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Immunomodulatory agents

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https://www.readbyqxmd.com/read/29454096/jak-stat-inhibitors-and-other-small-molecule-cytokine-antagonists-for-the-treatment-of-allergic-disease
#1
REVIEW
Michael D Howell, Carolyn Fitzsimons, Paul Smith
OBJECTIVE: To provide an overview of janus kinase (JAK), chemoattractant receptor-homologous molecule expressed on T-helper 2 cells (CRTH2), and phosphodiesterase 4 (PDE4) inhibitors in allergic disorders. DATA SOURCES: PubMed literature review. STUDY SELECTIONS: Articles included in this review discuss the emerging mechanism of action of small molecule inhibitors and their utilization in atopic dermatitis (AD), asthma, and allergic rhinitis (AR)...
February 14, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29452665/novel-agents-for-relapsed-and-refractory-follicular-lymphoma
#2
REVIEW
Chan Yoon Cheah, Nathan H Fowler
Follicular lymphoma is one of the most common non-Hodgkin's lymphomas. Although current frontline regimens are associated with high response rates, most patients still relapse. When progression is discovered, re-establishing the diagnosis and ruling out transformation in paramount. The outcomes following relapse have been improving due to the activity and increasing availability of novel agents with various mechanisms of action. Despite these advances, single agent activity is limited and the disease remains incurable in the majority of cases...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29450683/common-adverse-effects-of-novel-therapies-for-multiple-myeloma-mm-and-their-management-strategies
#3
REVIEW
Kristen B McCullough, Miriam A Hobbs, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The purpose of this review was to evaluate management strategies for common adverse effects of novel therapies in multiple myeloma (MM), including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and a histone deacetylase inhibitor. RECENT FINDINGS: There are several adverse effects that occur across multiple classes of antimyeloma drugs, including rash, peripheral neuropathy, infusion reactions, and cardiotoxicity, but most can be managed without complete discontinuation of the agent or abandonment of the class...
February 15, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29446723/immunomodulatory-effects-of-flavonoids-in-the-prophylaxis-and-treatment-of-inflammatory-bowel-diseases-a-comprehensive-review
#4
Daniela Ribeiro, Carina Proenca, Silvia Rocha, Jose L F C Lima, Felix Carvalho, Eduarda Fernandes, Marisa Freitas
Inflammatory bowel diseases (IBD) comprise two disorders of idiopathic chronic intestinal inflammation that affect about three million people worldwide: Crohn's disease and ulcerative colitis. Nowadays, the first-line of treatment for patients with mild to moderate symptoms of IBD comprises corticosteroids, immunosuppressants, antibiotics, and biological agents. Unfortunately, none of these drugs are curative, and their long-term use may cause severe side effects and complications. Almost 40% of IBD patients use alternative therapies to complement the conventional one, and flavonoids are gaining attention for this purpose...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29442205/antibacterial-and-immunomodulatory-activities-of-bovine-lactoferrin-against-escherichia-coli-o157-h7-infections-in-cattle
#5
Evelien Kieckens, Joanna Rybarczyk, Eric Cox, Daisy Vanrompay
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E...
February 13, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29438046/pregnancy-decision-making-in-women-with-multiple-sclerosis-treated-with-natalizumab-i-fetal-risks
#6
Emilio Portaccio, Pietro Annovazzi, Angelo Ghezzi, Mauro Zaffaroni, Lucia Moiola, Vittorio Martinelli, Roberta Lanzillo, Vincenzo Brescia Morra, Francesca Rinaldi, Paolo Gallo, Carla Tortorella, Damiano Paolicelli, Carlo Pozzilli, Laura De Giglio, Paola Cavalla, Eleonora Cocco, Maria Giovanna Marrosu, Francesco Patti, Claudio Solaro, Paolo Bellantonio, Antonio Uccelli, Alice Laroni, Luisa Pastò, Marta Giannini, Maria Trojano, Giancarlo Comi, Maria Pia Amato
OBJECTIVE: To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), with a specific focus on spontaneous abortion (SA) and congenital anomalies (CA). METHODS: Data of all pregnancies occurring between 2009 and 2015 in patients with MS treated with natalizumab and referring to 19 participating sites were collected and compared with those of pregnancies in untreated patients and patients treated with injectable immunomodulatory agents...
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29438041/pregnancy-decision-making-in-women-with-multiple-sclerosis-treated-with-natalizumab-ii-maternal-risks
#7
Emilio Portaccio, Lucia Moiola, Vittorio Martinelli, Pietro Annovazzi, Angelo Ghezzi, Mauro Zaffaroni, Roberta Lanzillo, Vincenzo Brescia Morra, Francesca Rinaldi, Paolo Gallo, Carla Tortorella, Damiano Paolicelli, Carlo Pozzilli, Laura De Giglio, Paola Cavalla, Eleonora Cocco, Maria Giovanna Marrosu, Claudio Solaro, Antonio Uccelli, Alice Laroni, Luisa Pastò, Marta Giannini, Maria Trojano, Giancarlo Comi, Maria Pia Amato
OBJECTIVE: To assess the risk of disease reactivation during pregnancy after natalizumab suspension in women with multiple sclerosis (MS). METHODS: Data of all pregnancies occurring between 2009 and 2015 in patients with MS treated with natalizumab and referring to 19 participating sites were collected and compared with those of pregnancies in untreated patients and patients treated with injectable immunomodulatory agents through a 2-factor repeated measures analysis...
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29435979/ibrutinib-alone-or-with-dexamethasone-for-relapsed-or-relapsed-and-refractory-multiple-myeloma-phase-2-trial-results
#8
Paul G Richardson, William I Bensinger, Carol Ann Huff, Caitlin L Costello, Nikoletta Lendvai, Jesus G Berdeja, Larry D Anderson, David S Siegel, Daniel Lebovic, Sundar Jagannath, Jacob P Laubach, Keith E Stockerl-Goldstein, Long Kwei, Fong Clow, Laurence Elias, Zeena Salman, Thorsten Graef, Elizabeth Bilotti, Ravi Vij
Novel therapies with unique new targets are needed for patients who are relapsed/refractory to current treatments for multiple myeloma. Ibrutinib is a first-in-class, once-daily, oral covalent inhibitor of Bruton tyrosine kinase, which is overexpressed in the myeloma stem cell population. This study examined various doses of ibrutinib ± low-dose dexamethasone in patients who received ≥2 prior lines of therapy, including an immunomodulatory agent. Daily ibrutinib ± weekly dexamethasone 40 mg was assessed in 4 cohorts using a Simon 2-stage design...
February 13, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29435436/osteosarcoma-accelerating-progress-makes-for-a-hopeful-future
#9
REVIEW
Amanda J Saraf, Joelle M Fenger, Ryan D Roberts
Patients who develop osteosarcoma in 2017 receive treatment that remains essentially unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large, collaborative, multinational efforts to improve therapy have evaluated strategies leveraging both cytotoxic intensification and immunomodulatory agents. While these have confirmed our capacity to conduct such trials, results have proved largely disappointing. This has motivated efforts to focus on the basic biology of osteosarcoma, where understanding remains poor but has improved significantly...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29432557/epigenetic-modifiers-as-new-immunomodulatory-therapies-in-solid-tumours
#10
S Aspeslagh, D Morel, J-C Soria, S Postel-Vinay
Background: Immune therapies have revolutionized cancer treatment over the last few years by allowing improvements in overall survival. However, the majority of patients is still primary or secondary resistant to such therapies, and enhancing sensitivity to immune therapies is therefore crucial to improve patient outcome. Several recent lines of evidence suggest that epigenetic modifiers have intrinsic immunomodulatory properties, which could be of therapeutic interest. Material and Methods: We reviewed preclinical evidence and clinical studies which describe or exploit immunomodulatory properties of epigenetic agents...
February 7, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29429748/the-syndrome-of-tubulointerstitial-nephritis-with-uveitis-tinu
#11
REVIEW
David M Clive, Vijay K Vanguri
The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a multisystemic autoimmune disorder that may occur in response to various environmental triggers, including drugs and microbial pathogens. Evidence exists of HLA antigen-related genetic predisposition to developing TINU. The resulting inflammation affects chiefly the ocular uvea and renal tubules, although other organs may be involved. TINU is uncommon; only about 200 cases are on record since its original description 40 years ago, although it is possible that new ones are no longer being reported...
February 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29425646/immunomodulatory-hemolytic-and-cytotoxic-activity-potentials-of-triterpenoid-saponins-from-eight-cephalaria-species
#12
Nazli Boke Sarikahya, Ayse Nalbantsoy, Hilal Top, Ramazan Suleyman Gokturk, Huseyin Sumbul, Suheyla Kirmizigul
BACKGROUND: Saponins isolated from a number of plants possess a broad spectrum of biological and pharmacological activities by using in vitro and in vivo bioassays. The recent investigations and findings in biological activity studies of saponins have mostly focused on immunomodulatory, hemolytic and cytotoxic properties. HYPOTHESIS/PURPOSE: Considering the great potential of saponins as bioactive agents, we investigated the cytotoxic, hemolytic and immunomodulatory activities of nineteen triterpenoid saponins from the aerial parts of eight Cephalaria species from Turkey...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29422905/immunomodulatory-properties-of-carvone-inhalation-and-its-effects-on-contextual-fear-memory-in-mice
#13
Aritz Lasarte-Cia, Teresa Lozano, Marta Pérez-González, Marta Gorraiz, Kristina Iribarren, Sandra Hervás-Stubbs, Pablo Sarobe, Obdulia Rabal, Mar Cuadrado-Tejedor, Ana García-Osta, Noelia Casares, Juan José Lasarte
A complex network of interactions exists between the immune, the olfactory, and the central nervous system (CNS). Inhalation of different fragrances can affect immunological reactions in response to an antigen but also may have effects on the CNS and cognitive activity. We performed an exploratory study of the immunomodulatory ability of a series of compounds representing each of the 10 odor categories or clusters described previously. We evaluated the impact of each particular odor on the immune response after immunization with the model antigen ovalbumin in combination with the TLR3 agonist poly I:C...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29421304/%C3%AE-defensins-underestimated-peptides-in-influenza-combat
#14
REVIEW
Barbara Małgorzata Kalenik, Anna Góra-Sochacka, Agnieszka Sirko
Defensins are a family of host defense peptides present in vertebrates, invertebrates and plants. They display broad antimicrobial activity and immunomodulatory functions. Herein, the natural anti-influenzal role of β-defensins, as well as their potential usage as anti-influenza vaccine adjuvants and therapeutic agents, is reviewed. This article summarizes previously published information on β-defensin modes of action, expression changes after influenza infection and vaccination, biotechnological usage and possible boosting of their production by dietary supplementation...
January 29, 2018: Virus Research
https://www.readbyqxmd.com/read/29420336/lenalidomide-at-the-dose-of-25%C3%A2-mg-every-other-day-in-patients-affected-by-multiple-myeloma-and-renal-failure-a-real-life-experience
#15
Claudio Cerchione, Davide Nappi, Anna E Pareto, Alessandra Romano, Vincenzo Martinelli, Marco Picardi, Fabrizio Pane, Lucio Catalano
Renal impairment (RI) is a relevant complication of patients affected by multiple myeloma (MM); it can be present in up to 30-35% of newly diagnosed MM and is linked to a poor outcome. However, early recognition and early treatment with novel agents can overcome the negative impact of RI and even reverse kidney damage in most cases. Lenalidomide, available as an oral compound, is an immunomodulatory drug with both antiproliferative and immunomodulatory activity that is largely used in the management of MM. Dose reduction is mandatory in RI; however, there is no theoretical assumption against the possibility that protracting the time of full standard doses can be equally effective and tolerated by patients requiring reduced doses...
February 7, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29408515/andrographolide-a-diterpene-lactone-from-andrographis-paniculata-and-its-therapeutic-promises-in-cancer
#16
Muhammad Torequl Islam, Eunüs S Ali, Shaikh Jamal Uddin, Md Amirul Islam, Subrata Shaw, Ishaq N Khan, Seyed Soheil Saeedi Saravi, Saheem Ahmad, Shahnawaz Rehman, Vijai Kumar Gupta, Mihnea-Alexandru Găman, Amelia Maria Gaman, Santosh Yele, Asish Kumar Das, João Marcelo de Castro E Sousa, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S Mubarak, Nagendra Sastry Yarla, Jamil A Shilpi, Siddhartha Kumar Mishra, Atanas G Atanasov, Mohammad Amjad Kamal
The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiseptic, antimicrobial, cytotoxic, hypolipidemic, cardioprotective, hepatoprotective, and neuroprotective effects. In addition, it has been reported to play a therapeutic role in the treatment of major human diseases, such as Parkinson's disease, rheumatoid arthritis, and colitis. This systematic review aims to highlight andrographolide as a promising agent in cancer treatment...
February 2, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29396902/differentiation-of-mscs-from-human-ipscs-results-in-downregulation-of-c-myc-dna-replication-pathways-with-immunomodulation-toward-cd4-cd8-cells
#17
Li-Tzu Wang, Shih-Sheng Jiang, Chiao-Hsuan Ting, Pei-Ju Hsu, Chia-Chi Chang, Huey-Kang Sytwu, Ko-Jiunn Liu, B Linju Yen
Multilineage tissue-source mesenchymal stem cells (MSCs) possess strong immunomodulatory properties and are excellent therapeutic agents, but require constant isolation from donors to combat replicative senescence. The differentiation of human induced pluripotent stem cells (iPSCs) into MSCs offers a renewable source of MSCs; however, reports on their immunomodulatory capacity have been discrepant. Using MSCs differentiated from iPSCs reprogrammed using diverse cell types and protocols, and in comparison to human embryonic stem cell (ESC)-MSCs and bone marrow (BM)-MSCs, we performed transcriptome analyses and assessed for functional immunomodulatory properties...
February 3, 2018: Stem Cells
https://www.readbyqxmd.com/read/29395342/purification-characterization-and-immunomodulatory-activity-of-a-novel-polysaccharide-from-grifola-frondosa
#18
Qian Li, Fenmin Zhang, Guangying Chen, Yao Chen, Weijie Zhang, Guanghua Mao, Ting Zhao, Min Zhang, Liuqing Yang, Xiangyang Wu
A novel bioactive polysaccharide, GFP-22, was isolated from the fruit bodies of Grifola frondosa by anion-exchange and gel filtration chromatography. Structure of GFP-22 was investigated using gas chromatography-mass spectrometry (GC-MS), methylation, nuclear magnetic resonance (NMR), high-performance size exclusion chromatography-multi-angle laser light scattering-refractive index detector (HPSEC-MALLS-RI) and atomic force microscopy (AFM) analysis. The backbone of GFP-22 is composed of 1,4-β-d-Glcp, 1,3-β-d-Glcp, 1,6-α-d-Glcp, 1,6-α-d-Galp, 1,4,6-α-d-Manp and 1,3,6-α-d-Manp units...
January 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29394499/anti-inflammatory-therapies-in-myocardial-infarction-failures-hopes-and-challenges
#19
REVIEW
Shuaibo Huang, Nikolaos G Frangogiannis
In the infarcted heart, damage-associated molecular patterns released by necrotic cells trigger both myocardial and systemic inflammatory responses. Induction of chemokines and cytokines and upregulation of endothelial adhesion molecules mediate leukocyte recruitment in the infarcted myocardium. Inflammatory cells clear the infarct from dead cells and matrix debris and activate reparative myofibroblasts and vascular cells, but may also contribute to adverse fibrotic remodeling of viable segments, accentuate cardiomyocyte apoptosis and exert arrhythmogenic actions...
February 2, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29392559/probiotic-potential-of-novel-lactobacillus-strains-isolated-from-salted-fermented-shrimp-as-antagonists-for-vibrio-parahaemolyticus
#20
Bao Le, Seung Hwan Yang
Lactobacillus strains have been considered good candidates as biological control agents for prevention or treatment of plant and animal infections. One L. plantarum strain FB003 and three strains (FB011, FB081, and FB110) which closed to L. sakei were isolated from fermented and salted shrimp and their abilities in inhibiting growth of Vibrio parahaemolyticus were characterized. These strains were selected as potential probiotics based on their oro-gastro-intestinal resistance, gut colonization, adhesion to Caco-2 cells, antimicrobial activities, antibiotic resistance, and safety aspects...
February 2018: Journal of Microbiology / the Microbiological Society of Korea
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