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https://www.readbyqxmd.com/read/28230733/ck2-molecular-targeting-tumor-cell-specific-delivery-of-rnai-in-various-models-of-cancer
#1
REVIEW
Janeen H Trembley, Betsy T Kren, Md Joynal Abedin, Rachel I Vogel, Claire M Cannon, Gretchen M Unger, Khalil Ahmed
Protein kinase CK2 demonstrates increased protein expression relative to non-transformed cells in the majority of cancers that have been examined. The elevated levels of CK2 are involved in promoting not only continued proliferation of cancer cells but also their resistance to cell death; thus, CK2 has emerged as a plausible target for cancer therapy. Our focus has been to target CK2 catalytic subunits at the molecular level using RNA interference (RNAi) strategies to achieve their downregulation. The delivery of oligonucleotide therapeutic agents warrants that they are protected and are delivered specifically to cancer cells...
February 21, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28223136/wnt3%C3%AE-and-transforming-growth-factor-%C3%AE-induce-myofibroblast-differentiation-from-periodontal-ligament-cells-via-different-pathways
#2
Hui Xu, Yao He, Jian Q Feng, Rui Shu, Zhe Liu, Jingyu Li, Yating Wang, Yang Xu, Huan Zeng, Xin Xu, Zichao Xiang, Chaoran Xue, Ding Bai, Xianglong Han
Myofibroblasts are specialized cells that play a key role in connective tissue remodeling and reconstruction. Alpha-smooth muscle actin (α-SMA), vimentin and tenascin-C are myofibroblast phenotype, while α-SMA is the phenotypic marker. The observation that human periodontal ligament cells (hPDLCs) differentiate into myofibroblasts under orthodontic force has provided a new perspective for understanding of the biological and biomechanical mechanisms involved in orthodontic tooth movement. However, the cell-specific molecular mechanisms leading to myofibroblast differentiation in the periodontal ligament (PDL) remain unclear...
February 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28223108/tenascin-c-is-a-prognostic-determinant-and-potential-cancer-associated-fibroblasts-marker-for-breast-ductal-carcinoma
#3
Zhaoting Yang, Weidong Ni, Chunai Cui, Longyun Fang, Yanhua Xuan
Tenascin C (TNC) is a key of extracellular matrix glycoprotein and highly express in numerous human malignancies. Herein, we attempted to clarify the clinicopathological significance of TNC as a prognostic determinant of breast ductal carcinoma. Then, we investigated TNC immunohistochemical expression in 150 breast ductal carcinomas and 27 normal breast tissue samples. Clinical relevance of TNC expression and the association TNC expression with other factors related to cancer-associated fibroblasts were also examined...
February 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28216675/extracellular-superoxide-dismutase-expression-in-papillary-thyroid-cancer-mesenchymal-stem-stromal-cells-modulates-cancer-cell-growth-and-migration
#4
Alessia Parascandolo, Francesca Rappa, Francesco Cappello, Jaehyup Kim, David A Cantu, Herbert Chen, Gianluigi Mazzoccoli, Peiman Hematti, Maria Domenica Castellone, Marco Salvatore, Mikko O Laukkanen
Tumor stroma-secreted growth factors, cytokines, and reactive oxygen species (ROS) influence tumor development from early stages to the metastasis phase. Previous studies have demonstrated downregulation of ROS-producing extracellular superoxide dismutase (SOD3) in thyroid cancer cell lines although according to recent data, the expression of SOD3 at physiological levels stimulates normal and cancer cell proliferation. Therefore, to analyze the expression of SOD3 in tumor stroma, we characterized stromal cells from the thyroid...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28214894/mechanical-loading-improves-tendon-bone-healing-in-a-rabbit-anterior-cruciate-ligament-reconstruction-model-by-promoting-proliferation-and-matrix-formation-of-mesenchymal-stem-cells-and-tendon-cells
#5
Fanglong Song, Dawei Jiang, Tianchen Wang, Yi Wang, Fengmei Chen, Guoxing Xu, Yifan Kang, Yinquan Zhang
BACKGROUND/AIMS: This study investigated the effect of mechanical stress on tendon-bone healing in a rabbit anterior cruciate ligament (ACL) reconstruction model as well as cell proliferation and matrix formation in co-culture of bone-marrow mesenchymal stem cells (BMSCs) and tendon cells (TCs). METHODS: The effect of continuous passive motion (CPM) therapy on tendon-bone healing in a rabbit ACL reconstruction model was evaluated by histological analysis, biomechanical testing and gene expressions at the tendon-bone interface...
February 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28197173/targeting-cell-surface-receptors-for-axon-regeneration-in-the-central-nervous-system
#6
REVIEW
Menghon Cheah, Melissa R Andrews
Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that forced expression of certain neuronal transmembrane receptors can recapitulate neuronal growth resulting in successful growth within and through inhibitory lesion environments. More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trkB which binds the neurotrophic factor BDNF, and receptor PTPσ which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28187162/loss-of-caveolin-1-alters-extracellular-matrix-protein-expression-and-ductal-architecture-in-murine-mammary-glands
#7
Christopher Thompson, Sahar Rahim, Jeremiah Arnold, Abigail Hielscher
The extracellular matrix (ECM) is abnormal in breast tumors and has been reported to contribute to breast tumor progression. One factor, which may drive ongoing matrix synthesis in breast tumors, is the loss of stromal caveolin-1 (cav-1), a scaffolding protein of caveolae, which has been linked to breast tumor aggressiveness. To determine whether loss of cav-1 results in the abnormal expression of matrix proteins, mammary glands from cav- 1-/- and cav- 1 +/+ mice were investigated for differences in expression of several ECM proteins...
2017: PloS One
https://www.readbyqxmd.com/read/28152318/hedgehog-signaling-stimulates-tenascin-c-to-promote-invasion-of-pancreatic-ductal-adenocarcinoma-cells-through-annexin-a2
#8
Kelly Foley, Stephen Muth, Elizabeth Jaffee, Lei Zheng
Pancreatic adenocarcinoma (PDA) is characterized by a dense desmoplastic reaction that comprises 60-90% of the tumor, while only 10-40% of the tumor is composed of malignant epithelial cells. This desmoplastic reaction is composed of stromal fibroblast cells, extracellular matrix proteins, and immune cells. Accumulating evidence has suggested that the stromal and epithelial cell compartments interact during the pathogenesis of this disease. Therefore, it is important to identify the signaling pathways responsible for this interaction to better understand the mechanisms by which PDA invades and metastasizes...
February 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28115252/micropatterning-of-nanocomposite-polymer-scaffolds-using-sacrificial-phosphate-glass-fibers-for-tendon-tissue-engineering-applications
#9
Feras Alshomer, Camilo Chaves, Tiziano Serra, Ifty Ahmed, Deepak M Kalaskar
This study presents a simple and reproducible method of micropatterning the novel nanocomposite polymer (POSS-PCU) using a sacrificial phosphate glass fiber template for tendon tissue engineering applications. The diameters of the patterned scaffolds produced were dependent on the diameter of the glass fibers (15 μm) used. Scaffolds were tested for their physical properties and reproducibility using various microscopy techniques. For the first time, we show that POSS-PCU supports growth of human tenocytes cells...
January 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28106752/the-promoting-effect-of-the-extracellular-matrix-peptide-tniiia2-derived-from-tenascin-c-in-colon-cancer-cell-infiltration
#10
Hideo Suzuki, Manabu Sasada, Sadahiro Kamiya, Yuka Ito, Hikaru Watanabe, Yuko Okada, Kazuma Ishibashi, Takuya Iyoda, Akinori Yanaka, Fumio Fukai
The extracellular matrix (ECM) molecule tenascin C (TNC) is known to be highly expressed under various pathological conditions such as inflammation and cancer. It has been reported that the expression of TNC is correlated with the malignant potential of cancer. In our laboratory, it was found that the peptide derived from the alternative splicing domain A2 in TNC, termed TNIIIA2, has been shown to influence a variety of cellular processes, such as survival, proliferation, migration, and differentiation. In this study, we investigated the effect of TNC/TNIIIA2 on the invasion and metastasis of colon cancer cells, Colon26-M3...
January 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28095396/tenascin-c-and-fibronectin-expression-divide-early-stage-tongue-cancer-into-low-and-high-risk-groups
#11
Elias Sundquist, Joonas H Kauppila, Johanna Veijola, Rayan Mroueh, Petri Lehenkari, Saara Laitinen, Juha Risteli, Ylermi Soini, Veli-Matti Kosma, Iris Sawazaki-Calone, Carolina Carneiro Soares Macedo, Risto Bloigu, Ricardo D Coletta, Tuula Salo
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) metastasises early, especially to regional lymph nodes. There is an ongoing debate on which early stage (T1-T2N0) patients should be treated with elective neck dissection. We need prognosticators for early stage tongue cancer. METHODS: Mice immunisation with human mesenchymal stromal cells resulted in production of antibodies against tenascin-C (TNC) and fibronectin (FN), which were used to stain 178 (98 early stage), oral tongue squamous cell carcinoma samples...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28074628/s100a4-metastasin-positive-mesenchymal-canine-mammary-tumour-spheroids-reduce-tenascin-c-synthesis-under-dmso-exposure-in-vitro
#12
S Kau, I Miller, A Tichy, C Gabriel
In breast cancer research S100A4-positive tumour-associated stromal cells are assumed as primary source of Tenascin C (TNC) in the metastatic environment. Aim of the present study was to isolate and characterize S100A4/TNC positive stromal canine mammary tumour (CMT) cells. Cells grown as scaffold-free spheroids were investigated for S100A4, TNC, and proliferative activity under 1.8% DMSO stimulation by means of Western blot and immunohistochemistry. DMSO is a commonly used drug solvent despite well-known side effects on cells including TNC expression...
January 11, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28071813/sex-differences-in-tendon-structure-and-function
#13
Dylan C Sarver, Yalda Ashraf Kharaz, Kristoffer B Sugg, Jonathan P Gumucio, Eithne Comerford, Christopher L Mendias
Tendons play a critical role in the transmission of forces between muscles and bones, and chronic tendon injuries and diseases are among the leading causes of musculoskeletal disability. Little is known about sex-based differences in tendon structure and function. Our objective was to evaluate the mechanical properties, biochemical composition, transcriptome, and cellular activity of plantarflexor tendons from 4 month old male and female C57BL/6 mice using in vitro biomechanics, mass spectrometry-based proteomics, genome-wide expression profiling, and cell culture techniques...
January 10, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28071602/microgrooved-topographical-surface-directs-tenogenic-lineage-specific-differentiation-of-mouse-tendon-derived-stem-cells
#14
Yuan Shi, Kaili Zhou, Wenjie Zhang, Zhiyong Zhang, Guangdong Zhou, Yilin Cao, Wei Liu
Tendon derived stem cells (TDSCs) are the endogenous cell source for tenocyte turnover and tendon functional maintenance. They are also the important cell source for tendon engineering and regeneration. In addition, TDSCs also play an important role in tendinopathy via their non-tenogenic lineage differentiation. It has been well demonstrated that cell shape could determine mesenchymal stem cell (MSC) lineage differentiation. In this study, a parallel microgrooved polydimethylsiloxane (PDMS) membrane (10 µm groove width and 3 µm depth) was employed to investigate the role of cell elongation via this particular topographic surface in directing murine TDSC (mTDSC) lineage differentiation...
January 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28054932/hiv-infection-rather-than-concurrent-opportunistic-infections-drives-most-systemic-procoagulant-vascular-and-damage-responses-a-prospective-cohort-study-in-central-africa
#15
Saskia Janssen, Michaela Am Huson, Kara K Osbak, Elie-Gide Rossatanga, Abraham Alabi, René Lutter, Martin P Grobusch, Tom van der Poll
BACKGROUND: HIV infection is accompanied by various systemic host responses, including activation of coagulation and the vascular endothelium. We sought to determine the impact of opportunistic co-infections in a Central-African setting. METHODS: This prospective study included 98 HIV-infected individuals in Gabon initiating combination antiretroviral therapy (cART) and followed them up for 6 months. Patients were stratified according to the presence of active tuberculosis (TB; n=19), mucocutaneous opportunistic infection (n=9), or no opportunistic infection (n=70)...
January 5, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28011588/transgenic-overexpression-of-macrophage-matrix-metalloproteinase-9-exacerbates-age-related-cardiac-hypertrophy-vessel-rarefaction-inflammation-and-fibrosis
#16
Hiroe Toba, Presley L Cannon, Andriy Yabluchanskiy, Rugmani Padmanabhan Iyer, Jeanine M D'Armiento, Merry L Lindsey
Advancing age is an independent risk factor for cardiovascular disease. Matrix metalloproteinase-9 (MMP-9) is secreted by macrophages and robustly increases in the left ventricle (LV) with age. The present study investigated the effect of MMP-9 overexpression in macrophages on cardiac aging. We compared 16-21 month old C57/BL6J wild type (WT) and transgenic (TG) male and female mice (n=15-20 /group). MMP-9 overexpression amplified the hypertrophic response to aging, as evidenced by increased LV wall thickness and myocyte cross sectional areas (p<0...
December 23, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28009347/an-integrin-approach-to-axon-regeneration
#17
J W Fawcett
Axon regeneration in the CNS is blocked by inhibitory molecules in the environment and by a developmental loss of regenerative potential in CNS axons. Axon growth is a specialized form of cell migration, and for any cell to migrate there must be an adhesion molecule at the growth tip that recognizes a ligand in the environment, and which is linked to signaling and cytoskeletal mechanisms. The reasons for this loss of regenerative ability in CNS axons are several, but important contributors are the developmental loss of integrins that recognize ligands in the mature CNS environment, and selective trafficking of integrins and other molecules to exclude them from axons and direct them to dendrites...
February 2017: Eye
https://www.readbyqxmd.com/read/27991921/rock2-ras-ha-co-operation-induces-malignant-conversion-via-p53-loss-elevated-nf-%C3%AE%C2%BAb-and-tenascin-c-associated-rigidity-but-p21-inhibits-rock2-nf-%C3%AE%C2%BAb-mediated-progression
#18
S F Masre, N Rath, M F Olson, D A Greenhalgh
To study ROCK2 activation in carcinogenesis, mice expressing 4-hydroxytamoxifen (4HT)-activated ROCK2 (K14.ROCK(er)) were crossed with mice expressing epidermal-activated ras(Ha) (HK1.ras(1205)). At 8 weeks, 4HT-treated K14.ROCK(er)/HK1.ras(1205) cohorts exhibited papillomas similar to HK1.ras(1205) controls; however, K14.ROCK(er)/HK1.ras(1205) histotypes comprised a mixed papilloma/well-differentiated squamous cell carcinoma (wdSCC), exhibiting p53 loss, increased proliferation and novel NF-κB expression...
December 19, 2016: Oncogene
https://www.readbyqxmd.com/read/27991696/linking-the-transcriptional-landscape-of-bone-induction-to-biomaterial-design-parameters
#19
Nathalie Groen, Huipin Yuan, Dennie G A J Hebels, Gülistan Koçer, Faustin Mbuyi, Vanessa LaPointe, Roman Truckenmüller, Clemens A van Blitterswijk, Pamela Habibović, Jan de Boer
New engineering possibilities allow biomaterials to serve as active orchestrators of the molecular and cellular events of tissue regeneration. Here, the molecular control of tissue regeneration for calcium phosphate (CaP)-based materials is established by defining the parameters critical for tissue induction and those are linked to the molecular circuitry controlling cell physiology. The material properties (microporosity, ion composition, protein adsorption) of a set of synthesized osteoinductive and noninductive CaP ceramics are parameterized and these properties are correlated to a transcriptomics profile of osteogenic cells grown on the materials in vitro...
December 19, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27974414/the-rodent-liver-undergoes-weaning-induced-involution-and-supports-breast-cancer-metastasis
#20
Erica T Goddard, Ryan C Hill, Travis Nemkov, Angelo D'Alessandro, Kirk C Hansen, Ori Maller, Solange Mongoue-Tchokote, Motomi Mori, Ann H Partridge, Virginia F Borges, Pepper Schedin
: Patients with postpartum breast cancer are at increased risk for metastasis compared with age-matched nulliparous or pregnant patients. Here, we address whether circulating tumor cells have a metastatic advantage in the postpartum host and find the postlactation rodent liver preferentially supports metastasis. Upon weaning, we observed liver weight loss, hepatocyte apoptosis, extracellular matrix remodeling including deposition of collagen and tenascin-C, and myeloid cell influx, data consistent with weaning-induced liver involution and establishment of a prometastatic microenvironment...
February 2017: Cancer Discovery
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