Atsuko Yonemura, Takashi Semba, Jun Zhang, Yibo Fan, Noriko Yasuda-Yoshihara, Huaitao Wang, Tomoyuki Uchihara, Tadahito Yasuda, Akiho Nishimura, Lingfeng Fu, Xichen Hu, Feng Wei, Fumimasa Kitamura, Takahiko Akiyama, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Masaaki Iwatsuki, Yuji Miyamoto, Keisuke Matsusaki, Juntaro Yamasaki, Osamu Nagano, Hideyuki Saya, Shumei Song, Patrick Tan, Hideo Baba, Jaffer A Ajani, Takatsugu Ishimoto
Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic profiling and a comprehensive proteomic analysis are conducted to comprehensively characterize malignant ascites. Here, we find defects in immune effectors along with immunosuppressive cell accumulation in ascites of patients with gastric cancer (GC) and identify five distinct subpopulations of CD45(-)/EpCAM(-) cells...
December 30, 2023: Cell Reports