keyword
MENU ▼
Read by QxMD icon Read
search

Prdm16

keyword
https://www.readbyqxmd.com/read/28099124/browning-of-white-adipose-tissue-lessons-from-experimental-models
#1
Thereza Cristina Lonzetti Bargut, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Beige or brite (brown-in-white) adipocytes are present in white adipose tissue (WAT) and have a white fat-like phenotype that when stimulated acquires a brown fat-like phenotype, leading to increased thermogenesis. This phenomenon is known as browning and is more likely to occur in subcutaneous fat depots. Browning involves the expression of many transcription factors, such as PR domain containing 16 (PRDM16) and peroxisome proliferator-activated receptor (PPAR)-γ, and of uncoupling protein (UCP)-1, which is the hallmark of thermogenesis...
January 18, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28058730/multilocus-analysis-reveals-three-candidate-genes-for-chinese-migraine-susceptibility
#2
Xing-Kai An, Jie Fang, Zhen-Zhen Yu, Qing Lin, Cong-Xia Lu, Hong-Li Qu, Qi-Lin Ma
Several genome-wide association studies (GWASs) in Caucasian populations have identified 12 loci that are significantly associated with migraine. More evidence suggests that serotonin receptors are also involved in migraine pathophysiology. In the present study, a case-control study was conducted in a cohort of 581 migraine cases and 533 ethnically matched controls among a Chinese population. Eighteen polymorphisms from serotonin receptors and GWASs were selected, and genotyping was performed using a Sequenom MALDI-TOF mass spectrometry iPLEX platform...
January 6, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28046166/expression-of-uncoupling-protein-1-in-bovine-muscle-cells
#3
M A Abd Eldaim, O Hashimoto, H Ohtsuki, T Yamada, M Murakami, K Onda, R Sato, Y Kanamori, Y Qiao, S Tomonaga, T Matsui, M Funaba
Uncoupling protein 1 (Ucp1) is predominantly expressed in brown/beige adipocytes in mammals. Although myogenic cells have been suggested to commit to a brown adipocyte lineage through the induction of Prdm16 expression, Prdm16 is also expressed in skeletal muscle. Thus, we examined expression of Ucp1 in bovine myogenic cells. Considering that Ucp1 is a principle molecule that induces energy expenditure in brown/beige adipocytes, expression of Ucp1 is not preferable in beef cattle because of potential decrease in energy (fattening) efficiency...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27993981/prdm16-is-critical-for-progression-of-the-multipolar-phase-during-neural-differentiation-of-the-developing-neocortex
#4
Mayuko Inoue, Ryota Iwai, Hidenori Tabata, Daijiro Konno, Mariko Komabayashi-Suzuki, Chisato Watanabe, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Fumio Matsuzaki, Koh-Ichi Nagata, Ken-Ichi Mizutani
The precise control of neuronal migration and morphological changes during differentiation is essential for neocortical development. We hypothesized that the transition of progenitors through progressive stages of differentiation involves dynamic changes in mitochondrial reactive oxygen species (mtROS) levels, depending on cell requirements. We found that progenitors had higher levels of mtROS, but that these levels were significantly decreased with differentiation. The Prdm16 gene was identified as a candidate modulator of mtROS using microarray analysis, and was specifically expressed by progenitors in the ventricular zone...
December 19, 2016: Development
https://www.readbyqxmd.com/read/27982067/brown-adipogenic-potential-of-brown-adipocytes-and-peri-renal-adipocytes-from-human-embryo
#5
Nan-Nan Wu, Chuan-Hai Zhang, Hyuek-Jong Lee, Yan Ma, Xin Wang, Xiao-Juan Ma, Wei Ma, Dong Zhao, Ying-Mei Feng
Both brown adipocytes (BAC) and beige cells hold therapeutic potential for the treatment of metabolic disorders. Unfortunately, the amount and activity of these cells are limited in adults. Although BAC marker expression has been shown in peri-renal adipose tissues in children and adults, functional assessment is lacking. Furthermore, it is entirely unknown whether adipose progenitors are present in human embryo and able to give rise to BAC in situ during evolution. Therefore, adipose tissues in the interscapular and peri-renal regions were dissected from human embryo and subcutaneous white adipose tissues (sWAT) were obtained from an adult...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893424/accumulated-promoter-methylation-as-a-potential-biomarker-for-esophageal-cancer
#6
Xianzhen Peng, Hengchuan Xue, Lingshuang Lü, Peiyi Shi, Jianping Wang, Jianming Wang
We performed a two-stage molecular epidemiological study to explore DNA methylation profiles for potential biomarkers of esophageal squamous cell carcinoma (ESCC) in a Chinese population. Infinium Methylation 450K BeadChip was used to identify genes with differentially methylated CpG sites. Sixteen candidate genes were validated by sequencing 1160 CpG sites in their promoter regions using the Illumina MiSeq platform. When excluding sites with negative changes, 10 genes (BNIP3, BRCA1, CCND1, CDKN2A, HTATIP2, ITGAV, NFKB1, PIK3R1, PRDM16 and PTX3) showed significantly different methylation levels among cancer lesions, remote normal-appearing tissues, and healthy controls...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27873458/resveratrol-enhances-brown-adipocyte-formation-and-function-by-activating-amp-activated-protein-kinase-ampk-%C3%AE-1-in-mice-fed-high-fat-diet
#7
Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B D Rodgers, Qingyan Jiang, Michael V Dodson, Min Du
SCOPE: Enhancing the formation and function of brown adipose tissue (BAT) increases thermogenesis and hence reduces obesity. Thus, we investigate the effects of resveratrol (Resv) on brown adipocyte formation and function in mouse interscapular BAT (iBAT). METHODS AND RESULTS: CD1 mice and stromal vascular cells (SVCs) isolated from iBAT were treated with Resv. Expression of brown adipogenic and thermogenic markers, and involvement of AMP-activated protein kinase (AMPK)α1 were assessed...
November 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27833050/eicosapentaenoic-acid-regulates-brown-adipose-tissue-metabolism-in-high-fat-fed-mice-and-in-clonal-brown-adipocytes
#8
Mandana Pahlavani, Fitia Razafimanjato, Latha Ramalingam, Nishan S Kalupahana, Hanna Moussa, Shane Scoggin, Naima Moustaid-Moussa
Brown adipose tissue (BAT) plays a key role in energy expenditure through its specialized thermogenic function. Therefore, BAT activation may help prevent and/or treat obesity. Interestingly, subcutaneous white adipose tissue (WAT) also has the ability to differentiate into brown-like adipocytes and may potentially contribute to increased thermogenesis. We have previously reported that eicosapentaenoic acid (EPA) reduces high-fat (HF)-diet-induced obesity and insulin resistance in mice. Whether BAT mediates some of these beneficial effects of EPA has not been determined...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27824141/nesfatin-1-promotes-brown-adipocyte-phenotype
#9
Yuexin Wang, Ziru Li, Xinyu Zhang, Xinxin Xiang, Yin Li, Michael W Mulholland, Weizhen Zhang
Nesfatin-1, an 82 amino acid gastric peptide, is involved in regulation of food uptake and in multiple metabolic activities. Whether nesfatin-1 modulates the differentiation and lipid metabolism of brown adipocytes remains unknown. In the present study, we found that nesfatin-1 mRNA and protein were detectable in isolated brown adipocytes and gradually decreased during differentiation (95% CI 0.6057 to 1.034, p = 0.0001). The decrease in nesfatin-1 was associated with a significant reduction in p-S6. Exposure to nesfatin-1 promoted differentiation of brown adipocytes as revealed by a significant increase in UCP1 mRNA (p = 0...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802075/kinase-inactive-tyrosine-kinase-tyk2-supports-differentiation-of-brown-fat-cells
#10
Vidisha Raje, Marta Derecka, Marc Cantwell, Jeremy Meier, Karol Szczepanek, Jennifer D Sisler, Birgit Strobl, Ana Gamero, Thurl E Harris, Andrew C Larner
It has been known for decades that brown adipose tissue plays a central role in maintaining body temperature in hibernating animals, and human infants. Recently it has become evident that there are also depots of brown fat in adult humans, and the mass of brown fat is inversely correlated with body weight. There are a variety of transcription factors implicated in the differentiation of classical Myf5+ brown preadipocytes, one of the most important of which is PRDM16. We have recently identified that in addition to PRDM16, the tyrosine kinase Tyk2 and the STAT3 transcription factor are required for the differentiation of Myf5 positive brown preadipocytes both in cell culture and in mice...
November 1, 2016: Endocrinology
https://www.readbyqxmd.com/read/27758866/mitochondrial-activity-in-human-white-adipocytes-is-regulated-by-the-ubiquitin-carrier-protein-9-microrna-30a-axis
#11
Eun Hee Koh, Yong Chen, David A Bader, Mark P Hamilton, Bin He, Brian York, Shingo Kajimura, Sean E McGuire, Sean M Hartig
The acquisition of beige adipocyte features by white fat cells corresponds to protection against obesity-induced metabolic diseases in humans and animal models of type 2 diabetes. In adipose tissue, expression of the E2 small ubiquitin-like modifier ligase ubiquitin carrier protein 9 (Ubc9) is positively correlated with markers of insulin resistance and corresponds with impaired browning of human white adipocytes. However, the molecular regulation of Ubc9 expression in adipocytes and other cells remains unclear...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27693382/effects-of-physical-exercise-on-myokines-expression-and-brown-adipose-like-phenotype-modulation-in-rats-fed-a-high-fat-diet
#12
Sílvia Rocha-Rodrigues, Amaia Rodríguez, Alexandra M Gouveia, Inês O Gonçalves, Sara Becerril, Beatriz Ramírez, Jorge Beleza, Gema Frühbeck, António Ascensão, José Magalhães
AIMS: Exercise-stimulated myokine secretion into circulation may be related with browning in white adipose tissue (WAT), representing a positive metabolic effect on whole-body fat mass. However, limited information is yet available regarding the impact of exercise on myokine-related modulation of adipocyte phenotype in WAT from obese rats. MAIN METHODS: Sprague-Dawley rats (n=60) were divided into sedentary and voluntary physical activity (VPA) groups and fed with standard (35kcal% fat) or high-fat (HFD, 71kcal% fat)-isoenergetic diets...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27642787/ipsc-derived-cardiomyocytes-reveal-abnormal-tgf-%C3%AE-signalling-in-left-ventricular-non-compaction-cardiomyopathy
#13
Kazuki Kodo, Sang-Ging Ong, Fereshteh Jahanbani, Vittavat Termglinchan, Keiichi Hirono, Kolsoum InanlooRahatloo, Antje D Ebert, Praveen Shukla, Oscar J Abilez, Jared M Churko, Ioannis Karakikes, Gwanghyun Jung, Fukiko Ichida, Sean M Wu, Michael P Snyder, Daniel Bernstein, Joseph C Wu
Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in children and its pathogenesis has been associated with the developmental defect of the embryonic myocardium. We show that patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from LVNC patients carrying a mutation in the cardiac transcription factor TBX20 recapitulate a key aspect of the pathological phenotype at the single-cell level and this was associated with perturbed transforming growth factor beta (TGF-β) signalling...
October 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27641099/ampk-%C3%AE-ketoglutarate-axis-dynamically-mediates-dna-demethylation-in-the-prdm16-promoter-and-brown-adipogenesis
#14
Qiyuan Yang, Xingwei Liang, Xiaofei Sun, Lupei Zhang, Xing Fu, Carl J Rogers, Anna Berim, Shuming Zhang, Songbo Wang, Bo Wang, Marc Foretz, Benoit Viollet, David R Gang, Buel D Rodgers, Mei-Jun Zhu, Min Du
Promoting brown adipose tissue (BAT) development is an attractive strategy for the treatment of obesity, as activated BAT dissipates energy through thermogenesis; however, the mechanisms controlling BAT formation are not fully understood. We hypothesized that as a master regulator of energy metabolism, AMP-activated protein kinase (AMPK) may play a direct role in the process and found that AMPKα1 (PRKAA1) ablation reduced Prdm16 expression and impaired BAT development. During early brown adipogenesis, the cellular levels of α-ketoglutarate (αKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 promoter...
October 11, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27601528/lsd1-a-pivotal-epigenetic-regulator-of-brown-and-beige-fat-differentiation-and-homeostasis
#15
Jean Z Lin, Stephen R Farmer
In this issue of Genes & Development, Zeng and colleagues (pp. 1822-1836) identify lysine-specific demethylase 1 (LSD1) as a pivotal regulator of whole-body energy expenditure by controlling the oxidative and thermogenic activity of brown adipose tissue (BAT). They show that LSD1 interacts with PRDM16 to repress select white adipose tissue (WAT) genes but also represses hydroxysteroid 11-β-dehydrogenase 1 (HSD11B1) independently of PRDM16 to prevent production of glucocorticoids that impair BAT functions. Their study provides important insight into epigenetic mechanisms regulating the function of BAT...
August 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27598888/artepillin-c-a-typical-brazilian-propolis-derived-component-induces-brown-like-adipocyte-formation-in-c3h10t1-2-cells-primary-inguinal-white-adipose-tissue-derived-adipocytes-and-mice
#16
Sho Nishikawa, Hiroki Aoyama, Misa Kamiya, Jun Higuchi, Aiko Kato, Minoru Soga, Taeko Kawai, Kazuki Yoshimura, Shigenori Kumazawa, Takanori Tsuda
Induction of brown-like adipocytes (beige/brite cells) in white adipose tissue (WAT) suggests a new approach for preventing and treating obesity via induction of thermogenesis associated with uncoupling protein 1 (UCP1). However, whether diet-derived factors can directly induce browning of white adipocytes has not been well established. In addition, the underlying mechanism of induction of brown-like adipocytes by diet-derived factors has been unclear. Here, we demonstrate that artepillin C (ArtC), which is a typical Brazilian propolis-derived component, significantly induces brown-like adipocytes in murine C3H10T1/2 cells and primary inguinal WAT (iWAT)-derived adipocytes...
2016: PloS One
https://www.readbyqxmd.com/read/27585642/genome-wide-dna-methylation-patterns-in-cd4-t-cells-from-chinese-han-patients-with-rheumatoid-arthritis
#17
Shicheng Guo, Qi Zhu, Ting Jiang, Rongsheng Wang, Yi Shen, Xiao Zhu, Yan Wang, Fengmin Bai, Qin Ding, Xiaodong Zhou, Guangjie Chen, Dong Yi He
INTRODUCTION: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Recent evidence indicated the epigenetic changes may contribute to the pathogenesis of RA. METHOD: To understand the extent and nature of dysregulated DNA methylation in RA CD4T cells, we performed a genome-wide DNA methylation study in CD4 + T cells in 12 RA patients compared to 12 matched normal healthy controls. Cytosine methylation status was quantified with Illumina methylation 450K microarray...
September 1, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27566776/lysine-specific-demethylase-1-promotes-brown-adipose-tissue-thermogenesis-via-repressing-glucocorticoid-activation
#18
Xing Zeng, Mark P Jedrychowski, Yi Chen, Sara Serag, Gareth G Lavery, Steve P Gygi, Bruce M Spiegelman
Brown adipocytes display phenotypic plasticity, as they can switch between the active states of fatty acid oxidation and energy dissipation versus a more dormant state. Cold exposure or β-adrenergic stimulation favors the active thermogenic state, whereas sympathetic denervation or glucocorticoid administration promotes more lipid accumulation. Our understanding of the molecular mechanisms underlying these switches is incomplete. Here we found that LSD1 (lysine-specific demethylase 1), a histone demethylase, regulates brown adipocyte metabolism in two ways...
August 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27560520/genome-wide-association-study-reveals-multiple-loci-influencing-normal-human-facial-morphology
#19
John R Shaffer, Ekaterina Orlova, Myoung Keun Lee, Elizabeth J Leslie, Zachary D Raffensperger, Carrie L Heike, Michael L Cunningham, Jacqueline T Hecht, Chung How Kau, Nichole L Nidey, Lina M Moreno, George L Wehby, Jeffrey C Murray, Cecelia A Laurie, Cathy C Laurie, Joanne Cole, Tracey Ferrara, Stephanie Santorico, Ophir Klein, Washington Mio, Eleanor Feingold, Benedikt Hallgrimsson, Richard A Spritz, Mary L Marazita, Seth M Weinberg
Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet little is known about how specific genetic variants relate to the phenotypic expression of many common facial features. We conducted genome-wide association meta-analyses of 20 quantitative facial measurements derived from the 3D surface images of 3118 healthy individuals of European ancestry belonging to two US cohorts. Analyses were performed on just under one million genotyped SNPs (Illumina OmniExpress+Exome v1.2 array) imputed to the 1000 Genomes reference panel (Phase 3)...
August 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27549402/central-chronic-apelin-infusion-decreases-energy-expenditure-and-thermogenesis-in-mice
#20
Anne Drougard, Audren Fournel, Alysson Marlin, Etienne Meunier, Anne Abot, Tereza Bautzova, Thibaut Duparc, Katie Louche, Aurelie Batut, Alexandre Lucas, Sophie Le-Gonidec, Jean Lesage, Xavier Fioramonti, Cedric Moro, Philippe Valet, Patrice D Cani, Claude Knauf
Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose production, and then contributes to the onset of type 2 diabetes. However, the molecular mechanisms behind deleterious effects of chronic apelin in the brain and consequences on energy expenditure and thermogenesis are currently unknown. We aimed to evaluate the effects of chronic intracerebroventricular (icv) infusion of apelin in normal mice on hypothalamic inflammatory gene expression, energy expenditure, thermogenesis and brown adipose tissue functions...
August 23, 2016: Scientific Reports
keyword
keyword
82394
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"