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https://www.readbyqxmd.com/read/28587950/anemia-considerations-when-assessing-natriuretic-peptide-levels-in-ed-patients
#1
Inanc Karakoyun, Ayfer Colak, Fatma Demet Arslan, Aybike Gunaslan Hasturk, Can Duman
INTRODUCTION: The incidence of heart failure (HF) has reached epidemic levels in western populations, and the majority of these patients are admitted to hospitals through the emergency department (ED). We aimed to aid clinicians assessing natriuretic peptide (NP) levels in cases with suspected HF. In this study, we investigated the effect of anemia on amino-terminal pro-BNP (NT-proBNP) and on B-type natriuretic peptide (BNP) levels. METHODS: This retrospective study examined patients who were admitted to the ED with suspected HF...
May 31, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28583572/effect-of-donor-recipient-age-match-in-expanded-criteria-deceased-donor-kidney-transplantation
#2
K Ko, Y H Kim, M H Kim, K W Jun, J K Hwang, S D Kim, S C Park, J I Kim, I S Moon
PURPOSE: Our objective was to investigate the effects of age on patient and graft survival in expanded criteria donor (ECD) renal transplantation. METHODS: Between February 2000 and December 2015, we analyzed 405 deceased donor renal transplants, including 128 grafts (31.9%) from ECDs. Based on recipient age and ECD criteria classification, the recipients were divided into four groups: Group I, non-ECD to recipient age <50 years; Group II, non-ECD to recipient age ≥50 years; Group III, ECD to recipient age <50 years; and Group IV, ECD to recipient age ≥50 years...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28583519/usefulness-of-multi-detector-computed-tomography-scanning-as-a-replacement-for-diethylenetriamine-pentaacetic-acid
#3
H H Lee, W K Han, S K Kang, K H Huh, M S Kim, S I Kim, Y S Kim, Y E Yoon
BACKGROUND: Diethylenetriamine pentaacetic acid (DTPA) and multi-detector computed tomography (MDCT) can predict postoperative estimated glomerular filtration rate (eGFR) in a live kidney donor. Accordingly, we compared predicted eGFR measured by use of DTPA and MDCT. METHODS: From January 2013 to May 2015, 264 live kidney donors were enrolled. All donors underwent preoperative DTPA and MDCT, and bilateral renal cortex volume was measured by use of MDCT. We estimated DTPA-eGFR [remaining split renal function (%) × preoperative eGFR] and Vol-eGFR [remaining renal volume/total renal volume (%) × preoperative eGFR] and analyzed DTPA-eGFR, Vol-eGFR, and Modification of Diet in Renal Disease (MDRD)-eGFR during week 1 and in months 1, 3, and 6...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28583518/cystatin-c-based-equation-for-predicting-the-glomerular-filtration-rate-in-kidney-transplant-recipients
#4
Y Yang, K Y Kim, I Hwang, T Yim, W Do, M J Kim, S Lee, H-Y Jung, J-Y Choi, S-H Park, Y-L Kim, C-D Kim, J-H Cho
BACKGROUND: Precise monitoring of the glomerular filtration rate (GFR) is needed to estimate the allograft function in kidney transplant recipients (KTRs). The GFR is widely estimated with the use of formulas based on serum cystatin C (SCys) and serum creatinine (SCr) levels. We compared the efficacy of SCys-based equations with that of SCr-based equations to predict the allograft function. METHODS: We calculated the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI Cr), CKD-EPI creatinine-cystatin C (CKD-EPI Cr/Cys), and CKD-EPI cystatin C (CKD-EP ICys) equations in 70 KTRs...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28569557/effects-of-acute-blood-pressure-elevation-on-biochemical-metabolic-parameters-in-individuals-with-hypertensive-crisis
#5
Days Oliveira Andrade, Sara Patrícia O Santos, Marcela Augusta S Pinhel, Flávia Mariana Valente, Marcela Cavichiolo Giannini, Michele Lima Gregório, Moacir Fernandes De Godoy, Dorotéia Rossi S Souza, José Fernando Vilela-Martin
Hypertensive crisis is a common clinical situation that presents a high rate of morbidity and mortality and it is characterized by symptomatic rise of blood pressure (BP), systolic (SBP) ≥ 180 mmHg and/or diastolic (DBP) ≥ 120 mmHg. It is classified as emergency (HE) or hypertensive urgency (HU). There is no description of laboratory findings in patients who present acute BP elevation. Thus, this study had the objective to assess the biochemical-metabolic parameters of patients with HC. We studied 74 normotensive individuals (NT), 74 controlled hypertensive patients (ContrHT), 50 subjects with HU, and 78 with HE for evaluating biochemical-metabolic parameters...
June 1, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28565889/renal-function-markers-and-metformin-eligibility
#6
Carlos Tavares Bello, Ricardo Castro Fonseca, Francisco Sousa Santos, João Sequeira Duarte, Jorge Azinheira, Carlos Vasconcelos
BACKGROUND: Metformin is the cornerstone of the pharmacological therapy for type 2 Diabetes (T2D). It belongs to the biguanide class of drugs and it improves hepatic insulin resistance and enhances GLP-1 and peptide YY secretion. Although being considered safe regarding hypoglycemic risk, renal dysfunction remains the main obstacle to its use due to the underlying risk of lactic acidosis. In the recent past many authors used creatinine values as the decisive marker when it came to choose between pharmacological agents in DM...
May 31, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28555040/body-composition-analysis-allows-the-prediction-of-urinary-creatinine-excretion-and-of-renal-function-in-chronic-kidney-disease-patients
#7
Carlo Donadio
The aim of this study was to predict urinary creatinine excretion (UCr), creatinine clearance (CCr) and the glomerular filtration rate (GFR) from body composition analysis. Body cell mass (BCM) is the compartment which contains muscle mass, which is where creatinine is generated. BCM was measured with body impedance analysis in 165 chronic kidney disease (CKD) adult patients (72 women) with serum creatinine (SCr) 0.6-14.4 mg/dL. The GFR was measured ((99m)Tc-DTPA) and was predicted using the Modification of Diet in Renal Disease (MDRD) formula...
May 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28550606/renal-injury-in-pediatric-anorexia-nervosa-a-retrospective-study
#8
Chantal Stheneur, Sebastien J Bergeron, Jean-Yves Frappier, Olivier Jamoulle, Danielle Taddeo, Marc Sznajder, Anne-Laure Lapeyraque
PURPOSE: Although primarily a mental health disorder, anorexia nervosa (AN) has many physical consequences. Among them, the consequences on kidney function are often underestimated. We evaluated renal function in adolescent AN inpatients and investigated the correlation between the GFR and intrinsic patient characteristics. METHODS: A single-center retrospective study was conducted on 51 patients hospitalized for the restrictive type of AN in 2013. Data were divided into: (1) medical history of AN; (2) growth parameters and vital signs upon admission; and (3) blood tests...
May 26, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28540990/change-in-renal-function-among-hiv-infected-koreans-receiving-tenofovir-disoproxil-fumarate-backbone-antiretroviral-therapy-a-3-year-follow-up-study
#9
Kyoung Hwa Lee, Ji Un Lee, Nam Su Ku, Su Jin Jeong, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim
PURPOSE: Tenofovir disoproxil fumarate (TDF) is commonly prescribed as a fixed-dose, co-formulated antiretroviral drug for HIV-1 infection. The major concern of long-term TDF use is renal dysfunction. However, little is known about the long-term patterns of changes in renal function in HIV-infected Koreans receiving TDF. MATERIALS AND METHODS: We prospectively followed 50 HIV-infected Koreans, performing laboratory tests every 3 months during the first year and every 6 months for the next 2 years...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28540888/assessment-of-renal-function-in-indian-patients-with-sickle-cell-disease
#10
Bhaskar V K S Lakkakula, Henu Kumar Verma, Mona Choubey, Suneeta Patra, Prafukka Kumar Khodiar, Pradeep Kumar Patra
Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin. Renal disease is one of the most frequent complications, and kidney damage starts very early and progresses throughout life causing severe complications. The present study is aimed to analyze creatinine-based estimated glomerular filtration rate (eGFR) in 616 SCD patients (507 HbSS and 109 HbSB+), receiving medical care at outpatient wing of Sickle Cell Institute, Chhattisgarh. Glomerular filtration rate (GFR) estimated using the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault, chronic kidney disease epidemiology collaboration (CKD-EPI) (<17 years analyzed with Schwartz), and SCD specific Jamaica Sickle Cell Cohort Study (JSCCS)-GFR equations were compared...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28540634/simplifying-contrast-induced-acute-kidney-injury-prediction-after-primary-percutaneous-coronary-intervention-the-age-creatinine-and-ejection-fraction-score
#11
Gustavo N Araujo, Fernando Pivatto Junior, Bruno Fuhr, Elvis P Cassol, Guilherme P Machado, Felipe H Valle, Luiz C Bergoli, Rodrigo V Wainstein, Carisi A Polanczyk, Marco V Wainstein
Contrast-induced acute kidney injury (CI-AKI) is a common event after percutaneous coronary intervention (PCI). Presently, the main strategy to avoid CI-AKI lies in saline hydration, since to date none pharmacologic prophylaxis proved beneficial. Our aim was to determine if a low complexity mortality risk model is able to predict CI-AKI in patients undergoing PCI after ST elevation myocardial infarction (STEMI). We have included patients with STEMI submitted to primary PCI in a tertiary hospital. The definition of CI-AKI was a raise of 0...
May 24, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28504869/kidney-outcomes-in-patients-with-liver-cirrhosis-and-chronic-kidney-disease-receiving-an-orthotopic-liver-transplant-alone
#12
Neeraj Singh, Shahab Ahmadzadeh, Hosein Shokouh-Amiri, Yasir Qazi, Adrian Sequeira, Hrishikesh Samant, Robert McMillan, Gazi B Zibari
Kidney transplant in patients with liver cirrhosis and non-dialysis chronic kidney disease (CKD) is controversial. We report 14 liver cirrhotic patients who had persistently low MDRD-6 estimated-glomerular filtration rate (e-GFR) < 40 ml/min/1.73m2 for ≥ 3 months and underwent either liver transplant alone (LTA) (n=9) or simultaneous liver-kidney transplant (SLKT) (n=5). Pre-transplant, patients with LTA compared with SLKT had lower serum creatinine (2.5±0.73 vs. 4.6±0.52 mg/dl, P= 0.001), higher MDRD-6 e-GFR (21...
May 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28499765/ckd-epi-equation-a-suitable-glomerular-filtration-rate-estimate-for-drug-dosing-in-hiv-infected-patients
#13
A Gagneux-Brunon, E Botelho-Nevers, P Delanaye, F Lucht, A Frésard, C Cazorla, C Guglielminotti, C Fafin, C Mariat, O Moranne
OBJECTIVES: To evaluate concordance between glomerular filtration rate (GFR) estimates (Cockcroft and Gault, modification of diet in renal diseases, chronic kidney disease epidemiology study group equations) for drug dosing in HIV-infected patients. PATIENTS AND METHODS: We performed a monocentric study. GFR was measured using the gold standard method (plasma clearance of iohexol) in 230 HIV-infected patients. Concordance rate was evaluated between measured GFR (mGFR) and estimated GFR (eGFR) for different GFR categories (GFR>90 mL/min, GFR<90 mL/min, GFR>70 mL/min, and GFR<70 mL/min)...
May 9, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28497083/impact-of-fgf23-level-on-calcium-and-phosphorus-levels-in-post-renal-transplantation
#14
Fereshteh Saddadi, Aida Rasoolzadeh, Mohammadreza Ganji, Maryam Miri
Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. Objectives: The present study aimed to evaluate the prognostic value of FGF23 level to predict renal function after renal transplantation. Patients and Methods: Fifteen consecutive patients scheduled for renal transplantation. To assess renal function status, the MDRD formula and isotope scan were applied. The study endpoint was to assess the level of FGF23 and other factors involving calcium and phosphorus metabolism before and also 3 and 12 months after transplantation and also to determine role of FGF23 to predict postoperative renal function...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28496044/comparison-of-nephrotoxicity-between-two-gadolinium-contrasts-gadodiamide-and-gadopentetate-in-patients-with-mildly-diminished-renal-failure
#15
Shokichi Naito, Hiromi Tazaki, Tomoko Okamoto, Kazuhiro Takeuchi, Shinichi Kan, Yasuo Takeuchi, Kouju Kamata
Although gadolinium (Gd)-based contrast media have been found to be nephrotoxic, their nephrotoxicity, and the dependence of nephrotoxicity on chelate types, have not been assessed in patients with normal or mildly diminished renal failure. This prospective, randomized study compared the nephrotoxicity of low doses of the nonionic Gd-based contrast medium gadodiamide (Omniscan®) and the ionic Gd-based contrast medium gadopentetate (Magnevist®) in patients with serum creatinine < 1.6 mg/dL. Patients aged 20 to 80 years, weighing 45 to 70 kg and with normal or < 1...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28474735/assessment-of-glomerular-filtration-rate-in-health-and-disease-a-state-of-the-art-review-state-of-the-art-review-for-clinical-pharmacology-and-therapeutics
#16
Andrew S Levey, Lesley A Inker
Acute and chronic kidney diseases affect pharmacokinetics and pharmacodynamics. There has been substantial progress in the past 20 years in the use of GFR estimating equations. In principle, use of a single equation for each filtration marker (creatinine, cystatin C or the combination) for detection, evaluation and management of kidney disease and for drug development and dosing would facilitate clinical practice. We review the principles for assessment of GFR, provide historical perspective and updates regarding use of GFR estimating equations, including assay methods for filtration markers, performance of estimating equations, and recommendations by clinical practice guideline groups and regulatory agencies...
May 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28473636/acute-declines-in-renal-function-during-intensive-bp-lowering-implications-for-future-esrd-risk
#17
Elaine Ku, George Bakris, Kirsten L Johansen, Feng Lin, Mark J Sarnak, Vito M Campese, Kenneth Jamerson, Jennifer J Gassman, Miroslaw Smogorzewski, Chi-Yuan Hsu
The magnitude of decline in renal function that should be tolerated during intensive BP lowering and its association with risk of ESRD are unclear. To determine whether the acute declines in kidney function in the intensive BP lowering arm of two trials in CKD associated with higher risk of ESRD, we performed a retrospective study of 899 African American Study of Kidney Disease and Hypertension (AASK) and 761 Modification of Diet in Renal Disease (MDRD) Trial participants previously randomized to strict versus usual BP control...
May 4, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28457375/evaluation-of-renal-function-in-patients-undergoing-lung-transplantation
#18
C Carillo, Y Pecoraro, M Anile, S Mantovani, A Oliva, A D'Abramo, D Amore, A Pagini, T De Giacomo, F Pugliese, E A Rendina, F Venuta, D Diso
BACKGROUND: Acute kidney injury and chronic kidney failure are serious complications after lung transplantation. Glomerular filtration rate (GFR) is the primary indicator of renal function. Several equations have been proposed to evaluate the estimated GFR (eGFR). We compared three different equations to determine which has the better correlation with the development of acute and chronic renal failure in lung recipients. METHODS: Twenty-two patients with a mean age of 54...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28454562/diagnosis-and-outcomes-of-acute-kidney-injury-using-surrogate-and-imputation-methods-for-missing-preadmission-creatinine-values
#19
Amélie Bernier-Jean, William Beaubien-Souligny, Rémi Goupil, François Madore, François Paquette, Stéphan Troyanov, Josée Bouchard
BACKGROUND: Missing preadmission serum creatinine (SCr) values are a common obstacle to assess acute kidney injury (AKI) diagnosis and outcomes. The Kidney Disease Improving Global Outcomes (KDIGO) guidelines suggest using a SCr computed from the Modification of Diet in Renal Disease (MDRD) with an estimated glomerular filtration rate of 75 ml/min/1.73 m(2). We aimed to identify the best surrogate method for baseline SCr to assess AKI diagnosis and outcomes. METHODS: We compared the use of 1) first SCr at hospital admission 2) minimal SCr over 2 weeks after intensive care unit admission 3) MDRD computed SCr and 4) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) computed SCr to assess AKI diagnosis and outcomes...
April 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28443676/pre-operative-nomograms-for-predicting-renal-function-at-1-year-after-partial-nephrectomy
#20
Cheuk Fan Shum, Clinton D Bahler, Clint Cary, Timothy A Masterson, Ronald S Boris, Thomas A Gardner, Hristos Z Kaimakliotis, Rick Foster, Richard Bihrle, Michael Koch, James E Slaven, Chandru P Sundaram
INTRODUCTION: Partial nephrectomy (PN) reduces the risk of post-operative chronic renal insufficiency (CRI). However, some patients still develop CRI after PN, and may eventually require dialysis. Being able to predict renal function before PN helps in counseling patients and managing expectations. We aimed to construct nomograms that predict estimated glomerular filtration rate (eGFR), defined by the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulae, at one year after PN, using only pre-operative covariates as predictors...
April 26, 2017: Journal of Endourology
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