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lead toxicity in herbal supplements

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https://www.readbyqxmd.com/read/27364782/case-of-acute-lead-toxicity-associated-with-ayurvedic-supplements
#1
Amelia Breyre, Judith Green-McKenzie
Use of traditional folkloric remedies not disclosed to the physician may be difficult to identify as a source of lead toxicity. This report illustrates the presentation of a 26-year-old man who, during his 1 month vacation in India, was treated for low back pain with Ayurvedic herbal medicine. On his return to the USA, he presented to the emergency department with epigastric pain, weight loss, dark stools, nausea and vomiting. He was admitted and noted to be anaemic with a blood lead level (BLL) of 94.8 µg/dL...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27058252/concentrations-of-trace-elements-in-organic-fertilizers-and-animal-manures-and-feeds-and-cadmium-contamination-in-herbal-tea-gynostemma-pentaphyllum-makino
#2
Sumontha Nookabkaew, Nuchanart Rangkadilok, Norratouch Prachoom, Jutamaad Satayavivad
Thailand is predominantly an agriculture-based country. Organic farming is enlisted as an important national agenda to promote food safety and international export. The present study aimed to determine the concentrations of trace elements in commercial organic fertilizers (fermented and nonfermented) composed of pig and cattle manures available in Thailand. Pig and cattle manures as well as animal feeds were also collected from either animal farms or markets. The results were compared to the literature data from other countries...
April 27, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/26210820/-phytovigilance-a-medical-requirement-and-a-legal-obligation
#3
H Lehmann, J-Y Pabst
Phytovigilance consists in supervision of side effects and drug interactions consequential to use of herbal medicinal products, herbal food supplements, herbal cosmetics and/or medicinal plants. It includes thus pharmacovigilance applied to phytotherapy, nutrivigilance and cosmetovigilance but also addictovigilance in case of plants, which lead to drug addiction, and toxicovigilance in case of toxic plants. Becoming necessary owing to (acute or chronic) toxicity risks or to drug interactions risks (of pharmacocinetical or pharmacodynamical kind)--as far as it concerns interactions between several associated plants or between a plant and a chemical or biotechnological allopathic medicine--phytovigilance represents moreover a legal obligation...
January 2016: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/26139922/comparative-inhibitory-potential-of-selected-dietary-bioactive-polyphenols-phytosterols-on-cyp3a4-and-cyp2d6-with-fluorometric-high-throughput-screening
#4
Thangavel Mahalingam Vijayakumar, Ramasamy Mohan Kumar, Aruna Agrawal, Govind Prasad Dubey, Kaliappan Ilango
Cytochrome P450 (CYP450) inhibition by the bioactive molecules of dietary supplements or herbal products leading to greater potential for toxicity of co-administered drugs. The present study was aimed to compare the inhibitory potential of selected common dietary bioactive molecules (Gallic acid, Ellagic acid, β-Sitosterol, Stigmasterol, Quercetin and Rutin) on CYP3A4 and CYP2D6 to assess safety through its inhibitory potency and to predict interaction potential with co-administered drugs. CYP450-CO complex assay was carried out for all the selected dietary bioactive molecules in isolated rat microsomes...
July 2015: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/25843124/a-cluster-of-lead-poisoning-among-consumers-of-ayurvedic-medicine
#5
Laura Breeher, Marek A Mikulski, Thomas Czeczok, Kathy Leinenkugel, Laurence J Fuortes
BACKGROUND: Use of alternative medications and herbal remedies is widespread in the United States and across the globe. These traditional medications can be contaminated with toxic metals. Despite several case reports of poisoning from such contamination, the epidemiological data are still limited. OBJECTIVES: To report on a cluster of lead and mercury toxicity cases in 2011 among a community of adherents of traditional medical practice of Ayurveda. METHODS: Adherents of Ayurveda were offered heavy metals screening following the identification of the index case...
2015: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/25029655/simultaneous-interstitial-pneumonitis-and-cardiomyopathy-induced-by-venlafaxine
#6
Pedro Gonçalo Ferreira, Susana Costa, Nuno Dias, António Jorge Ferreira, Fátima Franco
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an antidepressant. Interindividual variability and herb-drug interactions can lead to drug-induced toxicity. We report the case of a 35-year-old female patient diagnosed with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. The patient sought medical attention due to dyspnea and dry cough that started three months after initiating treatment with venlafaxine for depression. The patient was concomitantly taking Centella asiatica and Fucus vesiculosus as phytotherapeutic agents...
May 2014: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/24696463/metabolic-activation-of-the-indoloquinazoline-alkaloids-evodiamine-and-rutaecarpine-by-human-liver-microsomes-dehydrogenation-and-inactivation-of-cytochrome-p450-3a4
#7
Bo Wen, Vikram Roongta, Liling Liu, David J Moore
Evodiamine and rutaecarpine are the main active indoloquinazoline alkaloids of the herbal medicine Evodia rutaecarpa, which is widely used for the treatment of hypertension, abdominal pain, angina pectoris, gastrointestinal disorder, and headache. Immunosuppressive effects and acute toxicity were reported in mice treated with evodiamine and rutaecarpine. Although the mechanism remains unknown, it is proposed that metabolic activation of the indoloquinazoline alkaloids and subsequent covalent binding of reactive metabolites to cellular proteins play a causative role...
June 2014: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/24275167/emerging-drugs-of-abuse
#8
REVIEW
Michael E Nelson, Sean M Bryant, Steven E Aks
Many new emerging drugs of abuse are marketed as legal highs despite being labeled "not for human consumption" to avoid regulation. The availability of these substances over the Internet and in "head shops" has lead to a multitude of emergency department visits with severe complications including deaths worldwide. Despite recent media attention, many of the newer drugs of abuse are still largely unknown by health care providers. Slight alterations of the basic chemical structure of substances create an entirely new drug no longer regulated by current laws and an ever-changing landscape of clinical effects...
February 2014: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/23899130/herbal-drug-interaction-induced-rhabdomyolysis-in-a-liposarcoma-patient-receiving-trabectedin
#9
Sabino Strippoli, Vito Lorusso, Anna Albano, Michele Guida
BACKGROUND: Rhabdomyolysis is an uncommon side effect of trabectedin which is used for the second line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. This side effect may be due to pharmacokinetic interactions caused by shared mechanisms of metabolism involving the cytochrome P450 (CYP) system in the liver. Here, for the first time in literature, we describe the unexpected onset of heavy toxicity, including rhabdomyolysis, after the fourth course of trabectedin in a patient with retroperitoneal liposarcoma who at the same time was taking an alternative herbal medicine suspected of triggering this adverse event...
July 30, 2013: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/23836259/metabolic-pathways-leading-to-detoxification-of-triptolide-a-major-active-component-of-the-herbal-medicine-tripterygium-wilfordii
#10
Fuying Du, Zhaohua Liu, Xinxiu Li, Jie Xing
Triptolide (TP) shows promising anti-inflammatory and antitumor activity but with severe toxicity. TP is a natural reactive electrophile containing three epoxide groups, which are usually linked to hepatotoxicity via their ability to covalently bind to cellular macromolecules. In this study, metabolic pathways leading to detoxification of TP were evaluated in glutathione (GSH)-depleted (treated with L-buthionine-S,R-sulfoxinine, BSO) and aminobenzotriazole (ABT; a non-specific inhibitor for P450s)-treated mice...
August 2014: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/23289831/the-effects-of-flavonoids-on-the-abc-transporters-consequences-for-the-pharmacokinetics-of-substrate-drugs
#11
REVIEW
Yan Li, James W Paxton
INTRODUCTION: The flavonoids are a large group of dietary plant compounds with suggested health benefits. There is accumulating evidence that many of these flavonoids can interact with the major drug transporters (and metabolizing enzymes) in the body, leading to alterations in the pharmacokinetics of substrate drugs, and thus their efficacy and toxicity. AREAS COVERED: This review summarizes and updates the reported in vitro and in vivo interactions between common dietary flavonoids and the major drug-effluxing ABC transporters; these include P-glycoprotein, breast cancer resistance protein and multidrug resistance proteins 1 and 2...
March 2013: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/23185404/toxic-element-contamination-of-natural-health-products-and-pharmaceutical-preparations
#12
Stephen J Genuis, Gerry Schwalfenberg, Anna-Kristen J Siy, Ilya Rodushkin
BACKGROUND: Concern has recently emerged regarding the safety of natural health products (NHPs)-therapies that are increasingly recommended by various health providers, including conventional physicians. Recognizing that most individuals in the Western world now consume vitamins and many take herbal agents, this study endeavored to determine levels of toxic element contamination within a range of NHPs. METHODS: Toxic element testing was performed on 121 NHPs (including Ayurvedic, traditional Chinese, and various marine-source products) as well as 49 routinely prescribed pharmaceutical preparations...
2012: PloS One
https://www.readbyqxmd.com/read/23105753/lead-toxicity-as-a-result-of-herbal-medication
#13
A Ravi Raja, G N Vishal Babu, Geraldine Menezes, T Venkatesh
Awareness about the toxic effects of non-essential metals is still lacking in developing countries. Lead is one among them, which ranks second in the Agency for Toxic Substances and Disease Registry' s top 20 lists of toxic metals. Some of the herbal medicines prepared from certain roots and leaves are known to contain this toxic metal at alarming levels. We have a case of a person who suffered from the toxic effects of lead such as vomiting and colicky abdominal pain after consuming a herbal remedy for Jaundice treatment...
April 2008: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/22195249/drug-induced-liver-injury-twenty-five-cases-of-acute-hepatitis-following-ingestion-of-polygonum-multiflorum-thunb
#14
Kyoung Ah Jung, Hyun Ju Min, Seung Suk Yoo, Hong Jun Kim, Su Nyoung Choi, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee, Jong Sil Lee, Sang Goon Shim
BACKGROUND/AIMS: Complementary medicines, including herbal preparations and nutritional supplements, are widely used without prescriptions. As a result, there has been growing interest in the risk of hepatotoxicity with these agents. It is difficult to determine causal relationships between these herbal preparations and hepatotoxicity. We report on 25 patients diagnosed with toxic hepatitis following ingestion of Polygonum multiflorum Thunb. METHODS: Twenty-five patients (median age, 48 years [24 to 65 years]; M:F=18:7) with suspected P...
December 2011: Gut and Liver
https://www.readbyqxmd.com/read/21453474/prenatal-exposure-of-a-girl-with-autism-spectrum-disorder-to-horsetail-equisetum-arvense-herbal-remedy-and-alcohol-a-case-report
#15
Juan A Ortega García, Mario G Angulo, Elías J Sobrino-Najul, Offie P Soldin, Alberto Puche Mira, Eduardo Martínez-Salcedo, Luz Claudio
INTRODUCTION: Autism is a complex neurodevelopmental disorder in which the interactions of genetic, epigenetic and environmental influences are thought to play a causal role. In humans, throughout embryonic and fetal life, brain development is exquisitely susceptible to injury caused by exposure to toxic chemicals present in the environment. Although the use of herbal supplements during pregnancy is relatively common, little information is available on their association with fetal neurodevelopment...
March 31, 2011: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/20929054/effects-of-diesel-exhaust-heavy-metals-and-pesticides-on-various-organ-systems-possible-mechanisms-and-strategies-for-prevention-and-treatment
#16
REVIEW
Kavita Gulati, Basudeb Banerjee, Shyam Bala Lall, Arunabha Ray
Environmental pollutants have a significant impact on the ecosystem and disrupt balance between environment, human and non-human components that result in deleterious effects to all forms of life. Identifying environmental factors for potential imbalance are extremely crucial for devising strategies for combating such toxic dysregulation. Automobile exhaust (in air), heavy metals (in food and water) and pesticides (in air, food, soil and water) are the most common environmental pollutants and their short and long-term exposures can cause hazardous effects in humans leading to systemic disorders involving lungs, kidney and immune systems...
July 2010: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/20390968/gene-expression-profiling-as-an-initial-approach-for-mechanistic-studies-of-toxicity-and-tumorigenicity-of-herbal-plants-and-herbal-dietary-supplements
#17
REVIEW
Lei Guo, Nan Mei, Qingsu Xia, Tao Chen, Po-Chuen Chan, Peter P Fu
Dietary supplements are consumed by more than 300 million people worldwide, and herbal dietary supplements represent the most rapidly growing portion of this industry. Even though adverse health effects of many herbal dietary supplements have been reported, safety assurances are not being addressed adequately. Toxicological data on the identification of genotoxic and tumorigenic ingredients in many raw herbs are also lacking. Currently, more than 30 herbal dietary supplements and active ingredients have been selected by the National Toxicology Program (NTP) for toxicity and tumorigenicity studies...
January 2010: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/20387234/reversal-effect-of-stephania-tetrandra-containing-chinese-herb-formula-senl-on-multidrug-resistance-in-lung-cancer-cell-line-sw1573-2r120
#18
Meng Xu, Liang-He Sheng, Xi-Hai Zhu, Shi-Bin Zeng, Guo-Jun Zhang
This research is aimed on reversing multidrug resistance (MDR) of chemotherapy in lung cancer. According to our previous research, chemotherapeutic drugs resistance in lung cancer is mainly due to high expression of multidrug resistance-associated protein (MRP) gene and activation of caspases. The effect of stephania tetrandra-containing Chinese herbal formula, namely Supplement Energy and Nourish Lung (SENL), is effective in enhancing efficacy and reducing toxicity of chemotherapy in lung cancer. However, the underlying mechnism is largely unknown...
2010: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/20196838/pregnane-x-receptor-pxr-expression-in-colorectal-cancer-cells-restricts-irinotecan-chemosensitivity-through-enhanced-sn-38-glucuronidation
#19
Caroline Raynal, Jean-Marc Pascussi, Géraldine Leguelinel, Cyril Breuker, Jovana Kantar, Benjamin Lallemant, Sylvain Poujol, Caroline Bonnans, Dominique Joubert, Frédéric Hollande, Serge Lumbroso, Jean-Paul Brouillet, Alexandre Evrard
BACKGROUND: Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity. The topoisomerase I inhibitor irinotecan (CPT-11) is worldwide approved for the treatment of metastatic colorectal cancer and undergoes extensive peripheral and tumoral metabolism. PXR is a xenoreceptor activated by many drugs and environmental compounds regulating the expression of drug metabolism and transport genes in detoxification organs such as liver and gastrointestinal tract...
2010: Molecular Cancer
https://www.readbyqxmd.com/read/19334748/use-of-field-portable-xrf-analyzers-for-rapid-screening-of-toxic-elements-in-fda-regulated-products
#20
COMPARATIVE STUDY
Peter T Palmer, Richard Jacobs, Peter E Baker, Kelly Ferguson, Siri Webber
Analytical instrumentation continues its amazing evolution, especially in regard to generating ever more sensitive, faster, and reliable measurements. Perhaps the most difficult challenges are making these instruments small enough to use in the field, equipping them with well-designed software that facilitates and simplifies their use by nonexperts while preserving enough of their analytical capabilities to render them useful for a wide variety of applications. Perhaps the most impressive and underappreciated example of instruments that meet these criteria are field-portable X-ray fluorescence (XRF) analyzers...
April 8, 2009: Journal of Agricultural and Food Chemistry
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