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Adipose triglyceride lipase

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https://www.readbyqxmd.com/read/29472527/hints-on-atgl-implications-in-cancer-beyond-bioenergetic-clues
#1
REVIEW
Rolando Vegliante, Luca Di Leo, Fabio Ciccarone, Maria Rosa Ciriolo
Among metabolic rearrangements occurring in cancer cells, lipid metabolism alteration has become a hallmark, aimed at sustaining accelerated proliferation. In particular, fatty acids (FAs) are dramatically required by cancer cells as signalling molecules and membrane building blocks, beyond bioenergetics. Along with de novo biosynthesis, free FAs derive from dietary sources or from intracellular lipid droplets, which represent the storage of triacylglycerols (TAGs). Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis, catalysing the first step of intracellular TAGs hydrolysis in several tissues...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29457907/deletion-of-adipose-triglyceride-lipase-links-triacylglycerol-accumulation-to-a-more-aggressive-phenotype-in-a549-lung-carcinoma-cells
#2
Tamara Tomin, Katarina Fritz, Juergen Gindlhuber, Linda Waldherr, Bettina Pucher, Gerhard G Thallinger, Daniel K Nomura, Matthias Schittmayer, Ruth Birner-Gruenberger
Adipose triglyceride lipase (ATGL) catalyzes the rate limiting step in triacylglycerol breakdown in adipocytes but is expressed in most tissues. The enzyme was shown to be lost in many human tumors, and its loss may play a role in early stages of cancer development. Here we report that loss of ATGL supports a more aggressive cancer phenotype in a model system where ATGL was deleted in A549 lung cancer cells by CRISPR/Cas9. We observed that loss of ATGL led to triacylglycerol accumulation in lipid droplets, and higher levels of cellular phospholipid and bioactive lipid species (lyso- and ether-phospholipids)...
February 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29449313/impaired-thermogenesis-and-sharp-increases-in-plasma-triglyceride-levels-in-gpihbp1-deficient-mice-during-cold-exposure
#3
Mikael Larsson, Christopher M Allan, Patrick J Heizer, Yiping Tu, Norma P Sandoval, Rachel S Jung, Rosemary L Walzem, Anne P Beigneux, Stephen G Young, Loren G Fong
GPIHBP1, an endothelial cell protein, binds lipoprotein lipase (LPL) in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1-/- mice, LPL remains stranded in the subendothelial spaces, causing hypertriglyceridemia, but how Gpihbp1-/- mice respond to metabolic stress (e.g., cold exposure) has never been studied. In wild-type mice, cold exposure increases LPL-mediated processing of triglyceride-rich lipoproteins (TRLs) in brown adipose tissue (BAT), providing fuel for thermogenesis and leading to lower plasma triglyceride levels...
February 15, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29419410/fat-in-the-blood-fat-in-the-artery-fat-in-the-heart-triglyceride-in-physiology-and-disease
#4
REVIEW
Ira J Goldberg
Cholesterol is not the only lipid that causes heart disease. Triglyceride supplies the heart and skeletal muscles with highly efficient fuel and allows for the storage of excess calories in adipose tissue. Failure to transport, acquire, and use triglyceride leads to energy deficiency and even death. However, overabundance of triglyceride can damage and impair tissues. Circulating lipoprotein-associated triglycerides are lipolyzed by lipoprotein lipase (LpL) and hepatic triglyceride lipase. We inhibited these enzymes and showed that LpL inhibition reduces high-density lipoprotein cholesterol by >50%, and hepatic triglyceride lipase inhibition shifts low-density lipoprotein to larger, more buoyant particles...
February 1, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29390006/altering-lipid-droplet-homeostasis-affects-coxiella-burnetii-intracellular-growth
#5
Minal Mulye, Brianne Zapata, Stacey D Gilk
Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While C. burnetii initially infects alveolar macrophages, it has also been found in lipid droplet (LD)-containing foamy macrophages in the cardiac valves of endocarditis patients. In addition, transcriptional studies of C. burnetii-infected macrophages reported differential regulation of the LD coat protein-encoding gene perilipin 2 (plin-2). To further investigate the relationship between LDs and C...
2018: PloS One
https://www.readbyqxmd.com/read/29381829/maternal-l-carnitine-supplementation-improves-glucose-and-lipid-profiles-in-female-offspring-of-dams-exposed-to-cigarette-smoke
#6
S Saad, I Al-Odat, Y L Chan, K McGrath, C A Pollock, B G Oliver, H Chen
Sex differences in disease susceptibility due to maternal programming have been reported. We previously observed that maternal smoking induced renal disease and neurological changes are restricted to males, whilst both male and female offspring develop metabolic disorders. We have also found that maternal L-carnitine supplementation during gestation and lactation can significantly improve glucose intolerance and hyperlipidaemia in male offspring. This study aimed to determine whether such beneficial effects can also occur in female offspring...
January 30, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29377296/genipin-ameliorates-diet-induced-obesity-via-promoting-lipid-mobilization-and-browning-of-white-adipose-tissue-in-rats
#7
Lili Guan, Dezheng Gong, Sirao Yang, Nana Shen, Sai Zhang, Yuchen Li, Qiong Wu, Bo Yuan, Yiping Sun, Ning Dai, Liang Zhu, Yuan Zou
Genipin is the major active component of Gardeniae fructus and has been shown to ameliorate diabetes and insulin resistance in rat models. In this study, we first investigated the effect of genipin on obesity and the related lipid metabolism mechanisms in diet-induced obese rats. Our results showed that genipin reduced body weight, food intake, and visceral fat mass; ameliorated dyslipidemia, glucose intolerance, insulin intolerance, adipocyte hypertrophy, and hepatic steatosis; and reduced serum tumor necrosis factor-α level in diet-induced obese rats...
January 29, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29375048/effect-of-tachycardia-on-mrna-andf-protein-expression-of-the-principal-components-of-the-lipolytic-system-in-the-rat-s-heart-ventricles
#8
B Wojcik, A Miklosz, P Zabielski, A Chabowski, J Gorski
There is a convincing piece of evidence showing that most of free fatty acids (FFA) entering cardiomyocytes are first esterified into triacylglycerols (TG) before being oxidized or used for synthesis of complex lipids. The enzyme adipose triglyceride lipase (ATGL) initiates lipolysis of TG by hydrolyzing the first ester bond of the compound. As a result, free fatty acid and diacylglycerol (DG) are released in that process. Finally, DG may be further hydrolyzed by the enzyme hormone sensitive lipase (HSL). The aim of the present study was to examine effect of tachycardia on mRNA and protein expression of ATGL, CGI-58 (an activator of ATGL), G0S2 (an inhibitor of ATGL) and HSL in the left and right ventricle of the rat...
October 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29356901/glycine-enhances-expression-of-adiponectin-and-il-10-in-3t3-l1-adipocytes-without-affecting-adipogenesis-and-lipolysis
#9
Jingqing Chen, Xiaoshi Ma, Ying Yang, Zhaolai Dai, Zhenlong Wu, Guoyao Wu
Glycine supplementation has been reported to enhance white-fat loss and improve sensitivity to insulin in animals with obesity or type 2 diabetes. However, the underlying mechanisms responsible for the beneficial effects of glycine remain largely unknown. The purpose of this study was to test the hypothesis that glycine regulates adipocyte differentiation, adipogenesis, and lipolysis, therefore, contributing to white-fat reduction. 3T3-L1 pre-adipocytes were induced to differentiate into adipocytes in the presence of glycine (0, 0...
January 22, 2018: Amino Acids
https://www.readbyqxmd.com/read/29353597/medicarpin-induces-lipolysis-via-activation-of-protein-kinase-a-in-brown-adipocytes
#10
Khan Mohammad Imran, Dahyeon Yoon, Tae-Jin Lee, Yong-Sik Kim
Natural pterocarpan Medicarpin (Med) has been shown to have various beneficial biological roles, including inhibition of osteoclastogenesis, stimulation of bone regeneration and induction of apoptosis. However, the effect of the Med on lipolysis in adipocytes has not been reported. Here, we show the effect of Med on lipolysis in different mouse adipocytes and elucidate the underlying mechanism. We observed that Med treatment promoted release of glycerol in the media. Differentiated mouse brown adipose tissue cells were treated with Med...
January 22, 2018: BMB Reports
https://www.readbyqxmd.com/read/29342975/gallic-acid-alleviates-hypertriglyceridemia-and-fat-accumulation-via-modulating-glycolysis-and-lipolysis-pathways-in-perirenal-adipose-tissues-of-rats-fed-a-high-fructose-diet
#11
Da-Wei Huang, Wen-Chang Chang, Heng-Jui Yang, James Swi-Bea Wu, Szu-Chuan Shen
This study investigated the ameliorative effect of gallic acid (GA) on hypertriglyceridemia and fat accumulation in perirenal adipose tissues of high-fructose diet (HFD)-induced diabetic rats. The previous results showed that orally administered GA (30 mg/kg body weight) for four weeks significantly reduced the levels of plasma glucose and triglyceride (TG) in HFD rats. GA also markedly decreased the perirenal adipose tissues weight of HFD rats in present study (p < 0.05). Western blot assay indicated that GA restored expression of insulin signaling-related proteins, such as insulin receptor (IR), protein kinase C-zeta (PKC-ζ), and glucose transporter-4 (GLUT4) in the perirenal adipose tissues of HFD rats...
January 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29339381/cholecystokinin-is-involved-in-triglyceride-fatty-acid-uptake-by-rat-adipose-tissue
#12
Adrian Plaza, Beatriz Merino, Victoria Cano, Gema Domínguez, Javier Pérez-Castells, Maria S Fernandez-Alfonso, Coralie Sengenès, Julie A Chowen, Mariano Ruiz-Gayo
The incorporation of plasma triglyceride (TG) fatty acids to white adipose tissue (WAT) depends on lipoprotein lipase (LPL), which is regulated by angiopoietin-like protein-4 (ANGPTL-4), an unfolding molecular chaperone that converts active LPL dimers into inactive monomers. The production of ANGPTL-4 is promoted by fasting and repressed by feeding. We hypothesized that the postprandial hormone cholecystokinin (CCK) facilitates the storage of dietary TG fatty acids in WAT by regulating the activity of the LPL/ANGPTL-4 axis and that it does so by acting directly on CCK receptors in adipocytes...
January 16, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29326160/hypoxia-inducible-lipid-droplet-associated-protein-inhibits-adipose-triglyceride-lipase
#13
Krishna M Padmanabha Das, Lisa Wechselberger, Márton Liziczai, Montserrat De la Rosa Rodriguez, Gernot F Grabner, Christoph Heier, Roland Viertlmayr, Claudia Radler, Joerg Lichtenegger, Robert Zimmermann, Jan Willem Borst, Rudolf Zechner, Sander Kersten, Monika Oberer
Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis. Hypoxia inducible lipid droplet associated protein (HILPDA)/Hypoxia inducible gene-2 (Hig-2) has been shown to affect intracellular TAG levels, yet, the underlying molecular mechanisms are unclear. Here, we show that HILPDA inhibits adipose triglyceride lipase (ATGL), the enzyme catalyzing the first step of intracellular TAG hydrolysis. HILPDA shares structural similarity with G0/G1 switch gene 2 (G0S2), an established inhibitor of ATGL...
January 11, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29320510/adipose-tissue-atgl-modifies-the-cardiac-lipidome-in-pressure-overload-induced-left-ventricular-failure
#14
Janek Salatzki, Anna Foryst-Ludwig, Kajetan Bentele, Annelie Blumrich, Elia Smeir, Zsofia Ban, Sarah Brix, Jana Grune, Niklas Beyhoff, Robert Klopfleisch, Sebastian Dunst, Michal A Surma, Christian Klose, Michael Rothe, Frank R Heinzel, Alexander Krannich, Erin E Kershaw, Dieter Beule, P Christian Schulze, Nikolaus Marx, Ulrich Kintscher
Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. However, the impact of enhanced adipose triacylglycerol hydrolysis mediated by adipose triglyceride lipase (ATGL) on cardiac function is unclear. To investigate the role of adipose tissue lipolysis during heart failure, we generated mice with tissue-specific deletion of ATGL (atATGL-KO). atATGL-KO mice were subjected to transverse aortic constriction (TAC) to induce pressure-mediated cardiac failure...
January 10, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29317958/relationship-between-angiopoietin-like-protein-8-and-fasting-serum-triglyceride-level
#15
Hodaka Yamada, Ikuyo Kusaka, Rika Saikawa, Kazuo Hara, Masafumi Kakei, San-E Ishikawa
Background: The aim of the study was to evaluate the correlation between angiopoietin-like protein 8 (ANGPTL8) and metabolic parameters in non-diabetic healthy humans. Methods: We enrolled 30 healthy Japanese adults (25 men and five women). After 9 h of fasting, we collected blood samples and analyzed the ANGPTL8, lipoprotein lipase (LPL), plasma lipid and glucose metabolic parameters. In addition, we performed 75-g oral glucose tolerance test (OGTT) and measured adipokines (tumor necrosis factor-α, leptin and adiponectin)...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29315003/anti-obesity-effect-of-allium-hookeri-leaf-extract-in-high-fat-diet-fed-mice
#16
Seyeon Park, Kihoon No, Joomin Lee
Allium hookeri has been widely cultivated and used as a vegetable and medicine in Asia, but its anti-obesity effects have not been previously reported. In this study, the effects of a leaf extract of A. hookeri on obesity were investigated by administering a high-fat diet (HFD) to mice. Male Institute of Cancer Research mice (n = 32; 5 weeks old) were randomly divided into four groups: normal-diet group, HFD group, HFD containing 200 mg/kg/day A. hookeri leaf extract (HFD-A1), and HFD containing 400 mg/kg/day A...
January 9, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29304082/striated-muscle-gene-therapy-for-the-treatment-of-lipoprotein-lipase-deficiency
#17
Katherine E Gadek, Hong Wang, Monica N Hall, Mitchell Sungello, Andrew Libby, Drew MacLaskey, Robert H Eckel, Bradley B Olwin
Excessive circulating triglycerides due to reduction or loss of lipoprotein lipase activity contribute to hypertriglyceridemia and increased risk for pancreatitis. The only gene therapy treatment for lipoprotein lipase deficiency decreases pancreatitis but minimally reduces hypertriglyceridemia. Synthesized in multiple tissues including striated muscle and adipose tissue, lipoprotein lipase is trafficked to blood vessel endothelial cells where it is anchored at the plasma membrane and hydrolyzes triglycerides into free fatty acids...
2018: PloS One
https://www.readbyqxmd.com/read/29291086/curcumin-improves-glycolipid-metabolism-through-regulating-peroxisome-proliferator-activated-receptor-%C3%AE-signalling-pathway-in-high-fat-diet-induced-obese-mice-and-3t3-l1-adipocytes
#18
Yanyun Pan, Dandan Zhao, Na Yu, Tian An, Jianan Miao, Fangfang Mo, Yujie Gu, Dongwei Zhang, Sihua Gao, Guangjian Jiang
Curcumin is an active component derived from Curcuma longa L. which is a traditional Chinese medicine that is widely used for treating metabolic diseases through regulating different molecular pathways. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism in vivo and in vitro and then determine the underlying mechanism. Male C57BL/6 J obese mice and 3T3-L1 adipocytes were used for in vivo and in vitro study, respectively. Our results demonstrated that treatment with curcumin for eight weeks decreased body weight, fat mass and serum lipid profiles...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29285805/atmospheric-ammonia-alters-lipid-metabolism-related-genes-in-the-livers-of-broilers-gallus-gallus
#19
R N Sa, H Xing, S J Luan, Y B Sun, C Y Sun, H F Zhang
Atmospheric ammonia in animal housing is reported to have adverse effects on livestock performance and animal health. Previous experiments have found that 75 ppm ammonia reduced the production performance and altered body fat distribution quality of broilers. In this study, we examined the body fat distribution, serum metabolites and lipid metabolism gene expression of broiler exposed to ammonia. A total of 400 chickens were randomly allocated to four groups with four replicates and received ammonia treatments at 0, 25, 50 and 75 ppm, respectively, for 3 weeks...
December 29, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29244870/human-hepatic-lipase-overexpression-in-mice-induces-hepatic-steatosis-and-obesity-through-promoting-hepatic-lipogenesis-and-white-adipose-tissue-lipolysis-and-fatty-acid-uptake
#20
Lídia Cedó, David Santos, Núria Roglans, Josep Julve, Victor Pallarès, Andrea Rivas-Urbina, Vicenta Llorente-Cortes, Joan Carles Laguna, Francisco Blanco-Vaca, Joan Carles Escolà-Gil
Human hepatic lipase (hHL) is mainly localized on the hepatocyte cell surface where it hydrolyzes lipids from remnant lipoproteins and high density lipoproteins and promotes their hepatic selective uptake. Furthermore, hepatic lipase (HL) is closely associated with obesity in multiple studies. Therefore, HL may play a key role on lipid homeostasis in liver and white adipose tissue (WAT). In the present study, we aimed to evaluate the effects of hHL expression on hepatic and white adipose triglyceride metabolism in vivo...
2017: PloS One
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