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https://www.readbyqxmd.com/read/28640707/response-assessment-in-neuro-oncology-clinical-trials
#1
Patrick Y Wen, Susan M Chang, Martin J Van den Bent, Michael A Vogelbaum, David R Macdonald, Eudocia Q Lee
Development of novel therapies for CNS tumors requires reliable assessment of response and progression. This requirement has been particularly challenging in neuro-oncology for which contrast enhancement serves as an imperfect surrogate for tumor volume and is influenced by agents that affect vascular permeability, such as antiangiogenic therapies. In addition, most tumors have a nonenhancing component that can be difficult to accurately quantify. To improve the response assessment in neuro-oncology and to standardize the criteria that are used for different CNS tumors, the Response Assessment in Neuro-Oncology (RANO) working group was established...
June 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28632024/performance-validity-testing-in-a-clinical-sample-of-adults-with-sickle-cell-disease
#2
Katherine E Dorociak, Evan T Schulze, Lauren E Piper, Robert E Molokie, Julie K Janecek
OBJECTIVE: Neuropsychologists utilize performance validity tests (PVTs) as objective means for drawing inferences about performance validity. The Test of Memory Malingering (TOMM) is a well-validated, stand-alone PVT and the Reliable Digit Span (RDS) and Reliable Digit Span-Revised (RDS-R) from the Digit Span subtest of the WAIS-IV are commonly employed, embedded PVTs. While research has demonstrated the utility of these PVTs with various clinical samples, no research has investigated their use in adults with sickle cell disease (SCD), a condition associated with multiple neurological, physical, and psychiatric symptoms...
June 15, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28605723/a-combined-cognitive-and-gait-quantification-to-identify-normal-pressure-hydrocephalus-from-its-mimics-the-geneva-s-protocol
#3
Gilles Allali, Magali Laidet, Stéphane Armand, Shahan Momjian, Bruno Marques, Arnaud Saj, Frédéric Assal
OBJECTIVES: Idiopathic normal pressure hydrocephalus (iNPH) is very prevalent in aging, underdiagnosed, and represents a rare cause of reversible neurological condition. The clinical triad of iNPH - gait, cognitive and urinary symptoms - and its neuroradiological features (i.e. ventriculomegaly) are not specific and found a various neurodegenerative and/or vascular conditions. We present our iNPH standardized protocol at the Geneva University Hospitals involving a multispecialty team of behavioral neurologists, neurosurgeons, neuropsychologists, engineers, and physical therapists...
June 6, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28605690/potential-implications-of-luria-s-work-for-the-neuropsychology-of-epilepsy-and-epilepsy-surgery-a-perspective-for-re-examination
#4
REVIEW
Panayiotis Patrikelis, Giuliana Lucci, Anna Siatouni, Anastasia Verentzioti, Athanasia Alexoudi, Stylianos Gatzonis
The pioneeristic work of Alexander Romanovic Luria into the field of human neuropsychology offered eminent contributions to clinical praxis by providing theory guided methods and instruments for the study of higher cortical functions. However, lots of this knowledge corpus either remains untranslated and thus inaccessible, or in some cases selectively overlooked by academic authorities and consequently not passed to the future generations of experts. Although Luria was not exclusively devoted to the study of epilepsy, his theories and clinical approaches actually penetrate the whole neuropathology spectrum...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28598726/outer-and-inner-tolerance-limits-their-usefulness-for-the-construction-of-norms-and-the-standardization-of-neuropsychological-tests
#5
Erminio Capitani, Marcella Laiacona
OBJECTIVES: After adjustment of scores for demographic variables, especially when test scales have an upper limit that causes a ceiling effect, the original score variability is deeply altered and the scale properties degenerate. We present a method for fixing normality thresholds on scores previously adjusted for demographic variables that overcomes these problems. METHODS: We suggest to fix norms using non-parametric tolerance limits. These limits, valid even for asymmetrical distributions and adjusted scores, can also be used as a basis for a non-parametric standardization of adjusted scores...
June 9, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28590154/practice-parameters-facilitating-adoption-of-advanced-technologies-for-enhancing-neuropsychological-assessment-paradigms
#6
Thomas D Parsons, Timothy McMahan, Robert Kane
OBJECTIVE: Clinical neuropsychologists have long underutilized computer technologies for neuropsychological assessment. Given the rapid advances in technology (e.g. virtual reality; tablets; iPhones) and the increased accessibility in the past decade, there is an on-going need to identify optimal specifications for advanced technologies while minimizing potential sources of error. Herein, we discuss concerns raised by a joint American Academy of Clinical Neuropsychology/National Academy of Neuropsychology position paper...
June 7, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28557477/multivariate-normative-comparisons-for-neuropsychological-assessment-by-a-multilevel-factor-structure-or-multiple-imputation-approach
#7
Joost A Agelink van Rentergem, Nathalie R de Vent, Ben A Schmand, Jaap M J Murre, Hilde M Huizenga
Neuropsychologists administer neuropsychological tests to decide whether a patient is cognitively impaired. This clinical decision is made by comparing a patient's scores to those of healthy participants in a normative sample. In a multivariate normative comparison, a patient's entire profile of scores is compared to scores in a normative sample. Such a multivariate comparison has been shown to improve clinical decision making. However, it requires a multivariate normative data set, which often is unavailable...
May 29, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28555516/clinical-utility-of-the-rey-15-item-test-recognition-trial-and-error-scores-for-detecting-noncredible-neuropsychological-performance-in-a-mixed-clinical-sample-of-veterans
#8
K Chase Bailey, Jason R Soble, Justin J F O'Rourke
OBJECTIVE: This cross-sectional study examined the Rey 15-Item Test (RFIT), Recognition Trial, and Error Scores for identifying noncredible performance in a mixed clinical veteran sample compared to another widely used validity measure, the Test of Memory Malingering (TOMM). METHOD: Sixty-two veterans who completed the RFIT (Recall/Recognition Trials), TOMM, and Word Memory Test (WMT) during clinical evaluation were included. Using the WMT as the criterion, 71% (N = 44) were classified as valid and 29% (N = 18) as invalid...
May 30, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28544310/implementing-the-psychosocial-standards-in-pediatric-cancer-current-staffing-and-services-available
#9
Michele A Scialla, Kimberly S Canter, Fang Fang Chen, E Anders Kolb, Eric Sandler, Lori Wiener, Anne E Kazak
BACKGROUND: Fifteen evidence-based Standards for Psychosocial Care for Children with Cancer and Their Families (Standards) were published in 2015. The Standards cover a broad range of topics and circumstances and require qualified multidisciplinary staff to be implemented. This paper presents data on the availability of psychosocial staff and existing practices at pediatric oncology programs in the United States, providing data that can be used to advocate for expanded services and prepare for implementation of the Standards...
May 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28544168/presurgical-language-fmri-mapping-of-six-critical-regions
#10
Christopher F Benjamin, Patricia D Walshaw, Kayleigh Hale, William D Gaillard, Leslie C Baxter, Madison M Berl, Monika Polczynska, Stephanie Noble, Rafeed Alkawadri, Lawrence J Hirsch, R Todd Constable, Susan Y Bookheimer
Language mapping is a key goal in neurosurgical planning. fMRI mapping typically proceeds with a focus on Broca's and Wernicke's areas, although multiple other language-critical areas are now well-known. We evaluated whether clinicians could use a novel approach, including clinician-driven individualized thresholding, to reliably identify six language regions, including Broca's Area, Wernicke's Area (inferior, superior), Exner's Area, Supplementary Speech Area, Angular Gyrus, and Basal Temporal Language Area...
May 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28541543/validation-of-the%C3%A2-d%C3%A3-pistage-cognitif-de-qu%C3%A3-bec-a-new-cognitive-screening-tool-for-atypical-dementias
#11
Robert Laforce, Leila Sellami, David Bergeron, Audrey Paradis, Louis Verret, Marie-Pierre Fortin, Michèle Houde, Martin Roy, Stéphane Poulin, Joël Macoir, Carol Hudon, Rémi W Bouchard
Objective: This study aimed to validate and provide normative data for the Dépistage Cognitif de Québec (DCQ; www.dcqtest.org), a new cognitive screening tool for atypical dementias. Method: The DCQ was developed by expert behavioral neurologists and clinical neuropsychologists based on updated criteria for Alzheimer's disease, primary progressive aphasia, and behavioral variant frontotemporal dementia. It targets five relevant domains: Memory, Visuospatial, Executive, Language, and Behavior...
May 25, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28492460/performance-validity-testing-in-neuropsychology-methods-for-measurement-development-and-maximizing-diagnostic-accuracy
#12
Thomas R Wodushek, Michael R Greher
In the first column in this 2-part series, Performance Validity Testing in Neuropsychology: Scientific Basis and Clinical Application-A Brief Review, the authors introduced performance validity tests (PVTs) and their function, provided a justification for why they are necessary, traced their ongoing endorsement by neuropsychological organizations, and described how they are used and interpreted by ever increasing numbers of clinical neuropsychologists. To enhance readers' understanding of these measures, this second column briefly describes common detection strategies used in PVTs as well as the typical methods used to validate new PVTs and determine cut scores for valid/invalid determinations...
May 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28453603/the-effect-of-insomnia-on-neuropsychological-functioning-in-patients-with-comorbid-symptoms-of-pain-fatigue-and-mood-disorders
#13
Julie Aasvik, Tore C Stiles, Astrid Woodhouse, Petter Borchgrevink, Nils Inge Landrø
Objectives: To examine if elevated symptoms of insomnia affects neuropsychological functioning in patients with concurrent symptoms of pain, fatigue, and mood disorders. Methods and results: A total of seventy-six subjects participated in this (cross-sectional) study. Based on the cut-off score guidelines from The Insomnia Severity Index subjects were assigned to either a clinical insomnia group (N = 35) or a comparison group (N = 41). Factors such as age, general cognitive functioning, and symptoms of pain, fatigue, depression, and anxiety did not differ between the groups...
April 27, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28431032/neuropsychology-and-rehabilitation-services-in-the-united-states-brief-report-from-a-survey-of-clinical-neuropsychologists
#14
Cady Block, Octavio A Santos, Yvonne Flores-Medina, Diego Fernando Rivera Camacho, Juan Carlos Arango-Lasprilla
Objective: To provide a brief presentation of preliminary data on rehabilitation services provided by clinical neuropsychologists within the United States. Method: This survey utilized data extracted from a larger international research study conducted in 39 countries including N = 173 professionals who reported to engage in neuropsychological rehabilitative services within the past year (63.6% female, 44.36 ± 11.83 years of age) took part in the study. Results: Neuropsychologists providing rehabilitation services in the United States in the past year were more likely to provide individual versus group therapy, likely to employ technology (e...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28429633/the-reliability-of-multidimensional-neuropsychological-measures-from-alpha-to-omega
#15
Marley W Watkins
OBJECTIVE: To demonstrate that Coefficient omega, a model-based estimate, is more a more appropriate index of reliability than coefficient alpha for the multidimensional scales that are commonly employed by neuropsychologists. METHOD: As an illustration, a structural model of an overarching general factor and four first-order factors for the WAIS-IV based on the standardization sample of 2200 participants was identified and omega coefficients were subsequently computed for WAIS-IV composite scores...
April 21, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28406393/is-medical-environment-detrimental-to-memory-a-test-of-a-white-coat-effect-on-older-people-s-memory-performance
#16
Morgane Schlemmer, Olivier Desrichard
OBJECTIVES: Test if older people's memory assessment may be impacted by a medical environment and if memory self-efficacy (MSE) will moderate this effect. METHODS: We evaluated memory performance and MSE in 27 older adults in two different settings: a (control) university research environment, or a (proxy-medical) neuropsychological examination environment. RESULTS: The results showed a MSE × environment interaction effect on story-recall performance, with older people with low MSE performing less well in the proxy-medical situation than in the control situation and with elders with high MSE performing better in the proxy-medical situation than in the control situation...
March 27, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28397546/measuring-cognitive-change-with-impact-the-aggregate-baseline-approach
#17
Jared M Bruce, Ruben J Echemendia, Willem Meeuwisse, Michael G Hutchison, Mark Aubry, Paul Comper
OBJECTIVE: The Immediate Post-Concussion Assessment and Cognitive Test (ImPACT) is commonly used to assess baseline and post-injury cognition among athletes in North America. Despite this, several studies have questioned the reliability of ImPACT when given at intervals employed in clinical practice. Poor test-retest reliability reduces test sensitivity to cognitive decline, increasing the likelihood that concussed athletes will be returned to play prematurely. We recently showed that the reliability of ImPACT can be increased when using a new composite structure and the aggregate of two baselines to predict subsequent performance...
April 11, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28391739/taxonomy-for-education-and-training-in-clinical-neuropsychology-past-present-and-future
#18
Scott A Sperling, Cynthia R Cimino, Nikki H Stricker, Amy K Heffelfinger, Jennifer L Gess, Katie E Osborn, Brad L Roper
OBJECTIVE: Historically, the clinical neuropsychology training community has not clearly or consistently defined education or training opportunities. The lack of consistency has limited students' and trainees' ability to accurately assess and compare the intensity of neuropsychology-specific training provided by programs. To address these issues and produce greater 'truth in advertising' across programs, CNS, with SCN's Education Advisory Committee (EAC), ADECN, AITCN, and APPCN constructed a specialty-specific taxonomy, namely, the Taxonomy for Education and Training in Clinical Neuropsychology...
April 10, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28364295/objective-assessment-of-visual-pursuit-in-patients-with-disorders-of-consciousness-an-exploratory-study
#19
Sarah Wannez, Thomas Hoyoux, Thomas Langohr, Olivier Bodart, Charlotte Martial, Jérôme Wertz, Camille Chatelle, Jacques G Verly, Steven Laureys
Visual pursuit is a key marker of residual consciousness in patients with disorders of consciousness (DOC). Currently, its assessment relies on subjective clinical decisions. In this study, we explore the variability of such clinical assessments, and present an easy-to-use device composed of cameras and video processing algorithms that could help the clinician to improve the detection of visual pursuit in a clinical context. Visual pursuit was assessed by an experienced research neuropsychologist on 31 patients with DOC and on 23 healthy subjects, while the device was used to simultaneously record videos of both one eye and the mirror...
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28361565/education-training-and-practice-among-nordic-neuropsychologists-results-from-a-professional-practices-survey
#20
A Norup, J Egeland, M Løvstad, T Nybo, B A Persson, D Rivera, A-K Schanke, S Sigurdardottir, J C Arango-Lasprilla
OBJECTIVE: To investigate sociodemographic characteristics, clinical and academic training, work setting and salary, clinical activities, and salary and job satisfaction among practicing neuropsychologists in four Nordic countries. METHODS: 890 neuropsychologists from Denmark, Finland, Norway, and Sweden participated in an internet-based survey between December 2013 and June 2015. RESULTS: Three-fourths (76%) of the participants were women, with a mean age of 47 years (range 24-79)...
March 31, 2017: Clinical Neuropsychologist
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