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JOURNAL ARTICLE
Min Kyoung Kang, Dongwhane Lee, Mi Sun Oh, Ji-Sung Lee, Han-Yeong Jeong, Jung Hwan Shin, Byung-Woo Yoon, Jong-Moo Park
AIM: While the relationship between impaired kidney function and non-vitamin K antagonist oral anticoagulants (NOACs) is well established, there is limited research exploring the association between an elevated estimated glomerular filtration rate (eGFR) and the efficacy of NOACs, especially concerning the outcomes of acute ischemic stroke (AIS). This study aimed to examine the association between higher-than-normal eGFR and the severity of AIS during the use of NOACs using a nationwide multicenter stroke registry in Korea...
2023: Frontiers in Neurology
#22
JOURNAL ARTICLE
Shantanu Sapru, Nilotpal Choudhary, Abhilash Chandra, Rimpa Mudi, Rahul Tripathi, Satyawati Deswal
The glomerular filtration rate (GFR) is important for assessing renal function and must be calculated reliably and reproducibly. This study aimed to compare the reliability and accuracy of GFR estimated with 99m-technetium diethylene-triamine-pentaacetate (99mTc-DTPA) versus that calculated from the effective renal plasma flow (ERPF) (GFR is 20% of ERPF) determined by the 99m-technetium ethylene dicysteine (99mTc-EC) technique. Forty-five patients suffering from cancer requiring platinum compound-based chemotherapy or from chronic renal failure were recruited...
January 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
#23
JOURNAL ARTICLE
Wagner Luis da Cruz Almeida, Sandhi Maria Barreto, Pedro Guatimosim Vidigal, José Geraldo Mill
OBJECTIVE: To evaluate accuracy and agreement between creatinine clearance (CrCl) measured in 12-h urine and glomerular filtration rate (GFR) calculated by the Modification of Diet in Renal Disease (MDRD-4) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas, with and without adjustment for race/color. METHODS: Baseline data from the Longitudinal Study of Adult Health (ELSA-Brazil) in adults (35-74 years of age) of both genders were used...
2023: Brazilian Journal of Epidemiology
#24
JOURNAL ARTICLE
I-Wen Lee, Hung-Jen Wang, Hui-Ying Liu, Yin-Lun Chang, Yen-Tin Wu, Yen Ta Chen, Yuan Tso Cheng, Chih Hsiung Kang, Yao Chi Chuang, Hao-Lun Luo
OBJECTIVE: This study aimed to assess the impact of preoperative chronic kidney disease (CKD) on the oncological outcomes of patients with upper tract urothelial carcinoma (UTUC) who underwent standard radical nephroureterectomy (RNU). METHODS: A total of 1172 UTUC patients who received RNU at a single center in Taiwan between February 2005 and August 2019 were included. The patients were categorized into two groups based on their preoperative CKD stage: CKD stage ≤3 (811 patients) and CKD stage >3 (361 patients)...
December 2, 2023: Journal of the Formosan Medical Association
#25
JOURNAL ARTICLE
Remi Beunders, Leslie J Donato, Roger van Groenendael, Birte Arlt, Cristiane Carvalho-Wodarz, Janin Schulte, Anton Cc Coolen, John C Lieske, Jeffrey W Meeusen, Allan S Jaffe, Peter Pickkers
INTRODUCTION: In clinical practice, kidney (dys)function is monitored through creatinine-based estimations of glomerular filtration rate (eGFR: Modification of Diet in Renal Disease [MDRD], Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]). Creatinine is recognized as a late and insensitive biomarker of glomerular filtration rate (GFR). The novel biomarker proenkephalin (PENK) may overcome these limitations, but no PENK-based equation for eGFR is currently available. Therefore, we developed and validated a PENK-based equation to assess GFR...
November 2023: KI Reports
#26
JOURNAL ARTICLE
Firouzeh Moeinzadeh, Mohammad Hossein Rouhani, Shiva Seirafian, Sahar Vahdat, Mojgan Mortazavi, Cain C T Clark, Farnaz Shahdadian
Previous surveys suggests that body mass index (BMI) may be positively related to development of chronic kidney disease (CKD). However, this association might be altered by metabolic syndrome. Therefore, we aimed to evaluate the association of metabolic health status with CKD. The present cross-sectional study was carried out on 3322 representative sample of Iranian adults. Metabolic syndrome was identified based on the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) and BMI was assessed by anthropometric measurements...
November 27, 2023: Scientific Reports
#27
JOURNAL ARTICLE
Jeffrey S Forsse, Kathleen A Richardson, Ricardo Torres, Catherine Lowry, James Kyle Taylor, Cassidy L Beeson, Jacob Ward, Anurag Dhillon, Brock Niceler, Ahmed Ismaeel, Panagiotis Koutakis
Aerobic exercise, specifically high-intensity interval exercise (HIIE), and its effects on renal health and filtration (RHF) are not well understood. Several studies support incorporating contemporary biomarkers serum cystatin C (CyC) and urine epidermal growth factor (uEGF) to combat the volatility of serum creatinine (sCr). Using these biomarkers, we examined the acute influences HIIE has on RHF to determine if there is a ceiling effect in healthy populations. The purpose was to determine the influence of an acute bout of HIIE on RHF...
October 30, 2023: Sports
#28
JOURNAL ARTICLE
Yogesh M, Anjali K Dave, Shubham S Patel, Ram Parbat, Viral Shah, Rohankumar Gandhi
Background Sarcopenia, a syndrome characterized by a progressive decline in skeletal muscle mass, strength, and function, is frequently associated with chronic diseases such as chronic obstructive pulmonary disease (COPD). Chronic kidney disease (CKD) is a prevalent condition among patients with sarcopenia. Reports suggest that between 15% and 55% of stable COPD patients have sarcopenia. Therefore, the present study aims to determine the association between sarcopenia and chronic renal failure (overt and concealed) in COPD patients...
October 2023: Curēus
#29
JOURNAL ARTICLE
Francesco Cilla, Ilaria Sabione, Menno Pruijm, Marc Humbert, Patrizia D'Amelio
An accurate assessment of renal function is crucial for the diagnosis and follow up of kidney diseases. However, there is currently no clear consensus on the optimal method on how to measure renal function in older individuals (>65 years of age). The Cockcroft-Gault formula, the MDRD equation, and the CKD-EPI equation are among the most used equations. However, they have several limitations when applied to the older population. Other formulas specifically developed for the older, such as the Berlin Initiative Study (BIS) and the Full Age Spectrum (FAS) equation, demonstrated conflicting results and require more external validation...
November 1, 2023: Revue Médicale Suisse
#30
JOURNAL ARTICLE
Anna Olasińska-Wiśniewska, Tomasz Urbanowicz, Kajetan Grodecki, Piotr Kübler, Bartłomiej Perek, Marek Grygier, Marcin Misterski, Maciej Walczak, Mateusz Szot, Marek Jemielity
PURPOSE: The normal healthy valve is devoid of inflammatory cells, however background of aortic stenosis (AS) may include inflammatory processes. Moreover, the link between hyperparathyroidism and heart failure is postulated. Simple whole blood analysis with indices is a beneficial tool in cardiovascular diseases' assessment. The purpose of the study was to evaluate correlation between parathyroid hormone (PTH) and simple blood parameters in severe AS. MATERIAL AND METHODS: The study included 62 patients with severe AS...
October 12, 2023: Advances in Medical Sciences
#31
JOURNAL ARTICLE
Amir Kamel Rahimi, Moji Ghadimi, Anton H van der Vegt, Oliver J Canfell, Jason D Pole, Clair Sullivan, Sally Shrapnel
BACKGROUND: There are many Machine Learning (ML) models which predict acute kidney injury (AKI) for hospitalised patients. While a primary goal of these models is to support clinical decision-making, the adoption of inconsistent methods of estimating baseline serum creatinine (sCr) may result in a poor understanding of these models' effectiveness in clinical practice. Until now, the performance of such models with different baselines has not been compared on a single dataset. Additionally, AKI prediction models are known to have a high rate of false positive (FP) events regardless of baseline methods...
October 9, 2023: BMC Medical Informatics and Decision Making
#32
JOURNAL ARTICLE
Kubilay Sarikaya, Cengizhan Ayik, Serkan Akpinar, Fatih Celik, Sema Ayvaz
Purpose In this study, we aimed to demonstrate whether retrograde intrarenal stone surgery (RIRS) performed due to renal stones during the childhood period has any detrimental impact on renal functions. Materials and methods We retrospectively analyzed 121 patients aged 2 to 16 years who underwent RIRS for renal stones between March 2018 and February 2023. Data were available for 41 patients. The estimated glomerular filtration rate (eGFR) was computed using the modification of diet in renal disease (MDRD) formula on the day preceding the surgery and the third month after the surgery...
October 2023: Curēus
#33
JOURNAL ARTICLE
Ting Yu Lu, Wei Sen Zhang, Tong Zhu, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Tai Hing Lam, Kar Keung Cheng, Lin Xu
OBJECTIVE: To examine the associations of red meat, poultry, fish and seafood and processed meat consumption with kidney function in middle-aged to older Chinese. DESIGN: A cross-sectional study based on the Guangzhou Biobank Cohort Study. SETTING: Community-based sample. PARTICIPANTS: 9768 participants (2743 men and 7025 women) aged 50+ years. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome was estimated glomerular filtration rate (eGFR) derived from the Chinese-specific equation based on the Modification of Diet in Renal Disease (MDRD) equation (c-aGFR)...
October 6, 2023: BMJ Open
#34
JOURNAL ARTICLE
Piergiuseppe Agostoni, Francesca Romana Pluchinotta, Elisabetta Salvioni, Massimo Mapelli, Arianna Galotta, Alice Bonomi, Damiano Magrì, Enrico Perna, Stefania Paolillo, Ugo Corrà, Rosa Raimondo, Rocco Lagioia, Roberto Badagliacca, Pasquale Perrone Filardi, Anna Apostolo, Michele Senni, Annamaria Iorio, Michele Correale, Jeness Campodonico, Pietro Palermo, Mariantonietta Cicoira, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Mauro Contini, Beatrice Pezzuto, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Cosimo Carriere, Marco Cittar, Maria Vittoria Matassini, Andrea Salzano, Antonio Cittadini, Marco Masè, Francesco Bandera, Maurizio Bussotti, Irene Mattavelli, Federica Re, Carlo Vignati, Carlo Lombardi, Angela B Scardovi, Susanna Sciomer, Andrea Passantino, Michele Emdin, Andrea Di Lenarda, Claudio Passino, Caterina Santolamazza, Federica Moscucci, Denise Zaffalon, Massimo Piepoli
AIMS: Improvement of left ventricular ejection fraction is a major goal of heart failure (HF) treatment. However, data on clinical characteristics, exercise performance and prognosis in HF patients who improved ejection fraction (HFimpEF) are scarce. The study aimed to determine whether HFimpEF patients have a distinct clinical phenotype, biology and prognosis than HF patients with persistently reduced ejection fraction (pHFrEF). METHODS AND RESULTS: A total of 7948 patients enrolled in the Metabolic Exercise Cardiac Kidney Indexes (MECKI) score database were evaluated (median follow-up of 1490 days)...
November 2023: European Journal of Heart Failure
#35
JOURNAL ARTICLE
Alma Osmic-Husni, Fatima Hukic, Mirna Popovic Saric
BACKGROUND: Correct measuring of blood and urine creatinine level is necessary for identification and tracking of chronic kidney disease (CKD). OBJECTIVE: The aim of this study is a comparison of Jaffe and enzymatic methods for measuring creatinine in serum and in urine, in order to determine whether there are any statistical significant differences between them, and whether they are reflected on creatinine clearance calculation and estimated glomerular filtration rate (eGFR)...
2023: Materia Socio-medica
#36
JOURNAL ARTICLE
Pei-Chen Wu, Kuo-Tzu Sung, Jiun-Lu Lin, Ta-Chuan Hung, Yau-Huei Lai, Cheng-Huang Su, Hung-I Yeh, Chih-Jen Wu, Chung-Lieh Hung
BACKGROUND: Few studies have addressed early-stage kidney disease and preclinical cardiac structural and functional abnormalities from a large-scale Asian population. Further, the extent to which measures of myocardial function and whether these associations may vary by testing various formulas of renal insufficiency remains largely unexplored. OBJECTIVE: To explore the associations among renal function, proteinuria, and left ventricular (LV) structural and diastolic functional alterations...
2023: Front Nephrol
#37
JOURNAL ARTICLE
Ranjit Singh, Majibullah Ansari, Namrata Rao, Abhilash Chandra, Shashwat Verma, Prabhaker Mishra, Ayush Lohiya
PURPOSE: Serum creatinine-based glomerular filtration rate (GFR) estimating equations are imprecise and systemic overestimate GFR in chronic kidney disease (CKD) populations with low muscle mass. Bioimpedance devices can measure body cell mass (BCM), a surrogate for muscle mass which has been included in a published GFR estimating equation. This BCM GFR equation is validated and compared with MDRD and CKD-EPI 2021 equations in an Indian CKD population. METHODS: Patients with stable CKD stages 1-5 and voluntary kidney donors underwent measurement of serum creatinine, DTPA GFR and bioimpedance on the same day...
August 31, 2023: International Urology and Nephrology
#38
JOURNAL ARTICLE
John O Obasuyi, Mathias A Emokpae
There is an indication of abrupt rise in chronic kidney disease (CKD) in Nigeria and thyroid function involvement has not been sufficiently evaluated. This study determined thyroid gland function among subjects with CKD in Benin City, Nigeria. A total of 184 randomized CKD patients attending specialist clinic and 80 healthy control subjects were recruited for this study. A well-structured questionnaire was used to obtain data on socio-demography. Blood specimens were collected and used for the determination of thyroid function parameters; thyroid stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (fT3), thyroxine (T4), free thyroxine (fT4), thyroid peroxidase antibody (TPO-Abs), thyroid globulin antibody (Tg-Abs) and Deiodinase enzyme Type 1 (D1)...
August 9, 2023: Medicines (Basel, Switzerland)
#39
JOURNAL ARTICLE
Jin Ho Hwang, Sohee Oh, Ho Jun Chin, Sejoong Kim, Dong Ki Kim, Suhnggwon Kim, Jung Hwan Park, Sung Joon Shin, Sang-Ho Lee, Bum Soon Choi, Chun Soo Lim
OBJECTIVE: There are several equations for estimating the glomerular filtration rate (GFR), and each method has its limitations. We compared various estimated GFR (eGFR) equations with 24 hours urine creatinine clearance (24u-CCr). DESIGN: Sample analysis of randomised controlled trial participants. SETTING AND PARTICIPANTS: We compared the mean 24u-CCr values measured 2-3 times for 211 patients with eGFR values calculated using the following equations: isotope dilution mass spectrometry-Modification of Diet in Renal Disease (IDMS-MDRD) equation, Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, equations for Koreans (KOR-IDMS-MDRD and KOR-CKD-EPI) and full age spectrum equation...
August 23, 2023: BMJ Open
#40
RANDOMIZED CONTROLLED TRIAL
Norberto Perico, Giuseppe Remuzzi, Matthew D Griffin, Paul Cockwell, Alexander P Maxwell, Federica Casiraghi, Nadia Rubis, Tobia Peracchi, Alessandro Villa, Marta Todeschini, Fabiola Carrara, Bernadette A Magee, Piero L Ruggenenti, Stefano Rota, Laura Cappelletti, Veronica McInerney, Tomás P Griffin, Md Nahidul Islam, Martino Introna, Olga Pedrini, Josée Golay, Andrew A Finnerty, Jon Smythe, Willem E Fibbe, Stephen J Elliman, Timothy O'Brien
SIGNIFICANCE STATEMENT: Mesenchymal stromal cells (MSCs) may offer a novel therapy for diabetic kidney disease (DKD), although clinical translation of this approach has been limited. The authors present findings from the first, lowest dose cohort of 16 adults with type 2 diabetes and progressive DKD participating in a randomized, placebo-controlled, dose-escalation phase 1b/2a trial of next-generation bone marrow-derived, anti-CD362 antibody-selected allogeneic MSCs (ORBCEL-M). A single intravenous (iv) infusion of 80×10 6 cells was safe and well-tolerated, with one quickly resolved infusion reaction in the placebo group and no subsequent treatment-related serious adverse events (SAEs)...
October 1, 2023: Journal of the American Society of Nephrology: JASN
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