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https://www.readbyqxmd.com/read/29677075/measured-glomerular-filtration-rate-after-kidney-donation-no-evidence-of-accelerated-decay
#1
Danielle M Berglund, Lei Zhang, Arthur J Matas, Hassan N Ibrahim
BACKGROUND: The rate of measured GFR change in kidney donors years after donation has not been adequately addressed. Whether this change is accelerated in the setting of 1 kidney is also understudied. METHODS: 214 randomly selected donors underwent serial GFR measurements of nonradioactive iohexol. eGFR at each visit was calculated using the CKD EPI and MDRD study equations. RESULTS: GFR visits were 4.8 ±1.3 years apart and the second occurring 16...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29670671/the-association-between-glomerular-filtration-rate-estimated-using-different-equations-and-mortality-in-the-japanese-community-based-population-the-yamagata-takahata-study
#2
Asami Kabasawa, Tsuneo Konta, Natsuko Suzuki, Keita Kamei, Sayumi Watanabe, Akira Araumi, Eri Matsuki, Soichiro Kon, Midori Oyama, Kazunobu Ichikawa, Kenichi Ishizawa, Yoshiyuki Ueno, Hidetoshi Yamashita, Takamasa Kayama, Isao Kubota
Background: To evaluate renal function, the indices of estimated glomerular filtration rate (eGFR) obtained using several equations, including the Japanese versions of the serum creatinine-based MDRD equation (eGFRcreat), Chronic Kidney Disease Epidemiology Collaboration equation (eGFR-EPI), and serum cystatin C-based equation (eGFRcys), are utilized. This study prospectively examined the association between these eGFR values and all-cause mortality during a 12-year observational period in a community-based population...
2018: Disease Markers
https://www.readbyqxmd.com/read/29661746/effects-of-oral-vitamin-d-3-supplementation-in-stage-3-chronic-kidney-disease-subjects-insulin-resistance-syndrome-and-hormonal-disturb-interactions
#3
Amina Tahar, Faiza Zerdoumi, Messaoud Saidani, Lakhdar Griene, Elhadj-Ahmed Koceir
The 1-25-hydroxyvitamine D (1-25OHD) or calcitriol deficiency in chronic kidney disease (CKD) patients was associated with increases vascular calcification risk, nephrons reduction, bone deficit and cardiovascular mortality by atherosclerosis. The objective of this study was to investigate the pleiotropic effects of 200.000 IU (D200 group) every 3 months versus 30.000 IU (D30 group) every month dose vitamin D supplementation in stage 3 CKD patients. A cohort of 132 adult subjects was randomized into 2 groups according to dose vitamin D supplementation in deficient subjects (25OHD <50 nmol/L or <20 ng/mL)...
April 16, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29660234/evaluation-of-chronic-kidney-disease-in-cancer-patients-is-there-a-preferred-estimation-formula
#4
Ghassan Sleilalty, Elie El Rassy, Tarek Assi, Nathalie Al Rassy, Jessica Naseh, Jamale Rizkallah, Serge Finianos, Hiba Azar, Dania Nehme Chelala, Fadi El Karak, Joseph Kattan, Marwan Ghosn
BACKGROUND: The evaluation of chronic kidney disease in cancer patients seems to rely mostly on the Cockcroft-Gault (CG) formula or the creatinine levels to adjust treatment dosages which is a practice refuted by internists. AIMS: We evaluate the overall agreement of the CG, MDRD and CKD-EPI equation with the newly devised Janowitz and Williams' (JW) equation. METHODS: The renal function was estimated in 235 cancer patients according to the CG, MDRD, body surface area (BSA)-adjusted MDRD, CKD-EPI, BSA-adjusted CKD-EPI and JW formulae...
April 16, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29659605/chronic-kidney-disease-in-the-global-adult-hiv-infected-population-a-systematic-review-and-meta-analysis
#5
Udeme E Ekrikpo, Andre P Kengne, Aminu K Bello, Emmanuel E Effa, Jean Jacques Noubiap, Babatunde L Salako, Brian L Rayner, Giuseppe Remuzzi, Ikechi G Okpechi
INTRODUCTION: The widespread use of antiretroviral therapies (ART) has increased life expectancy in HIV patients, predisposing them to chronic non-communicable diseases including Chronic Kidney Disease (CKD). We performed a systematic review and meta-analysis (PROSPERO registration number CRD42016036246) to determine the global and regional prevalence of CKD in HIV patients. METHODS: We searched PubMed, Web of Science, EBSCO and AJOL for articles published between January 1982 and May 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29655951/acef-score-adapted-to-st-elevation-myocardial-infarction-patients-the-acef-stemi-score
#6
Martin Reindl, Sebastian Johannes Reinstadler, Christina Tiller, Markus Kofler, Markus Theurl, Nora Klier, Katherina Fleischmann, Agnes Mayr, Benjamin Henninger, Gert Klug, Bernhard Metzler
BACKGROUND: The age, creatinine and ejection fraction (ACEF) score has originally been developed for risk stratification of patients undergoing elective cardiac surgery. In patients with stable coronary artery disease treated by percutaneous coronary intervention (PCI), the prognostic accuracy of ACEF could be further improved by modifying the original scoring system (called "modified ACEF" or "ACEF-MDRD"). We aimed to specifically adapt the ACEF score for risk assessment of ST-elevation myocardial infarction (STEMI) patients...
April 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29652655/effect-of-tumour-necrosis-factor-alpha-inhibitors-on-renal-function-in-patients-with-rheumatoid-arthritis-from-the-kobio-registry-from-2012-to-2016
#7
Seong-Kyu Kim, Jung-Yoon Choe, Sang Gyu Kwak, Jisuk Bae, Sung-Hoon Park, Hwajeong Lee
OBJECTIVES: The effect of biological disease-modifying anti-rheumatic drugs (bDMARDs) on renal function in patients with rheumatoid arthritis (RA) has not been well established. We assessed whether tumour necrosis factor (TNF) inhibitors could affect renal function in RA. METHODS: A total of 2110 patients with RA enrolled in the Korean College of Rheumatology Biologics (KOBIO) registry were analysed. All patients were taking bDMARDs or conventional synthetic DMARDs (csDMARDs)...
April 13, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29643894/characteristics-of-clinical-drugs-for-elderly-chronic-heart-failure-complicated-with-different-degrees-of-renal-insufficiency
#8
Hepeng Yu, Jing Chang, Wenwen Zhong, Ping Ye
Objective: To investigate the characteristics of clinical therapeutic drugs in elderly chronic heart failure (CHF) patients complicated with different degrees of renal insufficiency. Methods: The elderly patients who were hospitalized from October 2010 to October 2015 in our hospital due to CHF for the first time were selected by means of retrospective case collection. The glomerular filtration rate was estimated by using the Modification of Diet in Renal Disease (MDRD) Study equation...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29615169/serum-cystatin-c-as-an-early-diagnostic-biomarker-of-diabetic-kidney-disease-in-type-2-diabetic-patients
#9
Ayesha Qamar, Asma Hayat, Tariq Mahmood Ahmad, Alamgir Khan, Mohammad Najam Ul Hasnat, Sufyan Tahir
OBJECTIVE: To determine the diagnostic accuracy and cut-off values of serum cystatin C as early diagnostic biomarker of diabetic kidney disease. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Department of Pathology, Army Medical College, Rawalpindi in collaboration with Endocrinology Department, Military Hospital (MH), Rawalpindi from November 2015 to November 2016. METHODOLOGY: One hundred and nineteen diagnosed patients of type 2 diabetes mellitus were enrolled in the study from the outpatient Endocrinology Department of the MH Rawalpindi...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29594677/monitoring-of-gentamicin-serum-concentrations-in-obstetrics-and-gynaecology-patients-in-namibia
#10
Bonifasius S Singu, Mwangana Mubita, Moses M Thikukutu, Josef K Mufenda, Shonag B McKenzie, Roger K Verbeeck
Background Therapeutic drug monitoring is frequently used to optimize the gentamicin dose. Objective The study investigated whether a 240 mg once daily standard dose achieves the recommended target serum gentamicin concentrations. Setting The prospective, observational study took place in the 2 major public hospitals in Namibia. Method Twenty-nine female patients receiving a standard dose (240 mg gentamicin once daily) participated in the study. Two blood samples were withdrawn to estimate gentamicin pharmacokinetic parameters...
March 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29579818/single-center-long-term-follow-up-of-kidney-donors-in-argentina-hospital-italiano-de-buenos-aires
#11
C A Mombelli, M C Giordani, N C Imperiali, S R Groppa, S K Villamil Cortez, C M Schreck, G J Rosa-Diez
INTRODUCTION: Living kidney donor (LKD) transplantation is increasing due to organ shortage. Clinical studies have shown that the risk of developing end-stage renal disease (ESRD) in donors is similar to that in the general population. Our goal was to evaluate postdonation renal outcomes assessed by glomerular filtration rate (GFR), proteinuria, and blood pressure. METHODS: A total of 210 LKD transplants were performed at Hospital Italiano de Buenos Aires between 2000 and 2014...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29576445/feasibility-of-cisplatin-based-neoadjuvant-chemotherapy-in-muscle-invasive-bladder-cancer-patients-with-diminished-renal-function
#12
Vadim S Koshkin, Pedro C Barata, Lisa A Rybicki, Haris Zahoor, Nima Almassi, Alicia M Redden, Amr F Fergany, Jihad Kaouk, Georges-Pascal Haber, Andrew J Stephenson, Moshe C Ornstein, Timothy Gilligan, Jorge A Garcia, Brian I Rini, Petros Grivas
BACKGROUND: Cisplatin-based neoadjuvant chemotherapy (NAC) before radical cystectomy is the standard of care in muscle-invasive bladder cancer. There are limited data regarding chemotherapy tolerability and outcomes for patients with low glomerular filtration rate (GFR) who receive cisplatin-based NAC. PATIENTS AND METHODS: A retrospective analysis of patients who received cisplatin-based NAC at Cleveland Clinic (2005-2016) was undertaken. Patients with pre-NAC GFR < 60 mL/min by either Cockcroft-Gault (CG) or Modification of Diet in Renal Disease (MDRD) formula were compared to patients with GFR ≥ 60 mL/min for NAC tolerability, pathologic complete and partial response (pPR), and the ability to undergo radical cystectomy...
February 22, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29575113/renal-volume-assessed-by-magnetic-resonance-imaging-volumetry-correlates-with-renal-function-in-living-kidney-donors-pre-and-postdonation-a-retrospective-cohort-study
#13
Daniel Lange, Andreas Helck, Axel Rominger, Alexander Crispin, Bruno Meiser, Jens Werner, Michael Fischereder, Manfred Stangl, Antje Habicht
Renal function of potential living kidney donors is routinely assessed with scintigraphy. Kidney anatomy is evaluated by imaging techniques such as magnetic resonance imaging (MRI). We evaluated if a MRI-based renal volumetry is a good predictor of kidney function pre- and postdonation. We retrospectively analyzed the renal volume (RV) in a MRI of 100 living kidney donors. RV was correlated with the tubular excretion rate (TER) of MAG3-scintigraphy, a measured creatinine clearance (CrCl), and the estimated glomerular filtration rate (eGFR) by Cockcroft-Gault (CG), CKD-EPI, and modification of diet in renal disease (MDRD) formula pre- and postdonation during a follow-up of 3 years...
March 25, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29566373/reclassification-of-chronic-kidney-disease-stage-eligibility-for-cystatin-c-and-its-associated-costs-in-a-uk-primary-care-cohort
#14
Rupert W Major, David Shepherd, Nigel J Brunskill
BACKGROUND AND AIMS: Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) estimations of glomerular filtration rate (eGFR), compared to modification of diet in renal disease (MDRD), have superior performance in predicting renal, cardiovascular and mortality events. Cystatin-C further improves prediction. Our primary aim was to assess the change in prevalence and classification of CKD in converting from MDRD to CKD-EPI in an unselected primary care CKD population. Our secondary aims were to determine the eligibility for cystatin-C testing based on National Institute for Health and Care Excellence guidance and the associated costs...
March 22, 2018: Nephron
https://www.readbyqxmd.com/read/29506739/chronic-kidney-damage-in-the-adult-fontan-population
#15
D Lee, A Levin, M Kiess, G Sexsmith, S Chakrabarti, A Barlow, D Human, J Grewal
OBJECTIVES: 1) To determine the accuracy of estimated GFR (eGFR) as compared to directly measured GFR (mGFR) in the adult Fontan population; 2) to determine the true prevalence of chronic kidney damage (CKD) as determined by uACR AND eGFR. METHODS: Prospective study of 81 patients Fontan patients (≥18years) followed at St. Paul's Hospital, University of British Columbia. CKD-EPI and MDRD equations used to calculate eGFR, mGFR determined by99m Tc-DTPA renal dynamic imaging and urine albumin to creatinine ratios were calculated...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29499890/estimated-glomerular-filtration-rate-laboratory-implementation-and-current-global-status
#16
REVIEW
W Greg Miller, Graham R D Jones
In 2002, the Kidney Disease Outcomes Quality Initiative guidelines for identifying and treating CKD recommended that clinical laboratories report estimated glomerular filtration rate (eGFR) with every creatinine result to assist clinical practitioners to identify people with early-stage CKD. At that time, the original Modification of Diet in Renal Disease (MDRD) Study equation based on serum creatinine measurements was recommended for calculating eGFR. Because the MDRD Study equation was developed using a nonstandardized creatinine method, a Laboratory Working Group of the National Kidney Disease Education program was formed and implemented standardized calibration traceability for all creatinine methods from global manufacturers by approximately 2010...
January 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29499039/performance-of-glomerular-filtration-rate-estimation-equations-in-congolese-healthy-adults-the-inopportunity-of-the-ethnic-correction
#17
Justine B Bukabau, Ernest K Sumaili, Etienne Cavalier, Hans Pottel, Bejos Kifakiou, Aliocha Nkodila, Jean Robert R Makulo, Vieux M Mokoli, Chantal V Zinga, Augustin L Longo, Yannick M Engole, Yannick M Nlandu, François B Lepira, Nazaire M Nseka, Jean Marie Krzesinski, Pierre Delanaye
CONTEXT AND OBJECTIVE: In the estimation of glomerular filtration rate (GFR), ethnicity is an important determinant. However, all existing equations have been built solely from Caucasian and Afro-American populations and they are potentially inaccurate for estimating GFR in African populations. We therefore evaluated the performance of different estimated GFR (eGFR) equations in predicting measured GFR (mGFR). METHODS: In a cross-sectional study, 93 healthy adults were randomly selected in the general population of Kinshasa, Democratic Republic of the Congo, between June 2015 and April 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29481686/estimated-glomerular-filtration-rate-for-longitudinal-follow-up-of-living-kidney-donors
#18
Marco van Londen, Anthony B Wijninga, Jannieta de Vries, Jan-Stephan F Sanders, Margriet F C de Jong, Robert A Pol, Stefan P Berger, Gerjan Navis, Martin H de Borst
Background: Living kidney donor safety requires reliable long-term follow-up of renal function after donation. The current study aimed to define the precision and accuracy of post-donation estimated glomerular filtration rate (eGFR) slopes compared with measured GFR (mGFR) slopes. Methods: In 349 donors (age 51 ± 10, 54% female), we analysed eGFR according to the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault/body surface area (CG/BSA), creatinine clearance (CrCl) and mGFR (125I-iothalamate) changes from 3 months until 5 years post-donation...
February 22, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29471510/moderator-s-view-low-protein-diet-in-chronic-kidney-disease-effectiveness-efficacy-and-precision-nutritional-treatments-in-nephrology
#19
Carmine Zoccali, Francesca Mallamaci
Intention-to-treat and per-protocol analyses provide complementary information about the usefulness of therapies. While intention-to-treat analyses of trials that tested low-protein diets remain debated, per-protocol analyses of the same trials show that low protein intake actually reduces the risk of kidney failure. Per-protocol analyses are notoriously open to bias but intention-to-treat analyses are less immaculate than commonly realized because they critically depend on adherence to the treatment being tested and therefore may not be directly relevant for informing clinical decisions when different degrees of adherence to therapy occur...
February 19, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29464547/comparative-evaluation-of-technetium-99m-diethylenetriaminepentaacetic-acid-renal-dynamic-imaging-versus-the-modification-of-diet-in-renal-disease-equation-and-the-chronic-kidney-disease-epidemiology-collaboration-equation-for-the-estimation-of-gfr
#20
Qi Huang, Yunshuang Chen, Min Zhang, Sihe Wang, Weiguang Zhang, Guangyan Cai, Xiangmei Chen, Xuefeng Sun
PURPOSE: We compared the performance of technetium-99m-diethylenetriaminepentaacetic acid (99m Tc-DTPA) renal dynamic imaging (RDI), the MDRD equation, and the CKD EPI equation to estimate glomerular filtration rate (GFR). METHODS: A total of 551 subjects, including CKD patients and healthy individuals, were enrolled in this study. Dual plasma sample clearance method of99m Tc-DTPA was used as the true value for GFR (tGFR). RDI and the MDRD and CKD EPI equations for estimating GFR were compared and evaluated...
February 20, 2018: International Urology and Nephrology
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