keyword
MENU ▼
Read by QxMD icon Read
search

Ctxm

keyword
https://www.readbyqxmd.com/read/28947474/pharmacokinetics-pharmacodynamics-of-cb-618-in-combination-with-cefepime-ceftazidime-ceftolozane-and-meropenem-the-pharmacological-basis-for-a-stand-alone-%C3%AE-lactamase-inhibitor
#1
Paul G Ambrose, Brian D VanScoy, Michael Trang, Jennifer McCauley-Miller, Haley Conde, Sujata M Bhavnani, Dylan C Alexander, Lawrence V Friedrich
A major challenge in treating patients is the selection of the "right" antibiotic regimen. Given that the optimal β-lactam-β-lactamase inhibitor pair is dependent upon the spectrum of β-lactamase enzymes produced and the frequency of resistance to the β-lactamase inhibitor, it might be useful if a stand-alone were available for the clinician to pair with the "right" β-lactam rather than only in a fixed combination. In this communication, we describe a one-compartment in vitro infection model studies conducted to identify the magnitude of the pharmacokinetic-pharmacodynamic (PK-PD) index for a β-lactamase inhibitor, CB-618, that would restore the activity of four β-lactam partner agents (cefepime, ceftazidime, ceftolozane, and meropenem) with varying dose (1 or 2 g) and dosing intervals (8 or 12 h)...
September 25, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28887772/fortuitous-detection-of-cmy-2-and-dha-1-from-esbl-producing-escherichia-coli-in-senegal
#2
S Lo, F Robin, A Ba-Diallo, O F Diallo, M L Dia, R Beyrouthy, A Gaye-Diallo, A I Sow, R Bonnet
Cephalosporinases, which are naturally present in some enterobacterial species, can be mobilized by transposons, migrate to plasmids, and spread into other species such as Escherichia coli. The aim of this study was to characterize genes responsible for the production of extended-spectrum β-lactamases (ESBL) in E. coli isolates from urinary origin isolated in two hospitals in Senegal. Thus, a fortuitous discovery of plasmidic cephalosporinase in two isolates was noted. One of the isolates produced dha-1 associated with ESBL CTX-M-14, the other produced cmy-2, ESBL CTXM-15, tem-1 penicillinase, and oxa-1...
October 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28799786/p1220-ctxm-a-pkp048-related-incfiik-plasmid-carrying-bla-ctx-m-14-and-qnrb4
#3
Defu Zhang, Zhe Yin, Yuzong Zhao, Jiao Feng, Xiaoyuan Jiang, Zhe Zhan, Weili Wu, Weijun Chen, Jinglin Wang, Jianrong Li, Dongsheng Zhou
AIM: This study aimed to characterize plasmid-mediated antimicrobial resistance in clinical Klebsiella pneumoniae 1220 carrying bla CTX-M-14 and qnrB4. MATERIALS & METHODS: Plasmid p1220-CTXM was transformed from the 1220 isolate into Escherichia coli through conjugal transfer and then fully sequenced. Antimicrobial susceptibility was determined by VITEK. RESULTS: p1220-CTXM was an IncFIIK plasmid genetically closely related to pKP048 and carried resistance markers including bla CTX-M-14, bla DHA-1, qnrB4, sul1 and qacEΔ1, all of which were harbored in a 35...
August 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28674848/epidemiology-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-an-intensive-care-unit-with-no-single-rooms
#4
Xavier Repessé, Margaux Artiguenave, Sophie Paktoris-Papine, Florence Espinasse, Aurélien Dinh, Cyril Charron, Faten El Sayed, Guillaume Geri, Antoine Vieillard-Baron
BACKGROUND: The transmission of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBL) is prevented by additional contact precautions, mainly relying on isolation in a single room and hand hygiene. Contact isolation cannot be achieved in our 12-bed ICU, which has only double rooms. We report the epidemiology of ESBL imported, acquired and transmitted in an ICU with no single rooms. METHODS: We prospectively conducted an observational and non-interventional study in a French 12-bed ICU...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/27956216/distribution-of-ctx-m-group-i-and-group-iii-%C3%AE-lactamases-produced-by-escherichia-coli-and-klebsiella-pneumoniae-in-lahore-pakistan
#5
Samyyia Abrar, Ayesha Vajeeha, Noor Ul-Ain, Saba Riaz
Extended-spectrum-lactamases (ESBLs) of the CTX-M type is worrisome issue in many countries of the world from past decade. But little is known about CTX-M beta-lactamase producing bacteria in Pakistan. Therefore, this study was carried out to investigate the distribution of CTX-M beta-lactamase producing E. coli and Klebsiella pneumoniae using phenotypic and molecular techniques. A total of 638 E. coli and 338 Klebsiella pneumoniae were isolated from patients attending two hospitals and one diagnostic Centre in Pakistan during 2013-2015...
February 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27766094/the-first-report-of-a-fully-sequenced-resistance-plasmid-from-shigella-boydii
#6
Li Wang, Lei Liu, Dong Liu, Zhe Yin, Jiao Feng, Defu Zhang, Haihong Fang, Yefeng Qiu, Weijun Chen, Ruisheng Yang, Jinglin Wang, Yunzhi Fa, Dongsheng Zhou
The purpose of this study was to characterize mechanisms of plasmid-mediated antimicrobial resistance in Shigella boydii. S. boydii strain 2246 with resistance to ciprofloxacin, ceftriaxone and azithromycin was isolated from a human case of watery diarrhea in a Chinese public hospital. Resistance in strain 2246 to ceftriaxone and azithromycin was attributable to the presence of blaCTX-M-14, and erm(B) and mph(A), respectively, which were co-located on a multidrug-resistant (MDR) plasmid p2246-CTXM. p2246-CTXM represented a novel IncFII-type MDR plasmid with a very complex chimera structure...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27166036/virulence-factor-profiles-phylogenetic-background-and-antimicrobial-resistance-pattern-of-lactose-fermenting-and-nonlactose-fermenting-escherichia-coli-from-extraintestinal-sources
#7
Arindam Chakraborty, Prabha Adhikari, Shalini Shenoy, Vishwas Saralaya
CONTEXT: In recent years, nonlactose fermenting (NLF) Escherichia coli have been increasingly isolated in the microbiology laboratory, but their clinical significance has not yet been clearly elucidated. AIMS: To characterize the lactose fermenting (LF) and NLF isolates on the basis of their virulence factors, phylogenetic background, and drug resistance property. SETTINGS AND DESIGN: This descriptive study was carried out in a multi-specialty tertiary care hospital...
April 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/26441926/assessment-of-combination-therapy-in-balb-c-mice-injected-with-carbapenem-resistant-enterobacteriaceae-strains
#8
Noor A Salloum, Kohar Annie B Kissoyan, Sukayna Fadlallah, Katia Cheaito, George F Araj, Rima Wakim, Souha Kanj, Zeina Kanafani, Ghassan Dbaibo, Ghassan M Matar
Monotherapeutic options for carbapenem resistant infections are limited. Studies suggest that combination therapy may be associated with better outcomes than monotherapies. However, this is still controversial. This study assessed, the efficacy of combination therapy against carbapenem resistant Enterobacteriaceae harboring singly various extended spectrum beta lactamase or carbapenemase encoding genes. Thus, four isolates harboring either bla CTXM-15, bla CTXM-15 and bla OXA-48, bla NDM-1, or bla KPC-2 genes were selected for testing...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26347725/complete-sequences-of-kpc-2-encoding-plasmid-p628-kpc-and-ctx-m-55-encoding-p628-ctxm-coexisted-in-klebsiella-pneumoniae
#9
Li Wang, Haihong Fang, Jiao Feng, Zhe Yin, Xiaofang Xie, Xueming Zhu, Jie Wang, Weijun Chen, Ruisheng Yang, Hong Du, Dongsheng Zhou
A carbapenem-resistant Klebsiella pneumoniae strain 628 was isolated from a human case of intracranial infection in a Chinese teaching hospital. Strain 628 produces KPC-2 and CTX-M-55 encoded by two different conjugative plasmids, i.e., the IncFIIK plasmid p628-KPC and the IncI1 plasmid p628-CTXM respectively. bla KPC-2 is captured by a Tn1722-based unit transposon with a linear structure. ΔTn3-ISKpn27-bla KPC-2-ΔISKpn6-ΔTn1722 and this transposon together with a mercury resistance (mer) gene locus constitutes a 34 kb acquired drug-resistance region...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/25625458/microbial-interaction-between-a-ctxm-15-producing-escherichia-coli-and-a-susceptible-pseudomonas-aeruginosa-isolated-from-bronchoalveolar-lavage-influence-of-cefotaxime-in-the-dual-species-biofilm-formation
#10
Lucinda J Bessa, Ângelo Mendes, Rita Gomes, Sara Curvelo, Sara Cravo, Emília Sousa, Vitor Vasconcelos, Paulo Martins da Costa
Two isolates, Escherichia coli ella00 and Pseudomonas aeruginosa ella01, obtained from bronchoalveolar lavage, were found to be closely associated in clusters in agar medium. Escherichia coli ella00 was multidrug resistant and CTXM-15 extended-spectrum β-lactamase producer, while P. aeruginosa ella01 was susceptible to all antimicrobials tested. These observations impelled for further studies aimed to understand their microbial interaction. The P. aeruginosa ella01 biofilm-forming capacity was reduced and not affected when it was co-cultured with E...
June 2015: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/25405884/plasmid-encoding-extended-spectrum-%C3%AE-lactamase-ctx-m-55-in-a-clinical-shigella-sonnei-strain-china
#11
Fen Qu, Zhe Ying, Chuanling Zhang, Zhenhong Chen, Suming Chen, Enbo Cui, Chunmei Bao, Huiying Yang, Jie Wang, Changting Liu, Yuanli Mao, Dongsheng Zhou
AIMS: To characterize a clinical Shigella sonnei strain harboring a conjugatable blaCTX-M-55-borne plasmid. MATERIALS & METHODS: S. sonnei strain #1081 was isolated from a dysentery patient in China. A CTX-M-55-encoding plasmid harbored in this strain was transformed to Escherichia coli, and then its complete nucleotide sequence was determined by next generation sequencing. The MIC values of bacterial strains were tested by using Vitec(®) 2 (Biomerieux, Marcy l'Etoile, France)...
2014: Future Microbiology
https://www.readbyqxmd.com/read/25154369/molecular-insight-of-putative-pathogenicity-markers-with-esbl-genes-and-lipopolysaccharide-in-laribacter-hongkongensis
#12
Krishna M Raja, Asit Ranjan Ghosh
Laribacter hongkongensis is an emerging bacterial pathogen causing gastroenteritis and traveller's diarrhoea. However, pathogenicity of L. hongkongensis has not yet been properly understood. We therefore, investigated putative pathogenicity markers like elt, est, stx1, stx2, eae, eaf, EAgg, bfpA, Int I, Int II, Int III and cnf respectively in strains received from Queen Mary Hospital, Hong Kong University. Above genes were commonly found among pathogenic member genera of Enterobacteriaceae-causing diarrhoea...
November 2014: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/24871975/diversity-of-extended-spectrum-and-plasmid-mediated-ampc-%C3%AE-lactamases-in-enterobacteriaceae-isolates-from-portuguese-health-care-facilities
#13
Daniela Jones-Dias, Vera Manageiro, Eugénia Ferreira, Deolinda Louro, Manuela Caniça
A group of 124 Enterobacteriaceae isolates resistant to third generation cephalosporins, and collected in distinct health care facilities of different Portuguese regions was analysed. The great majority of the isolates were also resistant to fourth generation cephalosporins (83.9%), monobactam (96%), amoxicillin plus clavulanic acid (85.5%), and piperacillin plus tazobactam (66.9%). Overall, 84.7% (105/124) were multidrug resistant. Molecular methods enabled us to identify 86.3% (107/124) extended-spectrum β-lactamases (ESBL) producers, revealing a diversity of class A β-lactamases from different families, like TEM (TEM-1, TEM-10, TEM-24, and TEM-52), SHV (SHV-1, SHV-12, and SHV-28), CTX-M (CTX-M-1, CTX-M-9, CTX-M-14, CTX-M-15, and CTXM-32), and GES (GES-1)...
June 2014: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/24256887/salmonella-enterica-serotype-paratyphi-a-carrying-ctx-m-15-type-extended-spectrum-beta-lactamase-isolated-from-a-japanese-traveller-returning-from-india-japan-july-2013
#14
M Mawatari, Y Kato, K Hayakawa, M Morita, K Yamada, K Mezaki, T Kobayashi, Y Fujiya, S Kutsuna, N Takeshita, S Kanagawa, M Ohnishi, H Izumiya, N Ohmagari
Emerging drug resistance in Salmonella Typhi and S. Paratyphi is a substantial public health concern. We report what appears to be the first case and isolation of multidrug resistant S. Paratyphi A carrying CTXM-15-type extended-spectrum beta-lactamase from a Japanese traveller returning from India.
2013: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/23593461/first-identification-of-novel-ndm-carbapenemase-ndm-7-in-escherichia-coli-in-france
#15
Gaelle Cuzon, Rémy A Bonnin, Patrice Nordmann
BACKGROUND: The NDM-1 carbapenemase has been identified in 2008 in Enterobacteriaceae. Since then, several reports have emphasized its rapid dissemination throughout the world. The spread of NDM carbapenemases involve several bla NDM gene variants associated with various plasmids among several Gram negative species. METHODOLOGY: A multidrug-resistant E. coli isolate recovered from urine of a patient who had travelled to Burma has been characterized genetically and biochemically...
2013: PloS One
https://www.readbyqxmd.com/read/22992193/occurrence-of-imp-8-imp-10-and-imp-13-metallo-%C3%AE-lactamases-located-on-class-1-integrons-and-other-extended-spectrum-%C3%AE-lactamases-in-bacterial-isolates-from-tunisian-rivers
#16
Chedly Chouchani, Rim Marrakchi, Isabel Henriques, António Correia
BACKGROUND: Antibiotic-resistant bacteria have been surveyed widely in water bodies, but few studies have determined the diversity of antibiotic-resistant bacteria in river waters. This study was undertaken to investigate the origin of resistance among polluted river bacterial isolates in Tunisia. METHODS: In this study 128 isolates resistant to β-lactam antibiotics were obtained from 2 polluted rivers in the north of Tunisia. Isolates were identified using Phoenix phenotyping criteria...
February 2013: Scandinavian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/22768702/ctx-m-15-extended-spectrum-beta-lactamases-in-enterobacteriaceae-in-the-intensive-care-unit-of-tlemcen-hospital-algeria
#17
Z Baba Ahmed, A Ayad, E Mesli, Y Messai, R Bakour, M Drissi
The aim of this study was to detect extended-spectrum beta-lactamases (ESBL) in Enterobacteriaceae isolates in the intensive care unit (ICU) of Tlemcen hospital in north-western Algeria. Antimicrobial susceptibility testing, molecular typing, characterization of ESBL-encoding genes and the genetic environment, conjugation experiments and plasmid analysis were carried out. In all, 28 Enterobacteriaceae isolates were isolated from specimens recovered from patients in the ICU and 2 from surfaces of the unit. Of these, 11 isolates (4 Escherichia coli, 5 Klebsiella pneumoniae and 2 Enterobacter cloacae) produced ESBL of the CT-X-M-15 type...
April 2012: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/22118027/high-prevalence-of-blactx-m-in-enterobacteriaceae-isolates-from-the-kingdom-of-bahrain
#18
Khalid M Bindayna, Mariam Murtadha
OBJECTIVE: To determine the molecular epidemiology of extended-spectrum β-lactamase (ESBL) by testing a cohort of clinical ESBL-producing bacterial isolates that were isolated in the Kingdom of Bahrain. METHODS: ESBL producing Enterobacteriaceae isolates (based on phenotypic tests) were collected from Microbiology Laboratory of the Salmaniya Medical Complex, Bahrain between January-June 2006. Antibiotic susceptibility to a panel of antibiotics was performed and bla(CTX-M) genes were detected by multiplex PCR...
December 2011: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/21894469/update-in-adult-urinary-tract-infection
#19
Lindsay E Nicolle
Urinary tract infection remains a common problem for many populations. Recent studies have expanded our understanding of the host innate immune response and its role in the familial association observed for recurrent uncomplicated urinary tract infection in healthy women. Therapeutic management for uncomplicated infection has been compromised by increasing antimicrobial resistance, particularly global dissemination of the CTXM-15 extended spectrum β-lactamase (ESBL) producing Escherichia coli ST-131 strain...
December 2011: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/21123154/detection-of-unrelated-escherichia-coli-strains-harboring-genes-of-ctx-m-15-oxa-1-and-aac-6-ib-cr-enzymes-in-a-tunisian-hospital-and-characterization-of-their-integrons-and-virulence-factors
#20
A Jouini, K Ben Slama, L Vinué, E Ruiz, Y Saenz, S Somalo, N Klibi, M Zarazaga, M Ben Moussa, A Boudabous, C Torres
Beta-lactamase characterization was carried out in a collection of 18 extended-spectrum beta-lactamase (ESBL)-positive Escherichia coli isolates from blood (n=8) and urine (n=10) obtained in 2007 in a tunisian Hospital. All isolates were clonally unrelated according to PFGE analysis. Seventeen strains presented the bla(CTX-M-)₁₅ gene associated with bla (OXA-)₁ and four of these strains with the (TEM-)₁(b) gene. The remaining ESBL-positive strain contained the bla (CTX-M-)₉ gene associated with the bla (OXA-)₁ and bla (TEM-)₁(b) genes...
October 2010: Journal of Chemotherapy
keyword
keyword
82402
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"