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https://www.readbyqxmd.com/read/29028125/ledipasvir-and-tenofovir-drug-interaction-in-hiv-hcv-co-infected-patients-impact-on-tenofovir-ctrough-and-renal-safety
#1
Caroline Solas, Sylvie Bregigeon, Olivia Faucher-Zaegel, Sylvie Quaranta, Véronique Obry-Roguet, Catherine Tamalet, Bruno Lacarelle, Isabelle Poizot-Martin
We evaluate the impact of ledipasvir on both tenofovir plasma trough concentration (Ctrough ) and estimated glomerular renal function (eGFR) in HIV-HCV co-infected patients receiving a tenofovir(TDF)-based antiretroviral regimen and treated with ledipasvir/sofosbuvir. Twenty-six patients [81% male, median age: 51years; HCV genotype 1(75%)/4(15%)] were included. Tenofovir Ctrough (interquartile:IQR) increased from 78ng/mL (53-110) at baseline to 141ng/mL (72-176) at M1 (p=0.003). No significant difference on eGFR using both Cockroft-Gault and MDRD formula, respectively [median(IQR)] was observed between baseline [101...
October 13, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29025406/impact-of-empagliflozin-on-subclinical-left-ventricular-dysfunctions-and-on-the-mechanisms-involved-in-myocardial-disease-progression-in-type-2-diabetes-rationale-and-design-of-the-empa-heart-trial
#2
Andrea Natali, Lorenzo Nesti, Iacopo Fabiani, Enrico Calogero, Vitantonio Di Bello
BACKGROUND: Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular death and risk factors, aside from lowering plasma glucose levels. With this study we aim at determining whether the treatment with empagliflozin is associated with an improvement in LV functions in diabetic patients with asymptomatic LV dysfunction against Sitagliptin, which is presumably neutral on myocardial function...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28977791/estimation-of-urinary-creatinine-excretion-and-prediction-of-renal-function-in-morbidly-obese-patients-new-tools-from-body-composition-analysis
#3
Carlo Donadio, Diego Moriconi, Rossana Berta, Marco Anselmino
BACKGROUND/AIMS: In obese subjects the accuracy of prediction of renal function is quite low. The aim of this study was to obtain a more accurate estimate of urinary creatinine excretion (UCr), creatinine clearance (CCr), and GFR from body cell mass (BCM). METHODS: Seventy-three adult morbidly obese patients (BMI 35.2-64.5 kg/m2) were examined. BCM was calculated from body impedance analysis. CCr was measured (mCCr) and was predicted from BCM and antropometric data (MR-BCMCCr), with Cockcroft and Gault (C&GCCr) and Salazar and Corcoran (S&CCCr) formulas...
October 5, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28971980/metabolomic-alterations-associated-with-cause-of-ckd
#4
Morgan E Grams, Adrienne Tin, Casey M Rebholz, Tariq Shafi, Anna Köttgen, Ronald D Perrone, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Josef Coresh
BACKGROUND AND OBJECTIVES: Causes of CKD differ in prognosis and treatment. Metabolomic indicators of CKD cause may provide clues regarding the different physiologic processes underlying CKD development and progression. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS: Metabolites were quantified from serum samples of participants in the Modification of Diet in Renal Disease (MDRD) Study, a randomized controlled trial of dietary protein restriction and BP control, using untargeted reverse phase ultraperformance liquid chromatography tandem mass spectrometry quantification...
September 28, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28969990/fasting-sugar-blood-pressure-and-uric-acid-are-factors-related-to-positive-proteinuria-and-an-impaired-egfr
#5
Meng-Hsuan Hsieh, Jeng-Fu Yang, Wen-Yi Lin, Hsu-Han Chien, Mei-Chuan Kuo, Ning-Chia Chang, Chao-Ling Wang, Wan-Long Chuang, Ming-Lung Yu, Chia-Yen Dai
BACKGROUND: The aim of this study was to ascertain the relationships of blood pressure, fasting sugar level, triglyceride (TG) level, uric acid level, and body mass index (BMI) with proteinuria and the estimated glomerular filtration rate (eGFR) in a population from southern Taiwan. METHODS: The 20,900 subjects enrolled in this study had undergone a free adult health examination under the National Health Insurance scheme between September 2005 and June 2011. Factors such as blood pressure, blood sugar, TG, uric acid and BMI were examined in terms of their relationships with the eGFR (calculated according to the Taiwanese Modification of Diet in Renal Disease (Taiwanese-MDRD)) and proteinuria...
September 29, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28964268/a-dual-regimen-of-ritonavir-darunavir-plus-dolutegravir-for-rescue-or-simplification-of-rescue-therapy-48%C3%A2-weeks-observational-data
#6
Amedeo F Capetti, Maria Vittoria Cossu, Giancarlo Orofino, Gaetana Sterrantino, Giovanni Cenderello, Giuseppe V De Socio, Anna Maria Cattelan, Alessandro Soria, Stefano Rusconi, Niccolò Riccardi, Gian Maria Baldin, Fosca P Niero, Giorgio Barbarini, Giuliano Rizzardini
BACKGROUND: Dolutegravir (DTG) plus darunavir/ritonavir (DRV/r) is a simple combination of drugs that has the best genetic barrier to HIV-1 resistance and may be fit for salvage therapy. METHODS: All HIV-1-infected subjects treated with DTG plus DRV/r between March 2014 and September 2015 in eight Italian centres were included in the analysis. The main metabolic data, efficacy parameters and safety data routinely collected were provided. This observational study is aimed to assess the efficacy of such approach...
September 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28929695/-effects-of-mongolia-astragali-radix-in-protecting-early-cardiac-and-nephritic-functions-of-patients-of-hypertension-with-metabolic-syndrome
#7
Ning-Yin Li, Xiu-Li Li, Xiao-Ping Zhai, Qiong-Ying Wang, Xiao-Wei Zhang, Feng Zhao, Xiao-Feng Wang, Jian-Yun Fan, Feng Bai, Jing Yu
To explore the effect of Mongolia Astragali Radix produced in Longxi of Gansu province in protecting cardiac and nephritic functions of patients of essential hypertension(EH) with metabolic syndrome(MetS). A total of two hundred and twenty-six EH patients with MetS aged above 18 were selected. Patients were randomly divided to control group(adopted conventional medical treatment), Astragali Radix group 1(added Astragali Radix capsules 10 g•d⁻¹ besides conventional medical treatment) and Astragali Radix group 2(added Astragali Radix capsules 5 g•d⁻¹ besides conventional medical treatment)...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28913589/estimating-renal-function-in-old-people-an-in-depth-review
#8
REVIEW
Maharajan Raman, Rachel J Middleton, Philip A Kalra, Darren Green
Estimates of glomerular filtration rate (eGFR) should provide accurate measure of an individual's kidney function because important clinical decisions such as timing of renal replacement therapy and drug dosing may be dependent on eGFR. Formulae from which eGFR is derived are generally based on serum creatinine measurement, such as Cockcroft-Gault, MDRD and CKD-EPI. More recently, calculation of eGFR using other laboratory biomarkers such as cystatin C has emerged with apparent greater accuracy. In old people, there is age-related physiological change in the kidney, which could lead to reduced GFR...
November 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28906351/prevalence-evolution-and-related-risk-factors-of-kidney-disease-among-spanish-hiv-infected-individuals
#9
Javier Juega-Mariño, Anna Bonjoch, Nuria Pérez-Alvarez, Eugenia Negredo, Beatriu Bayes, Josep Bonet, Buenaventura Clotet, Ramon Romero
Prevalence of kidney disease (KD) is increasing among human immunodeficiency virus (HIV)-infected population. Different factors have been related, varying on different published series.The objectives were to study prevalence of KD in those patients, its evolution, and associated risk factors.An observational cohort study of 1596 HIV-positive patients with cross-sectional data collection in 2008 and 2010 was conducted. We obtained clinical and laboratory markers, and registered previous or current treatment with tenofovir (TDF) and indinavir (IDV)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28892413/enhancing-the-real-world-prediction-of-cardiovascular-events-and-major-bleeding-with-the-cha2ds2-vasc-and-has-bled-scores-using-multiple-biomarkers
#10
Vanessa Roldán, José Miguel Rivera-Caravaca, Alena Shantsila, Amaya García-Fernández, María Asunción Esteve-Pastor, Juan Antonio Vilchez, Marta Romera, Mariano Valdés, Vicente Vicente, Francisco Marín, Gregory Y H Lip
BACKGROUND: Atrial fibrillation (AF)-European guidelines suggest the use of biomarkers to stratify patients for stroke and bleeding risks. We investigated if a multibiomarker strategy improved the predictive performance of CHA2DS2-VASc and HAS-BLED in anticoagulated AF patients. METHODS: We included consecutive patients stabilized for six months on vitamin K antagonists (INRs 2.0-3.0). High sensitivity troponin T, NT-proBNP, interleukin-6, von Willebrand factor concentrations and glomerular filtration rate (eGFR; using MDRD-4 formula) were quantified at baseline...
September 18, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28876690/evaluating-kidney-function-in-living-donors-in-south-africa
#11
J O Okuthe, G P Candy, A M Meyers, R Britz, N Malan, V Vangu, J Fabian
BACKGROUND: Measurement of glomerular filtration rate (GFR) is the best overall index of kidney function. Equations that estimate GFR (eGFR) have been developed for clinical use such as Cockroft and Gault (C+G), four variable Modification of Diet in Renal Disease (4-v MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Although widely used, they have not been validated in Sub-Saharan Africa. METHOD: Data on 350 adults evaluated for live kidney donation from 1996 to 2013 at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) and Wits Donald Gordon Medical Centre (WDGMC) was reviewed...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874181/effect-of-an-intensive-nutrition-intervention-of-a-high-protein-and-low-glycemic-index-diet-on-weight-of-kidney-transplant-recipients-study-protocol-for-a-randomized-clinical-trial
#12
Elis Forcellini Pedrollo, Bruna Bellincanta Nicoletto, Larissa Salomoni Carpes, Júlia de Melo Cardoso de Freitas, Julia Roberta Buboltz, Cristina Carra Forte, Andrea Carla Bauer, Roberto Ceratti Manfro, Gabriela Corrêa Souza, Cristiane Bauermann Leitão
BACKGROUND: Excessive weight gain is commonly observed within the first year after kidney transplantation and is associated with negative outcomes, such as graft loss and cardiovascular events. The purpose of this study is to evaluate the effect of a high protein and low glycemic-index diet on preventing weight gain after kidney transplantation. METHODS: We designed a prospective, single-center, open-label, randomized controlled study to compare the efficacy of a high protein (1...
September 6, 2017: Trials
https://www.readbyqxmd.com/read/28873373/biomarkers-of-renal-injury-in-cirrhosis-association-with-acute-kidney-injury-and-recovery-after-liver-transplantation
#13
Ashwani K Singal, Bradford Jackson, Glauber B Pereira, Kirk B Russ, Paul Stephen Fitzmorris, Donny Kakati, Page Axley, Sujan Ravi, Toni Seay, Satish P Ramachandra Rao, Ravindra Mehta, Yong-Fang Kuo, Karan P Singh, Anupam Agarwal
BACKGROUND: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). METHODS: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) <60 mL/min provided urine/blood samples at baseline and serially until LT for biomarkers in serum (pg/mL) and urine (pg/mg creatinine). RESULTS: Of 271 LT listed patients (mean age 57 years, 63% males, median listing MELD 17...
September 2, 2017: Nephron
https://www.readbyqxmd.com/read/28860731/egfrs-from-asian-modified-ckd-epi-and-chinese-modified-ckd-epi-equations-were-associated-better-with-hypertensive-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#14
Hongwei Ji, Han Zhang, Jing Xiong, Shikai Yu, Chen Chi, Bin Bai, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
BACKGROUND: With increasing age, estimated glomerular filtration rate (eGFR) decline is a frequent manifestation and is strongly associated with other preclinical target organ damage (TOD). In literature, many equations exist in assessing patients' eGFR. However, these equations were mainly derived and validated in the population from Western countries, which equation should be used for risk stratification in the Chinese population remains unclear, as well as their comparison. Considering that TOD is a good marker for risk stratification in the elderly, in this analysis, we aimed to investigate whether the recent eGFR equations derived from Asian and Chinese are better associated with preclinical TOD than the other equations in elderly Chinese...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28856234/evaluation-of-cystatin-c-in-malignancy-and-comparability-of-estimates-of-gfr-in-oncology-patients
#15
Melissa Jones, Stephanie Denieffe, Ciara Griffin, Willard Tinago, Maria C Fitzgibbon
OBJECTIVES: Creatinine is the biomarker of choice for use in estimates of kidney function in oncology patients. However as non-renal factors such as muscle mass can influence creatinine concentrations, we evaluated cystatin C as an alternative biomarker and its incorporation in GFR estimating formulae in an oncology setting. Measured GFR is infrequently undertaken in adult clinical practice with the consequent reliance on calculated GFR for patient assessment. DESIGN AND METHODS: Cystatin C and creatinine concentrations were evaluated from 134 oncology patients prior to commencing chemotherapeutic cycles...
August 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28827564/the-profile-of-selected-single-nucleotide-polymorphisms-in-patients-with-hypertension-and-heart-failure-with-preserved-and-mid-range-ejection-fraction
#16
Agata Bielecka-Dabrowa, Agata Sakowicz, Tadeusz Pietrucha, Małgorzata Misztal, Piotr Chruściel, Jacek Rysz, Maciej Banach
The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growth factor β (TGF β) rs1800471], endothelial function [-786 T/C nitric oxide synthase (NOS) rs2070744], glucose and lipid metabolism [Pro12Ala peroxisome proliferator activated receptor (PPAR)γ rs1801282], and vitamin D metabolism [cytochrome P450 27B1 (CYP27B1) C-1260A]...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818163/evaluation-of-ckd-epi-pakistan-equation-for-estimated-glomerular-filtration-rate-egfr-acomparison-of-egfr-prediction-equations-in-pakistani-population
#17
Sibtain Ahmed, Lena Jafri, Aysha Habib Khan
OBJECTIVE: To evaluate the results of 24-hour urinary creatinine clearance (CrCl) with estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI Pakistan (CKD-EPI Pak), Cockcroft Gault (CG) and 4-variable Modification of Diet in Renal Disease (MDRD) equations. STUDY DESIGN: Descriptive, cross-sectional study. PLACE AND DURATION OF STUDY: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, from June to October 2013...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28810595/sudoscan-an-effective-tool-for-screening-chronic-kidney-disease-in-patients-with-type-2-diabetes
#18
Fei Mao, Siying Liu, Xiaona Qiao, Hangping Zheng, Qian Xiong, Jie Wen, Shuo Zhang, Zhaoyun Zhang, Hongying Ye, Hongli Shi, Bin Lu, Yiming Li
SUDOSCAN is a non-invasive method of measuring peripheral small fiber and autonomic nerve activity by detection of abnormal sweat gland function through electrochemical skin conductance. It has been reported to be an effective screening tool in early detection of microvascular type 2 diabetes mellitus (T2DM) complications including diabetic neuropathy and nephropathy in recent studies. However, previous studies used estimated glomerular filtration rate (eGFR) as the golden standard, which has a 90% chance of being within 30% of the measured GFR at best...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28805266/hypothermic-pulsatile-preservation-of-kidneys-from-uncontrolled-deceased-donors-after-cardiac-arrest-a-retrospective-study
#19
Xavier Matillon, Fabrice Danjou, Palmina Petruzzo, Olivier Thaunat, Thomas Rimmele, Claire Delsuc, Alexandre Faure, Maud Rabeyrin, Vannary Meas Yedid, William Hanf, Emmanuel Morelon, Lionel Badet, Ricardo Codas
Kidneys from uncontrolled donors after cardiac arrest (uDCD) suffer from a period of warm ischemia between cardiac arrest and cold flushing. Aim of the study was to evaluate renal outcomes of uDCD kidneys selected on the basis of renal Resistance Index (RI) and its influence on graft function and survival. The study included 44 kidneys procured from 26 uDCD starting 1.1.2006 until 12.31.2013. The donors (Maastricht category II) underwent cardiopulmonary resuscitation by assisted ventilation and chest compression; the organs were preserved with in situ cold perfusion or a normothermic regional perfusion...
August 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28799304/comparison-of-two-creatinine-based-equations-for-routine-estimation-of-gfr-in-a-speciality-clinic-for-diabetes
#20
Satyavani Kumpatla, Anju Soni, Vijay Viswanathan
OBJECTIVE: To compare the bias, absolute bias, precision and accuracies between the equations, viz., CKD-EPI (Scr), CKD-EPI (Scys) and MDRD in Indian patients with type 2 diabetes. METHODS: 198 patients who underwent 24 h urinary collection for assessing kidney function between November 2014-January 2015 were included. Cohen's κ coefficient, Bland-Altman plot were calculated between estimated kidney function equations, and bias, precision, accuracies was calculated between the formulae...
August 2017: Journal of the Association of Physicians of India
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