keyword
MENU ▼
Read by QxMD icon Read
search

Excipient

keyword
https://www.readbyqxmd.com/read/29792987/the-rheological-and-textural-characterization-of-soluplus-%C3%A2-vitamin-e-composites
#1
Ahmad Salawi, Sami Nazzal
Soluplus® is a graft amphiphilic copolymer that is frequently used as an excipient in solid dosage forms as a dissolution and a solubility enhancer. We discovered that Soluplus® can be dissolved in vitamin E. The result is a tacky and highly adhesive material. Our research objective was to evaluate the rheological, adhesive, and textural properties of the Soluplus® /Vitamin E composites. In this study, Soluplus® was dissolved under heat in vitamin E at increasing concentrations from 0 to 40% (by weight)...
May 21, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29792985/novel-excipients-regulatory-challenges-and-perspectives-the-eu-insight
#2
Piotr Kozarewicz, Thorsteinn Loftsson
Novel excipients are indispensable in development of modern, advanced drug delivery systems and biotechnology-derived drugs. Although numerous novel excipients are developed for pharmaceutical use, they are not frequently seen in medicinal products due to the strict regulatory requirements and perception that their use makes new product evaluation more complex with risk of delays in the approval process. Regulators regard novel excipients as new substances and whenever new excipient is used in a formulation it must be subjected to full evaluation, similarly to the one required for new active substance...
May 21, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29792715/quantitative-analysis-of-peptide-matrix-interactions-in-lyophilized-solids-using-photolytic-labeling
#3
Yuan Chen, Elizabeth M Topp
Peptide-matrix interactions in lyophilized solids were explored using photolytic labeling and reversed phase high performance liquid chromatography (rp-HPLC) and mass spectrometric (MS) analysis. A model peptide (Ac-QELHKLQ-NHCH3 ) derived from salmon calcitonin was first labeled with a heterobifunctional cross-linker NHS-diazirine (succinimidyl 4,4'-azipentanoate; SDA) at Lys5 in solution, with ~ 100% conversion. The SDA labeled peptide was then formulated with the following excipients at a 1:400 molar ratio and lyophilized: sucrose, trehalose, mannitol, histidine, arginine, urea and NaCl...
May 24, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29791876/extraction-and-characterization-of-cashew-tree-anacardium-occidentale-gum-use-in-aceclofenac-dental-pastes
#4
M Saquib Hasnain, Poonam Rishishwar, Sanjay Rishishwar, Sadath Ali, Amit Kumar Nayak
In the current work, the usefulness of extracted cashew tree gum (CG) as pharmaceutical excipient in dental pastes containing AC (for the pain management in the periodontitis) was investigated. CG was extracted from crude exudate of cashew tree (Anacardium occidentale, family: Anacardiaceae) (yield 19.22%). Physicochemical characteristics like colour, odour, taste, solubility, pH and viscosity of extracted CG were estimated; the phytochemical identification tests indicated the presence of carbohydrates and mucilage within it...
May 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29787965/applications-of-various-analytical-techniques-in-quality-control-of-pharmaceutical-excipients
#5
REVIEW
Manish Kumar, Rohit Bhatia, Ravindra K Rawal
Although excipients are pharmacologically inert substances, still they are integral and significant ingredients of a pharmaceutical formulation. Their amount and concentration level along with the active pharmaceutical ingredients is of utmost importance to decide the pharmacokinetics and stability of a dosage form. It is becoming progressively more important to illustrate the purity of excipients throughout the development and manufacture of pharmaceutical products as the safety and efficacy of the pharmaceutical formulation is largely affected by the quality of excipients...
May 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29787800/the-effect-of-formulation-on-spray-dried-sabin-inactivated-polio-vaccine
#6
Gaurav Kanojia, Rimko Ten Have, Debbie Brugmans, Peter C Soema, Henderik W Frijlink, Jean-Pierre Amorij, Gideon Kersten
The objective of this study was to develop a stable spray dried formulation, containing the three serotypes of Sabin inactivated polio vaccine (sIPV), aiming for minimal loss of native conformation (D-antigen) during drying and subsequent storage. The influence of atomization and drying stress during spray drying on trivalent sIPV was investigated. This was followed by excipient screening, in which monovalent sIPV was formulated and spray dried. Excipient combinations and concentrations were tailored to maximize both the antigen recovery of respective sIPV serotypes after spray drying and storage (T= 40°C and t= 7 days)...
May 19, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29787579/conformity-of-package-inserts-information-to-regulatory-requirements-among-selected-branded-and-generic-medicinal-products-circulating-on-the-east-african-market
#7
Hiiti B Sillo, Nelson E Masota, Sunday Kisoma, Lembit Rago, Veronica Mgoyela, Eliangiringa A Kaale
BACKGROUND: Availability of correct and adequate information about medicines is an important aspect in ensuring rational use of medicines and hence facilitating safety and expected efficacy of medicines during therapy. Package inserts have proven to be a good source of information to the prescribers and patients whereby they have been useful in highlighting important information pertaining proper use and handling of the medicines. The present study was aimed at establishing the extent to which package inserts of medicines circulating on the markets of the East African Community (EAC) Partner States conform to medicines information requirements as established in the harmonized guidelines as well as national guidelines...
2018: PloS One
https://www.readbyqxmd.com/read/29783152/functionalized-graphene-oxides-for-drug-loading-release-and-delivery-of-poorly-water-soluble-anticancer-drug-a-comparative-study
#8
Neha Karki, Himani Tiwari, Mintu Pal, Alok Chaurasia, Rajaram Bal, Penny Joshi, Nanda Gopal Sahoo
In this work, the modification of graphene oxides (GOs) have been done with hydrophilic and biodegradable polymer, polyvinylpyrrolidone (PVP) and other excipient β -cyclodextrin (β-CD) through covalent functionalization for efficient loading and compatible release of sparingly water soluble aromatic anticancer drug SN-38 (7-ethyl-10-hydroxy camptothecin). The drug was loaded onto both GO-PVP and GO-β-CD through the π-π interactions.The release of drug from both the nanocarriers were analyzed in different pH medium of pH 7 (water, neutral medium), pH 5 (acidic buffer) and pH 12 (basic buffer)...
May 18, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29779922/safety-tolerability-acceptability-and-immunogenicity-of-an-influenza-vaccine-delivered-to-human-skin-by-a-novel-high-density-microprojection-array-patch-nanopatch%C3%A2
#9
Germain J P Fernando, Julian Hickling, Cesar M Jayashi Flores, Paul Griffin, Christopher D Anderson, S Rachel Skinner, Cristyn Davies, Katey Witham, Melinda Pryor, Jesse Bodle, Steve Rockman, Ian H Frazer, Angus H Forster
BACKGROUND: Injection using needle and syringe (N&S) is the most widely used method for vaccination, but requires trained healthcare workers. Fear of needles, risk of needle-stick injury, and the need to reconstitute lyophilised vaccines, are also drawbacks. The Nanopatch (NP) is a microarray skin patch comprised of a high-density array of microprojections dry-coated with vaccine that is being developed to address these shortcomings. Here we report a randomised, partly-blinded, placebo-controlled trial that represents the first use in humans of the NP to deliver a vaccine...
May 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29778806/evaluation-of-antioxidant-potential-of-novel-layered-double-hydroxides-with-caal-and-nial-loaded-with-olanzapine
#10
João Gomes Pontes-Neto, Danilo Augusto Ferreira Fontes, Magaly Andreza Marques de Lyra, Maria Dos Remédios Mendes de Brito, Luíse Lopes Chaves, Pedro José Rolim-Neto, Mônica Felts De La Roca Soares, Lucindo Jose Quintans Júnior, Rivelilson Mendes de Freitas, José Lamartine Soares-Sobrinho
Olanzapine (OLZ), Class II in the Biopharmaceutical Classification System, has low aqueous solubility, hindering its absorption after administration. It is used in the bipolar disorder and schizophrenia treatment, diseases that present the oxidative stress in their pathophysiology. In the search for new Drug Delivery Systems (DDS) that enhance the OLZ dissolution rate, it is also necessary to investigate its antioxidant potential for better understanding. Thus, this study aimed to evaluate the in vitro antioxidant potential of new olanzapine DDS based on two different types of Layered Double Hydroxides (LDH systems)...
May 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29777773/progress-in-formulation-development-and-sterilisation-of-freeze-dried-oligodeoxynucleotide-loaded-gelatine-nanoparticles
#11
Katharina J Geh, Madlen Hubert, Gerhard Winter
Oligodeoxynucleotide (ODN)-loaded gelatine nanoparticles (GNPs) have proven their outstanding potential in the treatment of allergic diseases such as equine asthma and canine atopic dermatitis, which are appropriate models for the corresponding human diseases. To encourage the development of a marketable product, long term stability and sterility needs to be ensured. In this work, we aimed to advance freeze-drying options to stabilise ODN-loaded GNPs. Matrix-assisted laser desorption/ionisation mass spectrometry time-of-flight was implemented as a versatile tool to assess ODN stability...
May 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29777772/improving-maraviroc-oral-bioavailability-by-formation-of-solid-drug-nanoparticles
#12
Alison C Savage, Lee M Tatham, Marco Siccardi, Trevor Scott, Manoli Vourvahis, Andrew Clark, Steve P Rannard, Andrew Owen
Oral drug administration remains the preferred approach for treatment of HIV in most patients. Maraviroc (MVC) is the first in class co-receptor antagonist, which blocks HIV entry into host cells. MVC has an oral bioavailability of approximately 33%, which is limited by poor permeability as well as affinity for CYP3A and several drug transporters. While once-daily doses are now the favoured option for HIV therapy, dose-limiting postural hypotension has been of theoretical concern when administering doses high enough to achieve this for MVC (particularly during coadministration of enzyme inhibitors)...
May 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29777764/deformation-behavior-of-crystallized-mannitol-during-compression-using-a-rotary-tablet-press-simulator
#13
Nicolas Tarlier, Ian Soulairol, Noelia Sanchez-Ballester, Gilles Baylac, Adrien Aubert, Philippe Lefevre, Bernard Bataille, Tahmer Sharkawi
Mannitol is commonly used as a pharmaceutical excipient for tablets; the most widely used oral dosage form for drug delivery. For tableting, mannitol is provided in two different forms: native crystals and textured particles. In order to optimize its formulation, a good understanding of the mechanical behavior mechanism of mannitol is necessary. Thus, the aim of this study is to evaluate the deformation mechanism of native mannitol crystals presenting different particle sizes. Pharmaco-technical and compression studies were performed using mannitol with different mean diameters (160 µm, 50 µm and 25 µm)...
May 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29773401/optimization-of-orodispersible-and-conventional-tablets-using-simplex-lattice-design-relationship-among-excipients-and-banana-extract
#14
Sureewan Duangjit, Pakorn Kraisit
The objective of this study was focused on the optimization of the pharmaceutical excipients and banana extract in the preparation of orally disintegrating banana extract tablets (OD-BET) and conventional banana extract tablets (CO-BET) using a simplex lattice design. Various ratios of banana extract (BE), dibasic calcium phosphate (DCP) and microcrystalline cellulose (MCC) were used to prepare banana extract tablets (BET). The results indicated that the optimal OD-BET and CO-BET consisted of BE: DCP: MCC at 10...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772284/effect-of-excipient-properties-water-activity-and-water-content-on-the-disproportionation-of-a-pharmaceutical-salt
#15
Mitulkumar A Patel, Suman Luthra, Sheri L Shamblin, Kapildev K Arora, Joseph F Krzyzaniak, Lynne S Taylor
Excipients are crucial components of most pharmaceutical formulations. In the case of a solid oral dosage formulation containing the salt form of a weakly ionizable drug, excipient selection is critical, as some excipients are known to cause salt disproportionation (conversion of salt to the free form). Therefore, robust formulation design necessitates an in-depth understanding of the factors impacting salt disproportionation during processing or storage as this can negatively impact product quality and performance...
May 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29771175/tamoxifen-citrate-loaded-chitosan-gellan-nanocapsules-for-breast-cancer-therapy-development-characterisation-and-in-vitro-cell-viability-study
#16
Pankaj Kumar Kathle, Nivedita Gautam, Karthikeyan Kesavan
The objective of this study was to evaluate the potential of Chitosan-Gellan nanocapsules (CGNCs) for encapsulation and sustained release of Tamoxifen Citrate (TMC) for breast cancer therapy. Polyelectrolyte complex coacervation method was used for production of CGNCs. Interaction studies were conducted by FT-IR, DSC and XRD to investigate any interaction between drug and excipients. Physicochemical parameters, in vitro drug release and release kinetic were studied. In vitro cell viability study using Michigan Cancer Foundation-7 (MCF-7) breast cancer cells was also investigated...
May 17, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29763689/surface-engineered-excipients-ii-simultaneous-milling-and-dry-coating-for-preparation-of-fine-grade-microcrystalline-cellulose-with-enhanced-properties
#17
Liang Chen, Xiaoyi Ding, Zizhou He, Siqi Fan, Kuriakose T Kunnath, Kai Zheng, Rajesh N Davé
A solventless process for simultaneously milling and dry coating microcrystalline cellulose (MCC) was investigated for producing fine excipients in five different sizes (∼20, 25, 30, 35, 40µm) having high bulk density (BD), good flow function coefficient (FFC), and excellent compaction. Avicel PH-102, used as the starting material, was milled and coated with two grades of silicas, hydrophobic and hydrophilic (R972P and A200), using a fluid energy mill (FEM). Through judicious selection of the FEM feed rate, feeding pressure, and grinding pressure, five desired milled sizes were produced...
May 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29762040/orally-bioavailable-and-effective-buparvaquone-lipid-based-nanomedicines-for-visceral-leishmaniasis
#18
Lindsay A Smith, Dolores Remedios Serrano, Marion Mauger, Francisco Bolás-Fernández, Maria Auxiliadora Dea-Ayuela, Aikaterini Lalatsa
Nano-enabled lipid based drug delivery systems offer a platform to overcome challenges encountered with current failed leads in the treatment of parasitic and infectious diseases. When prepared with FDA or EMA approved excipients, they can be readily translated without the need for further toxicological studies, while they remain affordable and amenable to scale-up. Buparvaquone (BPQ), a hydroxynapthoquinone with in vitro activity in the nanomolar range, failed to clinically translate as a viable treatment for visceral leishmaniasis due to its poor oral bioavailability limited by its poor aqueous solubility (BCS Class II drug)...
May 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29758513/new-approach-for-determination-of-sulfadiazine-in-pharmaceutical-preparations-using-4-4-sulphophenylazo-pyrogallol-kinetic-spectrophotometric-method
#19
Naser A Naser, Kasim M Alasedi, Zainab A Khan
A new trend describes the development and validation of a simple, sensitive and selective kinetic spectrophotometric methods for the determination of sulfadiazine in pharmaceutical formulations has been conducted. In this paper, sulfadiazine was derivatized as a new organic compound 4(4-sulphophenylazo) pyrogallol, 4-SPAP, by coupling pyrogallol with diazotized sulfadiazine in medium of controlled pH. 4-SPAP was characterized by techniques of FT-IR, H-NMR, GC-Mass, TG and DSC thermal analysis methods. Solvatochromic behavior in solvents of various polarities was also investigated...
May 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29758344/the-effects-of-three-absorption-modifying-critical-excipients-on-the-in-vivo-intestinal-absorption-of-six-model-compounds-in-rats-and-dogs
#20
Dahlgren David, Roos Carl, Johansson Pernilla, Tannergren Christer, Lundqvist Anders, Langguth Peter, Sjöblom Markus, Sjögren Erik, Lennernäs Hans
Pharmaceutical excipients that may affect gastrointestinal (GI) drug absorption are called critical pharmaceutical excipients (CPEs), or absorption-modifying excipients (AMEs) if they act by altering the integrity of the intestinal epithelial cell membrane. Some of these excipients increase intestinal permeability, and subsequently the absorption and bioavailability of the drug. This could have implications for both the assessment of bioequivalence and the efficacy of the absorption-enhancing drug delivery system...
May 11, 2018: International Journal of Pharmaceutics
keyword
keyword
82396
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"