified (PTCL-NOS). The patient presented with persistent neutropenia and splenomegaly 9 months after SCT when the chimerism study showed a 100% donor pattern...
August 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/26618356/substrate-induced-dimerization-of-engineered-monomeric-variants-of-triosephosphate-isomerase-from-trichomonas-vaginalis
#3
Samuel Lara-Gonzalez, Priscilla Estrella, Carmen Portillo, María E Cruces, Pedro Jimenez-Sandoval, Juliana Fattori, Ana C Migliorini-Figueira, Marisol Lopez-Hidalgo, Corina Diaz-Quezada, Margarita Lopez-Castillo, Carlos H Trasviña-Arenas, Eugenia Sanchez-Sandoval, Armando Gómez-Puyou, Jaime Ortega-Lopez, Rossana Arroyo, Claudia G Benítez-Cardoza, Luis G Brieba
The dimeric nature of triosephosphate isomerases (TIMs) is maintained by an extensive surface area interface of more than 1600 Å2. TIMs from Trichomonas vaginalis (TvTIM) are held in their dimeric state by two mechanisms: a ball and socket interaction of residue 45 of one subunit that fits into the hydrophobic pocket of the complementary subunit and by swapping of loop 3 between subunits. TvTIMs differ from other TIMs in their unfolding energetics. In TvTIMs the energy necessary to unfold a monomer is greater than the energy necessary to dissociate the dimer...
2015: PloS One
https://www.readbyqxmd.com/read/26036227/beyond-hemostasis-the-challenge-of-treating-plasminogen-deficiency-a-report-of-three-cases
#4
Verónica Pons, Pável Olivera, Roberto García-Consuegra, Laura López-Andreoni, Nieves Martín-Begué, Angel García, Juliana Hidalgo, Francesc Bosch, Amparo Santamaría
Congenital plasminogen deficiency is a rare autosomal recessive disorder, characterized by chronic mucosal membranous lesions. Although the most common clinical manifestation is eye involvement as ligneous conjunctivitis, extra-ocular lesions affecting other mucosal surfaces indicates a systemic disease. In this report we describe two cases with atypical extra-ocular involvement that includes pericarditis and recurrent hematocolpos, and one with paradoxical correlation between ocular lesions and plasminogen levels...
April 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/23575144/caldesmon-new-insights-for-diagnosing-endometriosis
#5
Juliana Meola, Gabriela Dos Santos Hidalgo, Julio Cesar Rosa E Silva, Lilian Eslaine Costa Mendes Silva, Claudia Cristina Paro Paz, Rui Alberto Ferriani
Considerable effort has been invested in searching for less invasive methods of diagnosing endometriosis. Previous studies have indicated altered levels of the CALD1 gene (encoding the protein caldesmon) in endometriosis. The aims of our study were to investigate whether average CALD1 expression and caldesmon protein levels are differentially altered in the endometrium and endometriotic lesions and to evaluate the performance of the CALD1 gene and caldesmon protein as potential biomarkers for endometriosis...
May 2013: Biology of Reproduction
https://www.readbyqxmd.com/read/23302395/rhoc-a-key-gene-for-endometriosis
#6
Juliana Meola, Daniel Blassioli Dentillo, Júlio César Rosa e Silva, Gabriela dos Santos Hidalgo, Cláudia Cristina Paro de Paz, Rui Alberto Ferriani
Considerable efforts have been invested in elucidating the potential mechanisms involved in the physiopathology of endometriosis. The aims of our study were to investigate whether RHOC expression is differentially altered in the endometrium and in endometriotic lesions. A total of 40 patients diagnosed with endometriosis and 15 healthy fertile women were selected for the study. Paired biopsies of endometrial tissue (eutopic endometrium) and endometriotic lesions (ectopic endometrium) were obtained from the patients with endometriosis...
August 2013: Reproductive Sciences
https://www.readbyqxmd.com/read/22926194/impact-of-the-time-in-an-animal-model-of-mood-disorder
#7
Etianne Martini Sasso, Juliana Luiza Vieira, Giovana Dantas, Camila Morelatto de Souza, Rosa Maria Levandovski, Maria Paz Loayza Hidalgo
UNLABELLED: The objective of the study is to evaluate whether intervening and testing in different rest-activity periods of the day would produce different measurements in animal behavior studies. METHODOLOGY: Thirty-five, 60-day-old male Wistar rats were submitted to an inescapable foot shock (IFS) stress model and behavioral tests (Light-Dark Box test). The animals received intervention and were tested in both light and dark phases, resulting in the following groups: control L (tested in the light), control D (tested in the dark), LL (IFS and tested in the light), LD (IFS in the light and tested in the dark), DL (IFS in the dark and tested in the light), and DD (IFS and tested in the dark)...
October 15, 2012: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/21763649/tagln-expression-is-deregulated-in-endometriosis-and-may-be-involved-in-cell-invasion-migration-and-differentiation
#8
Gabriela Dos Santos Hidalgo, Juliana Meola, Júlio César Rosa E Silva, Cláudia Cristina Paro de Paz, Rui Alberto Ferriani
We found an increased expression of the TAGLN gene in endometriotic lesions compared with the eutopic endometrium of the same patients by real-time polymerase chain reaction. It is possible that this deregulation contributes to the development and maintenance of endometriosis by being involved in the pathways of organization of cytoskeletal architecture.
September 2011: Fertility and Sterility
https://www.readbyqxmd.com/read/21112827/prevalence-of%C3%A2-psychiatric-comorbidities-in%C3%A2-temporal-lobe%C3%A2-epilepsy-the%C3%A2-value-of%C3%A2-structured-psychiatric-interviews
#9
José Augusto Bragatti, Carolina Machado Torres, Renata Gomes Londero, Juliana Bohn Assmann, Vivian Fontana, Kelin Cristine Martin, Maria Paz Loayza Hidalgo, Márcia Lorena Fagundes Chaves, Marino Muxfeldt Bianchin
BACKGROUND: Although many studies have demonstrated a high prevalence of psychiatric disorders in epileptic patients, most have used unstructured psychiatric interviews for diagnosis, which may lead to significant differences in results. Here we present a study evaluating the prevalence of major psychiatric comorbidities in a cohort of South Brazilian patients with temporal lobe epilepsy using a structured clinical interview. METHODS: Neuropsychiatric symptoms were analyzed in 98 patients (39 men and 59 women) with temporal lobe epilepsy...
December 2010: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/19762216/left-sided-eeg-focus-and-positive-psychiatric-family-history-are-independent-risk-factors-for-affective-disorders-in-temporal-lobe-epilepsy
#10
José Augusto Bragatti, Carolina Machado Torres, Juliana Bohn Assmann, Vivian Fontana, Clarice Pereira Rigotti, Maria Paz Loayza Hidalgo, Márcia Lorena Fagundes Chaves, Marino Muxfeldt Bianchin
OBJECTIVE: To identify independent risk factors for affective disorders in temporal lobe epilepsy. METHODS: We studied 97 patients with temporal lobe epilepsy (TLE) exploring variables like age, gender, family history of epilepsy and psychiatric disorders, duration of epilepsy, control of seizures, presence of aura and initial precipitant insult, abuse of substances, neuroimaging and EEG features. RESULTS: Forty-one patients (42.3% of the total population) had affective disorders...
December 2009: Epilepsy Research
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