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Adipose triglyceride lipase

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https://www.readbyqxmd.com/read/29627983/fish-oil-supplementation-alleviates-the-altered-lipid-homeostasis-in-blood-liver-and-adipose-tissues-in-high-fat-diet-fed-rats
#1
Chen-Yuan Chiu, Lou-Pin Wang, Shing-Hwa Liu, Meng Tsan Chiang
This study investigated the effects of dietary supplementation of fish oil on the signals of lipid metabolism involved in hepatic cholesterol and triglyceride influx and excretion in high-fat diet (HFD)-fed rats. Fish oil (FO) repressed body (HFD: 533±18.2 g, HFD+FO: 488±28.0 g, p<0.05) and liver weights (HFD: 5.7±0.6 g/100 g body weight, HFD+FO: 4.8±0.4 g/100 g body weight, p<0.05) in HFD-fed rats. Fish oil could also improve HFD-induced imbalance of lipid metabolism in blood, liver, and adipose tissues including the significant decreases in plasma and liver total cholesterol (TC) (plasma-HFD: 113±33...
April 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29627378/brown-adipose-tissue-derived-angptl4-controls-glucose-and-lipid-metabolism-and-regulates-thermogenesis
#2
Abhishek K Singh, Binod Aryal, Balkrishna Chaube, Noemi Rotllan, Luis Varela, Tamas L Horvath, Yajaira Suárez, Carlos Fernández-Hernando
OBJECTIVES: Brown adipose tissue (BAT) controls triglyceride-rich lipoprotein (TRL) catabolism. This process is mediated by the lipoprotein lipase (LPL), an enzyme that catalyzed the hydrolysis of triglyceride (TAG) in glycerol and fatty acids (FA), which are burned to generate heat. LPL activity is regulated by angiopoietin-like 4 (ANGPTL4), a secretory protein produced in adipose tissues (AT), liver, kidney, and muscle. While the role of ANGPTL4 in regulating lipoprotein metabolism is well established, the specific contribution of BAT derived ANGPTL4 in controlling lipid and glucose homeostasis is not well understood...
March 29, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29626981/placental-lipoprotein-lipase-activity-is-positively-associated-with-newborn-adiposity
#3
Margaret J R Heerwagen, Diane L Gumina, Teri L Hernandez, Rachael E Van Pelt, Anita W Kramer, Rachel C Janssen, Dalan R Jensen, Theresa L Powell, Jacob E Friedman, Virginia D Winn, Linda A Barbour
INTRODUCTION: Recent data suggest that in addition to glucose, fetal growth is related to maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids (FFA) and transported across the placenta, but regulation is uncertain. Placental lipoprotein lipase (pLPL) hydrolyzes TG, both dietary chylomicron TG (CM-TG) and very-low density lipoprotein TG (VLDL-TG), to FFA. This may promote fetal fat accretion by increasing the available FFA pool for placental uptake...
April 2018: Placenta
https://www.readbyqxmd.com/read/29617909/maternal-nicotine-exposure-mne-leads-to-augmented-expression-of-the-anti-oxidant-adipose-tissue-triglyceride-lipase-atgl-long-term-in-the-white-adipose-of-female-rat-offspring
#4
Nicole G Barra, Taylor VanDuzer, Alison C Holloway, Daniel B Hardy
Globally, approximately 10-25% of women smoke during pregnancy. Since nicotine is highly addictive, women may use nicotine containing products like nicotine replacement therapies for smoking cessation, but the long-term consequences of early life exposure to nicotine remain poorly defined. Our laboratory has previously demonstrated that maternal nicotine exposed (MNE) rat offspring exhibit hypertriglyceridemia due to increased hepatic de novo lipogenesis. Hypertriglyceridemia may also be attributed to impaired white adipose tissue (WAT) lipid storage; however, the effects of MNE on WAT are not completely understood...
March 30, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29604498/oxidative-stress-and-mitochondrial-dysfunction-mediated-cd-induced-hepatic-lipid-accumulation-in-zebrafish-danio-rerio
#5
Ya-Xiong Pan, Zhi Luo, Mei-Qing Zhuo, Chuan-Chuan Wei, Guang-Hui Chen, Yu-Feng Song
The present study was performed to determine the effect of waterborne CdCl2 exposure influencing lipid deposition and metabolism, oxidative stress and mitochondrial dysfunction, and explore the underlying molecular mechanism of cadmium (Cd)-induced disorder of hepatic lipid metabolism in fish. To this end, adult zebrafish were exposed to three waterborne CdCl2 concentrations (0(control), 5 and 25 μg Cd/l, respectively) for 30 days. Lipid accumulation, the activities of enzymes related to lipid metabolism and oxidative stress, as well as the expression level of genes involved in lipid metabolism and mitophagy were determined in the liver of zebrafish...
March 17, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29599420/brown-adipose-tissue-whitening-leads-to-brown-adipocyte-death-and-adipose-tissue-inflammation
#6
Petra Kotzbeck, Antonio Giordano, Eleonora Mondini, Incoronata Murano, Ilenia Severi, Wiebe Venema, Maria Paola Cecchini, Erin E Kershaw, Giorgio Barbatelli, Guenter Haemmerle, Rudolf Zechner, Saverio Cinti
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content and activity decline in obese subjects, mainly as a result of the conversion of brown adipocytes to white-like unilocular cells. Here, we show that BAT ″whitening″ is induced by multiple factors, including high ambient temperature, leptin receptor deficiency, beta-adrenergic signaling impairment, and lipase deficiency, each of which is capable of inducing macrophage infiltration, brown adipocyte death, and crown-like structure (CLS) formation...
March 29, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29593725/perilipin-1-mediates-lipid-metabolism-homeostasis-and-inhibits-inflammatory-cytokine-synthesis-in-bovine-adipocytes
#7
Shiqi Zhang, Guowen Liu, Chuang Xu, Lei Liu, Qiang Zhang, Qiushi Xu, Hongdou Jia, Xiaobing Li, Xinwei Li
Dairy cows with ketosis displayed lipid metabolic disorder and high inflammatory levels. Adipose tissue is an active lipid metabolism and endocrine tissue and is closely related to lipid metabolism homeostasis and inflammation. Perilipin 1 (PLIN1), an adipocyte-specific lipid-coated protein, may be involved in the above physiological function. The aim of this study is to investigate the role of PLIN1 in lipid metabolism regulation and inflammatory factor synthesis in cow adipocytes. The results showed that PLIN1 overexpression upregulated the expression of fatty acid and triglyceride (TAG) synthesis molecule sterol regulator element-binding protein-1c (SREBP-1c) and its target genes, diacylglycerol acyltransferase (DGAT) 1, and DGAT2, but inhibited the expression of lipolysis enzymes hormone-sensitive lipase (HSL) and CGI-58 for adipose triglyceride lipase (ATGL), thus augmenting the fatty acids and TAG synthesis and inhibiting lipolysis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29575257/variation-in-proteomics-and-metabolomics-of-chicken-hepatocytes-exposed-to-medium-with-or-without-folic-acid
#8
Yanli Liu, Shengru Wu, Wenqiang Sun, Si Chen, Xin Yang, Xiaojun Yang
Hepatocytes are suitable models for metabolism study. Combined proteomics and metabolomics approaches should provide a comprehensive understanding for the effect of folic acid on hepatic metabolism in vitro. Primary chicken liver cells were exposed to medium with or without folic acid. The combined analyses uncovered 61 differential proteins and 43 differential metabolites between groups with or without folic acid in culture medium. Further pathway annotations revealed that RNA transport, protein processing, TCA cycle, glycolysis, pyruvate metabolism, and so on were significantly enriched...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29555209/regulation-of-angiopoietin-like-4-and-lipoprotein-lipase-in-human-adipose-tissue
#9
Wieneke Dijk, Sophie Schutte, Edo O Aarts, Ignace M C Janssen, Lydia Afman, Sander Kersten
BACKGROUND: Elevated plasma triglycerides are increasingly viewed as a causal risk factor for coronary artery disease. One protein that raises plasma triglyceride levels and that has emerged as a modulator of coronary artery disease risk is angiopoietin-like 4 (ANGPTL4). ANGPTL4 raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL), the enzyme that catalyzes the hydrolysis of circulating triglycerides on the capillary endothelium. OBJECTIVE: The objective of the present study was to assess the association between ANGPTL4 and LPL in human adipose tissue, and to examine the influence of nutritional status on ANGPTL4 expression...
February 17, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29547398/lysosomal-acid-lipase-and-lipid-metabolism-new-mechanisms-new-questions-and-new-therapies
#10
Hanrui Zhang
PURPOSE OF REVIEW: Lysosomal acid lipase (LAL), encoded by the LIPA gene, is an essential lysosomal enzyme that hydrolyzes cholesteryl ester and triglyceride delivered to the lysosome. This review highlights the novel pathophysiological role of LAL, the functional genomic discoveries of LIPA as a risk locus for coronary heart diseases (CHD), and the clinical advance in therapies for LAL deficiency. RECENT FINDINGS: The essential role of LAL in lipid metabolism has been confirmed in human and mice with LAL deficiency...
March 15, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29527681/hormone-sensitive-lipase-preferentially-redistributes-to-perilipin-5-lipid-droplets-in-human-skeletal-muscle-during-moderate-intensity-exercise
#11
Katie L Whytock, Sam O Shepherd, Anton J M Wagenmakers, Juliette A Strauss
Hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) control skeletal muscle lipolysis. ATGL is present on the surface of lipid droplets (LD) containing intramuscular triglyceride (IMTG) in both the basal state and during exercise. HSL translocates to LD in ex vivo electrically stimulated rat skeletal muscle. Perilipin-2 and perilipin-5 associated lipid droplets (PLIN2+ and PLIN5+ LD) are preferentially depleted during exercise in humans indicating these PLINs may control muscle lipolysis. We aimed to test the hypothesis that in human skeletal muscle in vivo HSL (but not ATGL) is redistributed to PLIN2+ and PLIN5+ LD during moderate-intensity exercise...
March 11, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29525531/raspberry-ketone-induces-brown-like-adipocyte-formation-through-suppression-of-autophagy-in-adipocytes-and-adipose-tissue
#12
Sy-Ying Leu, Yung-Chieh Tsai, Wen-Chi Chen, Chih-Hsiung Hsu, Yen-Mei Lee, Pao-Yun Cheng
Promoting white adipose tissue (WAT) to acquire brown-like characteristics is a promising approach for obesity treatment. Although raspberry ketone (RK) has been reported to possess antiobesity activity, its effects on the formation of brown-like adipocytes remain unclear. Therefore, we investigated the effects and underlying mechanism of RK on WAT browning in 3T3-L1 adipocytes and rats with ovariectomy (Ovx)-induced obesity. RK (100 μM) significantly induced browning of 3T3-L1 cells by increasing mitochondrial biogenesis and the expression of browning-specific proteins (PR domain containing 16, PRDM16; peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1α; uncoupling protein-1, UCP-1) and lipolytic enzymes (hormone-sensitive lipase and adipose triglyceride lipase)...
February 13, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29524543/a-phosphoglycolate-phosphatase-aum-dependent-link-between-triacylglycerol-turnover-and-epidermal-growth-factor-signaling
#13
Gabriela Segerer, Daria Engelmann, Alexandra Kaestner, Martin Trötzmüller, Harald Köfeler, Christian Stigloher, Christoph Thiele, Elisabeth Jeanclos, Antje Gohla
Mammalian phosphoglycolate phosphatase (PGP, also known as AUM or glycerol-3-phosphate phosphatase) is a small molecule-directed phosphatase important for metabolite repair and lipid metabolism. Although PGP was first characterized as an enzyme involved in epidermal growth factor (EGF) signaling, PGP protein substrates have remained elusive. Here we show that PGP depletion facilitates fatty acid flux through the intracellular triacylglycerol/fatty acid cycle, and that phosphatidylinositol-4,5-bisphosphate (PIP2), produced in a side branch of this cycle, is critical for the impact of PGP activity on EGF-induced signaling...
March 7, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29512301/differential-response-of-adipose-tissue-gene-and-protein-expressions-to-4-and-8-week-administration-of-%C3%AE-guanidinopropionic-acid-in-mice
#14
Hisashi Kato, Shinya Masuda, Tomotaka Ohira, Luna Ohira, Hisashi Takakura, Yoshinobu Ohira, Tetsuya Izawa
β-Guanidinopropionic acid (β-GPA) feeding inhibits growth-associated gain of body mass. It remains unknown, however, whether and how β-GPA feeding affects growth-associated increase in white adipose tissue (WAT) mass. We examined the effects of 4- and 8-week β-GPA feeding on serum myostatin levels and expression of genes and proteins related to adipogenesis, lipolysis, and liposynthesis in epididymal WAT (eWAT) and brown adipose tissue (BAT) in 3-week-old, juvenile male mice. Body, eWAT, and muscle weights were significantly lower in β-GPA-fed mice than in controls after feeding...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29510148/responses-to-peripheral-neuropeptide-y-in-avian-adipose-tissue-are-diet-depot-and-time-specific
#15
Guoqing Wang, Mark A Cline, Elizabeth R Gilbert
The goal of this research was to determine the effect of dietary macronutrient composition on peripheral neuropeptide Y (NPY)-induced changes in adipose tissue dynamics in chicks. Chicks were fed one of three isocaloric diets from the day of hatch: high carbohydrate (HC), high fat (HF), or high protein (HP). On day 4 post-hatch, 0 (vehicle), 60, or 120 µg/kg BW of NPY was injected intraperitoneally, and subcutaneous, clavicular and abdominal adipose tissue samples were collected at 1 and 3 h post-injection...
March 3, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29509511/deletion-of-diacylglycerol-kinase-%C3%AE%C2%B5-confers-susceptibility-to-obesity-via-reduced-lipolytic-activity-in-murine-adipocytes
#16
Tomoyuki Nakano, Keiko Seino, Ichiro Wakabayashi, Diana M Stafforini, Matthew K Topham, Kaoru Goto
Lipid metabolism is closely involved with signal transduction and energy homeostasis. Excess calorie intake causes abnormal lipid metabolism, promoting obesity and insulin resistance. Diacylglycerol (DG) represents not only a lipidic second messenger but also an intermediate metabolite for triglyceride metabolism in the endoplasmic reticulum (ER). However, it remains undetermined how the roles of DG in signaling and energy homeostasis is regulated within the cell. Of DG kinases (DGKs), which are enzymes that phosphorylate DG, DGKε resides in the ER...
March 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29500454/the-effects-of-angiotensin-receptor-neprilysin-inhibition-by-sacubitril-valsartan-on-adipose-tissue-transcriptome-and-protein-expression-in-obese-hypertensive-patients
#17
R Stinkens, B W van der Kolk, J Jordan, T Jax, S Engeli, T Heise, J W Jocken, M May, C Schindler, B Havekes, N Schaper, D Albrecht, S Kaiser, N Hartmann, M Letzkus, T H Langenickel, G H Goossens, E E Blaak
Increased activation of the renin-angiotensin system is involved in the onset and progression of cardiometabolic diseases, while natriuretic peptides (NP) may exert protective effects. We have recently demonstrated that sacubitril/valsartan (LCZ696), a first-in-class angiotensin receptor neprilysin inhibitor, which blocks the angiotensin II type-1 receptor and augments natriuretic peptide levels, improved peripheral insulin sensitivity in obese hypertensive patients. Here, we investigated the effects of sacubitril/valsartan (400 mg QD) treatment for 8 weeks on the abdominal subcutaneous adipose tissue (AT) phenotype compared to the metabolically neutral comparator amlodipine (10 mg QD) in 70 obese hypertensive patients...
March 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29488641/short-chain-fatty-acids-enhance-the-lipid-accumulation-of-3t3-l1-cells-by-modulating-the-expression-of-enzymes-of-fatty-acid-metabolism
#18
Haining Yu, Ran Li, Haiyong Huang, Ru Yao, Shengrong Shen
Short-chain fatty acids (SCFA) such as acetic acid, propionic acid, and butyric acid are produced by fermentation by gut microbiota. In this paper, we investigate the effects of SCFA on 3T3-L1 cells and the underlying molecular mechanisms. The cells were treated with acetic acid, propionic acid, or butyric acid when cells were induced to differentiate into adipocytes. MTT assay was employed to detect the viability of 3T3-L1 cells. Oil Red O staining was used to visualize the lipid content in 3T3-L1 cells. A triglyceride assay kit was used to detect the triacylglycerol content in 3T3-L1 cells...
January 2018: Lipids
https://www.readbyqxmd.com/read/29472527/hints-on-atgl-implications-in-cancer-beyond-bioenergetic-clues
#19
REVIEW
Rolando Vegliante, Luca Di Leo, Fabio Ciccarone, Maria Rosa Ciriolo
Among metabolic rearrangements occurring in cancer cells, lipid metabolism alteration has become a hallmark, aimed at sustaining accelerated proliferation. In particular, fatty acids (FAs) are dramatically required by cancer cells as signalling molecules and membrane building blocks, beyond bioenergetics. Along with de novo biosynthesis, free FAs derive from dietary sources or from intracellular lipid droplets, which represent the storage of triacylglycerols (TAGs). Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis, catalysing the first step of intracellular TAGs hydrolysis in several tissues...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29457907/deletion-of-adipose-triglyceride-lipase-links-triacylglycerol-accumulation-to-a-more-aggressive-phenotype-in-a549-lung-carcinoma-cells
#20
Tamara Tomin, Katarina Fritz, Juergen Gindlhuber, Linda Waldherr, Bettina Pucher, Gerhard G Thallinger, Daniel K Nomura, Matthias Schittmayer, Ruth Birner-Gruenberger
Adipose triglyceride lipase (ATGL) catalyzes the rate limiting step in triacylglycerol breakdown in adipocytes but is expressed in most tissues. The enzyme was shown to be lost in many human tumors, and its loss may play a role in early stages of cancer development. Here we report that loss of ATGL supports a more aggressive cancer phenotype in a model system where ATGL was deleted in A549 lung cancer cells by CRISPR/Cas9. We observed that loss of ATGL led to triacylglycerol accumulation in lipid droplets, and higher levels of cellular phospholipid and bioactive lipid species (lyso- and ether-phospholipids)...
February 19, 2018: Journal of Proteome Research
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